Skip to comments.One protein mediates damage from high-fructose diet
Posted on 03/04/2009 1:41:57 AM PST by neverdem
Sweet reversal: Harmful effects of fructose traced to one protein in a study of mice
Knocking out a liver protein in mice can reverse the damaging effects of a super-sweet diet. Diets loaded with high-fructose corn syrup wreak havoc on metabolic processes, but how fructose does its damage has been a mystery. The new study, appearing in the March 4 Cell Metabolism, identifies a possible culprit, a protein in the liver called PGC-1 beta.
The new research is putting together things that we know and making a link, comments Carlos Hernandez of the University of Michigan in Ann Arbor. The paper highlights the importance of PGC-1 beta in the whole process, says Hernandez, who wrote a commentary in the same issue of Cell Metabolism on the new research.
Over the past decade, high-fructose corn syrup has made its way into Western diets through soda and processed foods in ever-increasing amounts. Diets high in fructose are linked to a slew of metabolic disorders, including nonalcoholic fatty liver disease, high blood levels of triglycerides, and insulin resistance, which is tied to type 2 diabetes, says study coauthor Yoshio Nagai, a physiologist at Yale University School of Medicine. Many people think fat is the enemy, but they dont care about sweeteners.
Just like humans, mice fed a high-fructose diet develop insulin resistance and fatty liver disease. But when Nagai and his colleagues reduced the levels of the PGC-1 beta protein specifically in mices livers and fat tissue, these mice no longer showed signs of either disease. The mice ate a very high-fructose diet and remained unscathed, the team reports.
PCG-1 beta knockdown can reverse the effects of a high-fructose diet in the development of insulin resistance, which is, in my opinion, a very novel, important finding, Hernandez says...
(Excerpt) Read more at sciencenews.org ...
I try to lay off HFCS, but it’s hard to do!
Thanks for posting, this will help sway me.
The HF corn syrup is not as good anyway. If you want it sweet just use cane sugar. I had a Mexican Coke once and it was so much better.
I have a real novel approach to solving this problem.
How about you don't eat HFCS in the first place?
As time goes by, I become more and more convinced that HFCS is poison, pure and simple.
Does this mean they can develop a pill that will let me start drinking whiskey again? Will I get it at the pharmacy or the liquor store?
Or sugar for that matter. Sugar is half fructose, you know.
If you like Mexican Coca-Cola, start looking for soda made for Jewish Passover.
Jewish people can't consume anything with HFCS during Passover, so soda companies do a run of sugar-based drinks around this time of year, every year. The bonus is that it costs the same as "regular" Coke; Mexican soda is oftentimes a lot more.
You may have bought it before without noticing, since in some places, it seems to just replace the regular sweetened stuff for a week or two.
Here is an article about what to look for. We don't generally drink sugared sodas, but have noticed this in the regular grocery store while shopping.
Kosher-for-Passover Coke and Pepsi Are Back!(^) from Serious Eats. If interested, pay attention to to subtle changes in packaging listed inthe article.
There are many sodas made with regular sugar now. Check out all health food stores or even BevMo and read the ingredients. “Cane Syrup” is sugar. Rarely I let my kids buy a soda or two as a treat. I far prefer them eating sugar to the hideous and dangerous corn syrup.
The latest news is that HFCS “might” contain mercury. Google it - it was in the WaPo.
Us, too. I shop at Whole Foods a lot due to a serious food sensitivity, and occasionally pick up a soda there for the kiddos. Mostly, though, we just don't "do" soda. Like your kids, it's a rare treat.
The latest news is that HFCS might contain mercury. Google it - it was in the WaPo.
Thank you for mentioning the potential mercury issue; I'd seen it before but was surprised that it didn't get very much airplay. Too much ad revenue in soda sales, I guess. At any rate, it is not worth the risk to us, so we avoid HFCS like the plague.
Here is an article: Mercury contaminates high fructose corn syrup(^), Statesville Record & Landmark.
What if BevMo, btw?
I didn’t know any of this, thanks. I will be on the lookout. I drink maybe a soda a month but when I want one, I want one. :)
Awesome news, I’m betting on a drug coming out to lessen the risks of Type II diabetes and childhood obesity based on this.
Thanks for the links.
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