Posted on 06/18/2008 8:04:26 PM PDT by kellynla
US doctors have for the first time successfully treated a skin cancer patient with cells cloned from his own immune system, a study released Wednesday showed. The ground-breaking treatment for advanced melanoma, or skin cancer, led to a long remission for the patient and used his own cloned infection-fighting T-cells, said doctor Cassian Yee, the lead author of the study in the New England Journal of Medicine.
Yee and his associates from the Clinical Research Division at Fred Hutchinson Cancer Research Center in Seattle removed CD4+ T-cells, a type of white blood cell, from a 52-year-old man whose melanoma had spread to a groin lymph node and to one of his lungs.
The melanoma was already well advanced and in stage four.
The T-cells which specifically fight melanoma were modified and expanded in the laboratory and some five billion cells were then infused into the patient, who received no other kind of treatment.
(Excerpt) Read more at breitbart.com ...
great, but how much does it cost?
not all insurance providers will provide.
A BTT for some very exciting news, best I’ve heard in the field in a long time. This wouldn’t be all that tough a thing to field if I understand what they did correctly. Still got a couple of friends working at The Hutch who must be dancing right about now.
Ping to some very important information to be aware of.
I found I had Prostate Cancer last October. Nothing like hearing those words: “You have cancer...” Lets hope we find a cure soon.
Now....killer T cells targeting liberals.......hey, bro!....you daed!!!....don’ come back no mo!
Glad somebody remembers Fred Hutchinson.
Long time Cardinal fan here.
Yes, progress, but it often takes years before it starts getting used on the general public. I did not go to the site to read the full article though.
BTTT!!!
Is this is further development of Steve Rosenburg’s therapy regimen, developed at NIH and announced (with great fanfare) about 20 years ago? That involved separating “killer” T-cells from a patient’s blood, “activating” them in some way (I think it involved interferon, which at the time was very very difficult to come by) and then re-introducing them to the donor patient.
This sort of thing is a little different - it isn’t a drug that has to be tested, manufactured, approved. This is the patient’s own cells. It might be facilitated much more quickly than the usual FDA track, especially if it shows success in multiple patients. What isn’t stated is precisely how it is determined which cells are “most effective” against the tumor and hence are to be cloned. That looks like the real trick here. I’ll be following this one closely.
I believe Bobby Murcer’s brain cancer was treated with the same technique.
Yes, you’re right about it not being like the long drawn out testing of drugs. I doubt many smaller town doctors are able to clone patients cells, most people will probably have to go to the larger cities to get this type of treatment.
But, they probably already have to do that for many other types of treatments now. Many here go to Houston for heart and cancer treatment.
My mother had a melanoma so I’m familiar with this.
What else you gonna spend your money on?
Always good news to learn of progress with this nasty disease. Thanks for the ping!
[All that hot south Florida summer sun years ago......]
Me too - Galveston, oh Galveston.....
How I love that song!
Yeah, we all need to know about this. Sounds good!
Keep your hope alive. These days, prostate cancer is beatable, and new treatments are always around the horizon.
Ahaaa, but your titles can be confusilating, lolol. Another new word.
Found it and you’ll never believe the name - Galveston!!
LOL.
Bump.
Great news!
A Canadian researcher took 15 men with prostate cancer who had
already completed treatment and demonstrated three sucessive increasing psa scores. The patients were given 2000 IU’s of vitamin D per day (5000 would have been much better). 14 of the 15 men experienced reduced or stabilized psa scores. Genestein (a soy derivitave) will likely improve those results
by increasing the numbers of d receptors.
“A Canadian researcher...”
Reinhold Veith?
Have you ever had to pay for cancer treatment?
You can certainly pickem correctly. Maybe you should consider
a trip to the race track. Would you care to comment on Dr. Veith’s research?
Amazing that you bring this up. I am taking between 4000-8000 IU of Vit D3 daily. I am very active, and have had 43 treatments of IMRT radiation for my early-stage Prostate Cancer. However, during my normal yearly Physical, my Dr checked my Vit D level. It was the very lowest number in the normal range. I am in the sun sometimes hours per day. How can this be? There are tons of studies that link Cancer and Vit D levels. I talk a daily multi Vit with 400IU, 1000IU of Calcium which also contains 800IU Vit D3, and I take a D3 supplement of 4000IU daily.
Make sure your multi-vitamin has NO IRON.
Iron is what causes the prostate cancer &
will accelerate it’s growth. Genestein will
increase the numbers-effectiveness of the D
receptors. Large doses of Omega 3 fish oil
will increase occult bleeding in the intestine
and lower your serum ferritin (blood storage of
iron). Lowering your serum ferritin levels is
essential in lowering your risk for all of the other
forms of solid tumor cancers, diabetes and heart disease.
My Multi Vit contains NO Iron...I use a product “equate - men’s health formula”. The Radiation Oncologist that I visit, and who took care of my radiation treatments, is starting a program for patients that will discuss supplements. The Vit D info is fascinating though...
A prostrate cancer cell is essentially a non-differentiated prostate cell that can reproduce and does not die. D enters the D receptor and causes differentiation. The differentiated prostate cell resumes its natural life expectancy.....and eventually dies (apoptosis). Bovine milk proteins interfere with the function of D receptors and so all dairy should be avoided.
Some day, someone will find the right combination but until then, Melanoma remains an especially difficult cancer to develop a therapy for. For decades, promising trials constantly come along yet ultimately fizzle out.
Thanks for the link.
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
Interesting thread. Especially so since I’m sitting here waiting for the results of my biopsy.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.