Witness the Prohibition Amendment, and then later, its repeal. The nation could decide that the freedoms of the First Amendment are too much trouble, and repeal that. The genius of the Constitution would die on that day, but that is possible under Article V.
I guess that depends on how one defines 'pursuance,' non? I don't think the Constitution died, it was the loyalties of those who were sworn to defend, preserve, and protect it.
And I would emphasize, those who were tasked with passing no laws that were not in pursuance. I don't think the founders would hold that the states were destined to become siblings.