Free Republic
Browse · Search
News/Activism
Topics · Post Article

Prion strain discrimination using luminescent conjugated polymers earlier work

Polythiophenes inhibit prion propagation by stabilizing PrP aggregates

The left sidebar is supposed to link a FReebie PDF. I didn't try it yet.

1 posted on 04/28/2012 2:17:01 AM PDT by neverdem
[ Post Reply | Private Reply | View Replies ]


To: texas booster

Ping


2 posted on 04/28/2012 2:19:01 AM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem

Prions, the lesser known first cousin of the moron.


3 posted on 04/28/2012 3:32:08 AM PDT by cripplecreek (What does it profit a man if he gains the whole world but loses his soul?)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem

Thank you for posting. This is excellent research. One step closer to understanding prions.

Questions from a novice:

“What causes the proteins to fold, replicate and become prions if there is no DNA, or RNA?” Another enzyme?

“Why is PrP so structurally sound and resistant to protease enzyme destruction?” Heat at 600 degree C., Boiling water, radiation .... Wow..

I find the research this past year showing how the lichen Parmelia sulcata when consumed by deer, elk and moose denature the prions in chronic wasting disease in the wild. Is is possible that the solution to denaturing prions is with fungal prions that do not affect humans? If PrPc is necessary for long term potentiation in the hippocampus and the variations of PrPsc block potentiation by creating amyloid plaques, the firewall to block Alzheimer’s just might be found in lichen prion research.

Natural Born Prion Killers: Lichens Degrade “Mad Cow” Related Brain Pathogen
By Philip Yam | May 19, 2011
http://blogs.scientificamerican.com/observations/2011/05/19/natural-born-prion-killers-lichens-degrade-mad-cow-related-brain-pathogen/?print=true

Too bad I’m over the hill. I would love to return to the university for a degree in microbiology/biochemistry. This stuff sure beats crossword puzzles! I find the whole field of epigenetic research and all of its sub fields absolutely fascinating.


4 posted on 04/28/2012 4:25:51 AM PDT by tired&retired
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem
I>Prions in the brain eliminated by homing molecules

No, I do not want to watch "Brokeback Mountain" with you.

5 posted on 04/28/2012 4:52:42 AM PDT by VRW Conspirator (Article 58)
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem

I would love to know more about this and CJD. A friend of mine died last week from this disease and there just doesn’t seem to be much out there on how one gets it and there is no cure. We watched my friend in her early 50’s go from her normal, active self to passing away in a matter of about six weeks.


6 posted on 04/28/2012 5:34:37 AM PDT by aberaussie
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem

**** has now shown that the same molecules can also render the prions harmless, and potentially cure fatal nerve-destroying illnesses.***

So there is potential hope for liberals?


7 posted on 04/28/2012 7:08:23 AM PDT by Ruy Dias de Bivar
[ Post Reply | Private Reply | To 1 | View Replies ]

To: neverdem

Thanks for the interesting post.


9 posted on 04/28/2012 1:11:10 PM PDT by Weirdad (Don't put up with ANY voter fraud...)
[ Post Reply | Private Reply | To 1 | View Replies ]

Free Republic
Browse · Search
News/Activism
Topics · Post Article


FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson