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Chinese Scientists Create Mice from Reprogrammed Skin Cells (bypasses need for embryonic cells)
Popular Science ^ | 7/26/2009 | Jeremu Hsu

Posted on 07/26/2009 7:10:01 PM PDT by SeekAndFind

Chinese scientists have created live mice from mature skin cells that had reverted to an embryonic-like state. The scientific success could further defuse controversy over harvesting embryonic stem cells, but also raises new ethical issues about potentially making clones selected for specific traits.

Reprogramming stem cells has become popular over recent years, because it avoids the cloning or embryo-destruction techniques which have traditionally been used by scientists to create embryonic stem-cell lines. The Chinese experiments now prove that reprogrammed adult stem cells can be made to create live offspring with normal bodies, at least in mice.

Two Chinese teams injected the reprogrammed mouse cells into a mouse embryo. They ended up with 37 reprogrammed stem-cell lines, which eventually led to 27 live offspring. One mouse pup went on to have offspring of its own by mating with a female.

Some offspring were 95-percent genetically identical to the adult mouse whose skin cells had been reprogrammed, which may lead to near-clones or clones as the technique gets refined.

The study, published in the journal Nature, signals another step toward possibly using patients' own reprogrammed stem cells for many different therapeutic applications. Scientists have already tinkered with using adult stem cells to repair specific parts of the human body. For instance, Australian researchers reported using healthy adult stem cells harvested from people's good eyes to restore vision in their damaged eyes.

However, the Chinese breakthrough also raises new ethical questions regarding the near-identical offspring. The Wall Street Journal talked with U.S. researchers who observed that a similar technique applied to humans could lead to a chimera -- a person who shares genes from two different people without being the result of natural reproduction.

Another leading U.S. stem cell researcher told The Washington Post that such techniques could eventually make it easy to steal a person's DNA to make a baby, if skin cells are all that are needed. Still, most scientists remain reluctant to tamper with anything resembling human cloning.

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TOPICS: Miscellaneous; News/Current Events
KEYWORDS: china; mice; stemcells

1 posted on 07/26/2009 7:10:02 PM PDT by SeekAndFind
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To: SeekAndFind

“Still, most scientists remain reluctant to tamper with anything resembling human cloning. “

yeah..... cause there’s no money in that. (/sarc)


2 posted on 07/26/2009 7:17:12 PM PDT by UCANSEE2 (Where's this tagline thing everyone keeps talking about?)
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To: SeekAndFind

“For instance, Australian researchers reported using healthy adult stem cells harvested from people’s good eyes to restore vision in their damaged eyes.”

How many ‘eyes’ do those Aussies have?


3 posted on 07/26/2009 7:21:03 PM PDT by UCANSEE2 (Where's this tagline thing everyone keeps talking about?)
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To: SeekAndFind

Freaky.


4 posted on 07/26/2009 7:48:41 PM PDT by mamelukesabre (Si Vis Pacem Para Bellum (If you want peace prepare for war))
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To: UCANSEE2

If they are referencing the same research I read, the Aussie procedure is pretty neat stuff. Apparently they cultivate the cells, grow the needed cells and apply them to affected eyes via a device similar to a contact lens. Procedure can be conducted in a field hospital. If it perfected, opens up many possibilities for treating disease say, in Africa, or other underdeveloped areas. Assuming, of course that the local muslim leadership allows procedures from the great satan or her allies


5 posted on 07/26/2009 7:53:39 PM PDT by The_Sword_of_Groo (Dum spiramus tuebimur - "While We Have Breath, We Will Defend")
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To: SeekAndFind
Reprogramming stem cells has become popular over recent years

This is my favorite line in the story.

Everybody's doing it! Don't be the last one on your block to create you very own freak of nature- order our starter kit for just $59.95 right now!

LOL. I guess Popular Science might have a bias towards that word...

6 posted on 07/26/2009 7:55:35 PM PDT by Prodigal Son
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