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Diabetes drug makes brain cells grow (neural stem cells)
EurekAlert! ^ | 5-Jul-2012 | NA

Posted on 07/12/2012 5:27:30 PM PDT by neverdem

Public release date: 5-Jul-2012

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press

Diabetes drug makes brain cells grow

The discovery is an important step toward therapies that aim to repair the brain not by introducing new stem cells but rather by spurring those that are already present into action, says the study's lead author Freda Miller of the University of Toronto-affiliated Hospital for Sick Children. The fact that it's a drug that is so widely used and so safe makes the news all that much better.

Earlier work by Miller's team highlighted a pathway known as aPKC-CBP for its essential role in telling neural stem cells where and when to differentiate into mature neurons. As it happened, others had found before them that the same pathway is important for the metabolic effects of the drug metformin, but in liver cells.

"We put two and two together," Miller says. If metformin activates the CBP pathway in the liver, they thought, maybe it could also do that in neural stem cells of the brain to encourage brain repair.

The new evidence lends support to that promising idea in both mouse brains and human cells. Mice taking metformin not only showed an increase in the birth of new neurons, but they were also better able to learn the location of a hidden platform in a standard maze test of spatial learning.

While it remains to be seen whether the very popular diabetes drug might already be serving as a brain booster for those who are now taking it, there are already some early hints that it may have cognitive benefits for people with Alzheimer's disease. It had been thought those improvements were the result of better diabetes control, Miller says, but it now appears that metformin may improve Alzheimer's symptoms by enhancing brain repair.

Miller says they now hope to test whether metformin might help repair the brains of those who have suffered brain injury due to trauma or radiation therapies for cancer.

###

Wang et al.: "Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation."


TOPICS: Culture/Society; Foreign Affairs; News/Current Events; Testing
KEYWORDS: diabetes; glucophage; metformin; neuralstemcells; neurogenesis
Hat tip to muawiyah! I'd like to see the U.S. Armed Forces and the VA get cracking on this for traumatic brain and spinal cord injuries.

Metformin Activates an Atypical PKC-CBP Pathway to Promote Neurogenesis and Enhance Spatial Memory Formation

EurekAlert was king enough to enclose the title within quotation marks. All I had to do was copy it incuding those quotation marks. After a Yahoo search, voila!

1 posted on 07/12/2012 5:27:52 PM PDT by neverdem
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To: neverdem; Shimmer1

I should be pretty smart by now...


2 posted on 07/12/2012 5:30:12 PM PDT by null and void (Day 1268 of our ObamaVacation from reality - Heroes aren't made Frank, they're cornered...)
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To: neverdem

The critical question here is does this drug require EXISTING brain cells for augmentation? If not, and new brain cells can be spontaneously created as well, THEN, there is promise for liberals and statists.


3 posted on 07/12/2012 5:32:58 PM PDT by C210N ("ask not what the candidate can do for you, ask what you can do for the candidate" (Breitbart, 2012))
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To: austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; texas booster; ...
FReepmail me if you want on or off the diabetes and/or stem cell ping lists.
4 posted on 07/12/2012 5:34:30 PM PDT by neverdem (Xin loi minh oi)
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To: neverdem

I wonder if berberine might work the same way?


5 posted on 07/12/2012 5:37:49 PM PDT by upsdriver
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To: null and void

I take metformin in the morning and insulin at night.

I am going to be a genius, a genius I tell you, a genius!!

In all seriousness, this ‘sounds’ like great news for folks with brain injuries.


6 posted on 07/12/2012 5:47:42 PM PDT by Gator113 (***YOU GAVE it to Obama. I would have voted for NEWT.~Just livin' life, my way~)
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To: surroundedbyblue; pieceofthepuzzle

Ping


7 posted on 07/12/2012 5:59:53 PM PDT by neverdem (Xin loi minh oi)
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To: null and void

me too...and it’s free by me


8 posted on 07/12/2012 6:07:07 PM PDT by Doogle ((USAF.68-73..8th TFW Ubon Thailand..never store a threat you should have eliminated))
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To: neverdem

List of drugs that contain or are related to metformin.

http://www.rxlist.com/script/main/srchcont_rxlist.asp?src=metformin&cat=rx-desc


9 posted on 07/12/2012 6:16:59 PM PDT by yefragetuwrabrumuy
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To: neverdem

I’ve been taking 2000mg of Metformin per day for three years. Funny, I don’t feel smarter :)


10 posted on 07/12/2012 6:28:18 PM PDT by upchuck (FACEBOOK... Share pointless stuff with friends you don't know. Beg for intrusion into your life.)
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To: neverdem

I’ve been taking 3000MG a day for years, and I’m still dumb as a brick. Maybe it requires a few working brain cells to start with.


11 posted on 07/12/2012 6:30:41 PM PDT by pallis
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To: upchuck

Metformin has also been shown to reduce cancer rates. Some doctors recommend all adults take it to reduce cancer prospects.


12 posted on 07/12/2012 6:33:33 PM PDT by aimhigh
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To: neverdem
I'll read the paper, but the bottom line here is that metformin has been around since 1922 and was FDA approved for diabetes in the early 1990s. There are a ton of people on it, but as far as I know no evidence that people with diabetes on metformin have an increase in brain function. That said, the results look interesting and I hope there is something here. Thanks for the alert.
13 posted on 07/12/2012 6:34:37 PM PDT by pieceofthepuzzle
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To: neverdem

I got smarter, but had to hang out on the john all the time. Now I’m dumb again, but not stuck in that little room.


14 posted on 07/12/2012 6:36:52 PM PDT by gitmo ( If your theology doesn't become your biography it's useless.)
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To: neverdem

I’m taking maximum dosages and still have CRS (Can’t remember Sh*t).


15 posted on 07/12/2012 6:46:37 PM PDT by Dogbert41 ("...The people of Jerusalem are strong, because the Lord Almighty is their God" Zech. 12:5)
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To: gitmo

FYI, my husband had the same problem with metformin. When he finally got up the nerve to mention it to his dr. he found out there is an extended release form that doesn’t give him any trouble. Alleluia.


16 posted on 07/12/2012 6:49:04 PM PDT by Wiser now (Socialism does not eliminate poverty, it guarantees it.)
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To: aimhigh

Thanks for that info. I also take 5000iu of Vit D3 daily. Been doing that for seven years. It is anecdotal, but I haven’t been sick one day since starting the Vit D.


17 posted on 07/12/2012 6:54:28 PM PDT by upchuck (FACEBOOK... Share pointless stuff with friends you don't know. Beg for intrusion into your life.)
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To: yefragetuwrabrumuy

Thanks for the link!


18 posted on 07/12/2012 7:06:12 PM PDT by neverdem (Xin loi minh oi)
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To: Marie Antoinette

ping


19 posted on 07/12/2012 7:25:26 PM PDT by Big Giant Head
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To: neverdem

Thanks you. Interesting information.


20 posted on 07/12/2012 7:30:40 PM PDT by Duchess47 ("One day I will leave this world and dream myself to Reality" Crazy Horse)
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To: neverdem

Thank you. Interesting information.


21 posted on 07/12/2012 7:31:24 PM PDT by Duchess47 ("One day I will leave this world and dream myself to Reality" Crazy Horse)
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To: neverdem

I should take it for my spinal cord injury


22 posted on 07/12/2012 7:45:49 PM PDT by STD ([You must help] people in theĀ…feel so frustrated, so defeated, so lost, so futureless)
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To: neverdem
So that's why I'm reading 1400 words a minute now!
23 posted on 07/12/2012 9:34:53 PM PDT by Lady Jag (If you can't make them see the light, let them feel the heat. - Reagan)
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To: STD; airborne
I should take it for my spinal cord injury

I was sorry to read that. Scar tissue formation interferes with regrowing neurons there. The normal inflammatory response is bad news with any transection of the spinal cord. I believe that they have tried giving high dose corticcosteroids for acute injuries, but no luck.

24 posted on 07/12/2012 9:40:34 PM PDT by neverdem (Xin loi minh oi)
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To: null and void

Nully knows everything. Just ask me, I’ll tell you.


25 posted on 07/13/2012 3:03:01 AM PDT by Shimmer1 (government health officials seem to have the haunting fear that someone, somewhere, may be happy.)
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To: upchuck

The best way to feel smarter is to talk to a liberal. You come away from the conversation feeling like a genius.


26 posted on 07/13/2012 5:25:17 AM PDT by Russ (Repeal the 17th amendment)
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To: neverdem

bttt


27 posted on 07/13/2012 11:20:34 AM PDT by aberaussie
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To: neverdem

bflr


28 posted on 07/13/2012 12:18:40 PM PDT by antisocial (Texas SCV - Deo Vindice)
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To: Gator113

Type 2 here. The “business” one. The first meds I took really messed with my short term memory. I had to do water tests where I had to put 5 drops into the test tube. I’d forget in the middle of that simple test, how many drops I’d put in! Changed to Metformin, and my memory was not being effected anymore, but I don’t think I’ve recovered from the first meds. I changed my diet, and got down to “borderline,” and take no meds now.


29 posted on 07/13/2012 3:38:36 PM PDT by Dr. Bogus Pachysandra ( Ya can't pick up a turd by the clean end!)
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To: neverdem

anybody now anything about artificial pancreas treatment?


30 posted on 07/15/2012 9:57:21 AM PDT by morphing libertarian
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To: neverdem

BTTT


31 posted on 07/16/2012 5:06:05 AM PDT by Dr. Scarpetta
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