Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Gamers Help Fight AIDS: Online players solve a tough problem that had scientists stumped for a...
Reason ^ | December 2011 | Peter Suderman

Posted on 11/22/2011 12:44:25 AM PST by neverdem

Online players solve a tough problem that had scientists stumped for a decade.



For more than 10 years, health researchers have been stumped by an enzyme that helps retroviral infections like AIDS reproduce. Biologists studying the enzyme were unable to model its shape, a crucial first step in figuring out how to beat it.

Recently scientists turned the problem over to an unusual team of collaborators: video gamers. Using Foldit, a free online protein folding game developed at the University of Washington in 2008, those gamers competed to see who could produce the most accurate virtual model of the real-life enzyme.

In just three weeks, gamers accomplished what scientists had been unable to do for more than a decade—no special scientific under- standing required. The game offers players an intuitive 3D modeling interface that can be learned in just a few minutes. It then awards a score for each model; a higher score means a virtual virus that more closely fits the known requirements for the enzyme.

For gamers, it’s a milestone. “This is the first instance that we are aware of in which online gamers solved a longstanding scientific problem,” according to an article published online by Nature Structural & Molecular Biology in September. But it won’t be the last. The game goes on, and according to Foldit’s blog, more scientific revelations are already on the way.


TOPICS: Culture/Society; News/Current Events; Technical; Testing
KEYWORDS: aids; foldit; hiv; hivaids
Crystal structure of a monomeric retroviral protease solved by protein folding game players
1 posted on 11/22/2011 12:44:30 AM PST by neverdem
[ Post Reply | Private Reply | View Replies]

To: neverdem

We’re just learning everything that was known a millenia ago, as if its freshly new.

The most efficient way to learn new things is through playing games.


2 posted on 11/22/2011 12:48:56 AM PST by Jonty30
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

What you will notice after you’ve been around gamers enough (I’m not a gamer), is that they are obsessive about getting into a game, and winning. They are willing to put in eighteen hours on a Saturday (their day off), and discuss open strategies (something that some scientist hate to do) to win.


3 posted on 11/22/2011 12:50:57 AM PST by pepsionice
[ Post Reply | Private Reply | To 1 | View Replies]

To: Jonty30

You had me going there... I thought you were gonna say something about Atlanteans knowing the secrets of protein folding.... lol


4 posted on 11/22/2011 12:56:28 AM PST by Uriah_lost (Is there no balm in Gilead?....MiE (Mainer in Exile))
[ Post Reply | Private Reply | To 2 | View Replies]

To: pepsionice

That is true.

What else helps is that, if you’re just playing a game, there is no fear of failure, either.

Unless you’re a professional gambler or something, it’s not going to ruin your life because you lost a game.

The lack of bad stress relaxes the mind.


5 posted on 11/22/2011 12:58:46 AM PST by Jonty30
[ Post Reply | Private Reply | To 3 | View Replies]

To: Uriah_lost

Well they did. Their constant playing of games allowed them to develop their technology to such a point, that they keep themselves invisible to our sense and technology. :)


6 posted on 11/22/2011 1:02:31 AM PST by Jonty30
[ Post Reply | Private Reply | To 4 | View Replies]

To: neverdem

Science, at it’s most basic, is simply problem solving, so on the one hand, a story like seems entirely reasonable. On the other hand, something about it doesn’t seem to sit well with me. It would be interesting to know the educational background of these unknown gamers.


7 posted on 11/22/2011 1:12:59 AM PST by csense
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

I’m running a PIII-1400-S CPU w/3x256 MB PC 133 (2-2-2-5) SDRAM.

Given that there’s no rational expectation to expect any change in my current situation; I can NOT help you.


8 posted on 11/22/2011 1:15:37 AM PST by raygun (http://bastiat.org/en/the_law DOT html)
[ Post Reply | Private Reply | To 1 | View Replies]

To: csense

It would be interesting to see how much firepower the gamers could bring to bear. :)


9 posted on 11/22/2011 1:17:45 AM PST by BenKenobi (Honkeys for Herman! 10 percent is enough for God; 9 percent is enough for government)
[ Post Reply | Private Reply | To 7 | View Replies]

To: csense

Even if the gamers are of average intelligence, you get a few thousand of them getting together, trying different ways of solving it, collaborating on solving pieces of it.

You don’t necessarily need geniuses to do what the scientists had the gamers do.


10 posted on 11/22/2011 1:26:20 AM PST by Jonty30
[ Post Reply | Private Reply | To 7 | View Replies]

To: Jonty30
Even if the gamers are of average intelligence, you get a few thousand of them getting together, trying different ways of solving it, collaborating on solving pieces of it.

But that's pretty much what you had before, albeit Biologists (and whoever else) instead of Gamers. Thousands of people collaborating over ten years. A dilemma like this would also attract academic competition, so game theory should apply making the two paradigms not entirely dissimilar. It could just be me, but I don't see anything distinct from one method to the other which would justify the implied conclusion that someone from outside the field of Biology, or who otherwise possesses not higher education, solved the dilemma presumably by method alone. I could be wrong, and probably so, but it's just my suspicious nature.

11 posted on 11/22/2011 1:52:32 AM PST by csense
[ Post Reply | Private Reply | To 10 | View Replies]

To: raygun

Processor: Intel(R) Core(TM) i7 CPU X 980 @ 3.33GHz
Memory (RAM): Memory (RAM) 12.0 GB
Graphics: NVIDIA GeForce GTX 480
Gaming graphics: 4095 MB Total available graphics memory


12 posted on 11/22/2011 2:01:31 AM PST by Berlin_Freeper (For years the Left protested "the occupation of Iraq"- now they want to "Occupy" all across the US)
[ Post Reply | Private Reply | To 8 | View Replies]

To: csense

Actually you don’t. :)

In a competitive like research, where billions of dollars are at stake, you have a few people on each research team competing against, not collaborating with each other, it’s almost like thousands of individuals who are trying to solve those pieces of the puzzle by themselves.

Secondly, that’s probably one weakness of being highly educated. When you’ve been told that one method is superior to another, there is a tendency to reject other ways, but the so-called superior way. On the other hand, if you take thousands of people who don’t know the superior way, they’re going to look at the problem very differently. They will try those inferior methods that you’ve rejected, just to see what it does. In gaming, you will jump off a cliff, just to see what happens. If you die, you know not to do that again. But there is a small chance that jumping down that cliff leads to some sort of secret passage.


13 posted on 11/22/2011 2:04:03 AM PST by Jonty30
[ Post Reply | Private Reply | To 11 | View Replies]

To: neverdem

Hey geniuses, AIDs can’t reproduce. It’s a syndrome of diseases and symptoms. Only a virus can reproduce. Which would be great if HIV actually caused 27 different diseases, but of course it doesn’t since it is nothing more than a harmless, ubiquitous retrovirus. Gamers. Yeah, they’ll save us! 40 year olds sitting in their mother’s basements in pee-stained underwear eating stale nachos and playing war! Good grief!


14 posted on 11/22/2011 4:01:39 AM PST by Doc Savage ("I've shot people I like a lot more,...for a lot less!" Raylan Givins)
[ Post Reply | Private Reply | To 1 | View Replies]

To: pepsionice

In my opinion it’s brilliant. And kudos to the scientist whom, ego aside, tapped into an unconventional resource and skill-set to solve a long-standing problem.


15 posted on 11/22/2011 4:23:11 AM PST by Thidwick
[ Post Reply | Private Reply | To 3 | View Replies]

To: neverdem

Enders Game.


16 posted on 11/22/2011 6:10:57 AM PST by Timocrat (Ingnorantia non excusat)
[ Post Reply | Private Reply | To 1 | View Replies]

To: texas booster

Ping


17 posted on 11/22/2011 6:58:50 AM PST by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies]

To: neverdem

Homo Ludens


18 posted on 11/22/2011 7:08:40 AM PST by Moltke (Always retaliate first.)
[ Post Reply | Private Reply | To 1 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson