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To: Conservative Goddess

My son had APL leukemia, which as far as I know, always involves a complete translocation between chromosome #15, and #17...these two chromosomes switch places...this transloction is one of the criteria, used to categorize anyones particular type of leukemia...my son also had a monosomy-trisomy switch between chromosome #7 and #8...dont remember exactly which chromosome did what, but the arm of one chromosome, split off, and joined itself to the chromosome next to it...this particular transloctions is seen in many AML leukemias...

The more interesting thing to me was that this genetic profile done on my son was done at diagnosis...once he was in remission, a follow up genetic study was done, and that genetic study revealed no translocations of any sort...his genetic study, while in remission showed a normal set of genetics...

However, when he relapsed a third genetic study was done, which again show the same two genetic translocations that my son had at diagnosis...

My question was, what does this mean?...did the translocations cause the disease or does the disease cause the translocations?...translocations are seen only when the disease is present and active...when the disease is in remission, no translocations are found..


23 posted on 09/07/2006 4:14:02 PM PDT by andysandmikesmom
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To: andysandmikesmom

Thank you for sharing that information. That is VERY interesting indeed. I'm a lawyer/accountant, not a geneticist (But I did stay at a Holiday Inn Express lastnight)....so I really don't know which came first, the translocation or the disease....but it is a VERY interesting question. If they are only present when the disease is active, that would suggest to me that the translocations are a manifestation of an underlying disease, not the cause....but again, I'm NOT a geneticist.

May God heal and bless your son...and you too.


27 posted on 09/07/2006 5:54:43 PM PDT by Conservative Goddess (Politiae legibus, non leges politiis, adaptandae)
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