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Pathologists Believe They Have Pinpointed Achilles Heel Of HIV
Science Daily ^ | July 16, 2008

Posted on 07/16/2008 11:11:38 AM PDT by LibWhacker

ScienceDaily (July 16, 2008) — Human Immunodeficiency Virus (HIV) researchers at The University of Texas Medical School at Houston believe they have uncovered the Achilles heel in the armor of the virus that continues to kill millions.

The weak spot is hidden in the HIV envelope protein gp120. This protein is essential for HIV attachment to host cells, which initiate infection and eventually lead to Acquired Immunodeficiency Syndrome or AIDS. Normally the body’s immune defenses can ward off viruses by making proteins called antibodies that bind the virus. However, HIV is a constantly changing and mutating virus, and the antibodies produced after infection do not control disease progression to AIDS. For the same reason, no HIV preventative vaccine that stimulates production of protective antibodies is available.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: News/Current Events
KEYWORDS: abzymes; achilles; aids; heel; hiv
Wow, the Achilles Heels for Ebola and AIDS found the same month.
1 posted on 07/16/2008 11:11:39 AM PDT by LibWhacker
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To: LibWhacker

Abstinence?


2 posted on 07/16/2008 11:13:47 AM PDT by polymuser (Those who believe in something eventually prevail over those who believe in nothing.)
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To: polymuser

No...can’t do that. Then we couldn’t send $50 billion to Africa.....year after year. We’d have to give our tax money to N. Korea or some thing.


3 posted on 07/16/2008 11:16:11 AM PDT by RC2
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To: LibWhacker

Great, now can we get some more money put on cancer and alzheimers research?


4 posted on 07/16/2008 11:23:29 AM PDT by AU72
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To: AU72

Not sure that it will free up money for other diseases. Unfortunately homosexual men are prone to a number of sexually transmitted diseases. My guess would be that they would lobby to shift funding to some of those other problems rather than ever say that AIDS is now under control.


5 posted on 07/16/2008 11:25:26 AM PDT by Dilbert San Diego
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To: RC2

Since the dollar has been devalued on the world market I think that the USA should provide foreign aid in the form of HD Converter coupons instead of devalued dollars.


6 posted on 07/16/2008 11:25:51 AM PDT by politicalwit (AKA... A Tradition Continues...Now a Hoosier Freeper)
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To: polymuser

28 years to figure out to attack the binding site???


7 posted on 07/16/2008 11:26:10 AM PDT by Chris DeWeese (http://www.firstcenturychristianity.net)
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To: Dilbert San Diego

AIDS will be under control the same time environmental activism and racial strife are under control.


8 posted on 07/16/2008 11:34:13 AM PDT by gimme1ibertee (Moonbats...visit my website! www.kissmybutt.com)
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To: polymuser
Abstinence?

What about all the innocent victims of HIV/AIDS? All of the boys and girls who are raped by infected people who now have to suffer a death sentence? If we can cure this disease, then by all means we should!

9 posted on 07/16/2008 11:35:18 AM PDT by pnh102 (Save America - Ban Ethanol Now!)
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To: LibWhacker

Oh I sure hope they solve this one.

Problem is that the same part of culture shall be the carriers of the next superbug disease.


10 posted on 07/16/2008 12:01:01 PM PDT by NoLibZone (All Democrats must be rationed fuel to reduce their hypocrisy about global warming.)
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To: LibWhacker; neverdem; SunkenCiv
How it's done:

*****************************EXCERPT************************

The abzymes are derived from HIV negative people with the autoimmune disease lupus and a small number of HIV positive people who do not require treatment and do not get AIDS. Stephanie Planque, lead author and UT Medical School at Houston graduate student, said, “We discovered that disturbed immunological events in lupus patients can generate abzymes to the Achilles heel of HIV. The human genome has accumulated over millions of years of evolution a lot of viral fragments called endogenous retroviral sequences. These endogenous retroviral sequences are overproduced in people with lupus, and an immune response to such a sequence that resembles the Achilles heel can explain the production of abzymes in lupus.  A small minority of HIV positive people also start producing the abzymes after decades of the infection.  The immune system in some people can cope with HIV after all.”

11 posted on 07/16/2008 12:05:23 PM PDT by Ernest_at_the_Beach (No Burkas for my Grandaughters!)
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To: All
Abzymes Student's Encyclopedia

************ABSTRACT****************

antibodies that perform task of enzymes—that is, they catalyze, or speed up, biological reactions by several million times uncatalyzed rate; previously thought an impossibility, they were first successfully applied in 1986 to mammalian immune system by two independent research teams (one led by Richard A. Lerner of Research Institute of Scripps Clinic in La Jolla, Calif.; …

12 posted on 07/16/2008 12:08:55 PM PDT by Ernest_at_the_Beach (No Burkas for my Grandaughters!)
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To: Chris DeWeese

See #11...


13 posted on 07/16/2008 12:10:05 PM PDT by Ernest_at_the_Beach (No Burkas for my Grandaughters!)
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To: Dilbert San Diego
"Unfortunately homosexual men are prone to a number of sexually transmitted diseases. My guess would be that they would lobby to shift funding to some of those other problems rather than ever say that AIDS is now under control."

Butt cancer.

14 posted on 07/16/2008 12:20:40 PM PDT by Nathan Zachary
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To: Ernest_at_the_Beach
A bit more:

Paul’s group has engineered antibodies with enzymatic activity, also known as abzymes, which can attack the Achilles heel of the virus in a precise way. “The abzymes recognize essentially all of the diverse HIV forms found across the world. This solves the problem of HIV changeability. The next step is to confirm our theory in human clinical trials," Paul said.

Unlike regular antibodies, abzymes degrade the virus permanently. A single abzyme molecule inactivates thousands of virus particles. Regular antibodies inactivate only one virus particle, and their anti-viral HIV effect is weaker.

“The work of Dr. Paul’s group is highly innovative. They have identified antibodies that, instead of passively binding to the target molecule, are able to fragment it and destroy its function. Their recent work indicates that naturally occurring catalytic antibodies, particularly those of the IgA subtype, may be useful in the treatment and prevention of HIV infection,” said Steven J. Norris, Ph.D., holder of the Robert Greer Professorship in the Biomedical Sciences and vice chair for research in the Department of Pathology and Laboratory Medicine at the UT Medical School at Houston.

The abzymes are derived from HIV negative people with the autoimmune disease lupus and a small number of HIV positive people who do not require treatment and do not get AIDS. Stephanie Planque, lead author and UT Medical School at Houston graduate student, said, “We discovered that disturbed immunological events in lupus patients can generate abzymes to the Achilles heel of HIV. The human genome has accumulated over millions of years of evolution a lot of viral fragments called endogenous retroviral sequences. These endogenous retroviral sequences are overproduced in people with lupus, and an immune response to such a sequence that resembles the Achilles heel can explain the production of abzymes in lupus. A small minority of HIV positive people also start producing the abzymes after decades of the infection. The immune system in some people can cope with HIV after all.”

15 posted on 07/16/2008 12:29:23 PM PDT by MHGinTN (Believing they cannot be deceived, they cannot be convinced when they are deceived.)
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To: LibWhacker

Limiting human orifices to their designed function has worked very well at limiting HIV to just certain segments of society.


16 posted on 07/16/2008 12:34:35 PM PDT by SampleMan (We are a free and industrious people, socialist nannies do not become us.)
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To: LibWhacker

Sweet, now we can redirect that money going to HIV research into diseases that are by and large caused by behavior.

If breast cancer had the sort of funding that HIV has had, it would have been wiped out long ago.


17 posted on 07/16/2008 12:37:24 PM PDT by HamiltonJay
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To: LibWhacker
Sounds like Nobel Prize work.

18 posted on 07/16/2008 12:55:55 PM PDT by conservatism_IS_compassion (The conceit of journalistic objectivity is profoundly subversive of democratic principle.)
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To: LibWhacker
The Achilles heel, a tiny stretch of amino acids numbered 421-433 on gp120, is now under study as a target for therapeutic intervention.

Pretty damn short. Better hope that the same sequence is not found in healthy body tissues.

19 posted on 07/16/2008 3:12:13 PM PDT by TChad
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To: Ernest_at_the_Beach

thanks, bfl


20 posted on 07/16/2008 5:58:01 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: Chris DeWeese; AU72; polymuser; LibWhacker; Ernest_at_the_Beach; SunkenCiv
28 years to figure out to attack the binding site???

gp120, glycoprotein 120, is pretty slick. Enter gp120 conformational changes and hiv binding into the query box at PubMed. I got 129 hits. This binding site is very well hidden, IMHO.

Great, now can we get some more money put on cancer and alzheimers research?

Catalytic antibodies to amyloid β peptide in defense against Alzheimer disease Link to free article

Catalytic antibodies to HIV: Physiological role and potential clinical utility. Link to abstract by all of the same authors as the previous link.

21 posted on 07/16/2008 7:18:49 PM PDT by neverdem (I'm praying for a Divine Intervention.)
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To: neverdem; AdmSmith; Berosus; Convert from ECUSA; dervish; Ernest_at_the_Beach; Fred Nerks; ...

I’m sure Whoopi “the f-ing president” Goldberg will find some way to make this into bad news. Thanks neverdem.


22 posted on 07/16/2008 9:49:37 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/_________________________Profile updated Friday, May 30, 2008)
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To: Ernest_at_the_Beach

whoops, thanks Ernest.


23 posted on 07/16/2008 10:11:01 PM PDT by SunkenCiv (https://secure.freerepublic.com/donate/_________________________Profile updated Friday, May 30, 2008)
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