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Families of Alzheimer's sufferers clamor for cancer drug -- reverses effects of disease in mice
Daily Mail UK ^ | Feb 12, 2012 | Daily Mail Reporter

Posted on 02/11/2012 9:43:08 PM PST by Innovative

A skin cancer drug has reversed Alzheimer's in mice - raising hope that it could be similarly successful against the incurable disease in humans. Now families of Alzheimer's sufferers are now bombarding physicians with requests for the drug, called bexarotene and marketed as Targretin.

In research published in the journal Science, mice were engineered to exhibit Alzheimer's symptoms - such as forgetfulness and rapid cell death. After they took the drug, they became instantly smarter, performing better

Researchers at Case Western Reserve University in Cleveland, Ohio added that plaque in the mice brains that was causing Alzheimer's had started to disappear within hours.

Six hours after mice were given the drug, amyloid levels fell 25 per cent, and eventually fell by 75 per cent. The effect lasted for three days.

Clinical trials for humans are being designed and should produce results his year, researchers said.

(Excerpt) Read more at dailymail.co.uk ...


TOPICS: Extended News
KEYWORDS: alzheimers; bexarotene; coconutoil; health; medicine; targretin
This is beyond amazing -- I hope it works as well for people.
1 posted on 02/11/2012 9:43:24 PM PST by Innovative
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To: Innovative

a true anti-alzheimer’s pill... whoo hoo! even if this isn’t a very good one, it will doubtless be the basis of others.


2 posted on 02/11/2012 9:47:29 PM PST by HiTech RedNeck (Sometimes progressives find their scripture in the penumbra of sacred bathroom stall writings (Tzar))
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To: neverdem; bonesmccoy

hey


3 posted on 02/11/2012 9:51:38 PM PST by HiTech RedNeck (Sometimes progressives find their scripture in the penumbra of sacred bathroom stall writings (Tzar))
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To: Innovative

I have heard that phophatidyserene also reverses Altzhimers. Available in oily cold water fish, organ meats and your local health food store.


4 posted on 02/11/2012 9:53:29 PM PST by American in Israel (A wise man's heart directs him to the right, but the foolish mans heart directs him toward the left.)
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To: Innovative

http://www.coconutoil.com/AlzheimersDiseaseDrMaryNewport.pdf


5 posted on 02/11/2012 9:53:39 PM PST by matthew fuller (Obama has definitely earned a second term- 99 years in Leavenworth USP.)
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To: Innovative

Spectacular results. Immediate humans trials are needed. Bexarotene does not seem to have much in the way of side effects (pancreatitis and nausea in some patients).


6 posted on 02/11/2012 9:55:30 PM PST by FormerACLUmember
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To: Innovative

My mom needs it right now.


7 posted on 02/11/2012 10:08:21 PM PST by pf flyers
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To: American in Israel

If a known nutraceutical actually had this power, it would quickly become too obvious to ignore.


8 posted on 02/11/2012 10:22:13 PM PST by HiTech RedNeck (Sometimes progressives find their scripture in the penumbra of sacred bathroom stall writings (Tzar))
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To: Innovative

Thank you, Lord, for inspiring someone to conduct this experiment.


9 posted on 02/11/2012 10:46:32 PM PST by Monitor ("The urge to save humanity is almost always a false-front for the urge to rule it." - H. L. Mencken)
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To: Innovative

Just now found this- “bexarotene”-
http://www.sciencedaily.com/releases/2012/02/120209144005.htm


10 posted on 02/11/2012 10:53:03 PM PST by matthew fuller (Obama has definitely earned a second term- 99 years in Leavenworth USP.)
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To: FormerACLUmember
It's already approved so shouldn't take long to add an indication if human trials confirm this. However, I warn folks to expect major FDA foot dragging. This is a retinoid, a vitamin A derivative, and the FDA is NOT fond of that class of drugs. They've been attacked politically, both from the left with the tort bar pursuing generally baseless side effect claims against isotretinoin (accutane and others), and from the right because they are teratogenic and those not careful enough to avoid pregnancy have generally gone for abortions. FDA has fought the pregnancies with a blizzard of paperwork and zero results. Strategies that would probably work better are alas not PC with many on our side of the issues. I think the bureaucrats are tired of the politics and wish the retinoids would go away. Even though pregnancy isn't an issue with Alzheimer's.
11 posted on 02/11/2012 11:07:57 PM PST by JohnBovenmyer (Obama been Liberal. Hope Change!)
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To: matthew fuller

I added coconut oil to my mother’s lineup of supplements and she does seem to be getting better since its introduction.


12 posted on 02/11/2012 11:23:04 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: TigersEye

How much and what kind of coconut oil are you getting your mother to take...my Mom is in the beginning stages of dementia....


13 posted on 02/11/2012 11:25:00 PM PST by goodnesswins (2012..."We mutually pledge our Lives, our Fortunes, and our Sacred Honor")
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To: goodnesswins
The recommendation was something like 2 tablespoons per day and she is pretty faithful about taking it. She goes through a 20 oz jar in about 3-4 weeks I would estimate. It was the lowest priced brand of cold-pressed organic coconut oil from drugstore.com. NOW brand.

Are there non-organically grown coconuts? lol

14 posted on 02/11/2012 11:32:04 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: Innovative
But he added: 'One obstacle is that the mice may not be a good model of Alzheimer's disease. We have so many things that work in mice and we try them in humans and they just completely fail.'

Then why expend precious research funds using mice as the test subjects? It's undoubtedly easier for scientists to induce Alzheimer's in a mouse than in a primate, but initial findings in primate subjects would have much greater applicability to human beings.
15 posted on 02/11/2012 11:32:49 PM PST by AnotherUnixGeek
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To: TigersEye

I’m trying to figure out how to give it to my mother- she’s in assisted living, has no cooking facilities, and I’m in another state. How are you giving it to your mother? It is available at walmart as a shortening ($5.98 for 1 lb., 15.5 oz., Lou-Ana brand.)


16 posted on 02/11/2012 11:33:19 PM PST by matthew fuller (Obama has definitely earned a second term- 99 years in Leavenworth USP.)
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To: TigersEye

Thanks...I believe I have some of that in storage in my long term pantry....


17 posted on 02/11/2012 11:42:03 PM PST by goodnesswins (2012..."We mutually pledge our Lives, our Fortunes, and our Sacred Honor")
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To: matthew fuller
My mom still fixes her own food for the most part and she puts it on bread or toast instead of butter. She says it doesn't taste bad. Her favorite snack is peanut butter and butter on bread so she substitutes coconut oil for the butter. She will eat a plain piece of toast or cinnamon-raisin toast with just coconut oil on it too.

I can't say I know anything about that brand but all coconut oil is used as a shortening. That one certainly costs much less than the kind I'm getting. It is $10.99 for 20 oz.

18 posted on 02/11/2012 11:44:57 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: goodnesswins

I think I will start using it too. Maybe I will feel sharper! :-)


19 posted on 02/11/2012 11:58:04 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: TigersEye

I bought a can from WM to try, and I have tried it in oatmeal, abt a tblsp, and it tastes fine. What I have is a semi-solid substance at room temp, but it melts @ 77 degrees. (My mother does not get along well with microwaves or any other kind of stove.)


20 posted on 02/11/2012 11:58:23 PM PST by matthew fuller (Obama has definitely earned a second term- 99 years in Leavenworth USP.)
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To: matthew fuller
I was just looking for Lou Ana brand at Wal-Mart and found a 31.5 oz jar for $5.98 but it's not in stock right now. But that is way cheaper than what I have been buying. It's not organic or virgin and it doesn't say cold pressed but it is non-hydrogenated. The NOW brand has a slight coconut smell but hardly any detectable taste. I bet the Lou Ana is every bit as good for the affect we are looking for.

My mom does a little micro-waving but no more cooking on the range. I share what I cook with her but she has lost so many teeth she doesn't like to eat things with meat in it and I don't like much that doesn't have meat in it. She's good with yogurt, pudding, cooked and dry cereal, tuna, p-butter (lots of peanut butter!) and a few other things that don't require cooking or just a bit of nuking.

I would do more cooking for her but I want her to remain as active as possible as long as it isn't too stressful for her to accomplish. I hated doing it but I had to make her stop using the stove. She would put bacon on and walk away and forget about it.

21 posted on 02/12/2012 12:27:15 AM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: TigersEye
"She would put bacon on and walk away and forget about it. "

My mother put a sweet roll in the microwave and fired it up for about 15 MINUTES, and brought the fire dept out. Twice. She now has only a mini-fridge, and eats in a cafeteria.

22 posted on 02/12/2012 1:15:14 AM PST by matthew fuller (Obama has definitely earned a second term- 99 years in Leavenworth USP.)
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To: Innovative
Speaker Newt Gingrich

Newt comments on clearing the way to use new drugs as soon as possible in his C-PAC speech.

23 posted on 02/12/2012 1:40:42 AM PST by Cincinatus' Wife
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To: matthew fuller

It has to be the pure organic virgin kind. You can get it on line like at amazon or iherb too.

My father is starting down The Alzheimer’s path too.

We take 2 tbsps a day of coconut oil in a smoothie. Frozen berries, milk (juice or other kinds of milk would work too), a little banana if you wish, and a tablespoon of ground flax seed, optional. Blended you can’t even taste or feel the coconut oil because it becomes minuscule solid bits because of the frozen fruit. I think it’s yummy.


24 posted on 02/12/2012 1:47:52 AM PST by Yaelle (Go Santorum!)
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To: AnotherUnixGeek

Mice are way cheaper than primates. They can be bred so a great number are genetically identical. Mice age much faster than primates.


25 posted on 02/12/2012 3:49:31 AM PST by count-your-change (You don't have to be brilliant, not being stupid is enough.)
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To: count-your-change; AnotherUnixGeek

http://bacteriality.com/2008/05/08/hiv/

Humans are not mice (yet).


26 posted on 02/12/2012 4:29:30 AM PST by pa_dweller (Thy princes are rebellious, and companions of thieves:... Isa 1:23)
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To: pa_dweller

Ever hear of Micemeat Pie? ‘You are what you eat’ goes the saying.


27 posted on 02/12/2012 4:37:43 AM PST by count-your-change (You don't have to be brilliant, not being stupid is enough.)
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To: pf flyers

So many do.


28 posted on 02/12/2012 5:09:32 AM PST by traderrob6
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To: TigersEye; Yaelle; goodnesswins

Look up Curcumin, also. A friend of mine has seen improvement in his mom with it.


29 posted on 02/12/2012 5:47:41 AM PST by TangoLimaSierra (To the left the truth looks Right-Wing.)
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To: TangoLimaSierra

Having a history of the disease in both of our families, my husband and I have been taking tumeric. The Linus Pauling Institute is doing studies on it and the preliminary studies look good.


30 posted on 02/12/2012 5:59:34 AM PST by esquirette ("Our hearts are restless until they find rest in Thee." ~ Augustine)
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To: Innovative

Ceasar is home!


31 posted on 02/12/2012 12:17:44 PM PST by Almondjoy
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To: aflaak

Ping


32 posted on 02/12/2012 2:30:52 PM PST by r-q-tek86 ("It doesn't matter how smart you are if you don't stop and think" - Dr. Sowell)
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To: aflaak

Ping


33 posted on 02/12/2012 2:31:17 PM PST by r-q-tek86 ("It doesn't matter how smart you are if you don't stop and think" - Dr. Sowell)
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To: TangoLimaSierra
Thank you.

My mom has been taking Turmeric for quite a while now. Both for dementia and arthritis. It is an exceptional anti-inflammatory. She also takes glucosamine-chondroitin and recently she has stopped using her walking stick and walker and comes downstairs regularly to show me she isn't hurting anymore and can walk upright instead of hunched over. For about four years she wouldn't use the stairs unless I was with her and she had no other choice.

In addition to the coconut oil, turmeric and glucosamine-chondroitin she takes inositol, a multi-vitamin, lithium (over the counter not Rx), 10k iu of Vit D3, fish oil and flax seed oil. I also bought some lecithin for her but haven't worked that into her lineup yet.

On her own she decided she wanted to start drinking coffee again which has been cited as potentially preventative for Alzheimer's so I said "go for it" and she drinks several cups per day now.

Oh, we also decided to dump her Namenda and Aricept as well as the Fosamax she was taking. I have my suspicions that her improvements may be due as much to that as the supplements she is taking.

34 posted on 02/12/2012 4:39:40 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: Yaelle; matthew fuller
It has to be the pure organic virgin kind.

Why?

35 posted on 02/12/2012 4:42:25 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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To: TigersEye

This is what Dr. mercola says about what it has to be extra vergin unrefined organic:

“In contrast, most commercial coconut oils are made from copra, the dried up meat from coconuts. Using the cheaper copra-grade coconut means that the oil extracted may not be sanitary, and, in my opinion, it is not suitable for human consumption.

It must not be refined or purified. In fact, this type of inferior coconut oil is called RBD — refined, bleached and deodorized.

Mass-producing coconut oil in this manner typically uses nutrient-removing heat, chemical solvents, bleaching agents and sometimes even hydrogenating processes, which can create trans fats.?


36 posted on 02/12/2012 5:14:28 PM PST by Yaelle (.Go Santorum!)
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To: Yaelle
The Lou Ana brand coconut oil is definitely for human consumption as it is sold for cooking and it is not hydrogenated. It may not be organic or a virgin pressing but it is not refined by any of those methods you mention that I can see.

At any rate here is 1 gal of Virgin Organic Coconut Oil for $44.95 + shipping on Amazon which is almost half the price of Wal-Mart's Lou Ana. Thanks to this discussion it looks like I've found a new source! ;-)

Organic Virgin 100% Coconut Oil, 1 Gallon

37 posted on 02/12/2012 6:31:04 PM PST by TigersEye (Life is about choices. Your choices. Make good ones.)
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