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Could our big brains come from Neanderthals?
Reuters via Yahoo ^ | Tue Nov 7, 2006 | Anon

Posted on 11/07/2006 7:27:55 PM PST by Pharmboy

Neanderthals may have given the modern humans who replaced them a priceless gift -- a gene that helped them develop superior brains, U.S. researchers reported on Tuesday.

And the only way they could have provided that gift would have been by interbreeding, the team at the Howard Hughes Medical Institute and the University of Chicago said.

Their study, published in the Proceedings of the National Academy of Sciences, provides indirect evidence that modern Homo sapiens and so-called Neanderthals interbred at some point when they lived side by side in Europe.

"Finding evidence of mixing is not all that surprising. But our study demonstrates the possibility that interbreeding contributed advantageous variants into the human gene pool that subsequently spread," said Bruce Lahn, a Howard Hughes Medical Institute researcher at the University of Chicago who led the study.

Scientists have been debating whether Neanderthals, who died out about 35,000 years ago, ever bred with modern Homo sapiens. Neanderthals are considered more primitive, with robust bones but a smaller intellects than modern humans.

Lahn's team found a brain gene that appears to have entered the human lineage about 1.1 million years ago, and that has a modern form, or allele, that appeared about 37,000 years ago -- right before Neanderthals became extinct.

"The gene microcephalin (MCPH1) regulates brain size during development and has experienced positive selection in the lineage leading to Homo sapiens," the researchers wrote.

Positive selection means the gene conferred some sort of advantage, so that people who had it were more likely to have descendants than people who did not. Lahn's team estimated that 70 percent of all living humans have this type D variant of the gene.

"By no means do these findings constitute definitive proof that a Neanderthal was the source of the original copy of the D allele. However, our evidence shows that it is one of the best candidates," Lahn said.

The researchers reached their conclusions by doing a statistical analysis of the DNA sequence of microcephalin, which is known to play a role in regulating brain size in humans. Mutations in the human gene cause development of a much smaller brain, a condition called microcephaly.

By tracking smaller, more regular mutations, the researchers could look at DNA'S "genetic clock" and date the original genetic variant to 37,000 years ago.

They noted that this D allele is very common in Europe, where Neanderthals lived, and more rare in Africa, where they did not. Lahn said it is not yet clear what advantage the D allele gives the human brain.

"The D alleles may not even change brain size; they may only make the brain a bit more efficient if it indeed affects brain function," Lahn said.

Now his team is looking for evidence of Neanderthal origin for other human genes.


TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: brain; godsgravesglyphs; humanevolution; neandertal; neanderthal
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To: Inyo-Mono; Verginius Rufus; BenLurkin

One point I would make is that before Neanderthalensis and Sapiens became separate species, they could then have had common ancestors.

A mixing and contest for beneficial genes could have resulted from that.


21 posted on 11/07/2006 8:45:17 PM PST by NicknamedBob (If the Supreme Court has "Judges for Life," why is there any question about Roe vs Wade?)
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To: Inyo-Mono
Hairy, smelly Neanderthals?

So now there is evidence that early Homo sapiens shaved and showered regularly?

22 posted on 11/07/2006 9:14:48 PM PST by Verginius Rufus
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Mammoth told me there'd be topics like this.
The Neandertal Enigma
by James Shreeve
Frayer's own reading of the record reveals a number of overlooked traits that clearly and specifically link the Neandertals to the Cro-Magnons. One such trait is the shape of the opening of the nerve canal in the lower jaw, a spot where dentists often give a pain-blocking injection. In many Neandertal, the upper portion of the opening is covered by a broad bony ridge, a curious feature also carried by a significant number of Cro-Magnons. But none of the alleged 'ancestors of us all' fossils from Africa have it, and it is extremely rare in modern people outside Europe." [pp 126-127]

23 posted on 11/07/2006 9:30:10 PM PST by SunkenCiv (Dhimmicrati delenda est! https://secure.freerepublic.com/donate/)
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To: Pharmboy; blam; FairOpinion; StayAt HomeMother; Ernest_at_the_Beach; 24Karet; 3AngelaD; ...
They also may be responsible for the Democrat Party.
Hey, don't insult the Neanderthals. :') Thanks Pharmboy.

To all -- please ping me to other topics which are appropriate for the GGG list. Thanks.
Please FREEPMAIL me if you want on or off the
"Gods, Graves, Glyphs" PING list or GGG weekly digest
-- Archaeology/Anthropology/Ancient Cultures/Artifacts/Antiquities, etc.
Gods, Graves, Glyphs (alpha order)

24 posted on 11/07/2006 9:32:41 PM PST by SunkenCiv (Dhimmicrati delenda est! https://secure.freerepublic.com/donate/)
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To: SunkenCiv

bump


25 posted on 11/07/2006 9:43:38 PM PST by Ciexyz (Satisfied owner of a 2007 Toyota Corolla.)
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To: Pharmboy

"See? I told you so!"

26 posted on 11/07/2006 9:59:15 PM PST by WestVirginiaRebel (Common sense will do to liberalism what the atomic bomb did to Nagasaki-Rush Limbaugh)
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To: Pharmboy

Maybe I will live long enough to see the false "Neanderthal" classification to go by the wayside and the various scientific disciplines realize we are just talking about homo sapiens, just homo sapiens....


27 posted on 11/07/2006 10:37:59 PM PST by Maeve
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To: NicknamedBob

Ugh. They are both homo sapiens. Neanderthalis is a false classification whose origin is in that same school that gave the world Nazi science.


28 posted on 11/07/2006 10:41:12 PM PST by Maeve
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To: Pharmboy

btt


29 posted on 11/07/2006 10:43:44 PM PST by Cacique (quos Deus vult perdere, prius dementat ( Islamia Delenda Est ))
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To: doc1019
Considering the election results of this night, I’m not sure just how big our brains are. Or, if big brains mean anything.

It is all in the matter of how they are used. Considering this election, there wasn't much usage going on.

30 posted on 11/07/2006 11:05:24 PM PST by taxesareforever (Never forget Matt Maupin)
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To: Pharmboy

...if you're a redhead.

Redheads 'are neanderthal'
http://www.freerepublic.com/forum/a3adc5573604d.htm


31 posted on 11/07/2006 11:17:07 PM PST by familyop
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To: Pharmboy

London - Red hair may be the genetic legacy of Neanderthals...
http://www.freerepublic.com/focus/f-news/1322006/posts


32 posted on 11/07/2006 11:18:30 PM PST by familyop
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To: doc1019
Considering the election results of this night, I’m not sure just how big our brains are. Or, if big brains mean anything.

Beat me to it.

33 posted on 11/07/2006 11:19:52 PM PST by pax_et_bonum (I will always love you, Flyer.)
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To: Pharmboy
>Could our big brains come from Neanderthals?

The answer is no. Apes, monkeys, and hominids are one family of creatures, we are another; we are not related to them at all other possibly than for similarity of design. The neanderthal has been ruled out as a plausible ancestor for modern man and his DNA described as "about halfway between ours and that of a chimpanzee" and all other hominids are further removed from us THAN the neanderthal. There is thus no plausible ancestor for modern man amongst the hominids. To be descended from something, at some point, you have to be able to interbreed with the something and we could no more interbreed with neanderthals, much less any other hominid, than we could with goats or horses.

34 posted on 11/07/2006 11:30:52 PM PST by tomzz
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To: doc1019
Considering the election results of this night, I’m not sure just how big our brains are. Or, if big brains mean anything.

The results seem consistent with the theory that man has and is getting dumber not smarter. This definitely seems true at least in some aspects.

35 posted on 11/08/2006 12:08:23 AM PST by Bellflower (A Brand New Day Is Coming!)
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To: Pharmboy
Well??.........how 'bout a "thank you".

I thought so.... typical Homo Sapien,....

Photobucket - Video and Image Hosting

36 posted on 11/08/2006 3:07:04 AM PST by Dick Vomer (liberals suck......... but it depends on what your definition of the word "suck" is.)
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To: blam
Good post, thanks. (We Are Neanderthals)

Oh, really?

Photobucket - Video and Image Hosting

37 posted on 11/08/2006 3:10:16 AM PST by Dick Vomer (liberals suck......... but it depends on what your definition of the word "suck" is.)
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To: tomzz

Uh...no.


38 posted on 11/08/2006 3:38:18 AM PST by Pharmboy (Vote American, not Democrat.)
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To: Verginius Rufus
According to the Random House dictionary (via www.dictionary.com), a the primary ENGLISH meaning for "canard" is: a false or baseless, usually derogatory story, report, or rumor.
39 posted on 11/08/2006 3:43:49 AM PST by kellynch ("Our only freedom is the freedom to discipline ourselves." -- Bernard Baruch)
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To: kellynch
You're right--my Webster's has a similar definition. But the English word was borrowed from French, where it does mean "duck."

As Chico might say, why a duck?

40 posted on 11/08/2006 5:53:55 AM PST by Verginius Rufus
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