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Advance Towards Early Alzheimer's Diagnosis
Medical News Today ^ | 20 Jun 2008 | NA

Posted on 06/22/2008 3:46:59 PM PDT by neverdem

The leader of the team that made the discovery, Professor Christopher Rowe of the Austin Hospital in Melbourne, says early diagnosis and treatment presents medical practitioners with the best opportunity to delay the onset of Alzheimer's.

"While the discovery is at an experimental stage, this work places Australia at the forefront of neuro-imaging in Alzheimer's disease," Professor Rowe says.

A 2004 Access Economics report calculated that if the average age of onset of Alzheimer's was raised by just five months, cumulative savings of A$1.3 billion would be realised by 2020 rising to A$6.6 billion by 2040.

Alzheimer's disease is characterised by very high levels of a molecule called beta-amyloid in the brain. The project has demonstrated that a neuro-imaging scan called PiB PET can be used to identify individuals who will develop Alzheimer's disease up to 18 months earlier than all currently available diagnostics.

PiB PET can show the beta-amyloid in the brain which potentially allows clinicians to distinguish patients with early Alzheimer's disease from others without the disease, even before clear signs of memory loss are present.

The research was undertaken as part of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Flagship

Study of Ageing.

The AIBL Flagship Study of Ageing is a collaboration initiated by the CSIRO Preventative Health National Research Flagship. AIBL is a joint activity between the University of Melbourne, Edith Cowan University - Western Australia, Neurosciences Australia, Mental Health Research Institute of Victoria and National Ageing Research Institute, and the Preventative Health Flagship.

The leader of the AIBL study, Professor David Ames, says the study has the potential to markedly reduce the burden this disabling illness places on both individuals and society.

"Early presymptomatic diagnosis is an essential development which will allow us to test new disease modifying therapies with the aim of delaying the onset of Alzheimer's disease in susceptible individuals," Professor Ames says.

The Director of CSIRO's Preventative Health National Research Flagship, Dr Richard Head, says the result highlights the value of a national collaborative team working together on one of Australia's biggest challenges.

Alzheimer's Australia has worked closely with AIBL to attract and co-ordinate the many volunteers who have made this study possible.

"Alzheimer's Australia is pleased to be part of this very exciting research and we look forward to its continuation," Alzheimer's Australia National Executive Director, Glenn Rees, says.

The findings were presented at international meetings in the USA on June 16 and will be presented in July at the International Conference on Alzheimer's disease in Chicago.

The AIBL Flagship Study of Ageing is a collaboration initiated by the CSIRO Preventative Health National Research Flagship. AIBL is a joint activity between the University of Melbourne, Edith Cowan University - Western Australia, Neurosciences Australia, Mental Health Research Institute of Victoria and National Ageing Research Institute, and the Preventative Health Flagship. The Biomedical Imaging Team from the Australian eHealth Research Centre is collaborating with the AIBL Study by developing image analysis methods to quantify disease progression with Magnetic Resonance and Positron Emission Tomography images.

National Research Flagships

CSIRO initiated the National Research Flagships to provide science-based solutions in response to Australia's major research challenges and opportunities. The nine Flagships form multidisciplinary teams with industry and the research community to deliver impact and benefits for Australia.

Source: Professor David Ames CSIRO Australia


TOPICS: Culture/Society; News/Current Events; Technical
KEYWORDS: alzheimers; alzheimersdisease; health; pibpet
Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.

Not the same study, but you get more of an explanation of the technique.

1 posted on 06/22/2008 3:46:59 PM PDT by neverdem
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To: All
Researchers find a clue in battle against Alzheimer's
2 posted on 06/22/2008 3:49:25 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem

I discovered this last year, but then I forgot about it.


3 posted on 06/22/2008 3:58:14 PM PDT by Nick Danger (www.swiftvets.com)
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To: neverdem

did you ever hear anything about that eye test that was supposed to early diagnose? They hyped it on the evening news probably five years ago as one of those serendipitous findings but I’ve never heard anything about it again.


4 posted on 06/22/2008 4:11:52 PM PDT by gusopol3
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To: neverdem
It's a positive step towards curring Alzheimer's but it won’t be a success until it can help me remember why I went upstairs.
5 posted on 06/22/2008 4:12:14 PM PDT by Man50D (Fair Tax, you earn it, you keep it!)
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To: texas booster
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Blocking TGF-beta–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

IIRC, you're interested in protein folding. This might interest you.

6 posted on 06/22/2008 4:13:57 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: gusopol3
did you ever hear anything about that eye test that was supposed to early diagnose? They hyped it on the evening news probably five years ago as one of those serendipitous findings but I’ve never heard anything about it again.

I don't recall it. No sarcasm, my mind is still intact.

7 posted on 06/22/2008 4:17:46 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: Man50D

To FReep. Duh!


8 posted on 06/22/2008 4:19:28 PM PDT by null and void (every Muslim, the minute he can start differentiating, carries hate of Americans, Jews & Christians)
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To: neverdem
Want to avoid Alzheimer's?

Avoid ingesting aluminum.

Fact: All Alzheimer's victims have aluminum deposits in there brains.

9 posted on 06/22/2008 4:20:34 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: Man50D

Bathroom?


10 posted on 06/22/2008 4:22:57 PM PDT by Tax-chick (There is no "overkill." There is only, "Open fire," and, "I need to reload.")
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To: Tax-chick
Bathroom?

I'll make a note to myself. Thanks for reminding me!
11 posted on 06/22/2008 4:26:32 PM PDT by Man50D (Fair Tax, you earn it, you keep it!)
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To: Barnacle
Can you supply additional information on the aluminum - Alzheimer’s link?

I seem to remember a rather tenuous link at best once further studies were completed in the 90’s.

12 posted on 06/22/2008 4:36:16 PM PDT by texas booster (Join FreeRepublic's Folding@Home team (Team # 36120) Cure Alzheimer's!)
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To: texas booster
Can you supply additional information on the aluminum - Alzheimer’s link?

If you wear a tin foil hat, you are more likely to have Alzheimer's. "Tin" foil is really aluminum foil. Also, "Alzheimer's" contains the chemical symbol for aluminum, Al.

Seriously, I thought the Al->Alzheimer's link had been discredited. The amyloid plaques just seem to trap metals, I thought; the plaques are the real problem.

13 posted on 06/22/2008 5:05:14 PM PDT by hellbender
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To: gusopol3

“A potential noninvasive neurobiological test for Alzheimer’s disease”

http://www.sciencemag.org/cgi/content/abstract/266/5187/1051


14 posted on 06/22/2008 5:17:51 PM PDT by M. Dodge Thomas (Opinion based on research by an eyewear firm, which surveyed 100 members of a speed dating club.)
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To: M. Dodge Thomas

oh my goodness, 1994! that looks like the study I remember hearing about. I guess it came to naught. Thank you.


15 posted on 06/22/2008 5:26:12 PM PDT by gusopol3
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To: neverdem

btt


16 posted on 06/22/2008 7:03:04 PM PDT by Cacique (quos Deus vult perdere, prius dementat ( Islamia Delenda Est ))
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To: Barnacle
Want to avoid Alzheimer's?

Avoid ingesting aluminum.

Fact: All Alzheimer's victims have aluminum deposits in there brains.

Maybe they got the wrong genes? You can't avoid it. It's all over the place.

Public Health Statement for Aluminum (Aluminio) Draft for Public Comment September 2006

However, it should be noted that aluminum is a very abundant and widely distributed element and will be found in most rocks, soils, waters, air, and foods. You will always have some exposure to low levels of aluminum from eating food, drinking water, and breathing air.

17 posted on 06/22/2008 7:44:16 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
I linked a bunch about Alzheimer's along the thread.

Chinese UFO Looks Like Emergency Life Raft, Spies on You

Poll: most Britons doubt cause of climate change

A plane with wings of glass?

FReepmail me if you want on or off my health and science ping list.

18 posted on 06/22/2008 8:13:49 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: All

bmp


19 posted on 06/22/2008 8:24:38 PM PDT by Sun (Pray that God sends us good leaders. Please say a prayer now.)
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To: neverdem

Thanks for the ping.


20 posted on 06/22/2008 8:25:27 PM PDT by Quix (WE HAVE THE OIL NOW http://video.google.com/videoplay?docid=3340274697167011147)
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To: neverdem
However, it should be noted that aluminum is a very abundant and widely distributed element and will be found in most rocks, soils, waters, air, and foods. You will always have some exposure to low levels of aluminum from eating food, drinking water, and breathing air.

Sure it's abundant. But, it is so tightly chemically bound in nature that it is not generally bio-assimilated.

However, when it is refined in its pure state by a very unnatural method, it exists in a very unstable form that can dissolve into food and drink when there is a sight acid or alkaline condition.

Case in point, put some tomato sauce in aluminum foil and watch what happens.

Bear in mind, aluminum was not used with food and drink products until after WWII. I believe that my grandmother died of Alzheimer's. She had all the symptoms. They just didn't have a name for it. She drank coffee, an acidic solution, from an aluminum coffee pot for as long as I can remember.

21 posted on 06/22/2008 9:47:05 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: texas booster
All you have to do is Google it.
22 posted on 06/22/2008 9:49:51 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: Barnacle
Case in point, put some tomato sauce in aluminum foil and watch what happens.

Yes, and once it has happened it is "so tightly chemically bound in nature that is is not benerally bio-assimilated".
23 posted on 06/22/2008 9:53:27 PM PDT by aruanan
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To: neverdem

Timely posting. I am making an appointment to find out if my mom is experiencing early Alzheimer’s. Her dad had advanced stages in his 70s. I will be working on this all week, I detest going to the doctor’s office unarmed.


24 posted on 06/23/2008 8:06:28 AM PDT by momincombatboots (Not a journey for the feeble. (Added to the Non- sheeple list of those Not voting for Mccain))
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To: aruanan
Do as you please (at your own risk).

I have a backgound in chemistry and know a PhD. professor of geochemistry who has come to the same conclusion as I have.

25 posted on 06/23/2008 4:45:00 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: hellbender
Seriously, I thought the Al->Alzheimer's link had been discredited. The amyloid plaques just seem to trap metals, I thought; the plaques are the real problem.

It has not been discredited. It's just no one wants to endure the wrath of the milti-billion dollar aluminum industry by declaring it as the cause.

All victims have aluminum deposits in their brains. If amyloid plaques trap metals, why is it that only aluminum is trapped? What about iron? The body is loaded with it.

26 posted on 06/23/2008 5:26:09 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: Barnacle
I have a backgound in chemistry and know a PhD. professor of geochemistry who has come to the same conclusion as I have.

I have a Ph.D. in human nutrition and neurobiology and four years neurobio/pharm/phys post-doc.
27 posted on 06/23/2008 5:48:21 PM PDT by aruanan
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To: neverdem

I had read that the only definitive way to diagnose Alzheimers is on autopsy of the brain, so why are they diagnosing it so much?

The docs said my dad had Alzheimers, but, in fact, he had a horrible stroke and then suffered major neurological deficits which continued til his death. My mother-in-law is said to have Alzheimers but, others have said it is simply dementia.

There is a good book out now by a physician saying that Alzheimers is turning into a big money making endeavor.


28 posted on 06/23/2008 5:51:14 PM PDT by Paved Paradise
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To: Barnacle
"There is circumstantial evidence linking this metal with Alzheimer's disease but no causal relationship has yet been proved. As evidence for other causes continues to grow, a possible link with aluminium seems increasingly unlikely."

Source: http://www.alzheimers.org.uk/site/scripts/documents_info.php?documentID=99

29 posted on 06/23/2008 6:11:43 PM PDT by hellbender
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To: Man50D
"It's a positive step towards curring Alzheimer's but it won’t be a success until it can help me remember why I went upstairs. "

I used to have that problem, then I bough a one-level house. Totally cured me overnight.

30 posted on 06/23/2008 6:19:37 PM PDT by cookcounty (Obama reach across the aisle? He's so far to the left, he'll need a roadmap to FIND the aisle.)
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To: aruanan
I have a Ph.D. in human nutrition and neurobiology and four years neurobio/pharm/phys post-doc.

Hopefully you'll remember that when you're 75.

31 posted on 06/23/2008 9:52:39 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: hellbender
I like to think that it woulld not take a warning lable on a pack of ciggarettes in the 1960’s before I concluded that smoking was unhealthy.

Everyone has to come to their own conclusion.

Oh well, it looks like there's going to be a lot of unnecessary suffering before this country acknowledges that using aluminum with food products makes about as much sense as using lead.

32 posted on 06/23/2008 10:05:12 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: Barnacle
I have a Ph.D. in human nutrition and neurobiology and four years neurobio/pharm/phys post-doc.

Hopefully you'll remember that when you're 75.


As far as anecdotal things go, my parents are both in their upper 80's, have eaten food prepared in aluminum pans since the late 1940's at least, and are extremely acute mentally. My mom recently had neurological testing done for Meniere's disease and the neurologist said she had the mind of a much younger woman. Of course, we all know that when our parents kick our butts playing Boggle. And my dad's still preparing sermons and doing memorial services for the much younger population at the retirement village chapel he pastored for 17 years after he officially retired.
33 posted on 06/24/2008 5:55:16 AM PDT by aruanan
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To: Barnacle

There are quite a few people who think mercury is the culprit. Mercury is one of the most toxic substances known, a neurotoxin. It’s far more toxic even than lead, and both are far more toxic than aluminum. The largest single source of mercury exposure is dental amalgam fillings, which are a whopping 50% mercury.


34 posted on 06/24/2008 6:46:30 AM PDT by hellbender
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To: aruanan

That’s wonderful. I wish you the best.


35 posted on 06/24/2008 7:00:51 PM PDT by Barnacle (Communists and Jihadists were at odds...Then came Barack.)
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To: Paved Paradise
I had read that the only definitive way to diagnose Alzheimers is on autopsy of the brain, so why are they diagnosing it so much?

Autopsy, or biopsy if there's a unique situation, e.g. trauma, gives the definitive diagnosis. Sometimes you have to make a make a presumptive diagnosis for third party payors so Alzheimer's meds can be given.

Neuropsychological Tests Used In The Evaluation Of Alzheimer's Disease

Dementia

Dementia: It's not always Alzheimer's

36 posted on 06/24/2008 8:57:53 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem

Thanks for the links.


37 posted on 06/25/2008 1:02:49 PM PDT by Paved Paradise
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