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Growth hormone, insulin may be key to longevity
Reuters via Yahoo ^ | Megan Rauscher

Posted on 05/08/2006 2:57:12 PM PDT by Pharmboy

A number of studies have shown that restricting calories increases the lifespan of animals, but the biological basis for this has remained elusive. A new report hints that growth hormone, as well as insulin, are key factors in the life-extending effects of calorie restriction.

"The implication ... for pharmaceutical development would be that the signaling pathways of growth hormone and insulin may be logical targets for development of anti-aging medicine," Dr. Andrezej Bartke from Southern Illinois University in Springfield told Reuters Health.

"Although it would be irresponsible to recommend that healthy people start using anti-diabetic drugs," said Bartke, "it is reasonable to suggest that treatment(s) causing an improvement in insulin sensitivity combined with modest reduction in insulin release would reduce risk of age-related disease and likely also delay aging."

Bartke's team tested whether growth hormone and insulin are tied to the life-extending effects of calorie restriction in a series of experiments with normal mice and mutant mice deficient in growth hormone.

The mutant mice do not express the receptor for growth hormone (and are therefore growth hormone resistant), have profoundly suppressed insulin levels, and are known to live longer and age more slowly than normal mice, the researchers note in Proceedings of the National Academy of Sciences.

As expected, the team observed that restricting food increases longevity in normal healthy mice. Reduced feeding increased lifespan by about 19 percent in normal male mice and by about 28 percent in normal female mice.

However, in sharp contrast to its effects in normal mice, calorie restriction failed to increase lifespan in mutant mice lacking growth hormone receptor. "The present findings show that growth hormone resistant mice fail to respond normally to calorie restriction, a very effective life-extending intervention," Bartke said.

"The key implication of this study is that growth hormone receptor and thus presumably the normal, physiological actions of growth hormone are important in regulation of aging and life span," Bartke said.

The team also found that calorie restriction for 12 months improves insulin sensitivity in normal mice but fails to further enhance the "remarkable insulin sensitivity" in growth hormone knockout mice.

This finding, Bartke said, "supports our hypothesis that increased sensitivity to the actions of insulin is a very important and perhaps the key mechanism of delayed aging and prolonged longevity in growth hormone deficient and growth hormone resistant mice."

SOURCE: PNAS, May 16, 2006.


TOPICS: Culture/Society; Front Page News; News/Current Events
KEYWORDS: growthhormone; health; insulin; longevity; medicine; zaq
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This is hot stuff--if replicated, a big breakthrough.
1 posted on 05/08/2006 2:57:14 PM PDT by Pharmboy
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To: jennyp; PatrickHenry; aculeus; thefactor; blam; SunkenCiv

Pinging just for the bio interested...no need to ping your lists.


2 posted on 05/08/2006 2:59:02 PM PDT by Pharmboy (Democrats lie because they must)
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To: Pharmboy; cyborg

I've learned one can live well past 100 by adopting a vegetarian lifestyle including juicing and low-caloric intake.


3 posted on 05/08/2006 3:01:35 PM PDT by Petronski (I just love that woman.)
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To: Pharmboy
I don`t care about all this, just tell me how to grow hair on my effin head.

By gum number one! The Borgs are gradually reducing my hairline!!!

AHHHH!

"Well there are always hats!"

4 posted on 05/08/2006 3:03:48 PM PDT by Screamname (By God, pray for me, someone help me please! Hillary is my Senator! HELP MEEE!)
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To: Petronski
"Learned"?

Or "Heard"?

5 posted on 05/08/2006 3:03:56 PM PDT by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: Pharmboy

This is what Dr. Sears (inventor of the zone diet) has been saying for over a decade.


6 posted on 05/08/2006 3:04:33 PM PDT by Chuckulator
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To: Petronski

Why would you want to live past 100 when the Kennedy infection in this country seems endless? Do you realy want to be 100 only to hear "And Ted Patrick Kennedy the IIIIIth has been elected!"


7 posted on 05/08/2006 3:07:07 PM PDT by Screamname (By God, pray for me, someone help me please! Hillary is my Senator! HELP MEEE!)
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To: Petronski
I've learned one can live well past 100 by adopting a vegetarian lifestyle including juicing and low-caloric intake.

Even if you get hit by a truck?

8 posted on 05/08/2006 3:08:26 PM PDT by cantfindagoodscreenname (Is it OK to steal tag lines from tee-shirts and bumper stickers?)
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To: Petronski
I've learned one can live well past 100 by adopting a vegetarian lifestyle including juicing and low-caloric intake.

Yeah but who wants to live to 100 if you can't eat a big fat juicy STEAK!

9 posted on 05/08/2006 3:12:30 PM PDT by montag813
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To: Pharmboy
Certain parts of the body such as the ears and nose continue to grow with age. For some reason this effect seems to be most noticeable in older men who sometimes have very large ears. If people were taking growth hormone to counteract aging, I wonder if this effect would be even more pronounced.

Acromegaly, a medical condition involving excess growth hormone secretion, does indeed affect the ears.

10 posted on 05/08/2006 3:15:23 PM PDT by wideminded
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To: Pharmboy
To go through life on a calorie restricted diet in an attempt to live longer sounds like torture. You might not live forever but it would seem like it. I have the genes for a long life, my great aunt died at 116. I am not sure I am thrilled at that possibility for myself.
11 posted on 05/08/2006 3:15:43 PM PDT by Ditter
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To: cantfindagoodscreenname
Even if you get hit by a truck?

ESPECIALLY if you get hit by a truck! In the impact, you steal the truck's lifeforce.

12 posted on 05/08/2006 3:16:31 PM PDT by Petronski (I just love that woman.)
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To: montag813
Yeah but who wants to live to 100 if you can't eat a big fat juicy STEAK!

Not me. Between now and the great beyond, I plan to have at least two big fat juicy steaks. Probably more.

13 posted on 05/08/2006 3:18:02 PM PDT by Petronski (I just love that woman.)
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To: DuncanWaring

Learned. The science is pretty good, as far as I can tell.


14 posted on 05/08/2006 3:18:31 PM PDT by Petronski (I just love that woman.)
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To: wideminded
This guy is 300 years old:


15 posted on 05/08/2006 3:20:12 PM PDT by Petronski (I just love that woman.)
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To: Pharmboy

I'm totally convinced that HGH is the key to slowing aging. I've been taking a combo of L-Arganine & L-Lysine (combo stimulates the natural production of HGH) for 15 years now with amazing results.


16 posted on 05/08/2006 3:25:45 PM PDT by Raebie
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To: Petronski
ESPECIALLY if you get hit by a truck! In the impact, you steal the truck's lifeforce.

Cool, man!

17 posted on 05/08/2006 3:28:14 PM PDT by cantfindagoodscreenname (Is it OK to steal tag lines from tee-shirts and bumper stickers?)
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To: Petronski
This guy is 50,000 years old, and definitely needs a hat:


18 posted on 05/08/2006 3:28:32 PM PDT by Mad_Tom_Rackham (Every vote for a Democrat is a vote for $10/gallon gas.)
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To: Petronski

Hi honey. Thanks for pinging me to this thread :D


19 posted on 05/08/2006 3:33:38 PM PDT by cyborg (I just love that man.)
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To: Raebie

Who are the products manufactured by?


20 posted on 05/08/2006 3:37:31 PM PDT by Sarajevo
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To: Sarajevo

Your body produces it during deep sleep for starters.


21 posted on 05/08/2006 3:39:21 PM PDT by cyborg (I just love that man.)
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To: Pharmboy
I'm not sure I understand this. Are they saying that HGH makes people live shorter lives?
22 posted on 05/08/2006 3:40:32 PM PDT by jennyp (WHAT I'M READING NOW: "The Great Influenza" by Barry)
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To: Sarajevo

You can get L-Lysine about anywhere (grocery, drug stores). I've only found the L-Arginine at health places...I get mine at GNC.


23 posted on 05/08/2006 3:40:55 PM PDT by Raebie
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To: Sarajevo

I'll post a mail message I just sent...thought some of you might find it interesting.

The theory is that one cannot consume enough amino acids to adquately get enough of them. Amino acids are our body's building blocks...they are amazing things. Each one has unique benefits, but when you combine some of them together, the benefits are greatly enhanced. Taking L-Arginine and L-Lysine in combination stimulate the body to naturally produce more human growth hormone. L-Orthonine is benefical as well...it's a key ingrediant in alot of the body building formulas on the market. As we age, our bodies produce less & less of this hormone, resulting in physical aging. This results in thinner skin, less lean muscle, higher blood pressure & cholesterol, slower wound healing, etc.

I've taken these supplements for about 15 years. I'm 43 years old, and no one can believe that I have a 15 year old child. I never get sick. Granted, alot of this may be that I'm blessed with good genes, but I swear by these supplemements. My mom started taking them about 10 years ago and she has completely gone off her blood pressure medication and her cholesteral levels have dropped dramtically.


24 posted on 05/08/2006 3:42:27 PM PDT by Raebie
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To: Pharmboy
Booze + cigarettes + drugs + good genes and you're virtually indestructible!


25 posted on 05/08/2006 3:46:09 PM PDT by Revolting cat! ("In the end, nothing explains anything.")
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To: Raebie
I've been taking a combo of L-Arganine & L-Lysine (combo stimulates the natural production of HGH) for 15 years now with amazing results.

I used to take L-orinithine for the same reason, but I probably didn't take a big enough dose (at bedtime) or use it long enough, since I didn't see any increased muscle mass.

How much of each have you been taking?

26 posted on 05/08/2006 3:48:07 PM PDT by Max in Utah ("Great Wall of America?" I'd settle for "Pretty Good Wall.")
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To: Sarajevo
Who are the products manufactured by?

Arginine & Lysine are sold in any drugstore in the nutrients section. They're basic amino acids.

I didn't know about those stimulating HGH production, that's intereting. I pop many Lysines whenever I get a canker sore - it's the only thing I've ever found that actually suppresses the pain and shortens the outbreaks. But I also read that Arginine can make canker sores worse. Weird.

27 posted on 05/08/2006 3:49:31 PM PDT by jennyp (WHAT I'M READING NOW: "The Great Influenza" by Barry)
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To: Max in Utah

I take 1000 mg of Arginine and 500 mg of Lysine daily. The research I've read indicates that a 2-1 ratio is the ideal combo.


28 posted on 05/08/2006 3:54:06 PM PDT by Raebie
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To: Pharmboy
"The key implication of this study is that growth hormone receptor and thus presumably the normal, physiological actions of growth hormone are important in regulation of aging and life span," Bartke said.

The yogis of old realized that in promoting the yoga headstand, and inverting the body causing the body weight to "crush" or "squeeze out" the treasures of the pituitary gland--one of which is growth hormone.

29 posted on 05/08/2006 3:57:51 PM PDT by BikerGold (Reliously Uncoooorrrrect...Reliously UUUUUUncorrect)
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To: Petronski
I've learned one can live well past 100 by adopting a vegetarian lifestyle including juicing and low-caloric intake.

But who would want to?

30 posted on 05/08/2006 4:01:44 PM PDT by FreedomCalls (It's the "Statue of Liberty," not the "Statue of Security.")
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To: Raebie

A link to check out:

http://www.futurescience.com/arginine.html


31 posted on 05/08/2006 4:01:47 PM PDT by Raebie
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To: Raebie
"I am not going to die. I take chromiumpicolonate in every orifice every day." -Dale Gribble


32 posted on 05/08/2006 4:13:29 PM PDT by rawcatslyentist ("Politically Correct" is the politically correct term for "f*cking retarded aka Patches Kennedy")
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To: Pharmboy

How do you make a hormone?


33 posted on 05/08/2006 4:17:01 PM PDT by toddlintown
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To: Chuckulator

I read some of his stuff. He mainly talked about prostaglandins, if I remember.


34 posted on 05/08/2006 4:45:29 PM PDT by Pharmboy (Democrats lie because they must)
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To: Revolting cat!

Lo effin' L!


35 posted on 05/08/2006 4:47:57 PM PDT by Pharmboy (Democrats lie because they must)
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To: BikerGold

Now THAT'S an interesting comment. The hypothesis should be tested by controlled human studies. Really.


36 posted on 05/08/2006 4:50:25 PM PDT by Pharmboy (Democrats lie because they must)
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To: Petronski

LOL


37 posted on 05/08/2006 5:45:20 PM PDT by wideminded
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To: Mad_Tom_Rackham

He'd also have one hell of a migraine if so predisposed...


38 posted on 05/08/2006 6:46:23 PM PDT by StAnDeliver
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To: Chuckulator
This is what Dr. Sears (inventor of the zone diet) has been saying for over a decade.

Agreed. He has polished his zone diet with the addition of omega-3 fish oils. You have to stick with the zone diet fairly strictly to enjoy the additional improvements offered by the fish oil (EPA/DHA).

Lysine, arginine and ornithine will stimulate growth hormone, but you need adequate sleep too. A zone diet with some exercise also kicks growth hormone levels up. You can completely negate the growth hormone inducing effects of exercise by spiking your insulin with excessive (out of the zone) levels of carbs. It's a delicate balance, but works like a charm. Switching to the zone and inline skating dropped my weight from 204 to 162 in 1996. I had been skating my butt off for months on a vegetarian diet with no results. It took 8 months to drop the weight. At the start of my efforts I could complete a 5 mile circuit of Miramar Lake in 34 minutes. Eight months later, I completed 3 circuits (15 miles) in 66 minutes.

39 posted on 05/08/2006 6:47:59 PM PDT by Myrddin
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Comment #40 Removed by Moderator

To: Mad_Tom_Rackham
Anyone else besides me see a resemblance?

Cheers!

41 posted on 05/08/2006 7:30:30 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: Myrddin
Not a slam, but in earnest, since I have read both the late Atkins, and Barry Sears with great attention.

How DO you cram down (say) the four cups of spinach with breakfast in the morning?

Any advice would be appreciated...

Cheers!

42 posted on 05/08/2006 7:33:15 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: Pharmboy

When heaven awaits why live longer?


43 posted on 05/08/2006 8:01:16 PM PDT by Almondjoy
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To: grey_whiskers
I don't cram down 4 cups of spinach. I controlled my protein amount with a small pudding dish full of small curd cottage cheese. I added a tablespoon of olive oil on top of the cottage cheese to get the right amount of fat with some flavor. After eating the cottage cheese, I would fill that same small bowl with some wheat bran and wet it with some rice milk.

Time for a quick digression. After eating the above, I would dutifully head back to the bathroom and brush my teeth. I then headed out to my driveway to get into my Porsche 914 to drive to work. Just about the time I would open the car door, I would experience a sudden runny nose and volumes of phlegm to the point of gagging. I blamed it on the mint in the toothpaste or something in the lambskin car seat covers. That turned out to be wrong. I'm horribly allergic to wheat. The timing after eating always repeated the pattern. When I stopped the wheat bran, my sinus problems disappeared entirely. No more gagging after breakfast.

Back to the main topic, the Zone diet recommends carbs with a low glycemic index. The objective is to avoid a sudden rush of glucose into the blood with a corresponding spike in insulin. Finding good quality, tasty, low glycemic carbs is the single most difficult thing to accomplish on a Zone, Atkins or low GI diet.

44 posted on 05/08/2006 8:08:30 PM PDT by Myrddin
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To: Revolting cat!
From Keith Richards: "ehhhhh... .....just don't fall out of a friggin coconut tree, right, boy, efrem, she gottta (urp) ... ... laughter...
45 posted on 05/08/2006 8:24:11 PM PDT by Secret Agent Man
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To: neverdem

ping


46 posted on 05/08/2006 9:18:57 PM PDT by traviskicks (http://www.neoperspectives.com/gasoline_and_government.htm)
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To: cantfindagoodscreenname

I've noticed that Asian Indians(I know a few) who have been vegies their whole lives seem to die off about 75 or 80, like most everyone else. The seem to have thes same elderly health problems that we all have.


47 posted on 05/08/2006 9:25:41 PM PDT by oyez (Appeasement is insanity)
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To: Revolting cat!

OK, Keith is not pretty, but he sure can play!


48 posted on 05/08/2006 9:51:51 PM PDT by CobaltBlue (Extremism in the defense of liberty is no vice. Moderation in the pursuit of justice is no virtue.)
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To: Pharmboy; Coleus

Fewer calories, eh? I guess that solution is out of the running...


49 posted on 05/08/2006 10:06:12 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/)
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To: cantfindagoodscreenname

Ironically, it was the truck that delivers organic juice.


50 posted on 05/08/2006 10:08:09 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/)
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