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Substance in Red Wine Could Extend Life, Study Says
NY Times ^ | November 1, 2006 | NICHOLAS WADE

Posted on 11/01/2006 12:08:01 PM PST by neverdem

Can you have your cake and eat it? Is there a free lunch after all, red wine included? Researchers at the Harvard Medical School and the National Institute of Aging report that a natural substance found in red wine, known as resveratrol, offsets the bad effects of a high-calorie diet in mice and significantly extends their lifespan.

Their report, published electronically today in Nature, implies that very large daily doses of resveratrol could offset the unhealthy, high-calorie diet thought to underlie the rising toll of obesity in the United States and elsewhere, should people respond to the drug as mice do.

Resveratrol is found in the skin of grapes and in red wine and is conjectured to be a partial explanation for the French paradox, the puzzling fact that people in France to enjoy a high-fat diet yet suffer less heart disease than Americans.

The researchers fed one group of mice a diet in which 60 percent of calories came from fat. The diet started when the mice, all males, were 1 year old, which is middle-aged in mouse terms. As expected, the mice soon developed signs of impending diabetes, with grossly enlarged livers, and started to die much sooner than mice fed a standard diet.

Another group of mice was fed the identical high-fat diet but with a large daily dose of resveratrol. The resveratrol did not stop them from putting on weight and growing as tubby as the other fat-eating mice. But it averted the high levels of glucose and insulin in the bloodstream, which are warning signs of diabetes, and it kept the mice's livers at normal size.

Even more strikingly, the substance sharply extended the mice's lifetimes. Those fed resveratrol along with the high-fat diet died many months later than the mice on high fat alone,...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Government; News/Current Events
KEYWORDS: health; medicine; oenology; resveratrol; science; sirtuin; supplements; wine
The Times linked the abstract.

Resveratrol improves health and survival of mice on a high-calorie diet

Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan extension is dependent on Sir2, a conserved deacetylase proposed to underlie the beneficial effects of caloric restriction. Here we show that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice on a standard diet and significantly increases their survival. Resveratrol produces changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin-like growth factor-1 (IGF-I) levels, increased AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor- coactivator 1 (PGC-1) activity, increased mitochondrial number, and improved motor function. Parametric analysis of gene set enrichment revealed that resveratrol opposed the effects of the high-calorie diet in 144 out of 153 significantly altered pathways. These data show that improving general health in mammals using small molecules is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.

1 posted on 11/01/2006 12:08:03 PM PST by neverdem
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To: neverdem

Is it in bourbon? :)


2 posted on 11/01/2006 12:09:42 PM PST by RexBeach
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Active Lifestyle Can Stave Off Age-Related Macular Degeneration

Divorced women have more illness: Study

FReepmail me if you want on or off my health and science ping list.

3 posted on 11/01/2006 12:12:25 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

Hopefully "becoming French" isn't a side effect of Resveratrol.


4 posted on 11/01/2006 12:13:42 PM PST by PBRSTREETGANG
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To: neverdem

I guess they're right. I had red wine last evening and when I woke up this morning I noticed that I was still alive.


5 posted on 11/01/2006 12:14:55 PM PST by Liberty Valance (Keep a simple manner for a happy life)
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To: Kermit the Frog Does theWatusi

The Wine List.


6 posted on 11/01/2006 12:18:11 PM PST by HowlinglyMind-BendingAbsurdity
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To: neverdem

I have been taking resveratrol for some time now.


7 posted on 11/01/2006 12:28:15 PM PST by oblomov (Join the FR Folding@Home Team (#36120) keyword: folding@home)
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To: RexBeach

Wouldn't red (purple) grape juice do the same thing for those who don't use alcohol?


8 posted on 11/01/2006 12:40:54 PM PST by RoadTest ( He that hath an ear, let him hear what the Spirit saith unto the churches. -Rev. 3:6)
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To: neverdem

Perhaps it's more than just the red wine in the French diet as traditional French cuisine is rich in olive oil and garlic, also thought to have positive health properties.


9 posted on 11/01/2006 12:56:29 PM PST by The Great RJ ("Mir we bleiwen wat mir sin" or "We want to remain what we are." ..Luxembourg motto)
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To: neverdem
resveratrol along with the high-fat diet

Sounds good to me! What can beat a good Cabernet accompanied by a great, grilled Ribsteak?

10 posted on 11/01/2006 12:59:25 PM PST by suzyjaruki (Beautiful and Calvinist!)
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To: oblomov
"I have been taking resveratrol for some time now."

LOL Me too.

11 posted on 11/01/2006 1:03:57 PM PST by jpsb
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To: RoadTest

One would think so as long as it is mostly real grape juice.


12 posted on 11/01/2006 1:05:46 PM PST by jpsb
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To: Liberty Valance
I guess they're right. I had red wine last evening and when I woke up this morning I noticed that I was still alive.

I'm not a drinker. The last time I drank red wine, I woke up the next morning with a pounding head and wished I wasn't still alive!

I'm hoping I can still get the benefits by eating grapes.

13 posted on 11/01/2006 1:09:17 PM PST by Tokra (I think I'll retire to Bedlam.)
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To: jpsb

"One would think so as long as it is mostly real grape juice."

Yeah. The bottlers play fast and loose with words and pictures on the FRONT label - subliminals.


14 posted on 11/01/2006 1:28:47 PM PST by RoadTest ( He that hath an ear, let him hear what the Spirit saith unto the churches. -Rev. 3:6)
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To: Liberty Valance

LOL!!!!!!!!!!!!


15 posted on 11/01/2006 1:47:35 PM PST by diamond6 (Everyone who is for abortion has been born. Ronald Reagan)
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To: Tokra
Migraines are the reason I stay away from Red wine.
However, i can do real grape juice.
16 posted on 11/01/2006 2:16:11 PM PST by rmlew (DeathKlok Rules!)
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To: RoadTest

The resveratrol in food such as wine is very small- on the order of 100 micrograms per liter. To get a therapeutic effect, you would likely need to take much more (via commercial tablets or capsules), just like the experimental mice (25 mg/kg body weight) and the researcher in the story (5mg/kg). I take much less myself - 20 mg/day at 70 kg. Maybe I should up my dose?


17 posted on 11/01/2006 2:51:26 PM PST by oblomov (Join the FR Folding@Home Team (#36120) keyword: folding@home)
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To: rmlew

Wine (and aged cheese) contains tyramine, which some people are allergic to. It's a product of the fermentation process. Grape juice doesn't contain much tyramine at all.


18 posted on 11/01/2006 2:52:53 PM PST by oblomov (Join the FR Folding@Home Team (#36120) keyword: folding@home)
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To: neverdem
Cain't argue with that!


19 posted on 11/01/2006 2:55:17 PM PST by Revolting cat! (We all need someone we can bleed on...)
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To: neverdem
Well, I am hosed. I am allergic to the skin of red grapes (and red wine).

Real allergic.

20 posted on 11/01/2006 2:57:51 PM PST by patton (Sanctimony frequently reaps its own reward.)
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To: oblomov
Thanks.
Now I have another reason to stay away from stinky cheeses.
21 posted on 11/01/2006 3:14:58 PM PST by rmlew (DeathKlok Rules!)
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To: oblomov

Where do you get it? I take meds that prohibit the use of alcohol.


22 posted on 11/01/2006 5:20:18 PM PST by From many - one.
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To: Liberty Valance

Thanks for the living proof. :-)


23 posted on 11/01/2006 6:55:50 PM PST by mcshot ("If it ain't broke it doesn't have enough features." paraphrased anon.)
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To: From many - one.

Sonmeone emailed me with a similar question, and also asked where he could get more information. Here was my reply:

Hello,

First, let me point out that I only take a small dose daily compared to the researcher (Dr. Sinclair, who still claimed to take something on the order of 5mg/kg body weight, which would be 375 mg daily for a 75kg person. That would be quite expensive based on the resveratrol prices I have been able to find.) Functional food-based nutrients are regarded as having the best bioavailability, and if you look at the articles below, you'll see that the amount found in ordinary servings of food (like wine and peanut butter) is quite low. But I expect food-based resveratrol to be marketed very soon. The experts seem to favor resveratrol that is derived from grapeskin extract (which has the highest concentration of any food). Generally the LEF and Jarrow products are quite good in terms of bioavailability.

There is a lot of good information on resveratrol (and other antioxidants) here:

http://search.lef.org/cgi-src-bin/MsmGo.exe?grab_id=0&page_id=885&query=Resveratrol&hiword=RESVERATROLA%20RESVERATROLS%20Resveratrol%20

LEF is a commercial site, and you can buy the products there- the dosage per pill for their product is 20 mg (I take this one).

I have also taken the Jarrow resveratrol:
http://www.vitacost.com/Jarrow-Formulas-Resveratrol-Synergy

This article is a good basic resource on gene silencing (includes refs to resveratrol):
http://www.benbest.com/lifeext/aging.html#silencing

Linus Pauling Institute on resveratrol:
http://lpi.oregonstate.edu/infocenter/phytochemicals/resveratrol/

PDR:
http://pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/res_0224.shtml

A somewhat skeptical view:
http://www.quackwatch.org/01QuackeryRelatedTopics/DSH/resveratrol.html

Note: I'm not a doctor-just an interested layman. I don't think that researchers yet understand potential interactions with certain health conditions, medicines, etc. so it would probably be smart to discuss with your doctor.

My best,
oblomov


24 posted on 11/01/2006 8:00:39 PM PST by oblomov (Join the FR Folding@Home Team (#36120) keyword: folding@home)
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To: oblomov

Many thanks. There was also a recent report that resveratrol helped prevent Alzheimer's:

Compound in Red Wine May Fight Alzheimer's
http://www.webmd.com/content/Article/114/111394.htm?printing=true


25 posted on 11/02/2006 2:19:54 AM PST by From many - one.
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To: Tax-chick

ping


26 posted on 11/02/2006 3:08:24 PM PST by MarMema
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To: RexBeach

So...how much of a drunk do I have to be to have an extended life? :)


27 posted on 11/02/2006 3:11:33 PM PST by Texas_shutterbug
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To: RoadTest

Paul Harvey says yes.


28 posted on 11/02/2006 3:14:16 PM PST by RightWhale (RTRA)
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To: neverdem; Amerigomag; andrew2527; AnAmericanMother; A Jovial Cad; Awgie; babaloo; Betis70; ...
Belated--yet better late than never. Please alert either quantim or myself to get the wine ping list going for a thread.

Click to be +/- on this low volume wine ping list.

Oenology news ping.

29 posted on 11/05/2006 4:08:08 AM PST by NautiNurse (Katherine Harris for U.S. Senate)
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To: PBRSTREETGANG
When they bottle a Grand Resveratrol let me know and I'll add a few to my cellar.

{{rimshot}}

30 posted on 11/05/2006 5:32:40 AM PST by IllumiNaughtyByNature (If a pug barks and no one is around to hear it... they hold a grudge for a long time!)
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To: RoadTest

Try "Ocean Spray" concord grape/cranberry juice. It contains no sugar and is sweetened with pear juice. It is great!:)


31 posted on 11/05/2006 5:41:52 AM PST by seekthetruth
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To: RoadTest
I saw the French test results years ago. I've been drinking 100% grape juice based on that idea.

I noticed that on directions for a cholesterol home test that it said no citrus drinks allowed for say 24 or 48??? hours before the test.

Part of the French tests also indicated that cheeses passed through the system with the fats still intact.

32 posted on 11/05/2006 5:46:42 AM PST by Sacajaweau (God Bless Our Troops!!)
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To: neverdem

Uncork me another bottle of Carmenere!

Mmmmmmmmmmmmmm.

Mmmmmmmmmmmmmmmmmmmmmmm.


33 posted on 11/05/2006 6:42:25 AM PST by roaddog727 (BullS##t does not get bridges built)
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To: seekthetruth

Thank you!


34 posted on 11/05/2006 8:08:09 AM PST by RoadTest ( He that hath an ear, let him hear what the Spirit saith unto the churches. -Rev. 3:6)
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To: Sacajaweau

Thanks


35 posted on 11/05/2006 8:08:25 AM PST by RoadTest ( He that hath an ear, let him hear what the Spirit saith unto the churches. -Rev. 3:6)
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To: NautiNurse; neverdem
Thanks for da ping. Would you please ask all those FReepers adverse to red wine to send me their allotment so I may continue my 55 year research project...
36 posted on 11/05/2006 12:44:13 PM PST by tubebender (Growing old is mandatory...Growing up is optional)
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To: neverdem

bookmark for later


37 posted on 11/05/2006 12:46:07 PM PST by TX Bluebonnet
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To: RoadTest

Just eat grapes. Alchohol affects every organ of your body.


38 posted on 11/05/2006 12:49:52 PM PST by cornelis
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To: cornelis

"Just eat grapes. Alchohol affects every organ of your body.'

You're right. And since I was filled with The Spirit I don't need those other spirits any more.


39 posted on 11/05/2006 2:56:52 PM PST by RoadTest ( He that hath an ear, let him hear what the Spirit saith unto the churches. -Rev. 3:6)
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To: oblomov
The resveratrol in food such as wine is very small- on the order of 100 micrograms per liter. To get a therapeutic effect, you would likely need to take much more (via commercial tablets or capsules), just like the experimental mice (25 mg/kg body weight) and the researcher in the story (5mg/kg). I take much less myself - 20 mg/day at 70 kg.

According to your numbers, I need to drink 5 liters of wine per day. A lot of people aren't so concerned about their health and wouldn't dedicate themselves to such a task, but luckily I'm very persistent...

40 posted on 11/05/2006 3:03:25 PM PST by NittanyLion
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To: neverdem

I wonder if regular concord grape juice contains resveratrol?


41 posted on 01/07/2008 5:07:19 PM PST by Lancey Howard
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To: Lancey Howard

http://www.ncbi.nlm.nih.gov/sites/entrez

concord grapes and resveratrol gets 2 hits

find the species biological name and you’ll probably find more

Vitis labrusca and resveratrol gets 3 hits


42 posted on 01/07/2008 5:29:13 PM PST by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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