There is a lot of bluster in that speech, the fact is the EU seems to matter very little in the global scheme of things.
True. Though, for 1,800 out of 2100 years, Europe and the U.K. were the major militaries and world-shaping forces. It can change pretty quickly nowadays, with our ever-more-intertwined economies, and everything happening globally at the speed of "bytes."
The Antichrist could easily come from Eastern Europe. Or Africa.