I can count only three times Syrians have cooperated with the United States:
1.Sepetember 11
2.Gulf War One
3.USS Cole.
The Syrians are on the list of State Sposored Terrorism list.
I'll bet that's three more times than a new Syrian Caliphate would cooperate with us.
Back in the 1970's, mobs protested violently against the Shah. Good ol' Jimmah Carter sided with the mob against the evil dictator. Shah out, Ayatollah in.
The situation is not identical today because Assad is not our ally as the Shah was. But there is still a lesson to be learned.