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Nanotubes protect brain tissue from stroke damage
Chemistry World ^ | 30 January 2011 | Simon Hadlington

Posted on 02/01/2011 9:30:02 PM PST by neverdem

Researchers in Korea and the US have shown that modified carbon nanotubes can protect brain tissue from the damage caused by ischaemic stroke, where the blood supply to the brain is interrupted. The work could lead to new treatments to help the brain repair itself after this type of stroke.

Sung Su Kim, of Chung Ang University in Seoul, and colleagues treated commercially available carboxylated nanotubes with a nitrogen and hydrogen plasma, resulting in positively-charged amine groups on the surface of the nanotubes. These amine-modified nanotubes were then injected in the brains of rats. A week later ischaemic stroke was artificially induced in the rats by surgery. The team showed that rats treated with the nanotubes were able to balance on a rotating rod more efficiently than those that had not had the treatment, and that under the microscope there was less brain damage in the treated animals.

Brain of a stroke patient
Brain of a stroke patient showing the damaged area
Precisely how the nanotubes protect the brain tissue is not yet clear, Kim says. 'This should be elucidated by further study. We hypothesise that positive charged effect and high surface energy by amine-modifying provide a favourable environment for neurons, followed by enhanced tolerance of neurons against environmental stress.'

Levels of a protein involved in cell adhesion remained higher in the treated brain tissue, suggesting that the nanotubes could stabilise this protein. There is also less inflammation. 

Maurizio Prato of the University of Trieste in Italy has researched the interaction of functionalised carbon nanotubes with nerve cells. He says that the work is 'impressive' and demonstrates the 'enormous potential of carbon nanotubes in nervous system applications.' Prato adds, 'A very important issue will be on what the   results will be once the stroke has occurred and the nanotubes are administered following stroke.' 

Kim says that a key issue in applying the nanotubes after a stroke will be to ensure that no further brain damage in caused, and that his group is looking into new formulations and treatment methods for such an approach. 

References

H J Lee et al, Nature Nanotechnology, 2011, DOI: 10.1038/nnano.2010.281

Also of interest

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Nanoparticles and ultrasound team up to treat tumours

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New treatment uses magnetic nanoparticles and focused ultrasound to get drugs across the blood-brain barrier


Memristor

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04 March 2010

New approach to embedding silver in silicon-based memristors set to help researchers imitate animal brains


MRI brain scan

Detecting brain damage before it happens

24 May 2006

New NMR technique could detect brain damage early enough to provide treatment for stroke victims.



TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: cva; medicine; nanotubes; stroke
Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model
1 posted on 02/01/2011 9:30:07 PM PST by neverdem
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To: neverdem

I know a 29-year-old woman that had one of those strokes. Saw the name and linked it to her on Facebook.


2 posted on 02/01/2011 9:41:48 PM PST by wastedyears (It has nothing to do with safety, and everything to do with control.)
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To: wastedyears

Did she have Lupus?


3 posted on 02/01/2011 9:56:44 PM PST by neverdem (Xin loi minh oi)
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To: neverdem

lots of research... lack of facts.
Who decided what the ....”plus....es” of carbon nano tubes are?
Where is the “science”?
NOVA on PBS is running a series on Monday nights right and their very lib scientists admit that they are not sure that these carbon nanotubes do not penetrate the blood/brain barrier and what would happen if they did.

This is like Global Warming Redux... let’s all bet on the “science” for Greed’s
Sake, make a bundle, and get out when the getting is good.

If God did not intend it to go in your body. don’t do it.

It’s not as if all of these “Scientist’s” have not been bought off before.
Pay for the Outcome.. You will eventually get the outcome.

It’s all about greed, funny how those two bit lawamker’s (i.e. Congress)
Go in as poor as church mice and come out like Big Fat Cats!

Oh, Yeah, I’ll keep believing their crap... “We are from the Government and We are here to help!”

God Save Us All!


4 posted on 02/01/2011 9:57:14 PM PST by acapesket
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To: neverdem
My husband had a stroke at age 50 ,two years ago. It left him with several disabilities.I pray there is something that could help him.
5 posted on 02/01/2011 10:00:40 PM PST by patriciamary (9)
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To: neverdem

This stuff will probably be invaluable to a stroke sufferer, but it’s still reminds me too much of the Borg. I could see this being misused bigtime.


6 posted on 02/01/2011 10:05:22 PM PST by Free Vulcan (Vote Republican! You can vote Democrat when you're dead.)
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To: neverdem

I don’t have a clue.


7 posted on 02/01/2011 10:08:07 PM PST by wastedyears (It has nothing to do with safety, and everything to do with control.)
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To: neverdem
As with many other maladies, the best cure for strokes is prevention. This involves a healthy diet, regular exercise and minimal sodium and caffeine intake, all from an early age.

Of course, this cannot be achieved with a typical North American diet and lifestyle. You will need to chart your own course.

8 posted on 02/01/2011 10:09:16 PM PST by Praxeologue (io)
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To: patriciamary

I’m 55 with Lupus and two strokes. I’m interested in this.


9 posted on 02/01/2011 10:11:20 PM PST by MWestMom (Tread carefully, truth lies here.)
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
The Chocolate Diet

World's largest steel maker will be...launching stronger nanostructured steel in 2 to 3 years

...Transistor...Combined Logic...Memory Functions...Power Consumption Reduced to One-Millionth...

Compounds to combat cold sores

FReepmail me if you want on or off my health and science ping list.

10 posted on 02/01/2011 10:16:14 PM PST by neverdem (Xin loi minh oi)
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To: neverdem

Nanotechnology to the rescue again.


11 posted on 02/01/2011 10:46:24 PM PST by Republic_of_Secession.
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To: acapesket
NOVA on PBS is running a series on Monday nights right and their very lib scientists admit that they are not sure that these carbon nanotubes do not penetrate the blood/brain barrier and what would happen if they did.

It apparently did penetrate the blood/brain barrier and they suffered less disability.

"Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model"

That's the title of the original article. The abstract is linked in comment# 1. Why don't you read it? Carbon is linked to nitrogen in all your amino acids and proteins.

This is like Global Warming Redux...

Please, as if all science is corrupt.

If God did not intend it to go in your body. don’t do it.

Who knows that except God?

12 posted on 02/01/2011 11:46:27 PM PST by neverdem (Xin loi minh oi)
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To: Kennard
As with many other maladies, the best cure for strokes is prevention. This involves a healthy diet, regular exercise and minimal sodium and caffeine intake, all from an early age.Some of us did all that and still had a stroke. I had a stroke in July. Although nobody would realize I had a stroke by looking at me I have not felt good since. I had minimal damage (4 millimeter x 6 millimeter damage to my brain) but it has drastically affected my energy and pain levels.
13 posted on 02/02/2011 3:57:00 AM PST by muggs (Hope and Change = Hoax and Chains)
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To: neverdem
Nanotubes protect brain tissue from stroke damage Chemistry World

Paging Jan Hendrik Schön(1).
Paging Professor Schön. Please pick up the White Courtesy Phonee.

Your once upon a time bright future in Nanotubes is holding on line three to mock you.

(1) Biggest FRAUD in science since ... Al Gore and his 'Hockey Stick' team.

14 posted on 02/02/2011 4:31:16 AM PST by Condor51 (Suppose you were an idiot. And suppose you were a Congressman. But I repeat myself. [Mark Twain])
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To: neverdem

Very interesting. My dad had a severely clogged artery that produced TIA’s . He had rotorooter surgery to clear them. Years later he had tests that showed the vessels were clogged further up, too much in his head to permit surgery. The Doctor said he didn’t know how he was making it. Somehow the blood was seeping up

The nanotubes would allow passage and flow I guess


15 posted on 02/02/2011 4:46:03 AM PST by bert (K.E. N.P. N.C. D.E. +12 .....( History is a process, not an event ))
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To: muggs

I hope that you recover soon.


16 posted on 02/02/2011 6:12:29 AM PST by Praxeologue (io)
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To: neverdem

THX


17 posted on 02/02/2011 6:45:31 AM PST by Quix (Times are a changin' INSURE you have believed in your heart & confessed Jesus as Lord Come NtheFlesh)
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To: Kennard

Thank you.


18 posted on 02/02/2011 7:34:04 AM PST by muggs (Hope and Change = Hoax and Chains)
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To: bert
Somehow the blood was seeping up.

They developed a collateral circulation. Do a search on "collateral circulation"

19 posted on 02/02/2011 9:23:33 AM PST by neverdem (Xin loi minh oi)
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To: Condor51

Mocking what you don’t understand is rather unbecoming. Getting published in Nature Nanotechnology is begging for being reproduced.


20 posted on 02/02/2011 9:40:25 AM PST by neverdem (Xin loi minh oi)
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To: muggs
I had a stroke in July. Although nobody would realize I had a stroke by looking at me I have not felt good since. I had minimal damage (4 millimeter x 6 millimeter damage to my brain) but it has drastically affected my energy and pain levels.

I would consider further imaging studies. Radiolical diagnoses are not ironclad. I've seen CT diagnoses changed after further history, a misplaced lab test was found and an MRI. The patient I admitted had Sheehan's syndrome, a postpartum pituitary lesion, a pituitary stroke if you will.

Although I had no further responsibility for her care as I was just the resident on call that night, I curious about her fate. I found the misplaced lab result that I ordered when I admitted her. It's not a common diagnosis in the US.

I'm not suggesting that's your diagnosis. Good luck!

21 posted on 02/02/2011 10:24:08 AM PST by neverdem (Xin loi minh oi)
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To: muggs
http://www.stroke.org/site/PageServer?pagename=pain

Only about 10 % of stroke patients have pain. That's why I put my 2 cents in.

22 posted on 02/02/2011 10:42:32 AM PST by neverdem (Xin loi minh oi)
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To: neverdem

Thanks for the information.

Much of the pain I experience is in my left shoulder. I have read that it is quit common for stroke patients to experience shoulder pain. The other pain is from ankylosing spondylitis in my back. I had back pain before the stroke but it is more intense since the stroke.


23 posted on 02/02/2011 11:04:28 AM PST by muggs (Hope and Change = Hoax and Chains)
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To: neverdem
Actually I do know a little about nanotechnology.
It could be like the Steam Engine and kick off a new 'Industrial Revolution'. Or, it could get so advanced, 'it' would think it no longer needed us, and see us as danger to 'it'. That would put us in a 'Terminator World' (man against 'machine'). And we'd likely lose that fight.

And I know a little about Jan Hendrik Schön too.

He set work in nanotechnology back at least a decade. Every new 'discovery' with nanotubes and in nanotechnology was looked at with skepticism, "Oh boy. Is this guy another Jan Hendrik Schön? Should we even bother reading his parer'

Schön was to nanotechnology, as Al Gore is to Global Warming.

24 posted on 02/02/2011 12:43:46 PM PST by Condor51 (Suppose you were an idiot. And suppose you were a Congressman. But I repeat myself. [Mark Twain])
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To: patriciamary
My husband had a stroke at age 50 ,two years ago. It left him with several disabilities.I pray there is something that could help him.
The Mind and the Brain:
Neuroplasticity and the Power of Mental Force
by Jeffrey M. Schwartz and Sharon Begley

Your mileage may vary, but I enjoyed reading that book and it has concrete ideas about stroke recovery.

25 posted on 02/02/2011 1:57:28 PM PST by conservatism_IS_compassion (DRAFT PALIN)
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To: Condor51
I know nothing about Schön, but if this pans out, this could be just the ticket for transient ischemic attacks, reversible ischemic neurological deficits or patients prone to making clots, aka hypercoagulable, to prevent strokes or lessen their severity.

These aren't plain ccarbon nanotubes. In vivo, my guess is that they are saturated with amino groups, IMHO.

26 posted on 02/02/2011 3:43:44 PM PST by neverdem (Xin loi minh oi)
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