How can a state opt out of federal law? Seems like we fought a war about that..
Actually we fought a couple of wars about this. The Civil War dealt with the injustice of slavery and the federal government forced the result. But before that we had the Revolutionary War and created a Constitution limiting government. Nullification would be more like the Revolutionary War, justified by things like natural law, the individual’s unalienable rights, and the Constitution confirmed by the 9th and 10th Amendments.