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FDA Approves Lyrica for Nerve Pain in Spinal Cord Injuries
Yahoo ^ | June 21, 2012 | Sherry Tomfeld

Posted on 06/21/2012 1:57:33 PM PDT by stillafreemind

Pfizer Inc.'s drug Lyrica has gotten FDA approval for use in treating nerve pain due to spinal injuries. Lyrica, a pain drug, is Pfizer's second-biggest selling drug. It is expected that this new approval will help Lyrica pass Lipitor, the company's largest-selling drug for reducing cholesterol.

(Excerpt) Read more at voices.yahoo.com ...


TOPICS: Extended News; Miscellaneous; News/Current Events
KEYWORDS: approved; fda; lyrica; spinalcord
Sounds like they rushed this one through for these patients, I hope it helps them.
1 posted on 06/21/2012 1:57:48 PM PDT by stillafreemind
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To: stillafreemind
Lyrica is an older version of the anti seizure medicine Gabapentin, which we have used for years "off label" ,without fda approval for this type of pain. link

I think of it as a blanket that you put over a irritable nerve or electric tape that you put over a wire that is sparking

It stops the "spark" from turning into seizures, but then, because it had less bad side effects than other seizure medicines, we started using it for shingles pain (herpes zoster, no relationship to herpes herpes). Then we started using it for our diabetics whose feet were numb but caused burning pain.

I haven't treated the bad neuropathic pains, but apparently it works for them too

the advantage is that different types of pain pills work for pain. Motrin/NSAIDS works for bone pain, but not for this type of pain.

A lot of these patients got addicted to narcotics in the past, because narcotics were the only thing that stopped the pain (and even then, the narcs didn't work very well)

the interesting thing about Lyrica is that it also seems to work for fibromyalgia.

2 posted on 06/21/2012 2:12:18 PM PDT by LadyDoc
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To: stillafreemind

I’m taking it for nerve pain *herniated disc/root nerve irritation/sciatica* I’m hoping once the dosage gets right that it will help alleviate some of my sciatica pain. However... it’s very expensive. If doc hadn’t given me the “co-pay card” that makes the co-pay a max of $25, I would have requested a cheaper medication.


3 posted on 06/21/2012 2:16:28 PM PDT by Grumpybutt ("Mothers go where angels fear to tread....")
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To: stillafreemind

“Pfizer Inc.’s drug Lyrica has gotten FDA approval for use in treating nerve pain due to spinal injuries. Lyrica, a pain drug, is Pfizer’s second-biggest selling drug. It is expected that this new approval will help Lyrica pass Lipitor, the company’s largest-selling drug for reducing cholesterol.”

http://www.drugs.com/sfx/lyrica-side-effects.html

“In clinical trials in patients with neuropathic pain associated with diabetic peripheral neuropathy, 9% of patients treated with Lyrica and 4% of patients treated with placebo discontinued prematurely due to adverse reactions.”

9-4=5% 1 in 20 discontinued due to adverse reactions. Nice to see our FDA’s on the job.

http://pogoblog.typepad.com/pogo/2011/08/janet-woodcock-miss-piñata-meets-clue-stick.html

And why would Dear Janet be so Drug Company friendly, since a Fifth of FDA’s budget comes directly from drug companies?

http://www.fda.gov/ForIndustry/UserFees/PrescriptionDrugUserFee/default.htm


4 posted on 06/21/2012 2:16:38 PM PDT by To-Whose-Benefit? (It is Error alone which needs the support of Government. The Truth can stand by itself.)
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To: LadyDoc

I have been taking it for diabetic neuropathy for two years.
Biggest problem is weight gain.


5 posted on 06/21/2012 2:20:38 PM PDT by golfisnr1
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To: stillafreemind

I’ve taken Lyrica before for nerve damage. Within a week, it had me feeling like I was drunk all the time. I could barely walk, my memory was shot and I was slurring my words. I don’t trust this or any other, as seen on TV, drugs since they’re so new to the market, they’re using people to further test their drug without telling the consumer like they did for Bextra during its follow up testing on huamans where they had to stop testing it after it had been approved since the incidents of heart attacks and strokes were way above the number you would expect from normal society and it’s banned to this day.

If you take this, keep an eye out for the symptoms I described. The doctor finally admitted that it was the drug causing all these weird symptoms and stopped me from taking it.

If they’re advertising drugs on TV, I would be leery as they seem to be using people who saw this drug on TV to ask their doctor for it and then they further test it. I would stick with drugs that have been around. Neurontin is another drug that does almost the same thing without most of Lyrica’s problems although it has issues of its own.


6 posted on 06/21/2012 2:22:16 PM PDT by Lx (Do you like it, do you like it. Scott? I call it Mr. and Mrs. Tennerman chili.)
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To: stillafreemind

Then you best do a LOT of research before you or any one you know take it. It has a whopping 50% sided effect failure rate.

It is an anti-seizure drug, they broadened it for Fibromyalgia patients not to long ago. Hope you like your hair falling out, if you have ‘arthur’ your joints will hurt terribly and you will GAIN WEIGHT. These are just a few of the ‘nice’ side effects of this nasty drug. This is it’s older sister drug
http://www.drugs.com/sfx/gabapentin-side-effects.html

Go back a few pages to the blogs and see what the patients are saying...not pretty.

My experience with it was terrible pain, as was my son’s. 50mg dose.

Other folks tolerate the side effects. I can’t.


7 posted on 06/21/2012 2:29:24 PM PDT by GailA (IF U don't/won't keep your promises to the Military, U won't keep them to the public)
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To: GailA

The gal that wrote the articles talks about some of the side effects her friend(s) have had with it.

But..if there is no other solution to the nerve pain from spinal injuries..anything would probably be welcomed.


8 posted on 06/21/2012 2:41:22 PM PDT by stillafreemind
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To: LadyDoc

I take Lyrica for nerve pain in my legs and hips. It enables me to sleep where before I was in awful pain and getting almost no sleep even though I take pain meds and Ambien. The constant hunger is the worst side effect for me. It has been a wonder drug as far as I am concerned.


9 posted on 06/21/2012 2:51:01 PM PDT by rightly_dividing (We are Scott Walker.)
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To: LadyDoc

“Lyrica is an older version of the anti seizure medicine Gabapentin,”

Just the opposite,gabapentin before pregabalin.


10 posted on 06/21/2012 3:22:39 PM PDT by Cyman
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To: rightly_dividing

I’m glad it helps your pain.

I should add to my previous post that it sometimes works for nerve pain (sciatica) from disc problems too (when the disc irritates the nerve and the pain goes down the leg)...this is another “off label” use.

Usually the “treatment” for such pain when it doesn’t go away with physical therapy etc. is surgery, but we also have folks whose pain is caused by scar tissue after the surgery, or because the nerve was so damaged that the surgery, taking the pressure off of the nerve, didn’t help.

it also works for Tic Doloreaux, the terrible facial pain caused by an irritated nerve...


11 posted on 06/21/2012 3:24:49 PM PDT by LadyDoc
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To: Grumpybutt

gabapentin works for many people and is generic so might be cheaper. It doesn’t work as well, and has to be taken a few times a day, but it is an alternative for some folks on a tight budget.


12 posted on 06/21/2012 3:28:49 PM PDT by LadyDoc
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To: stillafreemind

I had horrible unrelenting pain after a lung removal; diagnosed as post thoractotomy neuropathy. I thought I was doomed; truly wanted to die. Then the pain clinic started me on Lyrica; within a week the pain was better and my dose was gradually increased to reach maintenance level where I can tolerate the pain. I still get breakthrough electric charges throughout my body sometimes but it is sporadic. I do have lots of swelling in my feet and hands and have tried to taper the dose downward but I resigned myself that I probably will be on it for the long term. Very very thankful that it helps.


13 posted on 06/21/2012 3:41:21 PM PDT by Redrivergal
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To: Lx

Lyrica is not a “new” drug, but a version of the older one, gabapentin (This is a correction of my previous post, where I said it was an older drug.) Gabapentin came out for seizures back in the early 1990’s, so it’s not a new drug family.

The neurologists knew that some seizure medicines such as tegretol worked for terrible nerve pain (tic doloreaux or neuropathic pain) so they tried gabapentin, and it worked for the pain, with fewer liver/blood side effects than tegretol...Lyrica is the newer version of this, with less sleepiness and you take fewer pills... However, the FDA never “approved” of using gabapentin, so we had to tell our patients this.

The sedation is dose related, so the answer is to start at a lower dose until your body gets used to it. I am sensitive to being sleepy with medicine: I can’t take an allergy pill if I plan to work or drive, for example.

However, I agree with you about advertising: it’s dangerous, and sells expensive medicine you might not need.

But before gabapentin and Lyrica, our patients with nerve damage often ended up addicted to narcotics, and the pain was so bad some killed themselves.

So like all medicines, it is good for many people, but not for everyone, alas...


14 posted on 06/21/2012 3:54:49 PM PDT by LadyDoc
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To: LadyDoc

Thanks for the info :) If I find I can’t tolerate the side effects (feet swelling and my vision is a tiny bit blurry) then I’ll ask to switch to that other one.


15 posted on 06/21/2012 3:55:07 PM PDT by Grumpybutt
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To: stillafreemind

I sure hope it helps some. I took it for Fibromyalgia and Chronic Fatigue pain and aches. I had all the bad reactions and had to stop taking it. Even 3 years later I am fighting to get the weight off. I gained 25 pounds when taking it. Every one I know who has taken it has gained a lot of weight.


16 posted on 06/21/2012 3:56:02 PM PDT by Pilated
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To: GailA

Another site on side effects, reported to Medwatch Jan 2004-Sept 2009

http://lamplightersoftware.com/dsm.php

put Lyrica in the search box

Pregabalin Reported By
Adverse Reaction Cases MD CN OT PH LW NR
Suicidal Ideations 135 57 54 27 3 0 28
Attempted Suicides 41 21 11 8 3 0 19
Completed Suicides 18 15 1 3 0 0 9
Deaths Not From Suicide 335 290 87 61 28 0 72
Homicidal Ideations 13 6 5 1 0 0 2
Homicides 1 0 1 0 0 0 0
Hypomania/Mania 39 29 5 10 2 0 6
Heart Disease 350 250 62 60 32 1 72
Movement Disorders 1,283 567 467 193 100 5 377
Birth Defects 22 10 7 3 2 0 7
Premature Births 1 0 2 0 0 0 0
Prenatal/Neonatal Deaths 24 14 13 7 0 0 2


17 posted on 06/21/2012 4:20:40 PM PDT by To-Whose-Benefit? (It is Error alone which needs the support of Government. The Truth can stand by itself.)
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To: LadyDoc
Gabapentin under the name Neurontin has been used effectively for neuropathic pain for many years now. I am quite surprised that such use would be considered off-label.
18 posted on 06/21/2012 4:23:52 PM PDT by hinckley buzzard
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To: LadyDoc

Hi: I just withdrew from Gabapentin after 10 years on it (2400Mg/day) due to kidney problems. It was/is a very unpleasant experience!!! Now, I’m wondering about Lyrica. Does it have the same potential for kidney problems (high creatinine) as gabapentin? Right now, I’m almost overwhelmed with pain/discomfort. Death would be welcome relief for some neuropathic pain sufferers.


19 posted on 06/21/2012 4:29:07 PM PDT by oneolcop (Lead, Follow or Get the Hell Out of the Way!)
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To: LadyDoc

I was also on Gabpentin. My doctor said it was designed as a drug for seizures but that it didn’t work any better than the anti-seizure meds they already had. They prescribed it for off label use and gave it to me.

I took it exactly as they said to do and nothing happened, good or bad so they took me off of it. I’ve still got some laying around.

I just tried to find it and can’t, I know I put it somewhere where it wouldn’t get lost but of course, it’s in a nice and cosy place... somewhere.


20 posted on 06/21/2012 5:11:40 PM PDT by Lx (Do you like it, do you like it. Scott? I call it Mr. and Mrs. Tennerman chili.)
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To: Lx

yes, Gabapentin didn’t work very well for seizures, but because we didn’t have to check blood levels and because it didn’t interfere with the drug metabolism of the other seizure medicines, we often used it for people who needed a second medicine to help stop seizures.

It’s not quite as strong as tegretol for Tic doloreaux either, but because of the lack of problems with it, we might use it more.

However, for diabetics etc. neuropathy we rarely used the stonger anti seizure medicines, again because of side effects and drug interaction problems, but gabapentin could be used and it worked, especially when we just used it at night (because of sleepiness side effects with gabapentin).

Since I worked for the IHS, the federal clinics for native Americans, we had limited number of medicines for our patients, so usually we used the cheaper gabapentin...to use the newer medicine meant you had to prove the patient couldn’t use the cheaper drug. (something to remember when Obamacare starts).


21 posted on 06/21/2012 5:35:23 PM PDT by LadyDoc
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To: Lx

Not all medicines work for everyone, so your doctor will probably keep looking for something that does work.


22 posted on 06/21/2012 5:36:58 PM PDT by LadyDoc
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To: Lx
I couldn't afford Lyrica so my pain management doctor put me on Neurontin. Neurontin caused me so many mental issues that I stopped taking it. Thank God my back surgeries were a success and I no longer need oxicodone, morphine, Neurotin and Celabrex. The Celabrex is probably what caused me to have a stroke 2 years ago.

It will be one year, in July, since I had 2 surgeries and I am now off all meds and back to working out at the gym 4-5 days a week.

23 posted on 06/21/2012 5:54:37 PM PDT by muggs (Hope and Change = Hoax and Chains)
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To: hinckley buzzard

On Label or Off Label is cut and dry.

It shouldn’t come as a surprise.

http://www.medpagetoday.com/ProductAlert/Prescriptions/15639


24 posted on 06/21/2012 7:08:12 PM PDT by To-Whose-Benefit? (It is Error alone which needs the support of Government. The Truth can stand by itself.)
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To: stillafreemind

BFM.


25 posted on 06/21/2012 8:52:54 PM PDT by CH3CN (A stitch in time is worth two in the bush.)
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To: stillafreemind

Look up Bladder pace maker...I would NOT recommend it, as it is very invasive and scar or nerve tissue can grow over the probes and leave more pain. It is also being used for back pain.

When the side effects out weigh the illness it is NOT worth it.

Believe me I live with Fibromyalgia pain 24/7/365, and the back from Hades. C-3-7 nearly bone on bone, T-11-13 bone spurs, T 12 annul tear and herniated, L-2 annul tear, L-3-5 bulged, bone spurs, L-4-5 compression fracture. Osteo A and Osto P. Neurosurgeon won’t touch me, not only am I Medicare but Tricare Life...no money to be made, and they use the FMS as an excuse of not healing well.

I’ve had 2 surgeries this year, healed well from both. Won’t get into the first it was a nightmare of medical malpractice I can’t prove. 2nd one was a very major one and done well with great treatment.

I’m that 2-5% who are so sensitive to these newer drugs I dare not take them.

Whelcol..cholesterol...BIG horse pills supposed to take 6 per day, start with 1 and work up, by 3rd day gout pain, by day 5, I could barely walk..and this was SUPPOSED to be the most tolerated one! Then the idiot one time see cardiologist after typing in my entire list of bad reactions and health history issues a RX for Zetia...hits all 5 of my auto immunes for ‘common side effects” 2 pills later it is in the trash can.


26 posted on 06/22/2012 4:58:53 AM PDT by GailA (IF U don't/won't keep your promises to the Military, U won't keep them to the public)
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To: stillafreemind

This is used for both bladder and low back pain..but beware airports will be a nightmare to get through.

And do a LOT of googling before deciding to use this.

They tried to stick me with it...not thanks, I am not incontinent nor would it fix compression fracture or the bulges or spurs. Band
aid, a real expensive one at that. That could leave you in even MORE pain. And if one of the probes grows nerve tissue over it, it cannot be removed!

http://www.youtube.com/watch?v=PZ-2S-rCjKM&feature=related


27 posted on 06/22/2012 5:15:01 AM PDT by GailA (IF U don't/won't keep your promises to the Military, U won't keep them to the public)
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To: To-Whose-Benefit?

1 Lunesta pill, rotten copper taste for 3 days and anger enough that is was dangerous to leave the house for 24 hrs.

I take 4 drugs Synthroid name brand, as generic is garbage a good ENDO will NOT prescribe the generic. Valium for the FMS, Diazide to control soft tissue swelling and pain in hands, and Claritin, we live in the south, pollen deluxe.

It is to the drug companies benefit...take Crestor, it was supposed to be the DRUG OF LAST RESORT, yet through a slick multi-million $$ ad campaign became #1, with Lipitor as #2, both LAST resort drugs. Older drugs work just as well and have fewer side effects.

That is unless you are some one like me, the 2-5% who can’t take much of any thing. I’ve sent more drugs back to the pharmacist because of the side effects. I don’t have to take them to know what they will do, just reading them tells me that. And it seems strange they are always High Co-pay drugs.


28 posted on 06/22/2012 6:05:45 AM PDT by GailA (IF U don't/won't keep your promises to the Military, U won't keep them to the public)
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To: muggs

Celebrex caused your stroke? That’s terrible; I hope they gave you compensation for your problems. Damn.
I was on Celebrex and thought it was one of the best drugs ever. Then it attacked my stomach lining and gave me a bleeding ulcer so they stopped prescribing it to me.

Unfortunately, they gave me Bextra instead which provided no benefit along with a new round of ulcers and then they took me off that. Wasn’t soon after that the dire side effects of Bextra were known.

Celebrex, Bextra, Vioxx are all in the same family with Celebrex left standing as the only one still on the market.
My doctor told me my problem is that they didn’t give me something for my stomach so it could handle Celebrex. He said that something like protonix is good to take with Celebrex but since I’d already had two ulcers, they wouldn’t prescribe the combo to me.

They were happy to prescribe any narcotic they had though, Oxycontin, the faster acting oxycodone and hydrocodone which when taken over a long period of time turns you into a junkie which is far worse that Celebrex does but the worse was the fentanyl patches.


29 posted on 06/22/2012 9:28:54 AM PDT by Lx (Do you like it, do you like it. Scott? I call it Mr. and Mrs. Tennerman chili.)
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