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Ibuprofen Can Double Risk Of Heart Attack, Says Medical Study
The Telegraph (UK) ^ | 6-2-2006 | Celia Hall

Posted on 06/01/2006 6:35:06 PM PDT by blam

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To: Lancey Howard

You can still buy absinthe around Pamplona and points north over the Pyrinees into France. Don't. A Tech Seargant got busted by a piss test after he tried it out while he was up there for a little vacation with his 3 kids and his wife. His career ended because of that. Just walk away.

51 posted on 06/01/2006 8:29:02 PM PDT by BobS
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To: blam

Whooops! My drug of choice for arthritis, degenerative disc pain and the daily hangover. Whats a guy to do?

52 posted on 06/01/2006 8:30:55 PM PDT by nkycincinnatikid
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To: Always Right

Aspirin is an NSAID class medication.

53 posted on 06/01/2006 8:33:03 PM PDT by Sarajevo
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To: Lancey Howard
Like mothers and pediatricians discovered that Dramamine would quiet the sick child ... active ingredient (diphenhydramine) is the salt of what makes the antihistamine, Benadryl (diphenhydronate), work and we know how drowsy one gets on Benadryl!
54 posted on 06/01/2006 8:37:02 PM PDT by MHGinTN (If you can read this, you've had life support from someone. Promote life support for others.)
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To: blam

I am counting the seconds until the next Law Office of James Sokolove commercial...Have you taken ibuprofen? Do you want 2/3 (or less) of a lot of money?

55 posted on 06/01/2006 8:41:35 PM PDT by Sender ("Why, by God, I actually pity those poor sons-of-b*tches we're going up against. By God, I do".)
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To: FreedomCalls
Ibuprofen (800mg TID) is a normal prescription dosage for mild to moderate pain. Ibuprofen is safe at dosages of less than 3200mg per day.

The dosage warning is for over-the-counter ibuprofen.

56 posted on 06/01/2006 8:44:10 PM PDT by Sarajevo
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To: RepoGirl

800mg of Advil ping, FYI.

57 posted on 06/01/2006 8:45:12 PM PDT by ChuxsterS
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To: Sarajevo

The only exception is acetaminophen; it's usually classed in the discussion of pain relievers but is in a class by itself.

I took NSAIDS for thirty years on physician recommendation and nobody ever discussed acetaminophen as an effective pain reliever. Finally I had a bleeding ulcer from an allergic reaction to penicillin and so took a chance that acetaminophen could actually do something. My blood pressure readings dropped 20 points on both systolic and diastolic -- and no longer have chronic gastric distress.

A lot of people than suspected are probably allergic to NSAIDS in the same way I was with all these indeterminate afflictions that can't be explained. Acetaminophen is worth a try -- even if your doctor has been brainwashed into thinking it isn't as effective a pain reliever. Studies haven't indicated that; its weakness is that it doesn't possess as effective anti-inflammatory properties.

58 posted on 06/01/2006 8:54:17 PM PDT by MikeHu
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To: FreedomCalls

You are supposed to stop taking either aspirin or ibubrofin with sodium diclofenac. It is a big blood thinner along with being an anti-inflammatory. You are responsible for your own stroke.

59 posted on 06/01/2006 8:58:16 PM PDT by BobS
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To: ChuxsterS
Yikes. It's the only pain reliever that helps with my knees and elbows. Tylenol does nothing for me.
60 posted on 06/01/2006 9:07:06 PM PDT by RepoGirl ("That boy just ain't right..." Hank Hill)
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To: Sarajevo
Ibuprofen (800mg TID) is a normal prescription dosage for mild to moderate pain. Ibuprofen is safe at dosages of less than 3200mg per day. The dosage warning is for over-the-counter ibuprofen.

If a doctor prescribes it and you have a MI because of his prescription, he is responsible (i.e., subject to a malpractice lawsuit). You have no recourse if you exceed the dosage warning on the OTC box. A doctor would presumbaly be monitoring your progress under his prescription. You're on your own with the OTC dosage. That's the difference.

61 posted on 06/01/2006 9:27:08 PM PDT by FreedomCalls (It's the "Statue of Liberty," not the "Statue of Security.")
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To: blam

I would assume high dosages of anything would cause problems. They wasted money on this survey?

I'm still taking a couple of Ibuprofen for headaches, minor illness or pain when needed. I've tried the others (advil, etc...) and this one seems to work best for me. If a choice between the conclusions of an unneccessary survey vs relief of a headache... Ibuprofen wins.

62 posted on 06/01/2006 9:28:31 PM PDT by Soul Seeker (Deport the United States Senate)
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To: MikeHu
Aspirin (acetyl-salicylic acid) "Allergy" or Sensitivity

Aspirin (acetyl-salicylic acid or ASA) may cause allergy-type reactions in persons who develop this unusual sensitivity. This idiosyncratic type reaction can be very serious - sometimes even life-threatening.

Those people who have both moderate to severe asthma and chronic sinusitis are more likely to be aspirin sensitive.

The main types of reactions are:

1. SKIN REACTIONS- itching, rashes, hives, or swelling of extremities or mouth

2. RESPIRATORY / OCULAR - Acute or immediate: nasal congestion, itchy/watery eyes, swollen eyes, cough, difficulty breathing or wheezing (swelling of the inside of the throat and asthma attacks which can be mild to very severe). Chronic: nasal polyps, sinusitis (leading to loss of smell, cough, postnasal drip), and worsening of chronic asthma.

3. CARDIOVASCULAR - in very rare cases cardiovascular collapse (anaphylactic-type of shock) has occurred.

Stomach pains due to aspirin are not allergic or idiosyncratic types of reactions, but are usually due to irritation of the stomach lining.

One very important point is that most NSAID's (or Non-steroidal anti-inflammartory drugs) cross-react with aspirin - meaning that they can cause the same types of reactions in aspirin sensitive people. These drugs are mostly used for arthritis and other painful disorders. Common NSAID's (not a complete list) include: Advil, Anaprox, Ansaid, Butazolidin, Clinoril, Dolobid, Feldene, Ibuprofen, Indocin, Motrin, Naproxyn, Nuprin, Orudis, Rufen, Tolectin, and Voltaren.

A drug commonly used for aches and pains is Acetaminophen (TylenolÔ, e.g.) Acetaminophen, however, is very commonly safe in aspirin sensitive people when used at recommended doses. As with all medication decisions, you should discuss this with your doctor (you may want to ask the doctor about non-acetylated salicylates which are also mostly safe in ASA sensitive people.

ASPIRIN (acetyl salicylic acid or ASA) and NSAID's are found in many home remedies, over-the-counter (OTC) drugs, and prescription medications. Please check the list below. THIS IS NOT A COMPLETE LIST AS NEW PREPARATIONS ARE BEING ADDED ALL THE TIME. Look for ASA (aspirin) in medications for headaches, colds, coughs, allergies, sinus problems, arthritis, rheumatism (joint pain), menstrual cramps, stomach acidity, backache, or urinary pain. Please read all labels carefully, or ask the pharmacist before trying any medication. An over-the-counter medication label may say in small print "don't take this medicine if you are allergic to aspirin or NSAID's." Also, remember to tell your doctor, dentist, and nurse that you are sensitive to aspirin.

Artificial coloring, for example Tartrazine Yellow (FD&C No. 5), may rarely mimic aspirin sensitivity. This dye is present in many foods including alcoholic and soft drinks, candies, artificial orange juice (TANG), luncheon meats, preserves, jams, fruit gelatins, ice cream, colored baked goods, toothpaste, and mouth wash. Always read the labels on packaged foods and try to avoid those that contain this artificial coloring if you're sensitive to aspirin.

Tartrazine dyes are also present in some medicines including some antihistamine preparations used to treat allergies. Use only those medications prescribed by your doctor, and be suspicious of any colored pills if you develop an itch, rash, or stuffy nose after you start taking them.

MEDICATIONS CONTAINING ASPIRIN OR ASA-LIKE SUBSTANCE (NSAID's): (Again, please be aware that this is not a complete list)

Advil.,Alka-Seltzer, Alka-Seltzer Plus, A B C Compound, AC and C tabs, APC Tablets, Anacin, Anaprox, Anodynos, Ansaid, Arthralgen, Arthritis Pain Formula, Arthritis Strength, BC powder, Arthropan, ASA and Compound Ascriptin, Ascriptin A/D, Asperbuf, Aspergum, Aspirin and compounds, BC compounds, Bromo-Quinine, Bromo-Seltzer, Bufferin, Butazolidin, Cama, Chargers, Clinoril, Cogespirin, Cope, Coricidin, Coriforte, Cosprin, Cuprimine, Damason, Darvon compounds, Depen, Dia-Gesic, Dihydrocodeine Compound Tablets, Dolobid Dolprin #3 tablets, Dristan, Easpirin, Ecotrin, Empirin, Compoung, Equagesic, Excedrin, Duradyne, Empirin and compounds, Feldene, Fiorinal and compounds, Fiogesic 4 Way Cold Tablets, Hyco-Pap, Gemnisyn, Goody's Headache Powder, Haltram, Hyalex, Ibuprofen, Imuran, Indocin, Liquiprin tablets, Lodine, Measurin, Meclomen, Medipren, Mepro Compound tablets, Methocarbamol, Midol, Momentum, Motrin, Myochrysine, Nalfon, Naproxyn, Norgesic, Norwich aspirin, Novahistex with APC, Novahistine sinus tablets, Nuprin, Orudis, Oruvail, Oxycodone, Pabirin, Pediaprofen, Pepto-Bismol, Percodan compounds, Persisten, Penaphen compounds, Phenergan compound, Plaquenil, Ponstel, Pyroxte, Rheumatrex, Ridaura, Robaxisal family, Rufen, Saleto, Salflex, Sine-off, S K Oxycodone, S K 65 compound tablets, Solganal, Soma compounds, Stanback, St. Joseph Aspirin, Supac Synalgos - DC Talwin compound, Therapy, Bayer, Tolectin 200, Trac-tabs, Trendar, Triaminicin, Trigesic, Urisinus, Vanquish, Verin, Voltaren, Zactrin, Zorpin.

Treatment options includes use of antihistamines like benadryl or DPH elixir (H1 blockers) cimetidine ranatidine(H2 Blockers) . epinephrine sc , oral or intravenous steroids though more intense management may become necessary. Suggest seeing your doctor for optimal care! Continue to remind your doctor on every visit of your particular drug allergy. Ensure that your medical records clearly define all of your allergies as in the long run your are the one that benefits.

" "

63 posted on 06/01/2006 9:34:23 PM PDT by Sarajevo
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To: MikeHu
Here in Oz you can get get OTC acetaminophen, aspirin and ibuprofen with codeine --they all work better on pain than what you can get OTC in the USA.

By the way, most stomach ulcers are not caused by NSAIDS, most ulcers are actually caused by bacterial infection --this was only recently discovered and has been a sea change in the way ulcers have been treated. Now antibiotics are the main treatment for stomach ulcer.
64 posted on 06/01/2006 9:34:45 PM PDT by Aussiebabe
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To: MikeHu
>>>...suicical high dosages for the deliberate purpose of producing death in this manner.<<<

Actually Mike, the Seattle Seahawks had a player who was taking approximately double dosage Ibprouphen for his aches and pains and it cooked his liver - he had to retire early and was touch and go for a while whether he would make it.

Can't remember his name....Zeke???? Defensive back I think. Somebody help me out.

65 posted on 06/01/2006 9:36:56 PM PDT by HardStarboard (Hey, march some more - its helping get the wall built!)
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To: FreedomCalls

If a doctor prescribes it and you have a MI because of his prescription, he is responsible (i.e., subject to a malpractice lawsuit).

Not necessarily. No drug is effective in 100% of the population 100% of the time.

This is why Vioxx was banned in the US. IMO Vioxx was a great medication for those suffering from rheumatoid arthritis. It should not have been banned for a few adverse reactions.

66 posted on 06/01/2006 9:46:00 PM PDT by Sarajevo
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To: HardStarboard; MikeHu
Thanks to gooogle - I found the story; it was Kenney Easley, a class act, that got hit by Ibuprofen overdose -

A Get-Well Wish -- Ken Easley Gave A Lot

KENNY Easley, the finest defensive player to wear a Seattle Seahawks uniform, has faced more adversity than his 31 years deserve. If his kidney had not betrayed him, he'd surely still be the Pro Bowl safety he so often was.

Kidney disease cut short Easley's brilliant National Football League career two years ago. There'll be no football comeback. There will be a more important one - battling back from kidney deterioration after a weekend transplant.

Unresolved are the merits of a lawsuit filed against the Seahawks by Easley, now co-partner of a sports-management group. He alleges his kidney trouble was caused or aggravated by large doses of the pain reliever ibuprofen.

When word of the last week's transplant got out, many who remembered how much Easley gave to football wanted to help. Typically, he didn't want anything for himself. Instead, he suggested donations to the Northwest Kidney Foundation or to Friends of Youth......

He was a fine player, and a fine gentleman also!!!

67 posted on 06/01/2006 9:47:30 PM PDT by HardStarboard (Hey, march some more - its helping get the wall built!)
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To: Sarajevo

Thanks for the research.

That's a fairly good representation of the discussions on the topic -- and if one is not paying close attention, thinks acetaminophen is just another NSAID -- but less effective and recommended.

One of its indications is that it is well-known to be safer and to produce fewer allergic/negative side-effects. Like any product, it doesn't work for everyone -- but if it does, one is in luck because generic Tylenol (acetaminophen) is the cheapest thing one can buy at the discount stores.

If it doesn't work, then one has to proceed up the ladder of risk and cost. But I wouldn't start there.

68 posted on 06/01/2006 9:57:29 PM PDT by MikeHu
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To: MikeHu
Since the demise of Cox-2 inhibitors, I have went back to the acetominophen/ASA combination meds, especially where dental pain or arthritic pain is the culprit.

ASA gets on board quickly, and Acetominophen actually prolongs the pain reducing effects. I am especially fond of Exedrine Migraine in these cases.

I'm not attempting to promote one pain reducing medication over another, but I have found that plain old aspirin, in it's many forms, is still most effective in the majority of the population. Those who cannot tolerate NSAIDS have the option of using acetominophen.

69 posted on 06/01/2006 10:14:30 PM PDT by Sarajevo
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To: Sarajevo

I think the order should be reversed -- that one should try the acetamenophen first, and if it is not effective, the NSAIDS (aspirin, ibuprofen, naproxen, etc.), COX-2 inhibitors, etc.

The rationale for creating the COX-2 inhibitors in the first place was that they reduced the gastric irritation -- while acetaminophen is often prescribed for the treatment of gastritis. Especially in long time users, an extreme sensitivity can build up to a product.

70 posted on 06/01/2006 10:25:36 PM PDT by MikeHu
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To: MikeHu; grey beard

Greybeard and I were on another discussion a few months ago of another wonder common remedy in which a doctor claimed that gauifenesin was the cure for fibromyalgia. Critical to the protocol was the recognition that aspirin blocked the effectiveness of all other medications.

71 posted on 06/01/2006 10:38:49 PM PDT by MikeHu
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To: 308MBR
Take the danged narcotics.

This is a load of BS. Heroin = Bad, Oxycontin = Good. The only things that makes Oxy "good" are the facts that it is made by a legitimized drug company from synthetic substances to EXACTLY mimic the effects of Heroin.

Nothing inherently wrong with either drug. Heroin would be fine, as long as its purity is assured and the patients can get enough of it as tolerance builds. Don't think for one minute you can't develop tolerance/addiction problems with ANY synthetic opiate. Better to be a FUNCTIONING addict than debilitated by pain.

I never abused pain pills. I only took them when I was in a lot of pain, so I never got addicted to them. I prefer to use them after I have surgery or an accident. Doctors don't like to write prescriptions for narcotics because they are afraid they will get in trouble with the feds. It's really not worth the hassle. I can get relief from taking aspirin, so I'll just stick to them for pain. I have a very high tolerance level to pain so I'll be OK.:o)

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To: MikeHu
To say that acetaminophen is safer than NSAIDs is a dangerous statement and would get you into severe legal problems if you were a doctor or a pharmacist. It is safer in some cases, in other cases it is far more dangerous.

Acetaminophen/Tylenol should definitely not be taken with alcohol and it can cause severe liver damage.
73 posted on 06/01/2006 11:57:46 PM PDT by Aussiebabe
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To: BobS
From the article

It found that ibuprofen and diclofenac, two non-steroidal anti-inflammatory drugs (NSAIDs), could cause attacks when taken in high doses.

The source defined high dose diclofenac as " high dose diclofenac (75 mg twice daily)."

74 posted on 06/02/2006 3:12:36 AM PDT by dawn53
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To: Sarajevo

Thanks for the information -- great comment.

75 posted on 06/02/2006 6:41:56 AM PDT by GOPJ ("What we have learned from history is that we haven't learned from history." B.Disraeli)
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To: 308MBR

Absolutely. If you have a legitimate need, take the meds that work. Frankly, narcotics compare favorably to any NSAID, IMO, when taken as prescribed. Unfortunately, much pain goes untreated, undertreated, or treated with more dangerous and less effective medications because of the failed WOD and professional fear of the DEA.

76 posted on 06/02/2006 6:49:50 AM PDT by Lawdoc (Our military is the best trained and most humane in the world bar none! God bless them)
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To: dawn53

It has been shown that swallowing small amounts of saliva over a long period of time is nearly always fatal.

77 posted on 06/02/2006 6:58:40 AM PDT by mc5cents
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To: Aussiebabe

" By the way, most stomach ulcers are not caused by NSAIDS"

Your information is only partly correct.

NSAIDs can certainly cause stomach ulcers all by themselves. There's lots of valid data on how NSAIDs destroy the lining of the stomach.

But most all commonly occuring stomach ulcers (outside of heavy NSAID users) are caused by Helicobactor pylori infection.

78 posted on 06/02/2006 7:05:14 AM PDT by webstersII
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To: blam
I can't take Ibuprofen, at least in the doses they give you for pain, for more than about a day and half, it tears up my stomach too badly, even when taken with meals.

Instead I take Naproxen sodium (Alieve), two tablets twice a day. Mainly for my back, on recomendation of the surgeon who operated on it.

I recently flunked an arthritis screen test. Well that's what my doctor said I was getting, but I find they are testing for various types of inflammatory diseases. Given the two factors I failed on, it's probably something a mite worse, but it could just be arthritis. I haven't seen the Rheumatologist, it takes well over a month to get in, but I expect he'll want to put me on something or other. I'll do more research before I go, and will be ready with questions, but can't do much until I know what the problem is.

Heck all I had was some swelling of the ankles (like Hillary, but no so much) which concerned my wife, which I thought was a side effect from blood pressure medication (it's a listed side effect). So I asked my doc about it... maybe a mistake :). (Nah!).

79 posted on 06/02/2006 6:41:24 PM PDT by El Gato
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To: Aussiebabe

As I've said previously in that discussion on pain relievers, other than deliberate abuse and attempts to commit suicide with deliberate overdosages (usually consumed with nearly fatal doses of alcohol) -- in normally recommended, reasonable therapeutic dosages for the purpose and intent of getting better, acetaminophen has notably fewer adverse reactions.

So much so that one has to wonder if these occasional and fabled Tylenol scares, is the best the competition can do.

80 posted on 06/05/2006 1:12:28 PM PDT by MikeHu
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To: Aussiebabe

Yes, Tylenol OD will likely cause your Liver I believe to fail.. Yes, your advice to keep it away from children is absolutely spot on..

I would not recommend having grape flavored childrens tylenol anywhere where kids could get to it.

However, I am not aware of anything other than accidental or intentional overdoses where Tylenol causing problems.

81 posted on 06/05/2006 1:20:12 PM PDT by HamiltonJay
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