Top Scientists Ask Medical Journal Science To Retract Original AIDS Papers

SAN FRANCISCO (Rethinking AIDS) Dec. 9, 2008—The international nonprofit scientific organization Rethinking AIDS gave its full support today to 37 senior researchers, medical doctors and legal professionals who are requesting that the medical journal Science withdraw four seminal papers on HIV authored by Dr. Robert Gallo—papers widely touted as proof that HIV is the "probable cause of AIDS." An online posting of the letter can be found here.

"With new findings that undermine the scientific integrity and veracity of Gallo's four papers, the entire basis of the theory that HIV causes AIDS may now be questioned," says Rethinking AIDS president David Crowe.

The letter to the journal comes at a time when the microbiology world is abuzz about Gallo's omission from the 2008 Nobel Prize in medicine for the discovery of HIV, contrary to an international agreement that the two teams should share credit. French scientists Drs. Luc Montagnier and Francoise Barré-Sinoussi are instead to be given the award, a decision that also implicitly questions the scientific integrity of Gallo's claim of the discovery. Montagnier, however, admitted on camera more than a decade ago that his experiments did not purify any virus.

The four papers were originally published on May 4, 1984, a few days after a press conference by Gallo announcing he had discovered the "probable cause of AIDS." Now, a British investigative journalist has shown that Gallo's claim was based on last-minute alterations to documents that make false claims about the results of his lab work and research experiments. The letter to Science sent by the 37 experts on Monday, Dec. 1, 2008, includes a copy of Gallo’s handwritten changes to the article, a letter from an electron microscopy expert indicating that Gallo’s samples did not contain any virus, and a letter from Gallo to a researcher verifying that HIV could not be purified directly from human materials.

The investigative conclusion prompting the letter to Science was made by journalist Janine Roberts, author of Fear of the Invisible, a book that examines the origin of several disease theories. "I was shocked when I read the original draft of the key scientific paper now widely cited as proving HIV causes AIDS," says Roberts. "Gallo's handwritten last-minute changes had reversed what the scientists in his lab had originally concluded. This demonstrates a stunning disregard for the scientific process and a very disturbing breach of public trust."

It is clear that the seminal research published on HIV contained unjustified claims and alterations. In 1993, governmental investigators determined Gallo had so poorly recorded his key and much-cited experiment that it was impossible to repeat and verify it.

In the early 1990s, several highly critical reports on the research underlying Gallo's papers were produced as a result of governmental inquiries working under the supervision of scientists nominated by the National Academy of Sciences and the Institute of Medicine. The Office of Research Integrity (ORI) of the U.S. Department of Health and Human Services concluded that the lead paper of the four was "fraught with false and erroneous statements" and that the “ORI believes that the careless and unacceptable keeping of research records . . . reflects irresponsible laboratory management that has permanently impaired the ability to retrace the important steps taken." Further, a Congressional Subcommittee on Oversight and Investigations produced a staff report on the papers, containing scathing criticisms of their integrity.

Rethinking AIDS — an international group of more than 2,600 scientists, doctors, journalists, health advocates and others — offers several eminent medical and scientific experts to comment on this and other AIDS issues currently in the news:

Etienne de Harven, M.D.* Professor Emeritus, University of Toronto Saint Cézaire, France Member and professor in cell biology, Sloan Kettering Institute, New York, 1956-1981. Isolated and obtained the first electron microscopic studies of the murine Friend leukemia virus, and retroviral budding. Frequent critic of the "isolation" of HIV, and past president of Rethinking AIDS. Dr. de Harven can comment on the science of retrovirus isolation.

Janine Roberts Investigative Reporter Bristol, U.K. jan@fearoftheinvisible.com Author, Fear of the Invisible, a recent book exposing the fraud in the drafting of one of the original 1984 Science articles by Robert Gallo. Web site: www.fearoftheinvisible.com

David Crowe* President, Rethinking AIDS Calgary, Alberta, Canada (Mountain time zone) 1-403-289-6609 (office) 1-403-861-2225 (mobile) david.crowe@aras.ab.ca

Elizabeth Ely Public Relations Chairperson Rethinking AIDS Brooklyn, N.Y., U.S. (Eastern time zone) 1-718-704-9672 (mobile) publicrelations@rethinkingaids.com

Rethinking AIDS: The Group for the Scientific Reappraisal of the HIV/AIDS Hypothesis ("RA" or "the Group") was formed in 1991 to express the concerns of a growing number of renowned scientists and medical doctors about HIV research and the resulting human rights abuses. In 1995, by a letter published in Science, the Group called for a thorough reappraisal of the existing evidence for and against the HIV/AIDS hypothesis and recommended that critical epidemiological studies be undertaken.

Among RA's founders and key members are University of Toronto professor emeritus and former cancer researcher Dr. Etienne de Harven; Harvard microbiologist Dr. Charles Thomas; 1993 Nobel laureate for chemistry Dr. Kary Mullis; Nature/Biotechnology co-founder Dr. Harvey Bialy; University of California at Berkeley molecular biologist Dr. Peter Duesberg and the late Yale mathematician Dr. Serge Lang, both members of the National Academy of Sciences; physicist Eleni Papadopulos-Eleopulos of the Royal Perth Hospital in Australia; and Glasgow University professor emeritus of public health and World Health Organization consultant Dr. Gordon Stewart.

LETTER FROM RETHINKING AIDS SCIENTISTS CALLING FOR THE JOURNAL SCIENCE TO RETRACT ROBERT GALLO'S ORIGINAL PAPERS DECLARING HIV THE CAUSE OF AIDS:

Science/AAAS 1200 New York Avenue NW Washington, DC, 20005 +1-202-326-6400

December 1, 2008

To: Bruce Alberts, Editor in Chief, Science:

cc: Alan Lechner, CEO, AAAS

On May 4, 1984 your journal published four papers by a group led by Dr. Robert Gallo. We are writing to express our serious concerns with regard to the integrity and veracity of the lead paper among these four of which Dr. Mikulas Popovic is the lead author.[1] The other three are also of concern because they rely upon the conclusions of the lead paper.[2][3][4]

In the early 1990s, several highly critical reports on the research underlying these papers were produced as a result of governmental inquiries working under the supervision of scientists nominated by the National Academy of Sciences and the Institute of Medicine. The Office of Research Integrity of the US Department of Health and Human Services concluded that the lead paper was “fraught with false and erroneous statements,” and that the “ORI believes that the careless and unacceptable keeping of research records...reflects irresponsible laboratory management that has permanently impaired the ability to retrace the important steps taken.”[5] Further, a Congressional Subcommittee on Oversight and Investigations led by US Representative John D. Dingell of Michigan produced a staff report on the papers which contains scathing criticisms of their integrity.[6]

Despite the publically available record of challenges to their veracity, these papers have remained uncorrected and continue to be part of the scientific record.

What prompts our communication today is the recent revelation of an astonishing number of previously unreported deletions and unjustified alterations made by Gallo to the lead paper. There are several documents originating from Gallo's laboratory that, while available for some time, have only recently been fully analyzed. These include a draft of the lead paper typewritten by Popovic which contains handwritten changes made to it by Gallo.[7] This draft was the key evidence used in the above described inquiries to establish that Gallo had concealed his laboratory's use of a cell culture sample (known as LAV) which it received from the Institut Pasteur.

These earlier inquiries verified that the typed manuscript draft was produced by Popovic who had carried out the recorded experiment while his laboratory chief, Gallo, was in Europe and that, upon his return, Gallo changed the document by hand a few days before it was submitted to Science on March 30, 1984. According to the ORI investigation, “Dr. Gallo systematically rewrote the manuscript for what would become a renowned LTCB [Gallo's laboratory at the National Cancer Institute] paper.”[5]

This document provided the important evidence that established the basis for awarding Dr. Luc Montagnier and Dr. Francoise Barré-Sinoussi the 2008 Nobel Prize in Medicine for the discovery of the AIDS virus by proving it was their samples of LAV that Popovic used in his key experiment. The draft reveals that Popovic had forthrightly admitted using the French samples of LAV renamed as Gallo’s virus, HTLV-III, and that Gallo had deleted this admission, concealing their use of LAV. However, it has not been previously reported that on page three of this same document Gallo had also deleted Popovic's unambiguous statement that, "Despite intensive research efforts, the causative agent of AIDS has not yet been identified,” replacing it in the published paper with a statement that said practically the opposite, namely, “That a retrovirus of the HTLV family might be an etiologic agent of AIDS was suggested by the findings.”

It is clear that the rest of Popovic's typed paper is entirely consistent with his statement that the cause of AIDS had not been found, despite his use of the French LAV. Popovic’s final conclusion was that the culture he produced “provides the possibility” for detailed studies. He claimed to have achieved nothing more. At no point in his paper did Popovic attempt to prove that any virus caused AIDS, and it is evident that Gallo concealed these key elements in Popovic’s experimental findings.

It is astonishing now to discover these unreported changes to such a seminal document. We can only assume that Gallo’s alterations of Popovic’s conclusions were not highlighted by earlier inquiries because the focus at the time was on establishing that the sample used by Gallo's lab came from Montagnier and was not independently collected by Gallo. In fact, the only attention paid to the deletions made by Gallo pertains to his effort to hide the identity of the sample. The questions of whether Gallo and Popovic’s research proved that LAV or any other virus was the cause of AIDS were clearly not considered.

Related to these questions are other long overlooked documents that merit your attention. One of these is a letter from Dr. Matthew A. Gonda, then Head of the Electron Microscopy Laboratory at the National Cancer Institute, which is addressed to Popovic, copied to Gallo and dated just four days prior to Gallo’s submission to Science.[8] In this letter, Gonda remarks on samples he had been sent for imaging because “Dr Gallo wanted these micrographs for publication because they contain HTLV.” He states, “I do not believe any of the particles photographed are of HTLV-I, II or III.” According to Gonda, one sample contained cellular debris, while another had no particles near the size of a retrovirus. Despite Gonda’s clearly worded statement, Science published on May 4, 1984 papers attributed to Gallo et al with micrographs attributed to Gonda and described unequivocally as HTLV-III.

In another letter by Gallo, dated one day before he submitted his papers to Science, Gallo states, “It’s extremely rare to find fresh cells [from AIDS patients] expressing the virus... cell culture seems to be necessary to induce virus,” a statement which raises the possibility he was working with a laboratory artifact. [9]

Included here are copies of these documents and links to the same. The very serious flaws they reveal in the preparation of the lead paper published in your journal in 1984 prompts our request that this paper be withdrawn. It appears that key experimental findings have been concealed. We further request that the three associated papers published on the same date also be withdrawn as they depend on the accuracy of this paper.

For the scientific record to be reliable, it is vital that papers shown to be flawed, or falsified be retracted. Because a very public record now exists showing that the Gallo papers drew unjustified conclusions, their withdrawal from Science is all the more important to maintain integrity. Future researchers must also understand they cannot rely on the 1984 Gallo papers for statements about HIV and AIDS, and all authors of papers that previously relied on this set of four papers should have the opportunity to consider whether their own conclusions are weakened by these revelations.

Respectfully,

Mohammed A. Al-Bayati, PhD, DABT, DABVT. Toxicologist & Pathologist, Toxi-Health International, Dixon, CA.

David A. Ballok, PhD, Department of Surgery, Division of Neurosurgery and Neurosciences, McMaster University, Canada.

Henry H. Bauer, PhD, Dean Emeritus of Arts & Sciences, Professor Emeritus of Chemistry & Science Studies, Virginia Polytechnic Institute & State University.

André-Pierre Benguerel, PhD, Professor Emeritus, University of British Columbia, Vancouver, Canada. Terry Bennett, MD, MPH.

Harvey Bialy, PhD, founding scientific editor of Nature Biotechnology, author of Oncogenes, Aneuploidy and AIDS: A Scientific Life & Times of Peter H. Duesberg.

Christopher Black, Barrister, International Criminal Lawyer, Lead Counsel, Rwanda War Crimes Tribunal. Kelly Brennan-Jones, PhD, Associate Professor of Psychology, SUNY Brockport, New York, USA. Darin Brown, PhD, Mathematics.

Gordon Burns, PhD, Professor of Cancer Research, The University of Newcastle, Australia.

Jennifer L. Craig, BSN, MA, PhD.

Etienne de Harven, MD, Professor Emeritus, University of Toronto. Signature available on request.

Andrea G. Drusini, MD, PhD, Medical Anthropologist, Professor of Anthropology, Department of Medico-Diagnostic Sciences and Special Therapies, University of Padova, Italy.

Charles Geshekter, PhD, Professor Emeritus of History, Chair, History of Science Section, AAAS/Pacific Division (1990-95). California State University, Chico. Signature available on request.

Roberto Giraldo, MD, Specialist in internal medicine, infectious and tropical diseases. Member of the Department of Integral Psychosomatic Medicine, International Society of Analytical Trilogy, São Paulo, Brazil. Signature available on request.

Pablo L. E. Idahosa, PhD, Professor, Social Science Program Director, African Studies Graduate Program, International Development Studies Founders College, York University, Canada. Signature available on request. Matt Irwin, MD, MSW, Private practice, Alexandria, Virginia.

Joel M. Kauffman, Professor of Chemistry Emeritus, University of the Sciences in Philadelphia, Medical Writer.

Claus Koehnlein, MD, Specialist in internal medicine, Dept. of Oncology, Univ. of Kiel, Germany (1983 -1993). Since 1993, in private practice increasingly treating HIV-positive people who decline antiviral drugs. Member of South Africa Presidential AIDS Advisory Panel.

Hans J. Kugler,PhD, President, International Academy of Anti-Aging Medicine.

Helen Lauer, PhD, Associate Professor, Philosophy Department Head, University of Ghana.

Herbert G. Lebherz, PhD, Professor of Chemistry and Biochemistry (Emeritus). San Diego State University, USA.

Stoffer Loman, BSc, MSc, PhD.

Ahmed Makata, Dip (clin medicine–TZ), MD (USSR), certificate (Tropical pathology–Japan), PhD (Path–Japan), DFM (Path–RCPA– Australia), Forensic Consultant, Histopathologist, Head of Forensic Unit, Ministry of Health, Tanzania. Signature available on request.

Andrew Maniotis, PhD, University of Illinois at Chicago. Signature available on request.

Jonas Moses, PhD, PA, Former US Army clinician (in Ophthalmology), cancer biologist in the Dept. of Pathology, Univ. of Illinois – Chicago (2002-2007), and consulting cell and tissue engineer.

Paul Olisa Adaka Ojeih, PhD, MD, Medical Director, Iris Medical Foundation, Lagos, Nigeria.

Nikitah Okembe-RA Imani, Associate Professor of Sociology and African Studies, James Madison University. Signature available on request.

Philippe Packard, PhD, MPH. Signature available on request.

David Rasnick, PhD, Biochemist, Protease Inhibitor Developer, Chief Scientific Officer, Chromosome Diagnostics, LLC.

Prof. Dr. med. Jochen Schaefer, Director, International Institute for Theoretical Cardiology, Kiel, Germany.

Hugo Stenström, MD, Senior interventional radiologist, Department of Radiology, Linkoping University Hospital, Sweden.

Gordon T. Stewart, MD. Emeritus Professor of Public Health, University of Glasgow, and consultant physician (epidemiology and preventive medicine), NHS, UK. Former consultant to New York City, WHO and to other health authorities in Europe, North America, Africa and Asia on AIDS and related matters. Emeritus Fellow, Infectious Diseases Society of America and former member of the editorial board of the Journal of Infectious Diseases. Signature available on request.

Roberto P. Stock, PhD. Research Scientist Instituto de Biotecnologia – UNAM, Mexico.

Jean Umber, Professeur agrégé (Organic Chemistry), Académie de Nancy-Metz, Lorraine, France.

Rudolf Werner, Professor, Dept. of Biochemistry & Molecular Biology Univ. of Miami School of Medicine.

Chun Xu, MD, PhD, VP Global Clinical Services, Venturepharm Lab. Beijing, China.

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