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Safety Alerts Cite Cholesterol Drugs’ Side Effects
NY Times ^ | February 28, 2012 | GARDINER HARRIS

Posted on 02/29/2012 11:44:07 AM PST by neverdem

Federal health officials on Tuesday added new safety alerts to the prescribing information for statins, the cholesterol-reducing medications that are among the most widely prescribed drugs in the world, citing rare risks of memory loss, diabetes and muscle pain.

It is the first time that the Food and Drug Administration has officially linked statin use with cognitive problems like forgetfulness and confusion, although some patients have reported such problems for years. Among the drugs affected are huge sellers like Lipitor, Zocor, Crestor and Vytorin.

But federal officials and some medical experts said the new alerts should not scare people away from statins. “The value of statins in preventing heart disease has been clearly established,” said Dr. Amy G. Egan, deputy director for safety in the F.D.A.’s division of metabolism and endocrinology products. “Their benefit is indisputable, but they need to be taken with care and knowledge of their side effects.”

Diabetes patients and even those who develop diabetes while taking statins should continue taking the medicines, said Dr. Steven Nissen, chairman of cardiovascular medicine at the Cleveland Clinic, who has studied the medicines extensively...

--snip--

Statins seem to increase blood sugar levels in some patients by small amounts, and when millions are treated, that change leads to a diagnosis of diabetes for more people.

The F.D.A. had already placed an alert about diabetes risks on the label of Crestor, a big-selling statin made by AstraZeneca, because a Crestor trial showed an increased risk. The agency decided to extend that alert to all drugs in the class with the exception of Pravachol, an older medicine manufactured by Bristol-Myers Squibb.

A well-controlled trial of Pravachol previously showed that it reduced the risks of developing diabetes by 30 percent, but other trials have found Pravachol less effective in reducing cardiac risks...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Government; News/Current Events; Testing
KEYWORDS: diabetes; fda; medicine; memory; statins; vytorin
Thanks a lot for more confusion.

Mortality from Coronary Heart Disease in Subjects with Type 2 Diabetes and in Nondiabetic Subjects with and without Prior Myocardial Infarction

Our data suggest that diabetic patients without previous myocardial infarction have as high a risk of myocardial infarction as nondiabetic patients with previous myocardial infarction.

"1517 articles have cited this article"
1 posted on 02/29/2012 11:44:14 AM PST by neverdem
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To: neverdem

Dr. Steven Nissen has been shilling for statins and the drug company’s for a decade.


2 posted on 02/29/2012 11:49:17 AM PST by traderrob6
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To: neverdem

“The value of statins in preventing heart disease has been clearly established,” said Dr. Amy G. Egan, deputy director for safety in the F.D.A.’s division of metabolism and endocrinology products. “Their benefit is indisputable, but they need to be taken with care and knowledge of their side effects.”

Sounds a LOT like the Global Warming consensus statement doesn’t it.


3 posted on 02/29/2012 11:50:06 AM PST by Cyman
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To: neverdem

Those who regularly go to the doctor risk becoming someone’s chemistry experiment.


4 posted on 02/29/2012 11:53:01 AM PST by brownsfan (Aldous Huxley and Mike Judge were right.)
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To: neverdem

Took it for 15 years, found out three weeks ago I am highly allergic to statins....AND ace inhibitors!


5 posted on 02/29/2012 11:53:25 AM PST by Shady (The undeniable truth of the Obama Administration...The numbers do not lie.)
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To: neverdem

to be sure, those drugs serve a very good purpose but, they will cause cramping and mess with your head.

If you are over 75 it would be a good idea to consider the risk of falling, which happens frequently to those on ipitor, Zocor, Crestor.

My friend, who just passed away at 101 quit taking Crestor and any other cholesteral reducing drugs as they made her a little touched in the head, caused dizziness and severe pain in her quadriceps.

She had lived with a cholesterol count of 300 for who knows how many years before we placed her on it 5 years ago.

So it was decided “Heck, some people are just plain going to make it” and she dropped the drug.

She died of old age.

She lived well and passed into God’s loving arms well.


6 posted on 02/29/2012 11:54:48 AM PST by Vendome (Don't take life so seriously, you won't live through it anyway)
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To: Cyman

“Sounds a LOT like the Global Warming consensus statement doesn’t it.”

While it is “indisputable”, the warmists do not believe it should “be taken with care ...” They want big, promiscuous dollops of warmist remedies without regard to the consequences. Kind of like prescribing 10,000 mg of Simvistatin.


7 posted on 02/29/2012 11:55:45 AM PST by ModelBreaker
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To: neverdem

What’s the total count goal for cholesterol now - 95?

They keep dropping the acceptable total cholesterol numbers - pretty soon the percentage of people prescribed statins will be the same amount of people paying income taxes in this country....


8 posted on 02/29/2012 11:56:09 AM PST by libertarian27 (Check my profile page for the FReeper Online Cookbook 2011)
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To: neverdem
"The value of statins in preventing heart disease has been clearly established,” said Dr. Amy G. Egan,"

The value of Vitamin B3 (nicotinic acid) in preventing heart disease has been clearly established,” said Freeper Matthew Fuller.

9 posted on 02/29/2012 11:56:14 AM PST by matthew fuller (Elevators smell different to midgets.)
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To: brownsfan
Those who regularly go to the doctor risk becoming someone’s chemistry experiment.

Vigorous exercise and eating properly would solve the vast majority of today's ailments(which are mostly related to obesity) but the American people are just too lazy and they want their "bad" food.

Easier to just take pill.

10 posted on 02/29/2012 11:58:45 AM PST by trailhkr1
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To: neverdem; Impy; Perdogg; Clintonfatigued; fieldmarshaldj
My Mother can't raise her arms without pain. That started when she started taking these garbage “medications”. She also has to go for blood work every 4-6 months...and her initial “high” cholesterol was 230.

I've actually gotten into screaming matches with her telling her these statin medications are garbage (I'm a biochemist, so I do know a bit about this).

Change your diet and walk 3-4 times a week. It works and you're not filling your body with garbage or lining the pockets of pharma companies that push this sh*t.

11 posted on 02/29/2012 12:00:08 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: brownsfan

That is a fantastic (and sadly accurate) tagline!!!


12 posted on 02/29/2012 12:02:31 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: neverdem

Memory deficits? YESSS!! The excuse I’ve been looking for! “Hon, I really meant to take out the trash/clean the garage/wash your car/pick up veggies on the way home - it’s this darn lipitor!”

I’m not betting the farm on it...


13 posted on 02/29/2012 12:04:27 PM PST by jagusafr ("Write in Palin and prepare for war...")
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
FReepmail me if you want on or off the diabetes ping list.

Not all type II diabetics are the same, but with high blood pressure, central obesity, low HDL cholesterol and high triglycerides you have Syndrome X, also known as metabolic syndrome. Diets restricted in carbohydrate intake have benefited many with metabolic syndrome. If you enter Volek JS, Feinman RD into PubMed's query box, then you'll do an authors' search on two writers who have written at least 10 articles showing the benefit of carbohydrate restriction.

14 posted on 02/29/2012 12:06:59 PM PST by neverdem (Xin loi minh oi)
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To: neverdem

Results..
1..Attorneys preparing ads for class actions.
2..Big Pharmas going in to defense mode.
3..Sale of Red Yeast Rice skyrocket. A safe natural statin.
4.. Incidence of Altzheimers slowly reduces as use of statins declines.


15 posted on 02/29/2012 12:08:18 PM PST by codder too
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To: libertarian27

Sounds like the Nazi EPA if you ever get in compliance they lower the number.


16 posted on 02/29/2012 12:09:12 PM PST by boomop1 (term limits is the only way to save this country.)
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To: GOPsterinMA

Six months after a new hip I ride my bike an hour to an hour and a half almost daily. BP is now 100/70 resting, sometimes lower. I’m thinking about getting off BP medication now that I don’t have level 10 pain!


17 posted on 02/29/2012 12:15:22 PM PST by poobear
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To: libertarian27
What’s the total count goal for cholesterol now - 95?

The new level is probably the most insidious of all pronouncements. The "finding" was done by a non-medical committee. The logic was "lower" must be better. They completely ignored the TG/HDL Ratio. This also applies to men:

The TG/HDL Cholesterol Ratio Predicts All Cause Mortality in Women With Suspected Myocardial Ischemia A Report from the Women’s Ischemia Syndrome Evaluation (WISE)

High Ratio of Triglycerides to HDL-Cholesterol Predicts Extensive Coronary Disease

Keep the ratio at 2 or below and you will improve your risk factors. You can do this by going on a very low carb (VLC) diet and taking niacin. This reduces your triglyceride levels dramatically.

The original cholesterol studies were probably the greatest scam in medical history. The "life saved" numbers were massaged from the data when after seven years of study there was no evidence that the overall death rate was lowered. The weasel words that came out of the NIH were "relative" lives saved. The statistics were massaged to the point where a Kobe cow would be envious.
18 posted on 02/29/2012 12:16:42 PM PST by PA Engineer (Time to beat the swords of government tyranny into the plowshares of freedom.)
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To: poobear

Good for you - way to go!!!

If you don’t have to put the junk in your body - don’t!

Personally, I don’t take an aspirin unless I’m dying.

Everything you put in your body has a reaction. As you probably know, just because a doctor tells you to take it, doesn’t mean it’s good.


19 posted on 02/29/2012 12:20:07 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: GOPsterinMA

“That is a fantastic (and sadly accurate) tagline!!!”

Thanks. Not sure how many understand what I’m saying there, but sadly, I see it playing out before us.


20 posted on 02/29/2012 12:20:12 PM PST by brownsfan (Aldous Huxley and Mike Judge were right.)
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To: brownsfan
Your post, #4, is excellent as well!

Idiocracy: We don't have to wait til 2525, because like you said, it's playing out right now. That explains Obama getting elected and having any chance at reelection.

21 posted on 02/29/2012 12:24:49 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: libertarian27
They (FDA and organizations of doctors like the AMA) keep lowering the numbers until most need it...doing the same with high blood pressure..

when I was in nursing 140/90 was borderline, now its down to 130/80-- 120/60 is the norm....and hbp changes during the day depending on what you are doing....its not stable all the time.

.when my doctor didn't like my b/p 132/80 he said to consider medication...I reminded him I was a nurse and for me borderline will always be 140/90 for an extended period. When I left his office stopped at the drug store and bought a b/p cuff and keep a month long journal, taken several times a day and only 2 times did diastolic go to 90 and an hour later it was back in the 70’s...he had me bring in my cuff to test against his office cuff and it was right on with his....we didn't talk b/p any more.....I had to go off statins due to severe muscle weakness, but do have pretty high cholesterol...told him if I have to choose between the side effects and high cholesterol, high cholesterol wins.

nurses make tough patients but he always checks for generics when I need medication cause he knows I pay for my own prescription...still wouldn't trade him as primary doctor to any others... Its hard breaking in a new doctor.....

PS the statins did bring down my cholesterol quite a bit. Also tried Welcor and non statin cholesterol lowering drug. The major side effect was constitupation, since I have IBS that was not a problem, but 4 months into it, the muscle weakness and range of motion in the L shoulder was pretty bad and had to stop again....when you stoop down to get something off the bottom of the grocery shelf and cannot stand up without pulling yourself up by the shelves and cannot life a bag of dog food out of the cart, its time to stop....

22 posted on 02/29/2012 12:30:59 PM PST by goat granny
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To: neverdem

As far as anecdotal evidence goes ALL of the males in my immediate family have had bad side-effects from Statins. My father had it worst with permanent leg muscle damage.

On the other hand I can also report that since he started to take Anatabloc, (an over the counter nutraceutical), his leg pains have nearly gone away. As for myself the Anatabloc is showing good results one of which is the “trigger finger” effect I had in both hands has gone away.


23 posted on 02/29/2012 12:38:11 PM PST by The Working Man (The mantra for BO's reign...."No Child Left a Dime")
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To: traderrob6

Cholesterol can be lowered by eliminating sugar from one’s diet. But they can’t make money on that.


24 posted on 02/29/2012 12:50:09 PM PST by goodwithagun (My gun has killed fewer people than Ted Kennedy's car.)
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To: GOPsterinMA
About 20% of folks suffer intramuscular pain from the normally prescribed doses of statins.

The cause is a lack of an enzyme to metabolize them.

The solution is to take a smaller dose until you don't have pain.

It takes 4 or 5 days to work the stuff out of your system to get down to zero ~ so be patient.

Now, about cheese ~ made out of milk ~ baby cows, baby goats, baby horses, baby yaks, baby mammals of any kind eat huge quantities of fat laden mother's milk. That milk has chemical equivalents of statins in it. If you eat lots of cheese you might get intramuscular pain. Eat less cheese.

If you take statins and get pain, and eat cheese with it, your time spent figuring out your safe dose will be longer.

My cholesterol levels ~ LDL and HDL ~ are super low. That condition is somewhat associated with the intramuscular pain problem.

BTW, eating grapefruit with statins will give you an overdose ~ so watch it.

25 posted on 02/29/2012 1:12:26 PM PST by muawiyah
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To: neverdem

Thanx


26 posted on 02/29/2012 1:15:16 PM PST by morphing libertarian
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To: codder too

I’ve taken Red Yeast Rice for years. My cholesterol is normal. I buy the Red Yeast Rice at Sam’s Club.

A decade ago, I took Pravachol. It cost me $150.00 per month, and then several times a day I got a sharp pain in my right temple. I thought I was getting a brain tumor. I suspected the Pravachol and stopped taking it. Immediately, the pains in my temple went away for good.

Zetia was another new-fanged pill I tried for several years. $80.00 per month. It’s supposed to dissolve cholesterol in foods that are still in your intestine. My doctor told me not to take it anymore after new studies were published claiming that it didn’t do squat.


27 posted on 02/29/2012 1:22:46 PM PST by july4thfreedomfoundation (I'm NOT smitten' with Mittens)
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To: neverdem

With some of the side effects you can experience, I think sometimes it would be better to not take the pills.


28 posted on 02/29/2012 1:27:44 PM PST by I Drive Too Fast
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To: brownsfan
Those who regularly go to the doctor risk becoming someone’s chemistry experiment.

Buddy of mine had exactly this happen.

Cholesterol was a little high....nothing worrisome, just a little high. Doc prescribed something.

Buddy had side effects. Doc set him up with something for those.

2nd prescrip had side effects, Doc set him up with something for that. And so on and so on.... Buddy now swallows a handful of pills a day, for something that likely could have been treated by eating a little better and playing an extra round of golf a week.

29 posted on 02/29/2012 2:03:46 PM PST by wbill
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To: GOPsterinMA

Believe or not, the trick is (but it’s no trick) is prayer and the help of two wonderful doctors. I’m telling you, that day of 20 hours of surgery must have been the most successful results those gifted folks have had in a decade! I mean really! Those men and women were prayed for prior, during and afterwards of their efforts that day. I and many others prayed for a blessing on the entire hospital.

I don’t believe in luck but I do believe in work. I wasn’t satisfied in leaving the rest up to standards of medicine. I worked hard and am having the best year in a decade! They wrote articles about me, I chose to get my life back by breaking standards as far as recovery. Pretty boring but it beats dying or being handicapped. Amazing because they really do stress the exercise but no one really pushes it. I have also lost another 10 pounds since this article below.

Here is my story:

http://insighteastorlando.com/index.php/featured/surgery-changed-my-life


30 posted on 02/29/2012 2:54:01 PM PST by poobear
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To: neverdem
My wife was just diagnosed with high cholesterol. A tad over 220....She told her doctor there was NO WAY she was taking a Statin...

He changed her diet and take some fish oil and left it at that...

31 posted on 02/29/2012 3:12:52 PM PST by Popman (America is squandering its wealth on riotous living, war, and welfare.)
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To: GOPsterinMA

My dad had to get a checkup for a job several years ago. They scared him about cholesterol and high BP and put him on Lipitor. I don’t think it was necessary. Tt’s not like he had any symptoms.


32 posted on 02/29/2012 5:29:04 PM PST by Impy (Don't call me red.)
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To: Impy
Scare tactics indeed! My Mom had no symptoms either...that is until she started popping the Lipitor.

I actually printed the article from this thread and am going to give it to her to read.

33 posted on 02/29/2012 5:52:59 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: poobear
Very impressive! You're a celebrity!!!

Your story is a good one! Two thumbs up for your perseverance and hard work. And having doctors that actually know up from down makes a HUGE difference as well.

And last. but not least, the power of prayer!

34 posted on 02/29/2012 6:41:05 PM PST by GOPsterinMA (The Establishment is the establishment.)
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To: neverdem

I would like to add that daily prolonged and repetitive exercise in conjunction of watching what you eat will beat most any medication. You may want to note that the accent is on prolonged (1/2 to 1 hr preferably) and repetitive .This may be bicycling, walking, running, swimming, playing basket ball, almost anything what keeps the body in continuous motion for a prolonged period of time. Needless to say, stay within recommended weight limitations......if you follow these recommendations it will allow you to spend more time in a nursing home!


35 posted on 03/01/2012 12:02:57 AM PST by saintgermaine
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To: Vendome

“She had lived with a cholesterol count of 300 for who knows how many years before we placed her on it 5 years ago.”

She lived to be 101?

Not that surprising, actually. The Framingham study found that people with higher cholesterol actually lived longer.


36 posted on 03/02/2012 7:19:26 PM PST by webstersII
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To: webstersII

101 and five months.


37 posted on 03/02/2012 8:12:43 PM PST by Vendome (Don't take life so seriously, you won't live through it anyway)
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