Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Cheap, safe drug kills most cancers
New Scientist ^ | 01/23/2007 | Andy Coghlan

Posted on 01/31/2007 2:34:12 PM PST by SirLinksalot

Cheap, safe drug kills most cancers

What makes cancer cells different - and how to kill them ?

New Scientist has received an unprecedented amount of interest in this story from readers. If you would like up-to-date information on any plans for clinical trials of DCA in patients with cancer, or would like to donate towards a fund for such trials, please visit the site set up by the University of Alberta and the Alberta Cancer Board. We will also follow events closely and will report any progress as it happens.

It sounds almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their “immortality”. The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe.

It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar.

Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis’s experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died (Cancer Cell, DOI: 10.1016/j.ccr.2006.10.020).

(Excerpt) Read more at newscientist.com ...


TOPICS: Culture/Society; Miscellaneous; News/Current Events
KEYWORDS: cancer; cheap; drugs; health; healthcare; safe

1 posted on 01/31/2007 2:34:17 PM PST by SirLinksalot
[ Post Reply | Private Reply | View Replies]

To: SirLinksalot

http://www.depmed.ualberta.ca/dca/


2 posted on 01/31/2007 2:36:23 PM PST by bahblahbah
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot

Lord, I pray this works!


3 posted on 01/31/2007 2:41:17 PM PST by netmilsmom (To attack one section of Christianity in this day and age, is to waste time.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot

If it can't be patented, we will never see it approved for general cancer use.


4 posted on 01/31/2007 2:49:32 PM PST by Abby4116
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot
I want one of those posters in Fox Mulder's office, only with no UFO ....

I Want To Believe

5 posted on 01/31/2007 2:50:52 PM PST by knarf (Islamists kill each other ... News wall-to-wall, 24/7 .. don't touch that dial.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Abby4116

Kinda like DHEA.


6 posted on 01/31/2007 2:56:09 PM PST by polymuser (Neoliberalism is a mental disorder.)
[ Post Reply | Private Reply | To 4 | View Replies]

To: SirLinksalot

Bump in case I get cancer.


7 posted on 01/31/2007 3:14:56 PM PST by domenad (In all things, in all ways, at all times, let honor guide me.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot

So many 'cures' have turned out to be less than advertised. I pray this one does what they're saying it does. A lot of lives depend on it.


8 posted on 01/31/2007 3:16:56 PM PST by reagan_fanatic (Every time a jihadist dies, an angel gets its wings.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot
"It sounds almost too good to be true:"

Almost?

9 posted on 01/31/2007 3:50:46 PM PST by muir_redwoods (Free Sirhan Sirhan, after all, the bastard who killed Mary Jo Kopechne is walking around free)
[ Post Reply | Private Reply | To 1 | View Replies]

To: netmilsmom

Drug companies won't like this a bit if it's true. I hope it is.


10 posted on 01/31/2007 3:53:34 PM PST by derllak
[ Post Reply | Private Reply | To 3 | View Replies]

To: SirLinksalot
I hope it works.

But nothing, NOTHING, will keep me alive forever.

DAMN! :(

11 posted on 01/31/2007 3:56:12 PM PST by LibKill (ENOUGH! Take the warning labels off everything and let Saint Darwin do his job.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: muir_redwoods

BUMP!


12 posted on 01/31/2007 3:57:43 PM PST by Publius6961 (MSM: Israelis are killed by rockets; Lebanese are killed by Israelis.)
[ Post Reply | Private Reply | To 9 | View Replies]

To: SirLinksalot

If it works, the FDA will ban it.


13 posted on 01/31/2007 4:04:16 PM PST by gitmogrunt (Conservative and Republican are not synonymous.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot

If it works, the FDA will ban it.


14 posted on 01/31/2007 4:04:19 PM PST by gitmogrunt (Conservative and Republican are not synonymous.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: domenad
Bump in case I get cancer.

Me too ping...

15 posted on 01/31/2007 6:12:35 PM PST by BlueMondaySkipper (The quickest way of ending a war is to lose it. - George Orwell)
[ Post Reply | Private Reply | To 7 | View Replies]

To: Abby4116
If it can't be patented, we will never see it approved for general cancer use.

Is something ILLEGAL simply because the FDA has not "approved" it ?

Here is where the real PRO-CHOICE debate should be fought.
16 posted on 02/01/2007 7:42:51 AM PST by SirLinksalot
[ Post Reply | Private Reply | To 4 | View Replies]

To: SirLinksalot

In today's climate, can you expect a doctor to prescribe an unapproved treatment? If we were talking about an OTC (which we're not), yes the patient would have a choice. With a prescribed medication, however, what is to stop a malpractice suit if it doesn't work? So, while not illegal, non-approved drugs, while they may be effective in treatment, don't stand much of a chance. This is only my opinion - I do not agree with it, but it is how I see it.


17 posted on 02/01/2007 8:58:26 AM PST by Abby4116
[ Post Reply | Private Reply | To 16 | View Replies]

To: Abby4116
With a prescribed medication, however, what is to stop a malpractice suit if it doesn't work? So, while not illegal, non-approved drugs, while they may be effective in treatment, don't stand much of a chance. This is only my opinion - I do not agree with it, but it is how I see it.

There ought to be a law called : THE PATIENT's FREEDOM OF CHOICE LAW that ABSOLVES doctors and providers of a drug/herb/substance that a patient VOLUNTARILY and WITH FULL MENTAL CAPACITY takes for his own condition from lawsuits or jail.

This is the essence of liberty -- the freedom to take charge of your own health and make your own decisions for yourself. If after much discussions with people ( doctors and researchers included ), I personally conclude that DRUG X, although not legally approved by the FDA, is the best hope for my condition, I would want it available for myself.

I can understand the fear of malpractice suits coming from the provider of such drug. Well, I can sign a legal agreement which BY LAW, ought to be binding, that absolves the person from liabilities should it not work.

BUT IF IT DOES WORK !! That's going to be a boon for people with similar conditions.

I can understand the rigorous, bureaucratic procedures that the FDA has to go through to approve a drug ( costing on average something like 400 Million for a company to get to market ). But sometimes, I if I am desperate, I WANT TO TAKE THE RISK EVEN IF IT MIGHT NOT WORK. Currently, there is little legal recourse for such measure. I want such recourse to exist.
18 posted on 02/01/2007 9:13:11 AM PST by SirLinksalot
[ Post Reply | Private Reply | To 17 | View Replies]

To: SirLinksalot
A few weeks ago I had a friend who is a doctor over for dinner and I asked him if he had heard about a possible diabetes breakthrough I had read about here .
Well he gave me a most pitying look  and said he hadn't but not to worry that there would never be a vaccine to cure diabetes because the drug companies have to much money at stake to ever let one see the light of day.
19 posted on 02/01/2007 9:29:42 AM PST by grjr21
[ Post Reply | Private Reply | To 1 | View Replies]

To: SirLinksalot
the fact that they make their energy throughout the main body of the cell

Is this a known fact, a scientific fact, a true fact, or a marketing fact?

20 posted on 02/01/2007 9:32:06 AM PST by RightWhale (300 miles north of Big Wild Life)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Abby4116

--If it can't be patented, we will never see it approved for general cancer use.--

If it is truely simple and inexpensive, there would be plenty of off-shore outlets for it.


21 posted on 02/01/2007 9:36:04 AM PST by UpAllNight
[ Post Reply | Private Reply | To 4 | View Replies]

To: kristinn; MrConfettiMan
Bump!
22 posted on 02/01/2007 9:37:26 AM PST by spectre (Spectre's wife)
[ Post Reply | Private Reply | To 1 | View Replies]

To: RightWhale
Drug companies will never develop new drugs or medical appliances because they are too heavily invested in present technologies and making too much money.

Oil companies are suppressing the 200 mpg carburetor.

No wonder life is so horrible ....
23 posted on 02/01/2007 9:39:16 AM PST by UpAllNight
[ Post Reply | Private Reply | To 20 | View Replies]

To: UpAllNight

The motor in my basement runs with 121% efficiency and the problem is how to store the excess energy it produces every time I fire it up since batteries evolve so much hydrogen when they charge that there is danger of explosion.


24 posted on 02/01/2007 9:44:17 AM PST by RightWhale (300 miles north of Big Wild Life)
[ Post Reply | Private Reply | To 23 | View Replies]

To: SirLinksalot

Bump!


25 posted on 02/01/2007 6:33:57 PM PST by spectre (Spectre's wife)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson