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Scientists say crack HIV/AIDS puzzle for drugs
Reuters ^ | Jan 31, 2010 | Kate Kelland

Posted on 01/31/2010 3:55:57 PM PST by neverdem

* Study solves puzzle that eluded scientists for 20 years

* Finding should help development of new HIV/AIDS medicines

* Allows scientists to see how Merck and Gilead drugs work

LONDON, Jan 31 (Reuters) - Scientists say they have solved a crucial puzzle about the AIDS virus after 20 years of research and that their findings could lead to better treatments for HIV.

British and U.S. researchers said they had grown a crystal that enabled them to see the structure of an enzyme called integrase, which is found in retroviruses like HIV and is a target for some of the newest HIV medicines.

"Despite initially painstakingly slow progress and very many failed attempts, we did not give up and our effort was finally rewarded," said Peter Cherepanov of Imperial College London, who conducted the research with scientists from Harvard University.

The Imperial and Harvard scientists said that having the integrase structure means researchers can begin fully to understand how integrase inhibitor drugs work, how they might be improved, and how to stop HIV developing resistance to them.

When the human immunodeficiency virus (HIV) infects someone, it uses the integrase enzyme to paste a copy of its genetic information into their DNA, Cherepanov explained in the study published in the Nature journal on Sunday.

Some new drugs for HIV -- like Isentress from Merck & Co and elvitegravir, an experimental drug from Gilead Sciences -- work by blocking integrase, but scientists are not clear exactly how they work or how to improve them.

The only way to find out was to obtain high-quality crystals -- a project that had defeated scientists for many years.

"When we started out, we knew that the project was very difficult, and that many tricks had already been tried and given up by others long ago,"...

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TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: aids; hiv; hivaids; hivintegrase
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To: Smokin' Joe

Thanks for the ping!

21 posted on 02/01/2010 8:32:15 PM PST by Alamo-Girl
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To: Condor51
BUT as Chad says in #16: Be. Very. Careful. when emptying any Temp Folders. Many programs store required files in there (Bill Gates is evil). A couple weeks back I was downloading a new program/application and the 'Instruction' said to 'delete EVERYTHING' in my Temp Folder. Well I looked in it first and its a good thing I didn't "delete everything". Plus some 'Temp Folders' may be hidden and you won't see them unless you go into My Computer thru Explorer and uncheck two boxes.

I'll second that opinion. I downloaded a "trial" of Roxio Creator 9. The trial ran out. When I accessed it again, it asked if I wanted to purchase. I said yes. I was charged immediately and the software worked immediately. I cleaned my cache and temp areas a few days later. Now Roxio is looking for the "MSI" install file in a "temp" directory. I suspect my purchased copy is dead meat. It is most upsetting to deal with companies that are this brain dead.

22 posted on 02/01/2010 8:41:28 PM PST by Myrddin
[ Post Reply | Private Reply | To 17 | View Replies]

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