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Treatment of Anemia Questioned
NY Times ^ | November 30, 2006 | ALEX BERENSON

Posted on 11/30/2006 8:41:45 PM PST by neverdem

An expert panel of doctors for the National Kidney Foundation plans to assess whether hundreds of thousands of patients with kidney disease are being dangerously overtreated with drugs for anemia.

The decision to convene the panel comes two weeks after studies in The New England Journal of Medicine suggested that kidney patients whose anemia was more aggressively treated were more likely to die or suffer heart problems than those who were allowed to remain more anemic.

As a result, the panel, which will meet early next year, may recommend less aggressive treatment of anemia, potentially hurting sales for Amgen and Johnson & Johnson, which market the drugs, which are among the world’s best-selling prescription medicines.

“There are substantial sums of money involved here,” said Kerry Willis, vice president for medical and scientific activities of the National Kidney Foundation. The foundation, in response to a reporter’s question, confirmed the panel’s plans to meet. The panel’s recommendations would not have the force of law. But they are certain to be closely watched by kidney doctors as well as administrators of the federal Medicare program, which is by far the largest buyer of the drugs worldwide.

Sold under the brand names Epogen, Procrit, and Aranesp, the anemia drugs will reach almost $10 billion in sales worldwide in 2006. Medicare will spend $2 billion on them for kidney dialysis patients alone, and a similar amount for cancer patients and patients with kidney disease not yet on dialysis.

Nearly one million Americans, including 500,000 kidney patients, receive the drugs every year.

But some independent scientists say they believe that kidney patients are receiving too much of the drugs, in part because dialysis clinics make bigger profits for providing higher doses. The clinics make little profit on the actual dialysis services they provide for Medicare enrollees...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Government; News/Current Events
KEYWORDS: anemia; drugs; health; medicine
Correction of Anemia with Epoetin Alfa in Chronic Kidney Disease
1 posted on 11/30/2006 8:41:47 PM PST by neverdem
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To: neverdem
Oh yes, let's go after the evil biomed pharmaceutical companies and discredit the erythropoiesis meds. I smell the bloody lawyers already ...
2 posted on 11/30/2006 9:02:55 PM PST by rxgalfl
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To: rxgalfl
Oh yes, let's go after the evil biomed pharmaceutical companies and discredit the erythropoiesis meds. I smell the bloody lawyers already ...

The link goes to the abstract. The numbers speak for themselves.

3 posted on 11/30/2006 9:10:46 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: rxgalfl

California medical clinic doctors are being told by the pharmaceutical companies which drugs to prescribe, rather than using their own ability to determine what is best for the patient. It used to be the insurance companies would try to influence treatment, but physicians in this state tell me the pharmaceutical companies are excercising an unhealthy control over patient care in most clinics and hospitals.

There is a problem with pharmaceutical companies and their unconstitutional public-private partnerships pushed by both the Clinton and Bush administrations. They have way too much authority over the care of patients, and it is to the detriment of the patient.

Don't forget the pharmaceutical companies charge Americans the highest prices for their products, so they can, as required by "free trade" supply 'least developed countries' with drugs at little or no cost. Who knows what is behind their zeal to push these anemia drugs on patients? Are they trying to make money there, while giving away the same medicine in Africa or elsewhere? Or are the anemia drugs subsidizing other drugs or programs? This is the question you should ask.


4 posted on 11/30/2006 9:11:19 PM PST by hedgetrimmer (I'm a millionaire thanks to the WTO and "free trade" system--Hu Jintao top 10 worst dictators)
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To: hedgetrimmer
Allow me not to agree with this at all...these high cost injectables have their utilization highly monitored by the insurance companies. They require proof of appropriate lab work (particularly in this case HgB level) and they do not approve treatment otherwise.

I am NOT a pharm company employee, never was. My clinical work does include drug utilization and pharmacology consulting and while I do agree with the drug reps catering to the physicians' offices to the extreme, they do not have any influence when it comes simple insurance pre-certs. This is where the mighty dollar comes in.

P.S. I need to get some sleep so please do not interpret my immediate lack of replies to you (which I know they will be coming :) ) as a sign of my ignoring you, I wish you all a good night!
5 posted on 11/30/2006 9:36:34 PM PST by rxgalfl
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To: hedgetrimmer
no they're trying to increase the blood count without having to transfuse the kidney patients.

It also works for chemo patients for red blood cells and with "Neupogen" it will increase the white blood cell count in order to fight infections without antibiotics...

It's all the same BS...go after the deep pockets.

any company that has had profit growth within the last 10 years should expect the same treatment from the left and those in congress. It's all a shakedown.

6 posted on 11/30/2006 9:37:36 PM PST by Dick Vomer (liberals suck......... but it depends on what your definition of the word "suck" is.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Brain worms can be deadly

'The ugly disease'

FReepmail me if you want on or off my health and science ping list. Anyone can post any unposted link as they see fit.

7 posted on 11/30/2006 10:14:58 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: hedgetrimmer

What ever physician told you the drug companies tell physicians what to use is bound to be a lefty anti-drug company entity. They have no control over what I prescribe. NONE. I write the dang prescriptions they can NOT do that. Did you notice the hidden truth that Medicare barely pays for dialysis. Medicare is a horrible system. That is no excuse for fraud. And if you want free trade in medicines then gripe at socialist nations like our friends in Canada. They have price controls. We subsidize their medications.


8 posted on 11/30/2006 10:17:02 PM PST by therut
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To: Dick Vomer
These drugs are keeping my husband from having to be transfused every week or so. His hematacrit is up from 14 to 33.2 and holding after only two shots. He has had 20 transfusions since Sept. 9.
9 posted on 11/30/2006 11:01:49 PM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: therut

I know that the Medicare write off is really hurting the Dr.'s, but has really paid well for my husband's cancer treatment, including several thousand dollars every 21 days for a drug designed to slow down the growth of the tumor's.


10 posted on 11/30/2006 11:05:29 PM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: mariabush
maria: I wish your husband well however, I wonder if there may not be a safer, just as effective natural treatment. There are many out there and I just had a woman with an aggressive form of breast cancer tell me of natural treatments she is using that is providing dramatic improvement.

Her treatment is based on blood type. There are many types of treatments that warrant being examined. I do not envision myself with ever receiving cancer treatment by a conventional doctor.

The most suspicious part of treatment by conventional doctors is that most of them NEVER seem to even try a natural treatment before prescribing drugs.

I know for a fact that many of these treatments work but doctors have too much of a closed mind to even consider trying them.

11 posted on 12/01/2006 4:54:18 AM PST by Conservativegreatgrandma
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To: Conservativegreatgrandma
I am big on homeopathic methods. I am trying to cram all of the power foods down him that I can, but feel that we need to go with the conventional methods as well, including prayer.

Thanks for your advice. We need all of the help that we can get.

Maria
12 posted on 12/01/2006 5:15:19 AM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: mariabush

Good. You're informing yourself. Do you go to cancer message boards?


13 posted on 12/01/2006 5:24:08 AM PST by Conservativegreatgrandma
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Some doctors have been known to "fudge" the lab results or to "forget" to do the labwork before administering the epogen.


14 posted on 12/01/2006 5:25:22 AM PST by syriacus (Millions in South Korea are free because 30,000 US troops DIED in 3 years under TRUMAN.)
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To: neverdem

My once-a-month injection of Aranesp retails for $1140, but I'm sure my insurance company does not pay that. I pay $10 per dose. Before taking Aranesp, I got so anemic that I could not breathe and had to be rushed by ambulance to the emergency room and was hospitalized. My dosage keeps my hemoglobin around 13.0, so perhaps I should take it less frequently according to the article.


15 posted on 12/01/2006 5:43:50 AM PST by JoeGar
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To: Conservativegreatgrandma

No! It has never occured to me. Can you help, or at least point me in the right direction?

Maria


16 posted on 12/01/2006 5:48:02 AM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: syriacus

We demand a copy of the CBC every week.


17 posted on 12/01/2006 5:49:19 AM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: therut
Medicare is a horrible system.

I agree. The amount it pays my nephrologist and internist are pitiful and way too low. It rips them off for their time, talent, experience, and knowledge. However, my podiatrist bills Medicare $560 for shoes I could buy at Foot Locker for $75. Medicare pays him about $340 and I have to pay him $60. This is a racket. My dermatologist also has a good racket. Every time he sprays a freezing solution on a skin defect, he gets paid for "surgery" -- and he LOVES to spray. Judging by the ads I see on TV, there is also a good racket selling Medicare-paid electric scooters.

18 posted on 12/01/2006 5:52:49 AM PST by JoeGar
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To: mariabush

I'll try. I have an interest in this as my beloved grandson had testicular cancer two years ago. I want my grandson alive years from now. The phony yardstick of five years means nothing to me. I want 50 years. I have some book marks.


19 posted on 12/01/2006 6:03:00 AM PST by Conservativegreatgrandma
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To: Conservativegreatgrandma

The best to your grandson!

Thanks!

Maria


20 posted on 12/01/2006 6:18:04 AM PST by Coldwater Creek (The TERRORIST are the ones who won the midterm elections!)
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To: therut

Are you a private phsysician or associated with a medical foundation of any sort?


21 posted on 12/01/2006 6:29:57 AM PST by hedgetrimmer (I'm a millionaire thanks to the WTO and "free trade" system--Hu Jintao top 10 worst dictators)
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To: hedgetrimmer

Private. And you are right Medicare is a racket for certain industeries. Ie. The free shoes for Diabetic patients is a scam. But every patient I have on Medicare makes dang sure they get their pair every year. Even if they have plenty of money to buy them themselves. The same with diabetic supplies. Scam. Plus we do all the paper work. And do not get me started on the FREE motorized wheelchairs. I am surprised they do not throw in a FREE cell phone so they can be sure to be able to dial 911.


22 posted on 12/01/2006 9:47:28 AM PST by therut
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To: neverdem

Epogen. Great stuff...but 700 dollars a shot.

The alternative is to give blood transfusions, like we did in the old days.

We are also now using it to treat anemia from certain blood cancers and for "chronic disease" anemia....I had a lady with Rheumatoid Arthritis and skinny and weak...after having to transfuse her on and off, the hemotologist (blood specialist) suggested epogen...it took us six months to get her on medicaid/disability to get the drug paid for, but once that was done, it worked fine, but took about two months to work.

And I wonder if the "increase" in heart attacks is real, or if it's just that people feel so much better they over work.


23 posted on 12/01/2006 2:03:59 PM PST by LadyDoc (liberals only love politically correct poor people)
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To: LadyDoc; hocndoc; Ethrane; Born Conservative
And I wonder if the "increase" in heart attacks is real, or if it's just that people feel so much better they over work.

In an accompanying editorial, Giuseppe Remuzzi, M.D., of the Mario Negri Institute for Pharmacological Research in Bergamo, Italy, and Julie R. Ingelfinger, M.D., deputy editor of NEJM, wrote, "The most surprising finding is that high target hemoglobin levels did not ameliorate left ventricular hypertrophy in the CREATE study and, indeed, they increased the risk of congestive heart failure in both trials."

Increased CHF makes sense to me. Maybe you can use the CME/CE?

24 posted on 12/01/2006 2:56:22 PM PST by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: LadyDoc; rxgalfl; JoeGar
And I wonder if the "increase" in heart attacks is real..

There are a few odd things about the study and the NYT story.

The NYT story.
1. As a result, the panel, which will meet early next year, may recommend less aggressive treatment of anemia, potentially hurting sales for Amgen and Johnson & Johnson,
Any fair report on the study would surely mention that Johnson&Johnson was one of the sponsors of the study.
2. The NYT was in a hurry to get the story out with their spin on it. Let's wait until the expert panel of doctors for the National Kidney Foundation makes their report early next year. Save the histrionics till then, if it's appropriate.
3. Not really odd, but the typical NY Slimes hit job deserves mention. And very little info on the study.

Re heart attacks, etc and the study. From the abstract of the study: The primary end point was a composite of death, myocardial infarction, hospitalization for congestive heart failure (without renal replacement therapy), and stroke. However in the official announcement of the study and its details there is no mention of medical history of heart attack, CHF, or stroke, although some CV conditions are not allowed (scroll down in the linked article for details). Sloppy study IMO, or perhaps just a first look to see if a more detailed study should be done eg., several sub-groups going from no such history up to multiple such events.

So in reply to your question about "increased heart attacks" I would say "Who knows?" at this point.
25 posted on 12/01/2006 7:17:36 PM PST by caveat emptor
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To: neverdem

Thanks! That's a good site. I intend to steal ideas for my own.


26 posted on 12/02/2006 5:41:53 AM PST by hocndoc (http://www.lifeethics.org/www.lifeethics.org/index.html)
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