I'm set to go all night.
Posted on 11/24/2006 9:05:06 PM PST by neverdem
A drug already shown to reverse the effects of obesity in mice and make them live longer has now been shown to increase their endurance as well.
Experts say the finding may open up a new field of research on similar drugs that may be relevant to the prevention of diabetes and other diseases.
An ordinary laboratory mouse will run one kilometer on a treadmill before collapsing from exhaustion. But mice given resveratrol, a minor component of red wine and other foods, run twice as far. They also have energy-charged muscles and a reduced heart rate, just as trained athletes do, according to an article published online in Cell by Johan Auwerx and colleagues at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France.
“Resveratrol makes you look like a trained athlete without the training,” Dr. Auwerx (pronounced OH-wer-ix) said in an interview.
He and his colleagues said the same mechanism seemed likely to operate in humans, based on analysis in a group of Finnish subjects of the gene that is influenced by the drug.
Their rationale for testing resveratrol was evidence obtained three years ago that it could initiate a genetic mechanism known to protect mice against the degenerative diseases of aging and prolong their life spans by 30 percent.
Dr. Auwerx, whose interest is in the genetic control of metabolism, decided to see whether resveratrol would offset the effects of a high-fat diet, specifically the disturbances known as metabolic syndrome that are the precursors of diabetes and obesity. In his report, he and his colleagues say very large doses of resveratrol protected mice from weight gain and developing the syndrome.
Dr. Auwerx attributes this in large part to the significantly increased number of mitochondria he detected in the muscle cells of treated mice.
Mitochondria are...
(Excerpt) Read more at boston.com ...
http://www.freerepublic.com/focus/f-news/1730163/posts
Does this mean Olympic athletes are just a bunch of winos?
Sounds like I'll have to take my Ciallis with red wine.
Guess I'll try some red wine....I need more endurance...
Bump
but it giffs me more edurance ossifer...
It's also been reported a beer per day is good for the heart. That means if I drink a six pack I'll be good for almost one week!
And you guessed it only now?
http://www.freerepublic.com/focus/f-news/1730163/posts
Substance in Red Wine Could Extend Life, Study Says
I posted that too, but this is physical endurance as in running, not longevity.
Go distilled spirits. I read it somewhere that when they were autopsying the deceased heavy duty alcoholics, their arteries were as clean as those of babies [do not ask about the livers]
IIRC, the merck Index contains the reference to resveratrol synthesis - it is a rather simple molecule, not too hard to make.
That is NOT the same article.
They are both about resveratrol, but discuss two different studies.
Read, before you jump to conclusions.
ping
Sounds good. I don't want to go through an artery transplant.
I'm set to go all night.
If someone put me on a thread mill and made me run until I collapsed in exhaustion, I would probably loose weight too.
Bottom line....drink wine....don't be a Rat!
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