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Princeton researchers find that high-fructose corn syrup prompts considerably more weight gain
http://www.princeton.edu ^ | March 22, 2010; 10:00 a.m. | by Hilary Parker

Posted on 10/25/2011 8:59:04 AM PDT by Red Badger

A Princeton University research team has demonstrated that all sweeteners are not equal when it comes to weight gain: Rats with access to high-fructose corn syrup gained significantly more weight than those with access to table sugar, even when their overall caloric intake was the same.

In addition to causing significant weight gain in lab animals, long-term consumption of high-fructose corn syrup also led to abnormal increases in body fat, especially in the abdomen, and a rise in circulating blood fats called triglycerides. The researchers say the work sheds light on the factors contributing to obesity trends in the United States.

"Some people have claimed that high-fructose corn syrup is no different than other sweeteners when it comes to weight gain and obesity, but our results make it clear that this just isn't true, at least under the conditions of our tests," said psychology professor Bart Hoebel, who specializes in the neuroscience of appetite, weight and sugar addiction. "When rats are drinking high-fructose corn syrup at levels well below those in soda pop, they're becoming obese -- every single one, across the board. Even when rats are fed a high-fat diet, you don't see this; they don't all gain extra weight."

In results published online Feb. 26 by the journal Pharmacology, Biochemistry and Behavior, the researchers from the Department of Psychology and the Princeton Neuroscience Institute reported on two experiments investigating the link between the consumption of high-fructose corn syrup and obesity.

The first study showed that male rats given water sweetened with high-fructose corn syrup in addition to a standard diet of rat chow gained much more weight than male rats that received water sweetened with table sugar, or sucrose, in conjunction with the standard diet. The concentration of sugar in the sucrose solution was the same as is found in some commercial soft drinks, while the high-fructose corn syrup solution was half as concentrated as most sodas.

The second experiment -- the first long-term study of the effects of high-fructose corn syrup consumption on obesity in lab animals -- monitored weight gain, body fat and triglyceride levels in rats with access to high-fructose corn syrup over a period of six months. Compared to animals eating only rat chow, rats on a diet rich in high-fructose corn syrup showed characteristic signs of a dangerous condition known in humans as the metabolic syndrome, including abnormal weight gain, significant increases in circulating triglycerides and augmented fat deposition, especially visceral fat around the belly. Male rats in particular ballooned in size: Animals with access to high-fructose corn syrup gained 48 percent more weight than those eating a normal diet.

"These rats aren't just getting fat; they're demonstrating characteristics of obesity, including substantial increases in abdominal fat and circulating triglycerides," said Princeton graduate student Miriam Bocarsly. "In humans, these same characteristics are known risk factors for high blood pressure, coronary artery disease, cancer and diabetes." In addition to Hoebel and Bocarsly, the research team included Princeton undergraduate Elyse Powell and visiting research associate Nicole Avena, who was affiliated with Rockefeller University during the study and is now on the faculty at the University of Florida. The Princeton researchers note that they do not know yet why high-fructose corn syrup fed to rats in their study generated more triglycerides, and more body fat that resulted in obesity.

High-fructose corn syrup and sucrose are both compounds that contain the simple sugars fructose and glucose, but there at least two clear differences between them. First, sucrose is composed of equal amounts of the two simple sugars -- it is 50 percent fructose and 50 percent glucose -- but the typical high-fructose corn syrup used in this study features a slightly imbalanced ratio, containing 55 percent fructose and 42 percent glucose. Larger sugar molecules called higher saccharides make up the remaining 3 percent of the sweetener. Second, as a result of the manufacturing process for high-fructose corn syrup, the fructose molecules in the sweetener are free and unbound, ready for absorption and utilization. In contrast, every fructose molecule in sucrose that comes from cane sugar or beet sugar is bound to a corresponding glucose molecule and must go through an extra metabolic step before it can be utilized.

This creates a fascinating puzzle. The rats in the Princeton study became obese by drinking high-fructose corn syrup, but not by drinking sucrose. The critical differences in appetite, metabolism and gene expression that underlie this phenomenon are yet to be discovered, but may relate to the fact that excess fructose is being metabolized to produce fat, while glucose is largely being processed for energy or stored as a carbohydrate, called glycogen, in the liver and muscles.

In the 40 years since the introduction of high-fructose corn syrup as a cost-effective sweetener in the American diet, rates of obesity in the U.S. have skyrocketed, according to the Centers for Disease Control and Prevention. In 1970, around 15 percent of the U.S. population met the definition for obesity; today, roughly one-third of the American adults are considered obese, the CDC reported. High-fructose corn syrup is found in a wide range of foods and beverages, including fruit juice, soda, cereal, bread, yogurt, ketchup and mayonnaise. On average, Americans consume 60 pounds of the sweetener per person every year.

"Our findings lend support to the theory that the excessive consumption of high-fructose corn syrup found in many beverages may be an important factor in the obesity epidemic," Avena said.

The new research complements previous work led by Hoebel and Avena demonstrating that sucrose can be addictive, having effects on the brain similar to some drugs of abuse.

In the future, the team intends to explore how the animals respond to the consumption of high-fructose corn syrup in conjunction with a high-fat diet -- the equivalent of a typical fast-food meal containing a hamburger, fries and soda -- and whether excessive high-fructose corn syrup consumption contributes to the diseases associated with obesity. Another step will be to study how fructose affects brain function in the control of appetite.

The research was supported by the U.S. Public Health Service.


TOPICS: Business/Economy; Culture/Society; Government; US: New Jersey
KEYWORDS: cornsyrup; fructose; hfcs; highfructose; nutrition; obesity; sugar; sweetener
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To: Jack Hydrazine

[ How do you fatten up hogs? You feed them corn! DUH!!! ]
Neighbor used to have a dog that was gettign fatter and fatter even after they cut it’s food down to a cup of dog food a day....

It was sneaking into the hog feeders and eating the ground up corn.

So they made the fence around the hogs higher and the dog got thinner, then around august/september the dog was gainign weight again... They found it going intot he corn field and helping itself.....

Dog had to be kept on a leash.


21 posted on 10/25/2011 9:25:59 AM PDT by GraceG
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


22 posted on 10/25/2011 9:30:58 AM PDT by decimon
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To: GraceG

ROFLMAO! Going out to the cornfield to get loaded up, eh?

Put that dog on a leash or get an invisible fence for him.

If he barks to much because it just throw a anti-bark shock collar like this one!
http://www.youtube.com/watch?v=pOn9Ux0-pjo


23 posted on 10/25/2011 9:32:35 AM PDT by Jack Hydrazine (It's the end of the world as we know it and I feel fine!)
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To: GraceG

So, they had a real live ‘Corn Dog’?..................


24 posted on 10/25/2011 9:35:52 AM PDT by Red Badger (Obama's number one economics advisor must be a Magic Eight Ball.................)
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To: agrarianlady

Products with sugar cane are much more healthier for an individual than products with high-fructose corn syrup. Sugar Cane contains magnesium, calcium, and B2. Also, sugar cane is good for for digestion and has less calories than hfc.


25 posted on 10/25/2011 9:38:29 AM PDT by hippyhater
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To: agrarianlady

Products with sugar cane are much more healthier for an individual than products with high-fructose corn syrup. Sugar Cane contains magnesium, calcium, and B2. Also, sugar cane is good for for digestion and has less calories than hfc.


26 posted on 10/25/2011 9:38:42 AM PDT by hippyhater
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To: Red Badger

No worries here mate, I have no rats. :)


27 posted on 10/25/2011 9:39:54 AM PDT by TexasCajun (Fast & Furious , Solyndra & Light Squared would be enough to impeach any White President !!)
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To: dfwgator
Duh!

I know, right.. We already knew that high fructose sugar is the worse.

All foods with sugar, or carb-loaded foods that convert to sugar in the body, will pack on the pounds.
28 posted on 10/25/2011 9:42:01 AM PDT by DivineMomentsOfTruth ("Give me Liberty or I'll stand up and get it for myself!")
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To: Red Badger

Maybe someone can tell us of some sucrose-sweetened food items we can buy. Are there any drinks that are sucrose-sweetened?


29 posted on 10/25/2011 9:44:51 AM PDT by frposty (I'm a simpleton)
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To: frposty

Big Lots! here sell Cokes made in Mexico that are sweetened with sugar not HFCS. They don’t allow it in their foods..............


30 posted on 10/25/2011 9:47:38 AM PDT by Red Badger (Obama's number one economics advisor must be a Magic Eight Ball.................)
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To: Huck
Is it a coincidence that citric acid is in almost all processed foods, and the RX shelves are full of Previcid, Prilosec, et al?

Maybe not, but I would blame wheat (ADM) for the acid problems. Even for people without celiac disease the human stomach just isn't designed to digest wheat easily, and Big Wheat has taken over even more of the food industry than Big Corn. Americans have been put on a routine where they eat a huge pasta dish for dinner, then gulp down Prilosec for dessert as if the wheat-induced acid reflux problem were medical in nature.

I hope this study helps discredit the "Corn Sugar" BS, but I doubt it will make much difference.

31 posted on 10/25/2011 9:47:42 AM PDT by Mr. Jeeves (CTRL-GALT-DELETE)
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To: DivineMomentsOfTruth

I think a lot of people are missing the point. Both sugar and HFCS will pack on the pounds, but HFCS will do it very, very rapidly............


32 posted on 10/25/2011 9:50:34 AM PDT by Red Badger (Obama's number one economics advisor must be a Magic Eight Ball.................)
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To: Red Badger

this has been evident for decades.

the industry first worked on the so-called “high fructose” corn syrup in the ‘50s and ‘60s,

and then a japanese researcher finished the work in the ‘70s.

then they marketed it in “health food” stores to get the upscale consumers.

later, it gained wide acceptance,

ubiquitous in consumer products.


33 posted on 10/25/2011 9:53:43 AM PDT by ken21
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To: stylecouncilor; windcliff

sugary ping....


34 posted on 10/25/2011 9:53:54 AM PDT by onedoug (lf)
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To: frposty

Every now and then Pepsi will put out Pepsi and Mountain Dew sweetened with cane sugar. I think it is called Throwback or something like that. I saw it in the spring at Target.

Re: corn. We grew about 45 acres of corn and after harvest, there were some ears on the ground that had been missed. I went around on the gator with my dogs and picked up a bunch and hubby had them shucked and shelled. We had a huge ice chest filled with corn and he left it at the back of our farm. Stuff came up and we forgot about the corn for about a week. Well, I got back there and lifted the lid, Whoa!!! It had turned to alcohol!!! I dropped the lid down but didn’t lock it and went back up to the barn. When hubby got around to getting to the ice chest to dispose of it about 4 days later, he lifted the lid and not one kernel of corn was left. Best we can figure is that the raccoons and deer had themselves quite a party. And most likely a huge hangover.


35 posted on 10/25/2011 9:58:27 AM PDT by Cowgirl of Justice
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To: Red Badger

[ So, they had a real live ‘Corn Dog’?.................. ]

It was a golden retreiver, seriously it was.


36 posted on 10/25/2011 10:03:49 AM PDT by GraceG
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To: agrarianlady

My grandmother was a dietician, and I’m from a ranching/farming family-there was plenty of fruit from the small orchard, but refined sugar was only found in the occcasional pie or batch of oatmeal cookies. Breakfast was oatmeal or other hot cereal, sweetened with honey-I only saw sugary boxed cereal if I did a sleepover at a friend’s home.

I don’t have a “taste” for sugar, and did not encourage my own cub to do so. As soon as she went off to college and began eating “dorm food”, she gained 20 pounds and has had a sugar craving and an intermittent weight problem ever since.

I avoid processed food, particularly if words ending in “ose” are included in the ingredients-as you say, poison. I’m 5’9” and weigh 108-110, on a small frame. Granted, my business requires physical work, but I believe diet is just as important to maintaining healthy weight.


37 posted on 10/25/2011 10:04:58 AM PDT by Texan5 ("You've got to saddle up your boys, you've got to draw a hard line"....)
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To: Cowgirl of Justice

I swear the colas tasted different and better back in the, oh, fifties. Does the fructose-rich sweetener taste a little different from sucrose?


38 posted on 10/25/2011 10:07:18 AM PDT by frposty (I'm a simpleton)
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To: DivineMomentsOfTruth

[ Duh!

I know, right.. We already knew that high fructose sugar is the worse.

All foods with sugar, or carb-loaded foods that convert to sugar in the body, will pack on the pounds. ]

Step 1. Feed Animals like Cows, Chickens, and Pigs Corn

Step 2. Eat those animals instead of Corn.


39 posted on 10/25/2011 10:07:30 AM PDT by GraceG
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To: frposty

I think so. The hfc flavored drinks taste so syrupy to me - I don’t drink them anymore- while the sugar cane sodas taste like they did in the 70s before hfc was used.
You can buy the Mexican cane sugar cokes from cash and carry stores for about $10 for 24 bottles.


40 posted on 10/25/2011 10:20:18 AM PDT by Cowgirl of Justice
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