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Alzheimer's blood test 'most accurate' so far
Nature News ^ | 6 January 2011 | Ewen Callaway

Posted on 08/09/2011 1:59:17 PM PDT by neverdem

The blood of patients with the brain disease contains antibodies not found in healthy people.

A new blood test diagnoses Alzheimer's disease by sensing molecules produced by the immune systems of people with the neurodegenerative condition.

So far, the test has been applied to just a small number of blood samples, but if proven on a larger scale, the assay could help diagnose Alzheimer's disease in combination with other tests, says Thomas Kodadek, a professor of chemistry at the Scripps Research Institute in Jupiter, Florida. It could also be used to identify patients for trials of experimental Alzheimer's drugs, he adds. His team published its results online today in Cell1.

Currently, the only way to conclusively distinguish Alzheimer's from other dementias is by examining the gnarled plaques and tangles of protein found in the brains of those with the condition. This can only be done after death. A furious search is under way for earlier, less-invasive tests using brain scans, blood draws and spinal taps, for instance.

Globally, over 35 million people suffer from Alzheimer's. There are no effective treatments for the disease or proven means of preventing it.

Most trawls for blood biomarkers typically whittle down a list of potential molecules to a few that differ between people with a condition and healthy people. For instance, Tony Wyss-Coray's team at Stanford University in California screened 120 proteins involved in cell communication and found 18 of the proteins present at higher levels in the blood of people with Alzheimer's disease than others2.

However, such 'candidate' screens rely on assumptions about which molecules are likely to be affected by a disease. They also rely on sensing vanishingly small levels of proteins and other molecules.

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Antibodies — immune molecules in blood that stick to specific foreign...

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TOPICS: Culture/Society; Extended News; Testing
KEYWORDS: alzheimers; alzheimersbloodtest; alzheimersdisease; health; iggantibodies; medicine
I checked on Kodadek at PubMed. There's been no follow up on Alzheimer's.
1 posted on 08/09/2011 1:59:20 PM PDT by neverdem
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To: neverdem

If you are found to be positive does an Obama Care Wellness worker take you for a long drive down a country road?

2 posted on 08/09/2011 2:05:33 PM PDT by Scythian
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To: Scythian

Hell no! It’s back to the oubliette. You wait for the test. If it’s positive, a trap door opens, and you’re in a trash compacter. You think they’re going to waste gas on a ride in the country?

3 posted on 08/09/2011 2:10:38 PM PDT by Savage Beast (The Tea Party: La Resistance! America's best hope! America's ONLY hope!)
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...

immunology ping

4 posted on 08/09/2011 2:12:35 PM PDT by neverdem (Xin loi minh oi)
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To: Savage Beast

Soylent Green.

5 posted on 08/09/2011 3:06:39 PM PDT by Leroy S. Mort (Fiat justitia ruat caelum)
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To: neverdem

” and tangles of protein found in the brains of those with the condition. This can only be done after death. “

My dad talked about too much protein for years with his blood tests, and years later had an Alzheimer’s diagnosis.

6 posted on 08/09/2011 11:52:10 PM PDT by Sun (Pray that God sends us good leaders. Please say a prayer now.)
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