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Lessons about Alzheimer's disease
Nature News ^ | 5 August 2011 | Gwyneth Dickey Zakaib

Posted on 08/09/2011 1:06:58 PM PDT by neverdem

Psychologist Margaret Gatz explains what 25 years of research have taught her about reducing the risk of dementia.

Margaret Gatz, a psychologist at the University of Southern California, Los Angeles, is investigating the causes of Alzheimer's disease. To that end, she has studied the health of more than 14,000 Swedish twins for more than 25 years. On 5 August, she will tell the annual convention of the American Psychological Association in Washington DC what the study has taught her about how to reduce risk for the disease. Nature got a preview.

What first motivated you to study Alzheimer's disease?

Before I studied aging, I was a clinical psychologist. I talked to older adults and their families, and it became clear to me that cognitive changes and memory problems were a big concern for a demographic that, at the time, was fairly neglected in terms of research. Then, when I was on a sabbatical in Stockholm, I had the opportunity to get involved with the Swedish Twin Registry, a large cohort study in which some researchers were looking at cognition. It became clear to me that some of the twins would develop dementia, and that this was a unique opportunity for a study. My lab has been working with the Swedish twins now since 1985.

What does your research show?

Somewhere in the ballpark of 70% of risk for Alzheimer's disease across a population is due to heredity. In each individual, there's some combination of genes and environment. But on average, genes have a greater influence than environment in explaining the disease.

What will be the main message from your talk at the conference?

People need to be careful not to overstate what we know about preventing Alzheimer's disease. A lot of popular press says that there are things you...

(Excerpt) Read more at nature.com ...


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: alzheimers; alzheimersdisease; apoe4; dementia; diabetes; health; medicine; obesity
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To: SatinDoll

Praise God for modern medicine. I personally have reasons to be thankful for it myself.


21 posted on 08/09/2011 3:05:28 PM PDT by brytlea (Wake me when it's over...)
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To: brytlea

Thank you. The hardest day was today, when I began to make arrangements. I’m hope I can do it. My family is supportive, and I have no choice. He might hurt one of my grandchildren when he feels threatened.

I think, in time, he will like his new home. After all, I will be there most days. And, I will have a life for myself, and be able to enjoy the grandkids. Just getting it off my chest makes me feel better. I wrote about it before, and a couple freepers sent me mail and cheered me up. That’s the kind of support that works best for me. I need my humor back! ;)


22 posted on 08/09/2011 3:16:48 PM PDT by Jaidyn
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To: neverdem
One of the saddest things I have ever seen was my ex sister in law suffering from early onset Alzheimer's disease. She began getting lost and not being able to find her way home when she was about 50. She is 65 now and her mind is completely gone. She doesn't speak or even open her eyes. She sits and trembles and drools and that was several years ago the last time I saw her. For all intents and purposes, she is dead except she still breathes, it breaks my heart. Her 2 daughters, my nieces, are in line to get this also because my ex SIL’s father died of the same thing.
23 posted on 08/09/2011 3:45:58 PM PDT by Ditter
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To: Mr Rogers
took her off the medication - against the doctor’s desires - she was at peace

Yep, we did the same thing with my mom. She actually gathered all her tray belongings into a hankerchief and tied them on a broom like a hobo would. She was going on a trip, she said. She too was on medication for cancer....taking her off that stopped the hullucinations and fears. We could actully communicate with herin her own mind for that.

24 posted on 08/09/2011 3:55:38 PM PDT by caww
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To: neverdem

My grandparents and both my parents died from this.


25 posted on 08/09/2011 3:57:40 PM PDT by freedomtrail (EEOC- Eventual Elimination Of Caucasians)
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To: Jaidyn

I agree

May God bless you both


26 posted on 08/09/2011 3:59:02 PM PDT by Steve Newton
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To: Jaidyn

You are doing the right thing for him by making arrangements now. My Uncle saw two wifes thru Alzeimer’s. He was amazing in how he interacted with them..on their terms...When they picked flowers off the headboard he picked with them for a time. But there comes a time when it’s necessary to go the next step for their care. So try not to be hard on yourself...it really is for their good and the entire family. And you will be in much better form when you are with him...and I would chance saying if he knew what you were enduring he would have wanted you to make arrangements when the time came for.....just as you would if the situation was reversed.

May God give you much piece of heart and mind as you gingerly walk the walk before you...it is a good thing that you do now.


27 posted on 08/09/2011 4:05:35 PM PDT by caww
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To: Jaidyn

We all just have to make do with what God hands us. You are blessed to have a good place for him, and to be able to be nearby. Would’t it be nice if life were always like a movie of the week? But it’s not. It’s good that you have people around you (and that you have supportive FRiends here). <3


28 posted on 08/09/2011 4:11:16 PM PDT by brytlea (Wake me when it's over...)
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To: caww; brytlea; Steve Newton

Just reading your kind words makes me feel better. I even got a second wind, so might just do the dishes!


29 posted on 08/09/2011 5:45:36 PM PDT by Jaidyn
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To: Jaidyn

Prayers your way. You are doing the right thing for your husband and for your family. Enjoy your grandchildren, and restablish your friendships. It will get better...honest.

My m-i-l is a nursing home. She has mid late stage Alzheimers. She doesn’t recognize her two sons; and is afraid of her male grandchildren. My husband had a pretty bad heart attack last summer, and he was off work for nine weeks. During that time I went (with our 21 year old son) to visit...but she would get so upset by seeing a young man (her grandson) in her presence. She yells for ‘help.’ She always thinks I am a nurse. When I took my husband for his first visit to see his mom that upset her (not as bad as seeing her grandsons) but enough to upset my then very fragile husband. She had no idea who the strange man the ‘nurse’ brought to see her.

Your husband will receive good care; and you will not have to worry constantly what the next minute will bring.


30 posted on 08/09/2011 5:46:47 PM PDT by PennsylvaniaMom ( Barry, eat your own damn peas.)
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To: SatinDoll

Are you sure he doesn’t have an acoustic neuroma? I have one and those symptoms sound very like what I have. They of course hope that you die before the symptoms disable you.

I had proton radiation treatment at Loma Linda University, and they assured me the growth had been arrested. My feeling is that they didn’t slow it down much.

Two different ENT specialists missed the disease even though I described the symptoms exactly. I had a great GP that found it. Oh well life don’t get easier as you get older.


31 posted on 08/09/2011 6:35:58 PM PDT by itsahoot (--I will still vote for Sarah Palin, even if I have to write her in.--No more traitors.)
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To: neverdem

Please Post the results

Thanks

TT


32 posted on 08/09/2011 6:37:45 PM PDT by TexasTransplant (Radical islam is real islam. Moderate islam is the trojan horse.)
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To: itsahoot

Dad has had several brain scans, the most recent being last December. This scan I was able to view, and the areas most affected are, indeed, the areas of the brain concerning motor control.

No sign of any tumors.


33 posted on 08/09/2011 7:07:16 PM PDT by SatinDoll (NO FOREIGN NATIONALS AS OUR PRESIDENT!)
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To: neverdem

My story: My wife is a 61 year old female who developed a blood clot in her left leg 3 years ago while waiting in labor and delivery for the birth of our first grandchild. She was started on coumadin (after lovenox injections). She immediately got a headache and mental confusion. We thought she had a bleed from the thinners, so rushed her to the medical center. She cleared her headache and had negative scans so thought all was well. Gradually I noticed that her short term memory was not what it used to be. I would tell her something and would notice that she would go to a calender and write it down, and then would still forget whatever meeting or activity that was written down. She had just retired from 35 years as an elementary school teacher. Next I started getting messages from her friends telling me that she had near-accidents and other erratic behavior. I took her back to a neurologist and had her evaluated for sleep apnea (she had it). We attributed her symptoms to apnea and hooked her up to the machine at night with no improvement. She has gradually gone down hill and now can not balance her check book, type, play the piano, or remember any recent events. I have had her to multiple specialists and even to Duke University to their memory clinic where multiple testing including pet scans shows changes in the temporal areas of the brain consistent with “early onset alzheimers”. I have noted a marked downward trend in the last 6 months and dread the day when I have to place her in some type of adult daycare of assisted living.


34 posted on 08/09/2011 7:32:19 PM PDT by contrarian (proud new monthly contributor.)
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To: PennsylvaniaMom

Thank you! Your story is so sad! My husband is the opposite. He talks to everyone, even strangers. Of course, no one can understand what he is saying. A few months ago, I had surgery, and took him to a nursing home for three days. He thought it was a motel, and went from room to room chatting with everyone as though they were old friends. I don’t know how he will be this time, because he’s deteriorated the past month. I need to remember that he is not suffering, but his loved ones hurt. As a matter-of-fact, he’s mostly happy. Let your husband know that.


35 posted on 08/09/2011 7:58:08 PM PDT by Jaidyn
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To: kevslisababy

My dad, both uncles and my aunt died from Alzheimer’s. I’m approaching 60. How do you think I feel?


36 posted on 08/09/2011 8:18:06 PM PDT by irishtenor (Everything in moderation, however, too much whiskey is just enough... Mark Twain)
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To: neverdem

Can I get on your list, please? Thanks.

TC


37 posted on 08/09/2011 8:26:28 PM PDT by I_be_tc
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To: neverdem

The #1 risk factor for Alzheimer’s, most cancers, heart disease, and many other diseases? Getting old! So, my advice to everyone is to find the fountain of youth ASAP. Otherwise, we are all going to die of something, most of us before we reach 90.


38 posted on 08/09/2011 9:35:19 PM PDT by Pining_4_TX ( The state is the great fiction by which everybody seeks to live at the expense of everybody else. ~)
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To: Safetgiver
By the way, my dad died of this and my brother has it also. WHAT are you gonna do?

I'm sorry reading about your father and brother. I try to study it. My mother has a vascular dementia. I'm a family practice doc.

Alzheimer's Detected 20 Years before Symptoms Show

Alzheimer's blood test 'most accurate' so far

Is Alzheimer's Disease Written in Blood?

39 posted on 08/09/2011 9:54:21 PM PDT by neverdem (Xin loi minh oi)
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To: Jaidyn

You have to do what you have to do. Don’t dwell on it. You have my sympathy.


40 posted on 08/09/2011 10:15:31 PM PDT by neverdem (Xin loi minh oi)
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