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Brain regulates cholesterol in blood, study suggests
BBC ^ | June 06, 2010 | Emma Wilkinson

Posted on 06/27/2010 10:19:52 PM PDT by CutePuppy

The amount of cholesterol circulating in the bloodstream is partly regulated by the brain, a study in mice suggests.

It counters assumptions that levels are solely controlled by what we eat and by cholesterol production in the liver.

The US study in Nature Neuroscience found that a hunger hormone in the brain acts as the "remote control" for cholesterol travelling round the body.

Too much cholesterol causes hardened fatty arteries, raising the risk of a heart attack.

The research carried out by a US team at the University of Cincinnati found that increased levels of the hunger hormone ghrelin in mice caused the animals to develop higher levels of blood-circulating cholesterol.

Levels in the blood rise because signals from the brain prompt the liver to store less cholesterol, the researchers said.

It is known that ghrelin inhibits a receptor in the brain in its role in regulating food intake and energy use.

In a separate experiment, they found that blocking this receptor in mice also increased levels of cholesterol in the blood.

Potential treatment

The researchers said the finding needs to be replicated in humans but potentially opens up a new way of treating high cholesterol.

Study leader Professor Matthias Tschoep said: "We have long thought that cholesterol is exclusively regulated through dietary absorption or synthesis and secretion by the liver.

"Our study shows for the first time that cholesterol is also under direct 'remote control' by specific neurocircuitry in the central nervous system."

Fotini Rozakeas, cardiac nurse at British Heart Foundation, said: "This interesting study on mice shows for the first time that blood cholesterol levels can be directly controlled by signals transmitted from the brain to the liver where cholesterol is formed.

"This could potentially open up new forms of treatment to control cholesterol levels..."

.....

(Excerpt) Read more at news.bbc.co.uk ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: brain; brainscan; cholesterol; health; liedetector; polygraph; vitamind; vitamins; vitd
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Mind over matter!
1 posted on 06/27/2010 10:20:00 PM PDT by CutePuppy
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To: CutePuppy

WHICH kind of cholesterol????


2 posted on 06/27/2010 10:22:01 PM PDT by goodnesswins (DEMOCRATS LOSE.....America WINS!)
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To: CutePuppy

I guess they aren’t satisfied with screwing up livers and muscles, now they want some new drug that messes with our brains.

This attack on cholesterol is a giant con job.


3 posted on 06/27/2010 10:23:14 PM PDT by Pining_4_TX
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To: CutePuppy

move over brain, Obama will be regulating cholesterol in blood from now on.


4 posted on 06/27/2010 10:23:17 PM PDT by RC one (WHAT!!!!)
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To: Pining_4_TX

diet and exercise would probably be healthier than zocor and lipitor.


5 posted on 06/27/2010 10:25:36 PM PDT by RC one (WHAT!!!!)
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To: CutePuppy
On the other hand...

Brain scans being misused as lie detectors, experts say - BBC, 2010 June 06, by Caroline Parkinson


6 posted on 06/27/2010 10:26:02 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy

Nolan Strong and The Diablos : Mind Over Matter , 1962 Fortune Records

http://www.youtube.com/watch?v=RGko6th_7ko


7 posted on 06/27/2010 10:28:43 PM PDT by sheikdetailfeather (Who needs an enemy when we have Barack Obama?)
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To: goodnesswins
WHICH kind of cholesterol????

Since our brains are so powerful, then probably both HDL and LDL... As long as we know what the "good" numbers are, we tell the brain, brain tells the ghrelin gremlins, and they tell HDL to increase and LDL to decrease, to shape up or ship out.

Simple... once we know "who" is responsible for "what".

8 posted on 06/27/2010 10:35:20 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy

“Mind over matter!”

If you don’t mind it don’t matter!


9 posted on 06/27/2010 10:36:00 PM PDT by Lurkina.n.Learnin (Healthcare adds 16,000 new IRS agents and zero new doctors???)
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To: decimon; LucyT; JoeProBono; SunkenCiv; neverdem
Like, *PING*, dudes and dude-ettes.

Cheers!

10 posted on 06/27/2010 10:37:37 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: sheikdetailfeather
I suppose the phrase was popularized in the 1960s... though I was referring to the Twilight Zone episode.
11 posted on 06/27/2010 10:38:19 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy
Mind over matter!

Beyond wisdom of "you are what you eat" - have always added that as importantly; if not moreso; we are what we 'think' we eat/lol.

So what now; diet pills for cholesterol or hypnosis!

12 posted on 06/27/2010 10:39:00 PM PDT by cricket ('flies don't lie')
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To: Lurkina.n.Learnin
“Mind over matter!”
If you don’t mind it don’t matter!

I bet you say this to all the girls... ;-)
13 posted on 06/27/2010 10:40:44 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy
"The amount of cholesterol circulating in the bloodstream is partly regulated by the brain, a study in mice suggests."

Since I'm not a mouse I won't concern myself with this.

14 posted on 06/27/2010 10:41:17 PM PDT by blackbart.223 (I live in Northern Nevada. Reid doesn't represent me.)
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To: CutePuppy; All
Asphalt causes pot holes.

Dead doctors don't lie.

Is it so hard to study why the arteries get hard and crack despite low cholesterol intake, or why some folks don't get them at all, no matter what their diet is?

The cure is in the cause folks.

15 posted on 06/27/2010 10:41:49 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afganistan and Iraq))
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To: sheikdetailfeather
That sucks.

No wonder I've never heard of it.

This is from the same era but much, much better.

Sea Of Love

16 posted on 06/27/2010 10:43:22 PM PDT by blam
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To: cricket
So what now; diet pills for cholesterol or hypnosis!

Now that we may have a "choice", I guess whatever tickles you the most. :-)

17 posted on 06/27/2010 10:43:22 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: RC one

YEP...what you said....I changed my diet to primarily CAVEMAN, heavy protein....watched my bad (small, dense, non bouyant) LDL improve.....I already exercise...


18 posted on 06/27/2010 10:46:26 PM PDT by goodnesswins (DEMOCRATS LOSE.....America WINS!)
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To: CutePuppy

It would be interesting to see the impact of a sedentary lifestyle with a diet high in processed sugars on the brain, especially the impact of repeated high/low blood sugar cycles.

I have a feeling the entire US population has become lab rats as we moved into the world of processed foods and universal car ownership.


19 posted on 06/27/2010 10:47:50 PM PDT by MediaMole
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To: MediaMole

The goal is for the entire population to be on medication....for life...


20 posted on 06/27/2010 10:48:39 PM PDT by Sacajaweau (What)
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To: CutePuppy

It took a study to find that out?


21 posted on 06/27/2010 10:49:19 PM PDT by wastedyears (The Founders revolted for less.)
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To: grey_whiskers

22 posted on 06/27/2010 10:49:47 PM PDT by JoeProBono (A closed mouth gathers no feet - Visualize)
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To: blackbart.223
Since I'm not a mouse I won't concern myself with this.

Have right attitude, will sleep better... Oh, it's all in your mind, anyway.

23 posted on 06/27/2010 10:51:55 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: Pining_4_TX
....This attack on cholesterol is a giant con job.

I agree, it is the same dementia the ozone hole and man-made global warming idiots have.

Correlation = causation, no matter what the research says. It's NUTZ.

24 posted on 06/27/2010 10:53:39 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afganistan and Iraq))
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To: MediaMole
It would be interesting to see the impact of a sedentary lifestyle with a diet high in processed sugars on the brain, especially the impact of repeated high/low blood sugar cycles.

Apparently, sedentary lifestyle may not matter as much, as long as you get sufficient intake of Vitamin D...
Vitamin D Deficiency Linked to Diabetes, Metabolic Syndrome in Studies - FR, 2010 June 27

25 posted on 06/27/2010 10:59:03 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy
"Have right attitude, will sleep better.

Goodnight, sleep tight, don't let the bedbugs bite.

Regards, Bart.

26 posted on 06/27/2010 11:00:21 PM PDT by blackbart.223 (I live in Northern Nevada. Reid doesn't represent me.)
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To: goodnesswins

type II diabetes is another disease process that has way too many pills thrown at it when diet and exercise are clearly the healthier option IMO.


27 posted on 06/27/2010 11:04:33 PM PDT by RC one (WHAT!!!!)
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To: Pining_4_TX
This attack on cholesterol is a giant con job.

Yes it is, it sells lots of drugs with nasty side effects.

There are some, who think outside the box, that say high colesterol is a symptom of vitamin D deficency.

28 posted on 06/27/2010 11:10:53 PM PDT by c-b 1 (Reporting from behind enemy lines, in occupied AZTLAN.)
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To: PeaceBeWithYou
Is it so hard to study why the arteries get hard and crack despite low cholesterol intake, or why some folks don't get them at all, no matter what their diet is?

The cure is in the cause folks.

Yep. Remember when "everybody" had ulcer and the "established cause" of the ulcers was stress... until Australian physician Barry Marshall discovered the pattern of presence of H.pylory in GT, and effectiveness of antibiotic treatment.

Took him years to be taken seriously, but thereafter ulcers almost immediately disappeared from the A-list in the vocabulary of "serious" diseases.

29 posted on 06/27/2010 11:14:16 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: CutePuppy

Oh great, now my doctor is going to tell me I’m mentally ill.


30 posted on 06/27/2010 11:14:34 PM PDT by USNBandit (sarcasm engaged at all times)
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To: RC one
type II diabetes is another disease process that has way too many pills thrown at it when diet and exercise are clearly the healthier option IMO.

You may be interested in the link at post #25.

31 posted on 06/27/2010 11:16:26 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: wastedyears
It took a study to find that out?

It took a study to publish the findings.

32 posted on 06/27/2010 11:26:15 PM PDT by CutePuppy (If you don't ask the right questions you may not get the right answers)
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To: c-b 1

You’re close, it is A, C, and E, (mainly C) that cause the arteries to harden and crack, which triggers the liver to produce the patch material - Cholesterol.

You see your red blood cells like everything nice and smooth, those cracks are rough and destroy them, so they tell the liver to make something to make it smooth again.

This is the backup system. If you have high cholesterol and blocked arteries, you have hard cracked arteries underneath. Lowering your cholesterol intake just forces the liver to canabalize the needed patch materials from other parts of the body, or failing that you get the problems caused by lack of red blood cells and lack of sufficient patching on those hard brittle arteries.

In the Mr. Fit study, they almost got it right. The group that had strict control on their dietary intake of cholesterol had more deaths from heart attacks and anuerisms, but the ‘cholesterol is bad’ folks won out and the dark ages continue.


33 posted on 06/27/2010 11:28:52 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afganistan and Iraq))
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To: PeaceBeWithYou

The companys that make, and sell drugs are the real winners in all this.


34 posted on 06/27/2010 11:34:29 PM PDT by c-b 1 (Reporting from behind enemy lines, in occupied AZTLAN.)
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Humph, is this the ‘hate the drug companies’ thread?


35 posted on 06/27/2010 11:38:07 PM PDT by ReneeLynn (Socialism is SO yesterday. Fascism, it*s the new black. Mmm Mmm Mmm.)
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To: PeaceBeWithYou

And trailer parks attract tornadoes!


36 posted on 06/27/2010 11:41:33 PM PDT by matthew fuller (2012: Bachman, Bolton, Brewer, Liz Cheney, Coburn, DeMint, Inhofe, Jindal, Palin and Pence.)
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To: c-b 1

AMA doctors, that follow the heard are as much to blame, if not more, but the patient that has blind faith in them because they’re a doctor can claim some as well.


37 posted on 06/27/2010 11:46:53 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afganistan and Iraq))
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To: PeaceBeWithYou

Errr herd, dang it.


38 posted on 06/27/2010 11:47:51 PM PDT by PeaceBeWithYou (De Oppresso Liber! (50 million and counting in Afganistan and Iraq))
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To: CutePuppy
Too much cholesterol causes hardened fatty arteries

The hell it does. The mechanism of artery wall damage is rather less facile than "too much cholestrol".

39 posted on 06/28/2010 1:02:45 AM PDT by agere_contra (Obama did more damage to the Gulf economy in one day than Pemex/Ixtoc did in nine months)
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To: PeaceBeWithYou

Excellent post.


40 posted on 06/28/2010 1:05:18 AM PDT by agere_contra (Obama did more damage to the Gulf economy in one day than Pemex/Ixtoc did in nine months)
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To: PeaceBeWithYou

Excellent post.


41 posted on 06/28/2010 1:05:23 AM PDT by agere_contra (Obama did more damage to the Gulf economy in one day than Pemex/Ixtoc did in nine months)
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To: CutePuppy

The best cholesterol levels I ever had was after a few months on the Atkins diet. BP was normal, blood sugar levels normal.....Don’t see how the brain had anything to do with that.

My cardiologist is convinced it’s all in the genes.


42 posted on 06/28/2010 1:11:49 AM PDT by Terry Mross
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To: goodnesswins
YEP...what you said....I changed my diet to primarily CAVEMAN, heavy protein....watched my bad (small, dense, non bouyant) LDL improve.....I already exercise...

Ditto. Watched triglycerides drop from lifelong level of 800+ to <60. That was enough for me. I also exercise.
43 posted on 06/28/2010 1:14:27 AM PDT by PA Engineer (Liberate America from the occupation media.)
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To: PeaceBeWithYou

Exactly. Bad science all the way around.

In the early studies, they found cholesterol in clots and concluded it was the cause rather than the effect.

But cholesterol is everywhere in the body in relatively large amounts. In your skin, in your bones, in your organs and tendons, inside each and every cell.
I’ve read even among people who have bad diets, 85% of the cholesterol in their blood was made in their own liver.


44 posted on 06/28/2010 1:47:36 AM PDT by djf
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To: djf
Sorry, but the link between hypercholesterolemia and atherosclerosis is very strong. Patients with familial hypercholesterolemia have a defined gene mutation that causes high circulating LDL levels, and this leads to severe atherosclerosis at a young age. This is but one example.

Having said that, the pathogenesis of atherosclerosis is complex, and not completely understood by any means. Clearly hypertension is a big contributing risk factor, but how hypertension increases the risk of athero is not known. Vascular inflammation plays a major role, and undoubtedly there are strong genetic components.

45 posted on 06/28/2010 2:38:22 AM PDT by pieceofthepuzzle
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To: pieceofthepuzzle

To say that elevated cholesterol is a risk factor among people who are for whatever reason predisposed to arterial inflammation IS NOT the same as saying cholesterol caused the problem.


46 posted on 06/28/2010 2:49:17 AM PDT by djf
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To: djf

“To say that elevated cholesterol is a risk factor among people who are for whatever reason predisposed to arterial inflammation IS NOT the same as saying cholesterol caused the problem.”

The genetic defect leading to familial hypercholesterolemia is not involved in regulation of inflammatory responses. It results specifically in high blood cholesterol (specifically LDL), and this is what predisposes all those with this disease to develop atherosclerosis. Mice with various genetic mutations in cholesterol-related genes develop atherosclerotic lesions. There are many other examples. There are clearly many contributing mechanistic factors, but cholesterol is definitely a risk factor. When the diets of people from countries that traditionally ate low fat/low cholesterol foods changed to a Western diet, the incidence of coronary disease increased markedly.


47 posted on 06/28/2010 3:07:39 AM PDT by pieceofthepuzzle
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To: CutePuppy

I thought the Harmonic Convergence back in 1985 was supposed to take care of stuff like this. Another wasted trip to Mt. Shasta. Aum!


48 posted on 06/28/2010 3:52:35 AM PDT by sergeantdave
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To: CutePuppy

I thought the Harmonic Convergence back in 1985 was supposed to take care of stuff like this. Another wasted trip to Mt. Shasta. Aum!


49 posted on 06/28/2010 3:52:48 AM PDT by sergeantdave
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To: CutePuppy
We have long thought that cholesterol is exclusively regulated through...(i.e. they are rather clueless.)

"This could potentially open up new forms of treatment to control cholesterol levels..."

"This could potentially open up new invalidate all existing forms of treatment to control cholesterol levels..."

50 posted on 06/28/2010 5:07:49 AM PDT by Onelifetogive (I never make the mistake of arguing with people for whose opinions I have no respect.)
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