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New Malaria Vaccine Is Shown to Work in Infants Under 1 Year Old, a Study Finds
NY Times ^ | October 18, 2007 | DONALD G. McNEIL Jr.

Posted on 10/18/2007 4:22:21 PM PDT by neverdem

The world’s most promising malaria vaccine has been shown to work in infants less than a year old, the most vulnerable group, according to a study being published today.

The study, being published in The Lancet, a British medical journal, was small, comprising only 214 babies in Mozambique, and intended to show only that the vaccine was safe at such young ages. But it also indicated that the risk of catching malaria was reduced by 65 percent after the full course of three shots.

“We’re now a step closer to the realization of a vaccine that can protect African infants,” said Dr. Pedro Alonso, the University of Barcelona professor who leads clinical trials of the GlaxoSmithKline vaccine.

If it passes much larger clinical trials set to start in seven countries next year, and if it is accepted by national regulatory agencies, it could be ready for distribution by 2012, said Dr. W. Ripley Ballou, Glaxo’s vice president for international clinical trials.

In 2004, Dr. Alonso showed for the first time that the vaccine could protect children against infection or death. That study of 2,022 children aged 1 to 4 showed protection from infection about 45 percent of the time.

Such a relatively low level of protection would not be acceptable in a vaccine in the West, but malaria is a leading killer of African children, so even imperfect coverage is a major public health victory.

The vaccine, presently known as RTS,S and tentatively brand-named Mosquirix, is made by fusing a bit of outer protein of the deadly falciparum strain of the malaria parasite with a bit of hepatitis B virus and a chemical booster — the latter two added to provoke a stronger immune reaction.

At least nine malaria vaccine candidates are in development, but Mosquirix is the furthest along...

(Excerpt) Read more at ...

TOPICS: Culture/Society; News/Current Events
KEYWORDS: health; immunization; malaria; vaccination
Malaria Vaccine Prompts Victims' Immune System To Eliminate Parasite From Mosquitoes

not related

1 posted on 10/18/2007 4:22:34 PM PDT by neverdem
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
So similar, yet so different

Embryo screening 'doesn't improve' pregnancy success

Cross-species transplant in rhesus macaques is step toward diabetes cure for humans

FReepmail me if you want on or off my health and science ping list.

2 posted on 10/18/2007 4:37:39 PM PDT by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
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To: neverdem

Huh, interesting.

3 posted on 10/18/2007 10:25:29 PM PDT by SunkenCiv (Profile updated Tuesday, October 16, 2007.
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