Free Republic
Browse · Search
News/Activism
Topics · Post Article

To: All
The Role of Biomarkers in Clinical Trials for Alzheimer Disease

More recently, PET imaging studies using radioligands that bind directly to β-amyloid plaques have been performed.28,29 One of these ligands, Pittsburgh Compound-B (PIB), is a thioflavin derivative and appears to be relatively selective for β-amyloid plaques at the concentrations used for imaging studies. As shown in Figure 2, the binding of PIB to brain sections is highly correlated with total Aβ levels. Test/retest variability in clinical studies is less than 10% for most brain regions.30

15 posted on 12/06/2007 9:23:26 PM PST by neverdem (Call talk radio. We need a Constitutional Amendment for Congressional term limits. Let's Roll!)
[ Post Reply | Private Reply | To 1 | View Replies ]


To: neverdem

In laymens terms, they can’t work within the compound to destroy the plaque, thus the buildup of plaque disrupting the normal flow of impulses is continuous.


17 posted on 12/06/2007 9:26:39 PM PST by JoeSixPack1
[ Post Reply | Private Reply | To 15 | View Replies ]

To: neverdem
More recently, PET imaging studies using radioligands that bind directly to β-amyloid plaques have been performed.28,29 One of these ligands, Pittsburgh Compound-B (PIB), is a thioflavin derivative and appears to be relatively selective for β-amyloid plaques at the concentrations used for imaging studies. As shown in Figure 2, the binding of PIB to brain sections is highly correlated with total Aβ levels. Test/retest variability in clinical studies is less than 10% for most brain regions.30

I have been saying that for years. Nobody listens.

47 posted on 12/06/2007 10:33:48 PM PST by Mind-numbed Robot (Not all that needs to be done, needs to be done by the government.)
[ Post Reply | Private Reply | To 15 | View Replies ]

Free Republic
Browse · Search
News/Activism
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson