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Tinnitus discovery could lead to new ways to stop the ringing
http://medicalxpress.com ^ | 12 Sept 2011 | Provided by University of California - Berkeley

Posted on 09/12/2011 2:28:34 PM PDT by Red Badger

Neuroscientists at the University of California, Berkeley, are offering hope to the 10 percent of the population who suffer from tinnitus – a constant, often high-pitched ringing or buzzing in the ears that can be annoying and even maddening, and has no cure.

Their new findings, published online last week in the journal Proceedings of the National Academy of Sciences, suggest several new approaches to treatment, including retraining the brain, and new avenues for developing drugs to suppress the ringing.

"This work is the most clearheaded documentation to this point of what's actually happening in the brain's cortex in ways that account for the ongoing genesis of sound," said Michael Merzenich, professor emeritus of otolaryngology at UC San Francisco and inventor of the cochlear implant, who was not involved with the research. "As soon as I read the paper, I said, 'Of course!' It was immediately obvious that this is almost certainly the true way to think about it."

Merzenich is also chief scientific officer at Posit Science, which develops software to retrain the brain, primarily to improve learning and memory but more recently to address problems like schizophrenia, Alzheimer's Disease and tinnitus.

"Two million Americans are debilitated by tinnitus; they can't work, they can't sleep. Its life destroying and a substantial cause of suicide," he said. "These experiments have led us to rethink how we attack the tinnitus by our training strategies."

Loud noises kill hair cells

According to coauthor Shaowen Bao, adjunct assistant professor in the Helen Wills Neuroscience Institute at UC Berkeley, tinnitus – pronounced TIN-it-tus or tin-NIGHT-us – is most commonly caused by hearing loss. Sustained loud noises, as from machinery or music, as well as some drugs can damage the hair cells in the inner ear that detect sounds. Because each hair cell is tuned to a different frequency, damaged or lost cells leave a gap in hearing, typically a specific frequency and anything higher in pitch.

Experiments in the past few years have shown that the ringing doesn't originate in the inner ear, though, but rather in regions of the brain – including the auditory cortex – that receives input from the ear.

Bao's experiments in rats with induced hearing loss explain why the neurons in the auditory cortex generate these phantom perceptions. They showed that neurons that have lost sensory input from the ear become more excitable and fire spontaneously, primarily because these nerves have "homeostatic" mechanisms to keep their overall firing rate constant no matter what.

"With the loss of hearing, you have phantom sounds," said Bao, who himself has tinnitus. In this respect, tinnitus resembles phantom limb pain experienced by many amputees,

One treatment strategy, then, is to retrain patients so that these brain cells get new input, which should reduce spontaneous firing. This can be done by enhancing the response to frequencies near the lost frequencies. Experiments over the past 30 years, including important research by Merzenich, have shown that the brain is plastic enough to reorganize in this way when it loses sensory input. When a finger is amputated, for example, the region of the brain receiving input from that finger may start handling input from neighboring fingers.

Bao noted that retraining the ear has been tried before, but with limited success. Most such attempts have taken patients with some residual hearing and trained their ears to be more sensitive to the affected frequencies. This wouldn't work for patients with profound hearing loss, however.

Most retraining is also based on the assumption that reorganization of the brain – that is, changing how frequencies "map" to regions of the auditory cortex – is a cause of the tinnitus. This is the opposite of Bao's conclusion.

"We argue that reorganizing the cortical map should be the goal, so that the nerves get some input and stop their tinnitus activity," he said. "You don't want to leave these cells without sensory input."

"We changed our (brain training) strategy from one where we completely avoided the tinnitus domain to one where we directly engage it and try to redifferentiate or reactivate it, and we seem to be seeing improvement," Merzenich said.

Drugs can boost inhibitors

Another treatment strategy, Bao said, is to find or develop drugs that inhibit the spontaneous firing of the idle neurons in the auditory cortex. Hearing loss causes changes at junctions between nerve cells, the so-called synapses, that both excite and inhibit firing. His experiments showed that tinnitus is correlated with lower levels of the inhibitory neurotransmitter GABA (gamma-aminobutyric acid), but not with changes in the excitatory neurotransmitters.

He demonstrated that two drugs that increase the level of GABA eliminated tinnitus in rats. Unfortunately, these drugs have serious side effects and cannot be used in humans. He has applied for several grants to start screening drugs for their ability to enhance GABA receptor function, increase the synthesis of GABA, slow the re-uptake of GABA around nerve cells, or slow its enzymatic degradation.

"Our findings will guide the kind of research to find drugs that enhance inhibition on auditory cortical neurons," Bao said. "There are a lot of things we can do to change GABA functions, some of which could potentially alleviate tinnitus with fewer side effects."

Provided by University of California - Berkeley


TOPICS: Business/Economy; Culture/Society; Technical
KEYWORDS: health; hearing; medicine; tinnitus
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Can you hear me now?...............Tinnitus Ring List!.........

1 posted on 09/12/2011 2:28:44 PM PDT by Red Badger
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To: joe fonebone; SamiGirl; gitmogrunt; Freee-dame; ROCKLOBSTER; ryderann; Red_Devil 232; ...

Ring!.........


2 posted on 09/12/2011 2:29:26 PM PDT by Red Badger ("Treason doth never prosper.... What's the reason? Why if it prosper, none dare call it treason.")
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To: Red Badger

I have been ringing for about 42 years. First thing my kids say when we see each other is WHAT.


3 posted on 09/12/2011 2:36:42 PM PDT by boomop1
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To: Red Badger

Tinnitus, the problem that doesn’t exist until you think about it. Thanks a lot!


4 posted on 09/12/2011 2:36:43 PM PDT by HerrBlucher ("It is terrible to contemplate how few politicians are hanged." G.K. Chesterton)
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To: Red Badger

tinitus(a ringing in the ears) is one thing, but rin-tin-tinitus(a barking in the ears) is still another! (credit to The Farside, I think)

Not to make light of the suffering that can be caused....I have a touch myself, caused by migraines.....


5 posted on 09/12/2011 2:37:31 PM PDT by jimtorr
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To: Red Badger

Not sure that it is proven that it is always a “phantom” sound. I believe I read that there have been some cases where a microphone placed near the ear could actually pick the sound up!

Who knows? Some kind of weird feedback, maybe?

Anyways, good news for people. I have a bit of it but not enough to really bother me.


6 posted on 09/12/2011 2:40:57 PM PDT by djf (One of the few FReepers who NEVER clicked the "dead weasel" thread!! But may not last much longer...)
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To: HerrBlucher

Yeah, now I won’t be able to go to sleep tonight without the crickets. Thanks Van Halen for all the good times in my Camaro. Since then, I have been paying The Man his due.


7 posted on 09/12/2011 2:40:57 PM PDT by crusty old prospector
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To: HerrBlucher

I was thinking the same thing. I can largely tune it out unless I think about it.


8 posted on 09/12/2011 2:41:44 PM PDT by scott7278 ("...I have not changed Congress and how it operates the way I would have liked..." - BHO)
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To: Red Badger

I have had it for years now. I has become worse in the last year or so. It is quite maddening, especially at night when trying to sleep.


9 posted on 09/12/2011 2:44:19 PM PDT by Inyo-Mono (My greatest fear is that when I'm gone my wife will sell my guns for what I told her I paid for them)
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To: Red Badger

I hear the door bell ringing, I’ll be right back...(maybe its buzzing?)


10 posted on 09/12/2011 2:45:38 PM PDT by goat granny
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To: Red Badger

Sometimes the sound is so loud you would think everybody in the room has to be hearing it too. It does diminish at times, almost to the point of not being able to remember just what the nature of the sound was (chirping like crickets, or a high steady note, or something in between), but it does not stay away for long.

Of course, the fact is I am 73, and developed “farmer’s ear” mostly in the left ear, a result of looking back over the right shoulder to watch progress of the implement attached to or being towed by the farm tractor. The left ear is totally exposed to the rather high-decibel exhaust note from the tractor (especially bad on high-horsepower Diesels with turbochargers), the right ear is not nearly as exposed.

Still, the residual ringing is not nearly so loud as that 4020 John Deere. Or even a Farmall Super M.


11 posted on 09/12/2011 2:46:36 PM PDT by alloysteel (Are Democrats truly "better angels"? They are lousy stewards for America.)
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To: djf

I believe I read that there have been some cases where a microphone placed near the ear could actually pick the sound up!
- - - - - - - - - - - - - - - - - - - - - - - - - - - -
Mine is so loud, I really believe that people standing next to me surely must hear it.

I (don’t think) haven’t really suffered any hearing loss from it BUT I tend to mumble where, actually, I feel that I am talking so loud that I think I am yelling.

I have been ‘suffering’ nigh on to 50 years and I am just getting to ‘lazy’ to white it out...


12 posted on 09/12/2011 2:50:24 PM PDT by xrmusn ((6/98) If govt involved, the more outlandish a scheme appears, the truer it probably is.)
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To: crusty old prospector

I have it too, and I sleep with a fan on, or fishtank etc. It seems to drown out the ringing, and lets me sleep. And yes I am thinking about it now, and it is LOUD.


13 posted on 09/12/2011 2:51:50 PM PDT by ConservativeChris
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To: ConservativeChris

Mine is Beeeeeeeeeeeeeeeeeeeee. Beeeeeeeeeeeeeee. Beeeeeeeeeeeeeeeeeeee. Calgon, take me away!


14 posted on 09/12/2011 2:59:53 PM PDT by crusty old prospector
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To: ConservativeChris; HerrBlucher

I have the radio on low to drown it out at night. And it’s true, when you think about it, it gets really loud. Perfect.


15 posted on 09/12/2011 3:02:12 PM PDT by greatplains
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To: alloysteel

I have “farmer’s ear” as well. We had several tractors that did not have mufflers, just straight exhaust pipes.


16 posted on 09/12/2011 3:03:21 PM PDT by Arrowhead1952 (Dear God, please let it rain in Texas. Amen.)
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To: alloysteel

“the brain is plastic”

Mine certainly is! This is good news, but I’m probably to old to benefit by any discoveries, as the FDA will take forever to approve anything new.
My tinnitus is quite a bit louder than people speak, it never stops, or lessens. And it frequently changes. Several different sounds. A constant very high-pitched whine somewhat towards the right side. Sometimes a whooshing sound, like a steady wind through the trees. Sometimes clicking, like someone a few doors away, pounding in tent stakes. Never stops,,,,,,,,,,,,


17 posted on 09/12/2011 3:03:47 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: xrmusn

I think you can get GABA at a health food store. You might need the enteric kind.

Could be it won’t do anything, but hey, if it costs five bucks and it cures a lifelong problem, seems to me that’d be worth it!


18 posted on 09/12/2011 3:04:13 PM PDT by djf (One of the few FReepers who NEVER clicked the "dead weasel" thread!! But may not last much longer...)
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To: HerrBlucher

HAHAHAHA!!!!

You and me both, pard!


19 posted on 09/12/2011 3:05:13 PM PDT by Ronin (Obamanation has replaced Bizarroworld as the most twisted place in the universe.)
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To: Red Badger

20 posted on 09/12/2011 3:10:12 PM PDT by ari-freedom (It's time for Obama to get a downgrade.)
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To: Red Badger

How do they determine that the ringing is not bothering the rats anymore ? Do they ask them ?

I would love to have this ringing stop, I had a rocket impact about 5 feet from me in Vietnam, followed up by bombing runs dropping 500 lbers a few hundred yards away. The ringing is sometimes so loud as to drown out other sounds, but most of the time just an irritating background neverending whine.


21 posted on 09/12/2011 3:20:48 PM PDT by redcatcherb412
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To: HerrBlucher

That’s not far from the truth. I have pretty bad tinnitus that I mostly ignore. In fact, as I was writing this post, my smartphone started doing something stupid and that distracted me so much that I began to ignore the ringing again.


22 posted on 09/12/2011 3:23:18 PM PDT by Redcloak (Sans Couth)
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To: redcatcherb412; Red Badger

Ringing since 03-08-68. Bouncing Betty in a railroad tunnel started the show and other events the rest of the year completed the concert. Kind of an irritant, but since that was the only lasting injury during my tour, I’m just happy to be alive to hear it.


23 posted on 09/12/2011 3:38:36 PM PDT by onceone
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To: Red Badger
It is a strange thing to live with and I'm not sure what causes it or why. I can understand why it drives some people crazy. I've heard that was the case for Jack Klugman.

For me, sometimes it's so loud I can't hear much else, like right now. At other times it's completely quiet, something some audiologists I've seen seem to have trouble believing.

Speaking of audiologists...I hate those hearing tests where you have to raise your hand or push a button when you hear the tone.

Most of the time, the ringing in my ears is the same frequency and MUCH louder than the hearing test tones.

24 posted on 09/12/2011 3:41:50 PM PDT by GBA
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To: Red Badger

I’m pushing 50, and mine started a few months ago. I’ve since had a hearing test, and have excellent hearing with no loss.

I’ve enjoyed shooting, home construction projects, and I’m a recent drummer. But I’m obsessive about hearing protection. The doc said my drumming didn’t cause it, and it’s hereditary.

Coincidentally, it started (I first noticed it) the first night after new cymbals were delivered, and I was testing them at limited volumes (I’m a flinching wimp when it comes to loud noises) without protection. I woke up and asked my wife if she left an alarm on or something, but it was just my ears (mostly right ear).

My theory is that it’s caused by 100% agave reposado tequila on the rocks with a squeeze of lime.


25 posted on 09/12/2011 3:46:17 PM PDT by Atlas Sneezed (Are you better off now than you were four trillion dollars ago?)
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To: djf
I believe I read that there have been some cases where a microphone placed near the ear could actually pick the sound up!

What you are describing is called "objective" tinnitus, where there is an actual physical source for the sound--blood flow, or some body process being picked by the ear. The article is discussing "subjective" tinnitus, where there is NO physical source for the sound. It's not an ear problem, but rather a brain problem. The article compared it to phantom limb syndrome.

26 posted on 09/12/2011 3:50:51 PM PDT by nonsporting
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To: HerrBlucher
Tinnitus, the problem that doesn’t exist until you think about it. Thanks a lot!

LOL! As a lifelong tinnitus 'sufferer' myself, I wasn't thinking about or even noticing it until clicking on this thread ... now I've got a 13khz 'test tone' roaring thru my head ...

27 posted on 09/12/2011 3:53:37 PM PDT by Mr_Moonlight
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To: Red Badger

This article explains something that I’ve puzzeled over, to wit: why does a low-level white noise source help so much? It’s not really just distraction, it actually seems to lessen the volume. If these guys are right, it would make sense that having some sound input could turn some of the cells “off”, so the phantom noise actually subsides.

Whatever works though. It can be maddening.


28 posted on 09/12/2011 3:55:54 PM PDT by absalom01 (You should do your duty in all things. You can never do more, you should never wish to do less.)
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To: Red Badger

Several years ago I went to a audiologist and he gave me some exercises to do with your jaw. Seem to calm the noise down a bit.


29 posted on 09/12/2011 5:22:58 PM PDT by sig229 (The loonie left "FLUNKED" human nature 101)
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To: Red Badger

Can they also make the voices stop too?


30 posted on 09/12/2011 5:26:48 PM PDT by King Moonracer (Bad lighting and cheap fabric, that's how you sell clothing.....)
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To: Red Badger

You post some of the cutest/funniest pics for this topic.
:-)


31 posted on 09/12/2011 6:08:50 PM PDT by Vor Lady (Everyone should read The Importance of the Electoral College by Geo. Grant)
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To: AdmSmith; AnonymousConservative; Berosus; bigheadfred; Bockscar; ColdOne; Convert from ECUSA; ...

Thanks Red Badger.


32 posted on 09/12/2011 6:45:33 PM PDT by SunkenCiv (It's never a bad time to FReep this link -- https://secure.freerepublic.com/donate/)
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To: djf

Two comments, GABA is awesome stuff! You WILL sleep! You may feel like Timoth Leary is in your bedroom with you, however. Wild dreams!
Also Whole Foods carries a supplement called “Clear Tinnitus”
www.clearproductsinc.com
Not a cure but it helps.

Good Luck! Still taking the chromium as well.


33 posted on 09/12/2011 7:05:48 PM PDT by acapesket
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To: HerrBlucher
Exactly! The longer I read the article the more annoyingly worse my tinnitus got ...until I honestly felt like I should to stop reading.

But then? the worst part was that the article really had nothing new to say!.

Why did they bother writing it? just to bother ordinary folk like us?

34 posted on 09/12/2011 7:08:53 PM PDT by ThirstyMan
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To: SunkenCiv

Thanks, Civ.

Oz never did give nothing to the tinnitus man...


35 posted on 09/12/2011 7:21:53 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


36 posted on 09/12/2011 7:22:36 PM PDT by decimon
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To: acapesket
You may feel like Timoth Leary is in your bedroom with you, however. Wild dreams!

That is a good description for the "VIVID dreams" that can be produced by some antidepressants also, which share some biochemical properties with GABA. If I weren't so lazy I'd do the letters of vivid in different rainbow colors and blinking.

37 posted on 09/12/2011 7:40:20 PM PDT by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: djf

My Dad has it, he also has hearing loss, and I think it interferes with his hearing aids. I have a periodic sound in my ear, but they have not diagnosed it as tinnitis. For the time being it only bothers me off and on (sounds more like a humming bird flying past my ear, with doppler effect and everything). My ear dr has no good explanation for it.


38 posted on 09/12/2011 9:08:53 PM PDT by brytlea (Wake me when it's over...)
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To: crusty old prospector

Only Van Halen? Piker.

Explosives, guns, several years in power plants, wood shop tools, no muffler lawn mower, many live concerts in front row, shop vacs, exploding bicycle tires...you name it. I’m surprised I can hear anything at all.


39 posted on 09/13/2011 2:12:48 AM PDT by ProtectOurFreedom
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To: decimon

Oil can!


40 posted on 09/13/2011 3:57:19 AM PDT by SunkenCiv (It's never a bad time to FReep this link -- https://secure.freerepublic.com/donate/)
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To: djf

I worked the flight deck of 2 aircraft carriers...the noise I hear is the roar of the jet engines....can somebody shut those damn planes down???


41 posted on 09/13/2011 4:43:35 AM PDT by joe fonebone (Project Gunwalker, this will make watergate look like the warm up band......)
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To: joe fonebone

That would be one COOL JOB!

I’d almost give up my hearing to do stuff like that!

Thanks for your service!


42 posted on 09/13/2011 4:49:41 AM PDT by djf (One of the few FReepers who NEVER clicked the "dead weasel" thread!! But may not last much longer...)
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To: ProtectOurFreedom

Yeah, I left a lot off of the list. Guns were probably the worst. That is why I constantly try to warn my kids with those stupid earbuds.


43 posted on 09/13/2011 5:08:23 AM PDT by crusty old prospector
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To: steve86
VIVID dreams
44 posted on 09/13/2011 5:43:20 AM PDT by TheOldLady
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To: Beelzebubba
My theory is that it’s caused by 100% agave reposado tequila on the rocks with a squeeze of lime.

That's odd. That's what I take to ease mine.................

45 posted on 09/13/2011 6:31:41 AM PDT by Red Badger ("Treason doth never prosper.... What's the reason? Why if it prosper, none dare call it treason.")
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To: TheOldLady

Yep.


46 posted on 09/13/2011 8:33:11 AM PDT by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: Red Badger

I like smoky Islay Malt Scotch whiskey, but tequila is okay too.


47 posted on 09/13/2011 8:40:48 AM PDT by TheOldLady
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To: TheOldLady; Red Badger

I liked tequila a lot until the Sunday morning I woke up in Tijuana running a leaf blower!


48 posted on 09/13/2011 4:43:11 PM PDT by Eaker ("If someone misquotes you, it's because they know you're right.")
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To: alloysteel

I find my tinnitis goes astral if I do not get a decent night’s sleep. It goes off the chart....like my John Deere 6350 super cab.


49 posted on 09/13/2011 4:51:04 PM PDT by Texas Songwriter (I ou)
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To: Eaker

There are no trees in Tijuana!........


50 posted on 09/13/2011 5:06:44 PM PDT by Red Badger ("Treason doth never prosper.... What's the reason? Why if it prosper, none dare call it treason.")
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