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Tooth Regeneration Gel Could Replace Painful Fillings
Discovery ^ | Jun 28, 2010 | Eric Bland

Posted on 08/01/2010 10:05:39 PM PDT by neverdem

Could this new gel be the biggest dental breakthrough since the introduction of fluoride?

THE GIST

A new gel could soon eliminate painful fillings and root canals.

The technology doesn't prevent cavities; it heals teeth by regenerating them.

Although this is good news for teeth, the research could also be applied to heal bones and other tissues in the body.

Dentists could soon hang up their drills. A new peptide, embedded in a soft gel or a thin, flexible film and placed next to a cavity, encourages cells inside teeth to regenerate in about a month, according to a new study in the journal ACS Nano. This technology is the first of its kind.

The new gel or thin film could eliminate the need to fill painful cavities or drill deep into the root canal of an infected tooth.

"It's not like toothpaste," which prevent cavities, said Nadia Benkirane-Jessel, a scientist at the Institut National de la Sante et de la Recherche Medicale and a co-author of a recent paper. "Here we are really trying to control cavities (after they develop)."

Drilling teeth and filling them is safe and effective. Dentists fill millions of cavities each year across the United States. However, though dentists numb the tooth, many patients still rue the sound of that drill.

The new research could make a trip to the dentist's office more pleasant, said Berkirane-Jessel. Instead of a drill, a quick dab of gel or a thin film against an infected tooth could heal teeth from within.

Cavities are bacteria and pus-filled holes on or in teeth which can lead to discomfort, pain and even tooth loss. When people eat acidic foods, consume sugary snacks or simply don't maintain proper oral hygiene, bacteria begin to eat away at the protective enamel and other minerals inside teeth.

The causes of cavities are varied. But for most cavities, the treatment is the same: drilling into a tooth, removing the decay and filling in the hole to prevent further damage.

The gel or thin film contains a peptide known as MSH, or melanocyte-stimulating hormone. Previous experiments, reported in the Proceedings of the National Academy of Sciences, showed that MSH encourages bone regeneration.

Bone and teeth are fairly similar, so the French scientists reasoned that if the MSH were applied to teeth, it should help healing as well.

To test their theory, the French scientists applied either a film or gel, both of which contained MSH, to cavity-filled mice teeth. After about one month, the cavities had disappeared, said Benkirane-Jessel.

Benkirane-Jessel cautions that the MSH-containing films or gels only treat cavities; they don't prevent them. People will still need to brush, floss and use mouthwash to help prevent cavities from forming in the first place.

Treating cavities without drilling "would have its advantages," said Hom-Lay Wang, a dentist at the University of Michigan. Cavities and drilling can destroy the nerves and blood vessels inside a tooth, making it more brittle and likely to fracture. Regenerating a tooth could help avoid crowns after a cavity has been filled.

That said, regenerating a tooth from within would only be useful in a relatively small number of cases. Most cavities would still need to be drilled and filled.

In the meantime, patients can't slacken their oral hygiene either. Numerous clinical trials over several years will have to be completed before the MSH-containing gels or films are available to treat cavities in humans.


TOPICS: Culture/Society; News/Current Events; Technical
KEYWORDS: biotech; cavities; dentistry; msh; regenerativemedicine; teeth; tooth; toothteeth
Nanostructured assemblies for dental application.
1 posted on 08/01/2010 10:05:43 PM PDT by neverdem
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To: neverdem

cool


2 posted on 08/01/2010 10:09:10 PM PDT by americanophile (November can't come fast enough....)
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To: neverdem

Is it minty? Because I would rather take the drill than a gel that doesn’t also freshen my breath so I can please the babes of my neighborhood.


3 posted on 08/01/2010 10:11:00 PM PDT by casuist (Audi alteram partem.)
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To: neverdem
cavity-filled mice teeth.

So, they can breed a line of mice that are prone to cavities. And they don't focus on the genetic component. They only look at treatment options.

That certainly makes sense.

/johnny

4 posted on 08/01/2010 10:12:37 PM PDT by JRandomFreeper (Gone Galt)
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To: neverdem

Has to induce fangs.....put on to much an poof !

Yer Flicka ......


5 posted on 08/01/2010 10:19:04 PM PDT by Squantos (Be polite. Be professional. But have a plan to kill everyone you meet)
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To: neverdem

Sounds pretty neat.


6 posted on 08/01/2010 10:19:33 PM PDT by wastedyears (The Founders revolted for less.)
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To: neverdem

Anything that can replace root canal procedures is fine with me! I told my dentist that I will never submit to another root canal unless she gives me some drug that makes me forget my name for a week. The very thought of going through another one makes me shudder!


7 posted on 08/01/2010 10:22:17 PM PDT by Pining_4_TX
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To: neverdem
Pulp regeneration only, not effective for reversing caries. An improvement, but not a panacea.
8 posted on 08/01/2010 10:27:03 PM PDT by Carry_Okie (The Democrats were the Slave Party then; they are the Slave Party now.)
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To: neverdem

That said, regenerating a tooth from within would only be useful in a relatively small number of cases. Most cavities would still need to be drilled and filled.

oh well, I was ready to go the 7/11 and pick up some.


9 posted on 08/01/2010 10:30:50 PM PDT by TomasUSMC ( FIGHT LIKE WW2, FINISH LIKE WW2. FIGHT LIKE NAM, FINISH LIKE NAM)
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To: neverdem; Quix

Thanks for this info, I was sitting here using a bristle toothpick while reading this.

= = =
Qx ping.


10 posted on 08/01/2010 10:36:46 PM PDT by Joya (Lord Jesus Christ, Son of God, Savior, have mercy on me, a sinner!)
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To: Joya

thx thx


11 posted on 08/01/2010 10:38:59 PM PDT by Quix (THE PLAN of the Bosses: http://www.freerepublic.com/focus/religion/2519352/posts?page=2#2)
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To: neverdem
Numerous clinical trials over several years will have to be completed before the MSH-containing gels or films are available to treat cavities in humans.

The silver lining to waiting years is that maybe the Twilight vampire wannabees will be over themselves and not push for fang growing gels.

12 posted on 08/01/2010 10:41:44 PM PDT by bgill (how could a young man born here in Kenya, who is not even a native American, become the POTUS)
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To: Carry_Okie

“To test their theory, the French scientists applied either a film or gel, both of which contained MSH, to cavity-filled mice teeth. After about one month, the cavities had disappeared, said Benkirane-Jessel.”

Sounds like it got rid of the cavities to me.


13 posted on 08/01/2010 10:52:50 PM PDT by ReneeLynn (Socialism is SO yesterday. Fascism, it*s the new black. Mmm Mmm Mmm.)
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To: neverdem

There was a miracle filling cure I discovered in 1968 - there was no dentist available .. Dentyne ... chewed up and stuck in the molar, kept mouth open until dry ... worked like you would think it would ...


14 posted on 08/01/2010 11:10:45 PM PDT by jessduntno (I wonder...how will third Manassas turn out?)
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To: Carry_Okie

Or, the cavity has to get into the pulp before this treatment will do anything? But once it does, it will grow back the tooth, enamel and all?


15 posted on 08/02/2010 12:16:02 AM PDT by HiTech RedNeck (I am in America but not of America (per bible: am in the world but not of it))
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To: Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ...
regenerative medicine/stem cell ping

Stem cells from blood a 'huge' milestone (May prove easier/faster than other harvesting methods)

FDA OKs First Embryonic Stem Cell Research Trial on Humans, Despite Concerns

Resolve A DOI Name

16 posted on 08/02/2010 12:26:00 AM PDT by neverdem (Xin loi minh oi)
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To: HiTech RedNeck

Misleading headline, poorly-written misleading article. Otherwise, it was great!


17 posted on 08/02/2010 5:07:02 AM PDT by Right Wing Assault (The Obama magic is <strike>fading</strike>gone.)
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To: ReneeLynn
Sounds like it got rid of the cavities to me.

Read the source article the author is citing. When you go there, you'll note the professional commentary. Read that too.

18 posted on 08/02/2010 5:40:40 AM PDT by Carry_Okie (The Democrats were the Slave Party then; they are the Slave Party now.)
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To: HiTech RedNeck
Or, the cavity has to get into the pulp before this treatment will do anything? But once it does, it will grow back the tooth, enamel and all?

Unlikely. IIRC, the dentin is a high-density variant of cancellous bone originally built from the interface with the enamel downward, while the enamel is laminar bone built the other way from the outside. The process involves two different kinds of cells.

That's the cool thing about composite structures, and the difficulty in replicating them.

19 posted on 08/02/2010 5:44:48 AM PDT by Carry_Okie (The Democrats were the Slave Party then; they are the Slave Party now.)
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To: jessduntno; Quix

Post 14, thank you for that info, you said,

‘There was a miracle filling cure I discovered in 1968 - there was no dentist available .. Dentyne ... chewed up and stuck in the molar, kept mouth open until dry ... worked like you would think it would ...’

QUESTIONs ??? ??? ??? ??? ??? ???
Did the dried gum stay in as a filling would, or did it cause the tooth to grow back and just fall out or were you kidding?


20 posted on 08/02/2010 9:06:24 AM PDT by Joya (Lord Jesus Christ, Son of God, Savior, have mercy on me, a sinner!)
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To: Joya

Did the dried gum stay in as a filling would, or did it cause the tooth to grow back and just fall out or were you kidding?”

Actually stayed in place for a little while, kept the cold air out of the cavity when I breathed in, so cut down on the pain A LITTLE, until I got it yanked...still hurt...when I said it worked like you would think, I was kind of kidding...it wasn’t great, but it helped a while...


21 posted on 08/02/2010 9:12:54 AM PDT by jessduntno (I wonder...how will third Manassas turn out?)
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To: neverdem

Sounds like what my ortho put in my back when he did fusion to avoid having to do a bone graft from my hip. Worked enormously well for me - he’s the nearest thing to Jesus as far as I’m concerned. I heard they had to stop using it though. Don’t know why.


22 posted on 08/02/2010 11:55:29 AM PDT by ichabod1 (Hitler Was Their Fate and their Fate Could Not Be Stayed. Von Braustitch.)
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To: Pining_4_TX
The very thought of going through another one makes me shudder!

You need a better endodontist. I've had several and have had no problems.

23 posted on 08/02/2010 12:03:55 PM PDT by 6ppc (It's torch and pitchfork time)
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To: Pining_4_TX

Doesn’t the novacaine help?


24 posted on 08/02/2010 2:02:56 PM PDT by diamond6 (Pray the Rosary to defeat communism and Obamacare!!)
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To: 6ppc; diamond6

Well, the novocaine helps a bit, but it still feels as if they are pulling out pieces of brain. (That could explain my current state of goofiness.)

I have had root canals by 2 different dentists, and it has always been horrible! I have not been to an endodontist. Maybe they have better drugs. ;-)

Or, perhaps I am just a wimp.


25 posted on 08/02/2010 8:52:41 PM PDT by Pining_4_TX
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To: Pining_4_TX

I had one root canal done by a regular dentist (DMD) that later had to be redone by an endodontist. The first guy missed one of the roots.

Some DMDs just don’t want to pass up the business. Technically they have the knowledge and skill to do the job, but they don’t have the specialized equipment and training to do it right.

If your dentist doesn’t refer you to a specialist for things like root canals, dental surgery and gum problems (periodontist) then they are most likely in this category.


26 posted on 08/03/2010 5:37:07 AM PDT by 6ppc (It's torch and pitchfork time)
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To: Pining_4_TX

Also...if a dentist blows a procedure...find another dentist. There are a lot of bad dentists out there. My dad was a dental surgeon and he had a very low opinion of most dentists.


27 posted on 08/03/2010 5:40:07 AM PDT by 6ppc (It's torch and pitchfork time)
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To: bgill

That certainly is a disturbing, yet enlightening trend.

Young people diving headfirst into the occult in order to “belong” or to have some sort of “power”.

On the bright side, since they’re seeking something bigger than themselves, they’d be more open to the truth of the Gospel than some others.


28 posted on 08/03/2010 5:47:11 AM PDT by MrB (The difference between a (de)humanist and a Satanist is that the latter knows who he's working for.)
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To: Pining_4_TX
Sounds terrible. My aunt, about two years ago, had her fingernail bitten by her husband. She was feeding him something and he accidentally bit down on her finger. She has had so many problems since, infections and what not. She recently had to have her fingernail bed lasered. The doctor told her it would be painful and to hold her breath and hold on to something. The laser was only about a second but she said on a scale of 1 to 10 it was an 11. The thought of someone messing with my fingernail bed sends heeeby geebys up my spine.
29 posted on 08/03/2010 12:29:46 PM PDT by diamond6 (Pray the Rosary to defeat communism and Obamacare!!)
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To: diamond6

Ouchie!

This is why I avoid doctors as much as possible. ;-)


30 posted on 08/03/2010 1:16:29 PM PDT by Pining_4_TX
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