Skip to comments.Sex-deprived fruit flies drink more alcohol: New study could uncover answers for human addictions
Posted on 03/15/2012 1:22:12 PM PDT by Red Badger
Sexually deprived male fruit flies exhibit a pattern of behavior that seems ripped from the pages of a sad-sack Raymond Carver story: when female fruit flies reject their sexual advances, the males are driven to excessive alcohol consumption, drinking far more than comparable, sexually satisfied male flies.
Now a group of scientists at the University of California, San Francisco (UCSF) has discovered that a tiny molecule in the fly's brain called neuropeptide F governs this behavioras the levels of the molecule change in their brains, the flies' behavior changes as well.
The new work may help shed light on the brain mechanisms that make social interaction rewarding for animals and those that underlie human addiction. A similar human molecule, called neuropeptide Y, may likewise connect social triggers to behaviors like excessive drinking and drug abuse. Adjusting the levels of neuropeptide Y in people may alter their addictive behaviorwhich is exactly what the UCSF team observed in the fruit flies.
"If neuropeptide Y turns out to be the transducer between the state of the psyche and the drive to abuse alcohol and drugs, one could develop therapies to inhibit neuropeptide Y receptors," said Ulrike Heberlein, PhD, a Professor of Anatomy and Neurology at UCSF, who led the research.
Clinical trials are underway, she added, to test whether delivery of neuropeptide Y can alleviate anxiety and other mood disorders as well as obesity.
A Reward Switch in the Brain
The experiments, described this week in the journal Science, started with male fruit flies placed in a container with either virgin female flies or female flies that had already mated. While virgin females readily mate and are receptive toward courting males, once they have mated, females flies lose their interest in sex for a time because of the influence of a substance known as sex peptide, which males inject along with sperm at the culmination of the encounter. This causes them to reject the advances of the male flies.
The rejected males then gave up trying to mate altogether. Even when placed in the same cage as virgin flies, they were not as keen to have sex. Their drinking behavior also changed.
When placed by themselves in a new container and presented with two straws, one containing plain food and the other containing food supplemented with 15 percent alcohol, the sexually rejected flies binged on the alcohol, drinking far more than their sexually satisfied cousins whose advances were never spurned. The difference was not only apparent in their behavior. It was completely predicted by the levels of neuropeptide F in their brains.
"It's a switch that represents the level of reward in the brain and translates it into reward-seeking behavior," said Galit Shohat-Ophir, PhD, the first author of the new study.
A former postdoctoral researcher at UCSF, Shohat-Ophir is now a research specialist at the Howard Hughes Medical Institute (HHMI) Janelia Farm Research Center in Ashburn, VA. Later this year, Heberlein will also move to Janelia Farm, where she will become scientific program director.
Experiments Began as a "Crazy" Idea
When the work first started a few years ago, Shohat-Ophir said, it was just a crazy idea. The UCSF team suspected there might be a molecular mechanism in the brain linking social experiences like sexual rejection to psychological states such as depression of the brain system that responds to rewards. So they decided to test whether flies that were rejected sexually would be more prone to drinking.
Flies in the laboratory will normally drink to intoxication if given the choice, but this behavior is altered when neuropeptide F levels are altered in their brains because of their sexual experiences. Mated flies are less likely to seek out such rewarding experiences.
The male flies that were paired with receptive virgin females from the start and successfully mated had lots of neuropeptide F in their brains and drank very little alcohol.
Rejected flies, on the other hand, had lower levels of neuropeptide F in their brains, and sought alternative rewards by drinking to intoxication.
In their work, Heberlein, Shohat-Ophir, and their colleagues showed that they could induce the same behaviors by genetically manipulating the neuropeptide F levels in the flies' brains. Activating the production of neuropeptide F in the brains of virgin males flies made them act as if they were sexually satisfied, and they voluntarily curtailed their drinking.
Lowering the levels of the neuropeptide F receptor made flies that were completely sexually satisfied act as if they were rejected, inciting them to drink more.
The finding has great relevance to addressing human addiction, though it may take years to translate this discovery into any new therapies for addicts, given the much greater complexities of the human mind.
The human version of neuropeptide F, called neuropeptide Y, may work similarly, connecting socially rewarding experiences to behaviors like binge drinking. Already, scientists know that levels of neuropeptide Y are reduced in people who suffer from depression and post-traumatic stress disorderconditions that are also known to predispose people toward excessive alcohol and drug abuse.
Manipulating neuropeptide Y may not be so straightforward, however, since the molecule is distributed all over the human brainand based on rodent studies, it has roles in feeding, anxiety and sleep, in addition to alcohol consumption.
More information: The article, "Sexual Deprivation Increases Ethanol Intake in Drosophila" by Shohat-Ophir, K. R. Kaun, R. Azanchi and U. Heberlein appears in the March 16 issue of the journal Science: http://www.sciencemag.org
Time flies like an arrow.
Fruit flies like a banana.......
Well, that was a no-brainer. They’re self medicating. Poor bastards.
Probably because female fruit flies have those damn headaches so often.
The male fruit flies have it completely backwards here.
The female fruit flies need to drink excessive alcohol.
Then, you make your advance!
Hmmmmm, replacing a 12 step meeting with meeting the neighborhood working girl???
I really don’t believe in addiction. I believe in lack of willpower, laziness and weakness.
Yes, DHHS is working on getting health insurance to cover that as we speak
I’m no fruit fly, but I’m certainly picking up what they are laying down.
Bottoms up fellows.
It would have to be subsidized,
because we all know that a “right” is being deprived
if you lack the means to exercise that “right”.
You spend your life with everybody calling you a “fruit” and see if you don’t take to the bottle.
Well, since they only live a day or so, it’s not like they’re gonna worry about wearing out their livers.
Guess there’s a case for single guys, porn and masturbation - you know to combat drug and alcohol abuse. /sarc
Seeing that sex releases oxycontin hormones in the brain, you’re really just trading an internal high for an external high.
"I only got 24 hours to live, and I ain't gonna waste it here!"
The weakness is initially getting hoooked. Once hooked you are addicted. The brain chemistry actually changes. There’s plenty of science noting real physical changes in the body of people addicted. It’s not that they are not responsible for their own actions, sober or not. Just stating that physical changes are real and do happen in people who are hooked on many different kinds of substances.
Who knew they made beer goggles that small?
Top of the list...amore.
Third, another beer...this time with chips.
those male flies need to put down the booze and go find a Fluke Fly
“I really dont believe in addiction”
Depends on whether you are talking booze, drugs or pretty girls.
Got to get your “buzz” from somewhere . . . .
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