Of course, the required support would have to be at least a super-majority, and other issues would need to be addressed... but to say that such a region or population has, as its ONLY recourse, armed insurrection seems anathema to a just and righteous nation. IMHO.
That was the contradiction in the Confederate States. They set themselves up as principled opponents of unwanted centralized power yet they refused the clear wishes of East Tennessee to remain loyal to the United States and wanted no part of the Confederacy.