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Mounting Evidence Shows Red Wine Antioxidant Kills Cancer
Science Daily ^ | 3-27-2008 | University of Rochester Medical Center

Posted on 03/27/2008 2:59:29 PM PDT by blam

Mounting Evidence Shows Red Wine Antioxidant Kills Cancer

A natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells. (Credit: iStockphoto)

ScienceDaily (Mar. 27, 2008) — Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function.

The new study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated with the antioxidant, resveratrol, and irradiated -- the combination induced a type of cell death called apoptosis, an important goal of cancer therapy.

The research has many implications for patients, said lead author Paul Okunieff, M.D., chief of Radiation Oncology at the James P. Wilmot Cancer Center at the University of Rochester Medical Center. The study is published in the March edition of the journal, Advances in Experimental Medicine and Biology.

Although red wine consumption during chemotherapy or radiation treatment has not been well studied, it is not "contraindicated," Okunieff said. In other words, if a patient already drinks red wine moderately, most physicians would not tell the patient to give it up during treatment. Perhaps a better choice, Okunieff said, would be to drink as much red or purple grape juice as desired.

Yet despite widespread interest in antioxidants, some physicians are concerned antioxidants might end up protecting tumors. Okunieff's study showed there is little evidence to support that fear. In fact, the research suggests resveratrol not only reaches its intended target, injuring the nexus of malignant cells, but at the same time protects normal tissue from the harmful effects of radiation.

"Antioxidant research is very active and very seductive right now," Okunieff said. "The challenge lies in finding the right concentration and how it works inside the cell. In this case, we've discovered an important part of that equation. Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive."

Resveratrol is known for its ability to protect plants from bacteria and fungi. Purified versions have been described in scientific journals as potential anti-cancer, anti-inflammatory and anti-atherogenic agents, and for their ability to modulate cell growth. Other well-known antioxidants derived from natural sources include caffeine, melatonin, flavonoids, polyphenols, and vitamins C and E.

A flurry of antioxidant studies in recent years has not proven how and why they work at the cellular level. At the suggestion of a young scientist in his lab, Okunieff began studying resveratrol as a tumor sensitizer. That's when they discovered its link to the mitochondria.

The discovery is critical because, like the cell nucleus, the mitochondria contains its own DNA and has the ability to continuously supply the cell with energy when functioning properly. Stopping the energy flow theoretically stops the cancer.

Researchers divided pancreatic cancer cells into two groups: cells treated without resveratrol, or with resveratrol, at a relatively high dose of 50 mg/ml, in combination with ionizing radiation. (The resveratrol concentration in red wine can be as high as 30 mg/ml, the study said, and higher doses are expected to be safe as long as a physician is monitoring.)

They evaluated the mitochondria function of the cells treated with resveratrol, and also measured apoptosis (cell death), the level of reactive oxygen species in the cells, and how the cell membranes responded to the antioxidant.

Laboratory experiments showed that resveratrol:

Reduced the function of proteins in the pancreatic cancer cell membranes that are responsible for pumping chemotherapy out of the cell, making the cells chemo-sensitive. Triggered the production of reactive oxygen species (ROS), which are substances circulating in the human body that have been implicated in a number of diseases: when ROS is increased, cells burn out and die. Caused apoptosis, which is likely the result of increased ROS. Depolarized the mitochondrial membranes, which indicates a decrease in the cell's potential to function. Radiation alone does not injure the mitochondrial membrane as much. The team also wanted to investigate why pancreatic cancer cells seem to be particularly resistant to chemotherapy. The pancreas, a gland located deep in the abdomen, produces insulin and regulates sugar, and pumps or channels powerful digestive enzymes into the duodenum. This natural pumping process, however, ends up ridding the needed chemotherapy from cells in the pancreas. But just as reseveratrol interferes with the cancer cells' energy source, it also may decrease the power available to pump chemotherapy out of the cell.

"While additional studies are needed," Okunieff said, "this research indicates that resveratrol has a promising future as part of the treatment for cancer."

In the same journal, Okunieff and his group also reviewed why resveratrol protects normal tissue, and found that antioxidants can be designed to take advantage of certain biochemical properties or cellular targets, making them more effective.

The National Institute of Allergy and Infectious Diseases funded the research through a URMC program called the Center for Medical Countermeasures Against Radiation. Co-authors on the studies are: Weimin Sun, Wei Wang, Jung Kim, Peter Keng, Shanmin Yang, Hengshan Zheng, Chaomei Liu, Lurong Zhang, Jacqueline P. Williams, Steven Swarts and Amy K. Huser. All are from the Department of Radiation Oncology, University of Rochester Medical Center.

Adapted from materials provided by University of Rochester Medical Center, via EurekAlert!, a service of AAAS.


TOPICS: News/Current Events
KEYWORDS: alcohol; cancer; grapeseed; kills; nutraceuticals; nutrition; oenology; red; redwine; resveratrol; supplements; vitamins; wine

1 posted on 03/27/2008 2:59:31 PM PDT by blam
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To: Lil'freeper

Ping


2 posted on 03/27/2008 3:01:02 PM PDT by big'ol_freeper ("Preach the Gospel always, and when necessary use words". ~ St. Francis of Assisi)
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To: blam
As I age, I find myself going from room temp Colt 45 to 100 proof Southern Comfort, to now, some nice red wine. Peace and tranquility. surcease of strife and aggravation.
3 posted on 03/27/2008 3:04:05 PM PDT by isrul (Help make koranimals an endangered species)
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To: blam

I’d be skeptical of any such miraculous claims. Let the evidence accumulate.


4 posted on 03/27/2008 3:04:30 PM PDT by PC99
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To: blam

I’M CURED!! (GLUB, GLUB, SLOSH, SLOSH)


5 posted on 03/27/2008 3:04:51 PM PDT by Extremely Extreme Extremist
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To: PC99
I'll be running some tests this weekend.

Break out the Shiraz!

6 posted on 03/27/2008 3:09:31 PM PDT by Bloody Sam Roberts (Great spirits will always encounter violent opposition from mediocre minds.)
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To: isrul

“Peace and tranquility, surcease of strife and aggravation”.

Works. Has for thousands of years. Newer is not always better.


7 posted on 03/27/2008 3:18:26 PM PDT by elcid1970 (io)
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To: blam
I've written columns on this years ago = they still emphasize wine...but the cancer fighting constituent is, as they say, “reservatrol” that comes from red grapes - (It also comes from Concord grapes, which are almost black) -

http://www.zambroza-juice.co.uk/zambroza_Grape.htm

I'm waiting for the juice makers to start advertising this. One does not have to become a daily wine imbiber to get reservatrol...

When getting juice, though, I myself will get ONLY 100% juice - NOTHING with HFCS in it!

I also like the Concord grapes. It's getting increasingly hard to get grapes with the seeds still in. The reservatrol is in the skins of the grapes, but the seeds, as do most fruit seeds and nuts, contain nitrilocides - and I'll let you do your own research on that, if you are curious. (You might want to also research ‘grape seed extract’ for it's claims to being an excellent antioxidant)

8 posted on 03/27/2008 3:19:08 PM PDT by maine-iac7 (",,,but you can't fool all of the people all the time" LINCOLN)
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I was under the impression drinking grape juice (red) or eating the red grapes would be the same benefit as the wine...or is it specifically red wine?


9 posted on 03/27/2008 3:19:54 PM PDT by Crimson Elephant
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To: Crimson Elephant

“I was under the impression drinking grape juice (red) or eating the red grapes would be the same benefit as the wine...or is it specifically red wine?”

Red grape juice or grapes are fine. In fact you can get large quantities of resveratol in pills containing extract.


10 posted on 03/27/2008 3:28:10 PM PDT by No.6 (www.fourthfightergroup.com)
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To: PC99

Let me guess, the wine industry paid for the study?


11 posted on 03/27/2008 3:28:17 PM PDT by BurbankKarl
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To: blam

“pre-treated with the antioxidant, resveratrol, and irradiated...”

So grab and glass of red wine, and lets all sit in the Microwave Sauna!


12 posted on 03/27/2008 3:29:40 PM PDT by Wiseghy ("You want to break this army? Then break your word to it.")
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To: blam
let's see:

red wine is good for the heart.
gin soaked raisins are good for the flu
beer is good for the digestion
vodka is also good to reduce the size of cancer tumors.

I am pleased to say, that I am healthy as someone could be...
I just have to keep going to these damn meetings every day.

13 posted on 03/27/2008 3:30:45 PM PDT by stylin19a
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To: blam
Does this mean that the little Grape Seed Extract pill I take every morning is keeping me alive?

I'm not sure but it sounds like I should be able to substitute a glass of Two Buck Chuck in the afternoon and get the same result. Food for thought.

14 posted on 03/27/2008 3:32:38 PM PDT by InterceptPoint
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To: blam

Grape juice will do the same thing, won’t it?


15 posted on 03/27/2008 3:54:48 PM PDT by LiberConservative (Part of the "Vast Whitey Wing Conspiracy")
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To: blam; Peanut Gallery

Save Water, Drink Wine!


16 posted on 03/27/2008 3:56:22 PM PDT by Professional Engineer (www.pinupsforvets.com)
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To: InterceptPoint

“natural antioxidant found in grape skins”


17 posted on 03/27/2008 4:02:11 PM PDT by Steve Van Doorn (*in my best Eric cartman voice* 'I love you guys')
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To: Bloody Sam Roberts
I am right behind you; my Dr. said I should drink one glass of red wine a night; he just did not clarify how big the glass should be :)
18 posted on 03/27/2008 4:11:04 PM PDT by martinidon
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To: elcid1970

I’ll drink to that.


19 posted on 03/27/2008 4:22:36 PM PDT by isrul (Help make koranimals an endangered species)
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To: martinidon
should drink one glass of red wine a night

I have a glass that I use for Iced Tea in the summer, it holds about a quart and a half. Will that work?

20 posted on 03/27/2008 5:21:14 PM PDT by Blackhawk
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To: blam

I wish I had started my studies of cellular biology twenty years ago...

Oh well...

But if I’m going to add one single word to the discussion, just one word, maybe the most important word some folks might ever hear, it’s this one:

Carnosine


21 posted on 03/27/2008 5:25:47 PM PDT by djf
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To: martinidon
he just did not clarify how big the glass should be :)

I let my wallet be my guide.

22 posted on 03/27/2008 5:32:38 PM PDT by Bloody Sam Roberts (Great spirits will always encounter violent opposition from mediocre minds.)
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To: blam

When you get the report about good beer doing the same, give me a ping - after the games tonight, of course.


23 posted on 03/27/2008 5:51:35 PM PDT by VanShuyten ("Ah! but it was something to have at least a choice of nightmares.")
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To: blam
Red Wine Antioxidant Kills Cancer

Just finishing my first bottle right now. If they're wrong, I'm in no condition to care...........

24 posted on 03/27/2008 5:54:41 PM PDT by Hot Tabasco (Congress needs to investigate the increasing disappearance of socks from washers)
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To: Blackhawk

I just drink the entire bottle; it is glass.....


25 posted on 03/27/2008 6:19:56 PM PDT by martinidon
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To: DixieOklahoma; reuben barruchstein; theprophetyellszambolamboromo; Alusch; house of cards; ...
Resveratrol inhibits proliferation and induces apoptosis in human cells, (2002 study)
Further Research on Resveratrol Shows Promise for Treatment of Cancer
Mounting Evidence Shows Red Wine Antioxidant Kills Cancer

26 posted on 04/17/2008 9:03:27 PM PDT by Coleus (Abortion and Physician-assisted Murder (aka-Euthanasia), Don't Democrats just kill ya?)
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To: blam; Coleus; AdmSmith; Berosus; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...

The trick is, getting the cancer to hoist a few.


27 posted on 04/17/2008 10:15:28 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/_____________________Profile updated Saturday, March 29, 2008)
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To: blam
a type of cell death called apoptosis

I think that is Cell Death....

From Wikipedia:

***************************EXCERPT****************************

Apoptosis (/̩æ.pəpˈto.səs/[1]) is a form of programmed cell death in multicellular organisms. It is one of the main types of programmed cell death (PCD) and involves a series of biochemical events leading to a characteristic cell morphology and death, in more specific terms, a series of biochemical events that lead to a variety of morphological changes, including blebbing, changes to the cell membrane such as loss of membrane asymmetry and attachment, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation (1-4). Processes of disposal of cellular debris whose results do not damage the organism differentiate apoptosis from necrosis.

In contrast to necrosis, which is a form of traumatic cell death that results from acute cellular injury, apoptosis, in general, confers advantages during an organism's life cycle. For example, the differentiation of fingers and toes in a developing human embryo occurs because cells between the fingers apoptose; the result is that the digits are separate. Between 50 billion and 70 billion cells die each day due to apoptosis in the average human adult. For an average child between the ages of 8 and 14, approximately 20 billion to 30 billion cells die a day. In a year, this amounts to the proliferation and subsequent destruction of a mass of cells equal to an individual's body weight.

Research on apoptosis has increased substantially since the early 1990s. In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases. Excessive apoptosis causes hypotrophy, such as in ischemic damage, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer.

28 posted on 04/17/2008 10:50:10 PM PDT by Ernest_at_the_Beach (No Burkas for my Grandaughters!)
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To: maine-iac7
But will it reduce blood pressure and remove the plaque in the veins?
29 posted on 04/17/2008 10:53:15 PM PDT by Ernest_at_the_Beach (No Burkas for my Grandaughters!)
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To: Coleus

thanks, bfl


30 posted on 04/17/2008 11:40:01 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: SunkenCiv

Just think, if Billy Carter had been a wino instead of a beer-drinker, he’d be alive today.


31 posted on 04/18/2008 2:18:25 AM PDT by Berosus (Support our troops, bring them home -- from the Balkans.)
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