Let's see, gain proper sight alignment for each one and with the proper angle of tragectory, and at the same time think what is behind each one.
THAT is a reasonable standard while you are being attacked?????
You must be joking. That standard guarantees to good guy dies 100% of the time.
No one said self defense was a piece of cake. The fact remains...you DO NOT have any right whatsoever to endanger your innocent neighbors just because you are under attack. If you can not reconcile this during a 2 am intrusion, you should probably not consider firearms as part of your self defense plan...or at least move out to a farm house away from any neighbors.
Unless you have a metal backstop in your home, you will almost always be endangering someone outside to some point if you fire a firearm inside your home.
Mitgating the danger is all one can do; mitigating the danger to ZERO Percent is impossible (unless you want to be dead from home invaders). I say this because in any firefight there will be necessary movement, and it is impossible to see the terminal trajectory of every every possible shot if fighting off 2 armed atackers in the middle of the night.