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Scientists ferret out a key pathway for aging
EurekAlert! ^ | 11/18/2010 | Tomas A. Prolla

Posted on 11/18/2010 9:39:08 AM PST by FreeAtlanta

For decades, scientists have been searching for the fundamental biological secrets of how eating less extends lifespan.

It has been well documented in species ranging from spiders to monkeys that a diet with consistently fewer calories can dramatically slow the process of aging and improve health in old age. But how a reduced diet acts at the most basic level to influence metabolism and physiology to blunt the age-related decline of tissues and cells has remained, for the most part, a mystery.

Now, writing in the current online issue (Nov. 18) of the journal Cell, a team of scientists from the University of Wisconsin-Madison and their colleagues describe a molecular pathway that is a key determinant of the aging process. The finding not only helps explain the cascade of events that contributes to aging, but also provides a rational basis for devising interventions, drugs that may retard aging and contribute to better health in old age.

"We're getting closer and closer to a good understanding of how caloric restriction works," says Tomas A. Prolla, a UW-Madison professor of genetics and a senior author of the new Cell study. "This study is the first direct proof for a mechanism underlying the anti-aging effects we observe under caloric restriction."

The Wisconsin study focuses on an enzyme known as Sirt3, one of a family of enzymes known as sirtuins, which have been implicated in previous studies in the aging process, gene transcription, programmed cell death and stress resistance under reduced calorie conditions. In mammals, including humans, there are seven sirtuins that seem to have wide-ranging influence on cell fate and physiology.

Sirt3 has been less studied than other members of the sirtuin family, but the new study provides "the first clear evidence frpa

(Excerpt) Read more at eurekalert.org ...


TOPICS: Miscellaneous; News/Current Events
KEYWORDS: aging; oldage; science
I could use something to make me feel younger...
1 posted on 11/18/2010 9:39:10 AM PST by FreeAtlanta
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To: FreeAtlanta

A new POTUS would add years to our lives....


2 posted on 11/18/2010 9:41:07 AM PST by stephenjohnbanker
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To: FreeAtlanta

Becareful what you ask for. The White House will pass a regulation that you can only have so many calories a day.


3 posted on 11/18/2010 9:41:39 AM PST by RC2
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To: FreeAtlanta

So far I’ve accomplished aging by not dying...


4 posted on 11/18/2010 9:42:00 AM PST by null and void (We are now in day 667 of our national holiday from reality. - 0bama really isn't one of US.)
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To: FreeAtlanta

I tried feeling younger once. She told me to stop...


5 posted on 11/18/2010 9:44:34 AM PST by 2dollarbill
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To: FreeAtlanta
I could use something to make me feel younger...

So how young does she have to be?

6 posted on 11/18/2010 9:45:53 AM PST by Hot Tabasco (There's only one cure for Obamarrhea......)
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To: RC2
I thought that was what QE2 was for?
7 posted on 11/18/2010 9:51:26 AM PST by fireforeffect (A kind word and a 2x4, gets you more than just a kind word.)
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To: RC2

“The White House will pass a regulation that you can only have so many calories a day.”

Nope. The opposite. Mandated maximum calories. Gotta keep the social security and medicaid scams running as long as possible. Increase life expectancy by ten years . . .


8 posted on 11/18/2010 9:53:26 AM PST by ModelBreaker
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To: FreeAtlanta

Bookmark


9 posted on 11/18/2010 9:57:14 AM PST by GOP Poet (Obama is an OLYMPIC failure.)
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To: FreeAtlanta

I can’t help but be skeptical about these claims. We’re fatting than ever nowadays, and living longer than ever. In places where people can’t get enough food, disease kills off people at very early ages.


10 posted on 11/18/2010 9:58:52 AM PST by Mr Ramsbotham (Laws against sodomy are honored in the breech.)
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To: FreeAtlanta

I dunno, what’s the life span in Ethiopia and Somalia?

I also hear that starving is euphoric, like in Terri Schiavo’s case.


11 posted on 11/18/2010 10:00:23 AM PST by Retired Greyhound
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To: RC2
The White House will pass a regulation that you can only have so many calories a day.

OR they could require us to stuff ourselves so we die off sooner and save on health care costs.

12 posted on 11/18/2010 10:14:10 AM PST by Right Wing Assault (The Obama magic is <strike>fading</strike>gone.)
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To: 2dollarbill
I tried feeling younger once. She told me to stop...

So, you work for TSA?

13 posted on 11/18/2010 10:15:03 AM PST by Right Wing Assault (The Obama magic is <strike>fading</strike>gone.)
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To: ModelBreaker
Mandated maximum calories.

The death panels will be delivering free bags of potato chips, cartons of ice cream, and all kinds of goodies.

14 posted on 11/18/2010 10:16:50 AM PST by Right Wing Assault (The Obama magic is <strike>fading</strike>gone.)
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To: FreeAtlanta

So by this logic if you never eat you’ll live forever?


15 posted on 11/18/2010 11:47:49 AM PST by RickB444 (Beat your sword into plowshares, but wined up plowing the fields of someone who kept their sword.)
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To: decimon; AdmSmith; Arthur Wildfire! March; Berosus; bigheadfred; ColdOne; Convert from ECUSA; ...

Boy, is this good news. I’m just not aging fast enough. What a terrible burden.


16 posted on 11/19/2010 6:02:51 PM PST by SunkenCiv (The 2nd Amendment follows right behind the 1st because some people are hard of hearing.)
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To: SunkenCiv

Thanks. I’ve been starved for this information.


17 posted on 11/19/2010 6:14:34 PM PST by decimon
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To: SunkenCiv

I’m gonna live FOREVER. Damn the bad luck. I have a half pot of coffee in the morning. Gets me through the day. We treated ourselves to a bowl EACH of Tootie Fruities for supper tonight. (date night)


18 posted on 11/19/2010 6:30:37 PM PST by bigheadfred (/s)
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To: 2dollarbill
I tried feeling younger once. She told me to stop...

Join the TSA(*)!

(aka "Testicle Squeezers' Association"
aka "Tickle Someone's *ss"
aka "Thousands Sexually Assaulted"
aka "Tossers Stalking Airports" (Brit slang 'Tossers' == American'Wankers')
aka "Terminal Stupidity Alliance"
aka "Ticketed Sexual Arousal"
aka "Terrorists Snicker At"
aka "Touching Sexual Areas"
aka "Tickets, Sex, and Airports"
aka "Told to Search Anus")
Cheers!

19 posted on 11/19/2010 10:09:10 PM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: bigheadfred

:’) I’ve got the tootin’ part of that down.


20 posted on 11/20/2010 6:33:49 AM PST by SunkenCiv (The 2nd Amendment follows right behind the 1st because some people are hard of hearing.)
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To: decimon

:’D

Life is banquet.


21 posted on 11/20/2010 6:37:25 AM PST by SunkenCiv (The 2nd Amendment follows right behind the 1st because some people are hard of hearing.)
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To: FreeAtlanta

When it´s figured out how to keep cells from oxidizing, that´ll be news.


22 posted on 11/20/2010 10:09:01 AM PST by onedoug
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