There are Europeans, Africans, East Asians, South Asians, North Asians and American Indians with this problem.
One of the more famous studies focused on Northern and Skolt Sa'ami for a substantial period of time and demonstrated that there were extended families that simply couldn't metabolize alcohol. Some Sa'ami nations have a lower than normal incidence of alcoholism because they adhere to the dicta of a very conservative church that fights alcohol 24/7.
The Oglala Sioux have a widespread problem that can be solved if and only if someone gives them new livers with some new genes.
Yea, yea. Let me guess. I'm Indian and German. German side makes me want to drink and Indian side doesn't let me stop. Or I might just be a big, fat loser that wants to get billions more so my tribe can dish more FREE money my way....
Your last sentence is quite out there.....
The widespread problem could be arrested if not solved, by placing the disease process in remission. And that is done by drying out and followed by complete abstinence. It's a choice they could make. Or not.