Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Ecuadorean Villagers May Hold Secret to Longevity
NY Times ^ | February 16, 2011 | NICHOLAS WADE

Posted on 02/18/2011 9:29:36 PM PST by neverdem

People living in remote villages in Ecuador have a mutation that some biologists say may throw light on human longevity and ways to increase it.

The villagers are very small, generally less than three and a half feet tall, and have a rare condition known as Laron syndrome or Laron-type dwarfism. They are probably the descendants of conversos, Sephardic Jews from Spain and Portugal who were forced to convert to Christianity in the 1490s but were nonetheless persecuted in the Inquisition. They are also almost completely free of two age-related diseases, cancer and diabetes.

A group of 99 villagers with Laron syndrome has been studied for 24 years by Dr. Jaime Guevara-Aguirre, an Ecuadorean physician and diabetes specialist. He discovered them when traveling on horseback to a roadless mountain village. Most such villages are inhabited by Indians, but these were Europeans, with Spanish surnames typical of conversos.

As Dr. Guevara-Aguirre accumulated health data on his patients, he noticed a remarkable pattern: though cancer was frequent among people who did not have the Laron mutation, those who did have it almost never got cancer. And they never developed diabetes, even though many were obese, which often brings on the condition.

“I discovered the population in 1987,” Dr. Guevara-Aguirre said in an interview from Ecuador...

--snip--

The Laron patients’ mutation means that their growth hormone receptor lacks the last eight units of its exterior region, so it cannot react to growth hormone. In normal children, growth hormone makes the cells of the liver churn out another hormone, called insulinlike growth factor, or IGF-1, and this hormone makes the children grow. If the Laron patients are given doses of IGF-1 before puberty, they can grow to fairly normal height...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Front Page News; News/Current Events; Testing
KEYWORDS: cancer; diabetes; hobbits; laronsyndrome; longevity
Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans
1 posted on 02/18/2011 9:29:38 PM PST by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

ping


2 posted on 02/18/2011 9:31:31 PM PST by Walkingfeather
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

These folks would live forever except, according to the article, they’re all accident-prone alcoholics. So maybe the gene that keeps them cancer free also makes them accident-prone alcoholics instead?


3 posted on 02/18/2011 9:41:12 PM PST by Alter Kaker (Gravitation is a theory, not a fact. It should be approached with an open mind...)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Walkingfeather

On the plus side, you can go Halloweening forever.


4 posted on 02/18/2011 9:53:48 PM PST by Jonty30
[ Post Reply | Private Reply | To 2 | View Replies]

To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
This discovery could lead to a drug that inhibits a part of this cell signaling pathway, thus restoring the insulin sensitivity in many, if not most, type II diabetics. I wouldn't hold my breath. If it pans out, it could take a number or years.

FReepmail me if you want on or off the diabetes ping list.

5 posted on 02/18/2011 9:56:39 PM PST by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

A 67-year-old man who has Laron-type dwarfism with his daughter, 5, and sons, 7 and 10.

6 posted on 02/18/2011 10:03:06 PM PST by Charles Henrickson
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Little things mean a lot.


7 posted on 02/18/2011 10:03:14 PM PST by bunkerhill7
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem; All

My grandfather was a smallish man of Welsh, Scots, English ancestry who lived to be 98. All his siblings except the youngest lived into their 90’s, and one lived to 103 or 104. I have heard that large men tend to die sooner.


8 posted on 02/18/2011 10:04:13 PM PST by gleeaikin
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Also probably were never vacinnated with tainted vaccines that had SV-40 and other cancer causing agents in them.


9 posted on 02/18/2011 10:05:07 PM PST by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

So? Helen Thomas was there at the signing of the Declaration of Independence and this deficiency explains her longevity...aside from sucking the blood of virgins every full moon.


10 posted on 02/18/2011 10:06:16 PM PST by max americana
[ Post Reply | Private Reply | To 1 | View Replies]

To: gleeaikin

“I have heard that large men tend to die sooner”

Hope not! My husband is a tall and broad guy.


11 posted on 02/18/2011 10:11:48 PM PST by Spudx7
[ Post Reply | Private Reply | To 8 | View Replies]

To: gleeaikin

I don’t think so.

My dad is 83 and 6’-5” tall. His grandmother died at 98, and she was 6’-1” tall in her stockinged feet.


12 posted on 02/18/2011 10:32:09 PM PST by SatinDoll (NO FOREIGN NATIONALS AS OUR PRESIDENT!)
[ Post Reply | Private Reply | To 8 | View Replies]

To: Charles Henrickson

He looks like LBJ.


13 posted on 02/18/2011 10:32:27 PM PST by rfp1234 (Le Parti du The'. Ne marchez pas sur moi!)
[ Post Reply | Private Reply | To 6 | View Replies]

To: SunkenCiv; blam

may be of interest


14 posted on 02/18/2011 10:32:41 PM PST by Tainan (Cogito Ergo Conservitus.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Charles Henrickson

He fathered children in his 60s. I’d like to see what his wife looks like. Is she his age, and able to be fertile longer than normal, or did he marry someone quite a bit younger?


15 posted on 02/18/2011 10:37:32 PM PST by married21 (As for me and my house, we will serve the Lord.)
[ Post Reply | Private Reply | To 6 | View Replies]

To: neverdem

Bilbo Baggins lived a long life, too.


16 posted on 02/18/2011 10:48:46 PM PST by Defiant (There is no line on the march towards marxism that Democrats won't cross. Democrat=CPUSA)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem
Oompa loompa, doo-pah-dee-doo! I've got another riddle for you!

Yes, but can they mix chocolate?

17 posted on 02/18/2011 11:37:39 PM PST by mrreaganaut (weltschmerz: the sadness one feels when contemplating how far the real world is from an ideal world.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Alter Kaker
These folks would live forever except, according to the article, they’re all accident-prone alcoholics. So maybe the gene that keeps them cancer free also makes them accident-prone alcoholics instead?

Maybe being a dwarf in the boondocks is a risk factor for hitting the sauce or accidents when using adult sized tools?.

From the abstract linked in comment# 1:

A possible explanation for the very low incidence of cancer was suggested by in vitro studies: Serum from subjects with GHR deficiency reduced DNA breaks but increased apoptosis in human mammary epithelial cells treated with hydrogen peroxide.

It is an assumption that the growth hormone receptor mutation is the only abnormality. Something in their serum either repairs damaged DNA or tells the cell to die, i.e. apoptosis, aka programmed cell death. This is just the beginning of the story, IMHO. One treatment for all of the different cancers has been oncology's Holy Grail.

18 posted on 02/19/2011 12:14:59 AM PST by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 3 | View Replies]

To: Slings and Arrows

I’m sure you have some kind of comment...like “ewoks”, or something.


19 posted on 02/19/2011 12:32:35 AM PST by dixiechick2000 ("First they ignore you, then they ridicule you, then they fight you, then you win." - Gandhi)
[ Post Reply | Private Reply | To 1 | View Replies]

To: gleeaikin

Ditto my grandfather from Scotland.
Short, thin, (130 pounds, maybe?) lived to 93, in New York.
His son, my father, also Scottish born, was a few inches taller, always thin but a few pounds heavier, lived only to 83 - back in 1999.

You said you heard large (meaning tall?) men tend to die sooner, but did I read once that really tall men usually have good arteries - - - because they’re good and stretched out, or something?

Help, somebody!


20 posted on 02/19/2011 2:18:31 AM PST by USARightSide (At last! I'm actually here, after reading FR for 6 years! Pardon any fumbles - -)
[ Post Reply | Private Reply | To 8 | View Replies]

To: USARightSide

PS
We know someone, still living in NY, who is about 80 years old and is six feet nine inches.
In his late 20’s, he had his ski boots ordered from Italy because there was nothing in the U.S. for his huge foot, at that time!
Back in those days, he was always the tallest person around, stood out like the proverbial (must I say it?) - - sore thumb.
He was the best man at a wedding where the bride was probably five feet tall. What a sight! I was young, but I remember!


21 posted on 02/19/2011 2:36:55 AM PST by USARightSide (At last! I'm actually here, after reading FR for 6 years! Pardon any fumbles - -)
[ Post Reply | Private Reply | To 20 | View Replies]

To: gleeaikin

Same here. The colonial welsh ancestors all lived into their eighties when they lived on the farm in chester county. Philadelphia/ city dwelling colonials had half the life span. Must be the epidemics and alcoholism concurrent with higher population density.


22 posted on 02/19/2011 3:09:16 AM PST by x_plus_one
[ Post Reply | Private Reply | To 8 | View Replies]

To: neverdem
Very interesting. My brother was diagnosed with deadly melanoma just two weeks ago and he has diabetes. The PET scan just came back this morning negative for metastases, making him maybe the luckiest guy on the planet. I just about wrote a whole book on melanoma in the last two eeks and te link to diabetes came up.
23 posted on 02/19/2011 3:54:28 AM PST by DaxtonBrown (HARRY: Money Mob & Influence (See my Expose on Reid on amazon.com written by me!))
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

-——Sephardic Jews from Spain and Portugal who were forced to convert to Christianity in the 1490s but were nonetheless persecuted in the Inquisition-———

Hmmm...... the inquisition of peace


24 posted on 02/19/2011 4:43:31 AM PST by bert (K.E. N.P. N.C. D.E. +12 ....( History is a process, not an event ))
[ Post Reply | Private Reply | To 1 | View Replies]

To: bert
Hmmm...... the inquisition of peace

Closer than you think. Spain had just evicted the muslim moors, cruel "justice" was all they had known for centuries. It took them a while to unlearn it.

25 posted on 02/19/2011 6:11:20 AM PST by null and void (We are now in day 760 of our national holiday from reality. - It's almost 3 AM)
[ Post Reply | Private Reply | To 24 | View Replies]

To: Defiant
Bilbo Baggins lived a long life, too.

One does wonder if the Homo floresiensis skeletons are the earthly remains of another colony of Laron-type dwarfs?

26 posted on 02/19/2011 6:14:11 AM PST by null and void (We are now in day 760 of our national holiday from reality. - It's almost 3 AM)
[ Post Reply | Private Reply | To 16 | View Replies]

To: Tainan
"May be of interest"

It is, thanks.

27 posted on 02/19/2011 6:25:37 AM PST by blam
[ Post Reply | Private Reply | To 14 | View Replies]

To: neverdem

My grandmother lived to 106. Of normal stature, her longevity was attributed to the bowl of oatmeal she had for breakfast every morning. BTW, in her late 90s she flipped her walker at a home intruder and scared him off :) Oatmeal power!


28 posted on 02/19/2011 7:04:18 AM PST by StraightDave (.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Tainan; decimon; blam; martin_fierro; StayAt HomeMother; Ernest_at_the_Beach; 1010RD; 21twelve; ...

· GGG managers are SunkenCiv, StayAt HomeMother, and Ernest_at_the_Beach ·
· join list or digest · view topics · view or post blog · bookmark · post a topic · subscribe ·

 
 Antiquity Journal
 & archive
 Archaeologica
 Archaeology
 Archaeology Channel
 BAR
 Bronze Age Forum
 Discover
 Dogpile
 Eurekalert
 Google
 LiveScience
 Mirabilis.ca
 Nat Geographic
 PhysOrg
 Science Daily
 Science News
 Texas AM
 Yahoo
 Excerpt, or Link only?
 


Thanks Tainan! This is pretty interesting! And I say that as a somewhat tall person...
The villagers are very small, generally less than three and a half feet tall, and have a rare condition known as Laron syndrome or Laron-type dwarfism. They are probably the descendants of conversos, Sephardic Jews from Spain and Portugal who were forced to convert to Christianity in the 1490s but were nonetheless persecuted in the Inquisition. They are also almost completely free of two age-related diseases, cancer and diabetes.
To all -- please ping me to other topics which are appropriate for the GGG list.
 

· History topic · history keyword · archaeology keyword · paleontology keyword ·
· Science topic · science keyword · Books/Literature topic · pages keyword ·


29 posted on 02/19/2011 8:19:55 AM PST by SunkenCiv (The 2nd Amendment follows right behind the 1st because some people are hard of hearing.)
[ Post Reply | Private Reply | To 14 | View Replies]

To: neverdem

The villagers are very small, generally less than three and a half feet tall, and have a rare condition known as Laron syndrome or Laron-type dwarfism. They are probably the descendants of conversos, Sephardic Jews from Spain and Portugal who were forced to convert to Christianity in the 1490s but were nonetheless persecuted in the Inquisition. They are also almost completely free of two age-related diseases, cancer and diabetes.

30 posted on 02/19/2011 8:32:06 AM PST by martin_fierro (< |:)~)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Simple explanation: Not tainted by liberalism!


31 posted on 02/19/2011 10:18:55 AM PST by Citizen X_Area 51 ( Obama: Our first Halfrican President)
[ Post Reply | Private Reply | To 1 | View Replies]

To: dixiechick2000

32 posted on 02/19/2011 10:52:49 AM PST by Slings and Arrows (You can't have Ingsoc without an Emmanuel Goldstein.)
[ Post Reply | Private Reply | To 19 | View Replies]

To: neverdem

The Life Extension Foundation funded a study to search for common drugs that activated some of the same genes activated by calorie restriction. Bingo! Metformin, a common anti-diabetes drug induces some of the same gene activation.

Have been on low-dose metformin for seven years now. I noticed that my body temp seems to be 1-2F low at all times and my metabolism has noticeably slowed. The life extension effect could be due simply to slower chemical processes in the body. Roy Walford found similar life extension in animals with lower body temps.

Still experimenting!

BTW, you can buy metformin from a European pharmacy from Anti-Aging Systems. Have been buying from them for decades.

See Life Extension Foundation’s website, www.lef.org, for journal articles, etc.


33 posted on 02/19/2011 1:01:29 PM PST by darth
[ Post Reply | Private Reply | To 5 | View Replies]

To: Slings and Arrows

Well...that’s bold...and gold! lol

I’m happy to “see” you! ;o)


34 posted on 02/19/2011 11:51:12 PM PST by dixiechick2000 ("First they ignore you, then they ridicule you, then they fight you, then you win." - Gandhi)
[ Post Reply | Private Reply | To 32 | View Replies]

To: Secret Agent Man
Also probably were never vacinnated with tainted vaccines that had SV-40 and other cancer causing agents in them.

So true.

There was NO cancer in previous generations in my very large extended family. Now it is beginning in my generation, with my sister, who was among the first to receive a polio vaccination in the 50s(Our Dad was affiliated with a medical school) developing an extremely rare sarcoma in her muscles. Coincidence?

35 posted on 02/20/2011 1:55:24 PM PST by happygrl
[ Post Reply | Private Reply | To 9 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson