2010 looks very difficlut, with lots of COP retirements coming and FL, IA, MO, NH, NC, PA seats to defend.
not easy to pick up any seats, and quite possible to lose another 3 or 4.
2012 and 2014 will be quite good, though
2012 will be great, as long as that Mayan apocalypse comes through.
Looking ahead to 2010, I think the map is against the GOP. They have numerous vulnerable incumbents including:
Mel Martinez (FL)
Lisa Murkowski (AK)
David Vitter (LA)
Jim Bunning (KY)
Arlen Specter (PA)
George Voinovich (OH)
Richard Burr (NC)