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Stress signal causes abnormal implantation location and pregnancy loss
Journal of Biological Chemistry ^ | 2011-2-25 | Journal of Biological Chemistry

Posted on 08/21/2012 11:10:29 AM PDT by Maelstorm

Pregnancy loss is a common and painful condition for gestational women, accounting for 25-40% of total pregnancy, having become a serious social-medical issue worldwide. Animal studies and clinical investigations have indicated that the cause of many mid-term miscarriage/abnormal pregnancy has been seeded very early during the onset of embryo implantation. Epidemiological study also showed that maternal stress at early pregnancy is strongly associated with various complications during ongoing gestation. However, whether and how the process of embryo implantation is affected by environmental factors such as stress induced sympathetic activation remained elusive. Considering the mammalian uterus is an organ with extensive sympathetic innervations, the research group leads by Prof. Enkui Duan at Institute of Zoology, Chinese Academy of Sciences hypothesized that it is possible that around the time of embryo implantation, stress-induced sympathetic activation may directly affect embryo-maternal interactions through adrenergic receptors, therefore affecting the quality of ongoing pregnancy.

By using mouse model, the research group found an unexpected, transient effect of β2-Adrenoceptor (β2-AR) activation (Day4 postcoitus) in disrupting embryo spacing at implantation (without changing implantation timing), leading to substantially increased mid-term pregnancy loss. In vitro and in vivo studies demonstrated that the transient β2-AR activation abolished normal preimplantation uterine contractility, without adversely affecting blastocyst quality. The contractility inhibition is mediated by activation of cAMP-PKA pathway and accompanied with specific downregulation of lpa3, a gene previously found to be critical for uterine contraction and embryo spacing. These results recapitulated the concept that “on-site” intrauterine embryo location mediated by concerted uterine contraction is crucial for successful ongoing pregnancy.

(Excerpt) Read more at rpb.ioz.ac.cn ...


TOPICS: Culture/Society; News/Current Events; US: Missouri
KEYWORDS: akin; miscarriage; pregnancy; stress
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Finally found what I was looking for. Strange how in a rush to condemn one often gives up the potential to learn something.
1 posted on 08/21/2012 11:10:36 AM PDT by Maelstorm
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To: Maelstorm

Well, well, well..........


2 posted on 08/21/2012 11:16:58 AM PDT by Red Badger (Anyone who thinks wisdom comes with age is either too young or too stupid to know the difference....)
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To: Maelstorm

The ole rush to judgement again!


3 posted on 08/21/2012 11:19:26 AM PDT by b4its2late (A Liberal is a person who will give away everything he doesn't own.)
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To: Maelstorm

Nope, sorry, this can’t be right. Four out of five experts at FreeRepublic agree this is bull$hit. There is no magic button that turns off the pregnancy machinery during rape.

Besides, this was probably written by a man, who knows nothing about women’s bodies.


4 posted on 08/21/2012 11:20:27 AM PDT by LearsFool ("Thou shouldst not have been old, till thou hadst been wise.")
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To: Maelstorm

I would bet that millions of government dollars have been spent on studies having something to do with preventing stress from destroying a pregnancy - probably funding supported by Democraats. For what it’s worth.


5 posted on 08/21/2012 11:26:24 AM PDT by cvq3842 (Thanks for all responses, and flames, in advance.)
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To: Maelstorm

We’re in a society where science and facts don’t matter; all that matters is what the media can get people to believe.

I think that’s the definition of post-modernism, and it is one of the last steps before the death of a society.

Sad.


6 posted on 08/21/2012 11:27:55 AM PDT by butterdezillion
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To: Maelstorm

This is a horrific insult to any women who has ever been impregnated by a rapist. Basically, you’re saying, just as that nitwit Akin said: if a women reports that she was raped and is then impregnated, it wasn’t rape after all? She enjoyed it? SHe asked for it?

Please explain.


7 posted on 08/21/2012 11:28:26 AM PDT by EnquiringMind
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To: Maelstorm
Thank you!

I've been on the net for the last three hours trying to find something to bolster my comment of yesterday that wondered whether a raped woman secreted adrenaline or some other antigen that would make her womb inhospitable to unwanted sperm.

Freepers tore into me for my stupidity!

8 posted on 08/21/2012 11:32:40 AM PDT by Noob1999 (Loose Lips, Sink Ships)
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To: Noob1999

This should be very simple to determine. I’m sure there are statistics on pregnancy rates of rape victims. This can be compared to the risk of pregnancy for a one-time sexual encounter.


9 posted on 08/21/2012 11:45:10 AM PDT by Hillary'sMoralVoid
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To: EnquiringMind

Are you being serious or just doing a darn good immitation of an FR bed wetter?


10 posted on 08/21/2012 11:45:11 AM PDT by MEGoody (You shall know the truth, and the truth shall make you free.)
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To: EnquiringMind

This is a horrific insult to any women who has ever been impregnated by a rapist. That would be a false perception.

Usually it is dems that are insulted by truth. We do know that rape and incest pregnancies, are extremely rare.


11 posted on 08/21/2012 11:47:32 AM PDT by wita
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To: Noob1999

“Freepers tore into me for my stupidity!”

That should be a major insult to “real” freepers.


12 posted on 08/21/2012 11:51:31 AM PDT by wita
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To: Noob1999

Then you must be really P.Oed at Akin. First he spoke your truth then he apologized and called it a lie.


13 posted on 08/21/2012 12:04:04 PM PDT by DManA
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To: Maelstorm

If they are saying that women so traumatized and shaken are at a higher risk of miscarriage, then yes, that’s likely true.

That’s a long way from what Akin said.


14 posted on 08/21/2012 12:13:42 PM PDT by Buckeye McFrog
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To: Maelstorm

Nice find. There is a difference between reduce the chance and eliminate all possibility, and so there is a difference between rare and non-existant. The first problem is that most people aren’t up for subtle distinctions, and the second is that poorly phrased it is a loosing issue. That said, if one is interested in truth and life, the facts are worth thinking about.


15 posted on 08/21/2012 12:15:48 PM PDT by Hieronymus ( (It is terrible to contemplate how few politicians are hanged. --G.K. Chesterton))
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To: EnquiringMind

This issue involves statistics and probability. I think you didn't understand the point of the article.

16 posted on 08/21/2012 12:32:17 PM PDT by fishtank (The denial of original sin is the root of liberalism.)
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To: Maelstorm

A ChiCom study. Really?


17 posted on 08/21/2012 12:35:28 PM PDT by jboot (This isn't your father's America. Stay safe and keep your powder dry.)
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To: jboot

Bookmark


18 posted on 08/21/2012 12:38:36 PM PDT by publius911 (Formerly Publius 6961, formerly jennsdad)
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To: Maelstorm

Thanks, Maelstrom. I’m still of the opinion that factors such as this are not enough to make pregnancy resulting from rape “rare,” but it’s useful to see the research and the possible mechanisms at work.

I’m not going to criticize this for being an experiment on mice, because one of the articles I posted, that acute stress may induce ovulation, largely relied on animal models as well.

Human reproduction differs from the reproduction of other mammals and I don’t think animal experiments can settle the quesstion.


19 posted on 08/21/2012 12:53:02 PM PDT by heartwood
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To: EnquiringMind
It would seem that I’m jumping into the middle of an argument here so forgive me if I’m not aware of what may have been discussed previously. I think one of the issues at hand with this article is the phrase “substantially increased mid-term pregnancy loss”. Statistically this could be just a few percentage points and it also refers to mid-term. Unfortunately rape victims may still implant and show pregnancy within the first few weeks. I’m sure most such pregnancies are aborted before midterm and this may skew human data on the survivability of the embryo.

In plain English this journal appears to be saying that stress reduces the chance of a full term pregnancy. Personal antidotal evidence suggests this may be true since my girl friend lost 4 pregnancies with her ex-husband and she was very stressed during that marriage.

As far at this notion that if you were raped you shouldn’t get pregnant - I don’t know where that started but the idea is reprehensible (IMO).
20 posted on 08/21/2012 12:53:47 PM PDT by chaos_5
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To: Maelstorm
Yeah, too bad the GOP shot one of their own out of the saddle in cold blood before the facts came out. Democraps always circle the wagons. Republicrats circle the firing squad.

AKIN WAS RIGHT.

21 posted on 08/21/2012 1:01:07 PM PDT by backwoods-engineer (My game is disruption. I will use lethal force --my vote-- in self-defense against Obama.)
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To: wita

“We” do? Who are “WE”?

You people HAVE to be kidding.


22 posted on 08/21/2012 1:08:45 PM PDT by EnquiringMind
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To: wita

“We” do? Who are “WE”?

You people HAVE to be kidding.


23 posted on 08/21/2012 1:08:49 PM PDT by EnquiringMind
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To: heartwood

Extreme stress can also delay ovulation, which may prevent pregnancy following the traumatic event, but allow pregnancy to happen unexpectedly somewhat later in the cycle from another procreative act. (My wife and I learned this after the fact from our fourth child).


24 posted on 08/21/2012 1:10:10 PM PDT by Hieronymus ( (It is terrible to contemplate how few politicians are hanged. --G.K. Chesterton))
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To: backwoods-engineer

maybe not...
http://www.freerepublic.com/focus/f-news/2921209/posts


25 posted on 08/21/2012 1:10:14 PM PDT by chaos_5
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To: LearsFool

Uh, the PROBABILITY of pregnancy during a rape may be somewhat lower, but it’s nowhere near ZERO. anyone who thinks pregnancy after rape doesn’t happen is an idiot.


26 posted on 08/21/2012 1:41:42 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: LearsFool

Uh, the PROBABILITY of pregnancy during a rape may be somewhat lower, but it’s nowhere near ZERO. anyone who thinks pregnancy after rape doesn’t happen is an idiot.


27 posted on 08/21/2012 1:41:42 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: Kozak

What’s your point?


28 posted on 08/21/2012 1:47:07 PM PDT by LearsFool ("Thou shouldst not have been old, till thou hadst been wise.")
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To: Maelstorm

I am not a mouse.


29 posted on 08/21/2012 1:47:26 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: Kozak

I’ve read several pro-life articles about rape victims who decided to keep the resulting offspring. The above article doesn’t establish a 100% scenario of protection for the victim. Only idiots are pushing this theme.


30 posted on 08/21/2012 1:48:22 PM PDT by aimhigh
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To: backwoods-engineer
Maybe in your mind he WAS right but now he must be wrong because he recanted what he said and apologized for it.
31 posted on 08/21/2012 1:50:39 PM PDT by DManA
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To: EnquiringMind
This is a horrific insult to any women who has ever been impregnated by a rapist. Basically, you’re saying, just as that nitwit Akin said: if a women reports that she was raped and is then impregnated, it wasn’t rape after all? She enjoyed it? SHe asked for it?

you really need to pay attention to what was said. If a woman experiences an actual rape, there are times when her body will react differently and she will suffer a spontaneous abortion (miscarriage) or she will not be impregnated at all.

nowhere does anyone say that she cannot become pregnant, we all know that she can. That having been said, do we then execute the child for the crime of its father???

sheesh

32 posted on 08/21/2012 2:05:38 PM PDT by terycarl
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To: terycarl

A woman, or a Chinese mouse?


33 posted on 08/21/2012 2:17:03 PM PDT by EnquiringMind
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To: Maelstorm
For many reasons, this post is the height of freeper scientific and statistical ignorance.

It reminds me why there are only a very few Freepers I trust with science. Also one of the reasons the Global Warming threads here are mostly a joke.

Its not even worth getting into it here, I give up.

34 posted on 08/21/2012 2:22:25 PM PDT by Paradox (I want Obama defeated. Period.)
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To: Maelstorm

That isn’t “prevention of pregnancy”. It’s “messes up the pregnancy and causes a spontaneous abortion”.

If the argument is that we don’t need to allow abortion for rape victims, because if they are stressed out and sad enough long enough, they will self-abort, then I guess you have us there.

Oddly, there are many living people who were conceived in rape, where I guess their mothers didn’t stress enough.


35 posted on 08/21/2012 2:24:42 PM PDT by CharlesWayneCT
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To: EnquiringMind

We, refers to folks familiar with the research and statistics on completed rapes and resulting pregnancies, which you may not be interested in.


36 posted on 08/21/2012 2:30:29 PM PDT by wita
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To: Hillary'sMoralVoid

There are many statistics. Of course, you can’t find an easy apples-to-apples comparison. For example, overall, you are slightly more likely to end up pregnant from a consumated rape than from a consensual consumated sexual encounter.

But that is in part because protection is more often used by those in consensual sexual relationships. And because the statistics are years old, and don’t take into account the recent practice of using post-rape abortion morning-after pills to stop pregnancy resulting from rape.

It is clear that stress has some impact on the ability to get pregnant. While some here were laughing about that yesterday, most of us who opposed Akin’s comments weren’t making that mistake. The problem is that stress does not “greatly reduce” pregnancy. Even Wilke, cited here yesterday in support of the concept, chose to believe it had a 50% reductive effect. Large, but not orders of magnitude.

Unfortunately, that is somewhat mitigated by the virtual certainty that the rapist isn’t using condoms, and the good chance that the woman wasn’t prepared and didn’t therefore have her own protection deployed. And of course, the man wasn’t trying to choose times when the woman was less likely to get pregnant.

Of course, the fact that we are even TALKING about this is the reason many of us were upset at Akin’s comments. It was an absurd choice of argument, it muddied the waters for the legitimate pro-life argument, and it distracted from the real issues. It allowed the liberals to smear all republicans with the false charge that we don’t think women can get pregnant from rape.

It also fed right into the “war on women” meme, with his use of “legitimate rape”. It reminded people of Ryan’s vote for the “forcible rape” bill — which actually can be explained, but is again a distraction and hurts us with women.

If we are going to argue about abortion, let’s keep it simple — abortion is wrong because it kills human beings, and we don’t kill innocent people to fix criminal actions.


37 posted on 08/21/2012 2:35:19 PM PDT by CharlesWayneCT
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To: Kozak

anyone who thinks pregnancy after rape doesn’t happen is an idiot.

Just who has been suggesting such? The suggestion that it happens frequently is another idiotic suggestion, and I know you aren’t suggesting such.


38 posted on 08/21/2012 2:35:30 PM PDT by wita
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To: Paradox

Its not even worth getting into it here, I give up.

...and I contend that based on your home page it is incumbent on you to never give up, having come from the dark side into the light. There are those listening and watching for wisdom if it proves to be.


39 posted on 08/21/2012 2:42:59 PM PDT by wita
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To: LearsFool

The point is Akin is an idiot. Raped women do get pregnant.


40 posted on 08/21/2012 3:11:22 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: wita

Research of Chinese mice? LOLOL!!!


41 posted on 08/21/2012 3:14:19 PM PDT by EnquiringMind
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To: wita

It is infrequent, but does happen. For a politician to stick his foot so far down his throat his toes are coming out the other side has to be an idiot.
If he doesn’t understand that basic concept he has no business running for Senate. He should back out and let someone who has a chance of winning run.


42 posted on 08/21/2012 3:22:07 PM PDT by Kozak (The means of defence against foreign danger, have been always the instruments of tyranny at home JM)
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To: Kozak

That’s two points. Will you be arguing them separately?

(You can probably skip the second one, since nobody seems to disagree with it.)


43 posted on 08/21/2012 3:35:36 PM PDT by LearsFool ("Thou shouldst not have been old, till thou hadst been wise.")
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To: EnquiringMind

Just keep on laughing, that isn’t the research I was referring to, as I stated, you probably aren’t interested.


44 posted on 08/21/2012 4:16:36 PM PDT by wita
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To: EnquiringMind

Some women, just some, have this happen. Not all, has nothing to do with any circumstances except stress and how SOME women react.

This is what I got from the article.


45 posted on 08/21/2012 4:17:15 PM PDT by jch10 (America needs some R and R!)
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To: b4its2late

A. It was in mice
B. The stress signal was 4 days after the sex act, not at the time of the sex act

Women have been conceiving and carrying pregnancies is stressful situations since the human race was brought forth. My BS meter is pegged on Akins remarks. He was wrong.


46 posted on 08/21/2012 4:22:30 PM PDT by Mom MD (T he country needs Obamacare like Nancy Pelosi needs a Halloween mask)
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To: wita
that isn’t the research I was referring to, as I stated, you probably aren’t interested

Oh, but I am! Do tell.

47 posted on 08/21/2012 4:22:30 PM PDT by EnquiringMind
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To: Maelstorm

http://www.rebeccakiessling.com/index.html

http://www.lifenews.com/2012/08/20/woman-conceived-in-rape-responds-to-akin-abortion-controversy/

http://www.christianliferesources.com/article/rape-pregnancies-are-rare-461


48 posted on 08/21/2012 4:23:05 PM PDT by Para-Ord.45
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To: Maelstorm
Ok, then would people please explain to me the existence of the women in the article in this thread?

Or the existence of the friends of other FReepers who have been cited in many of the threads the last two days of being the product of rape?

Or the fact that a measurable portion of the former East German population are the products of rape of German women by Soviet soldiers?

Hell, I recall reading not too long ago that modern-day DNA testing allows for mapping of various invasions over the millenia ... because of all the progeny left by (and the descendents of) soldiers engaging in looting/pillaging/raping.
49 posted on 08/21/2012 4:25:36 PM PDT by tanknetter
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To: Kozak

You are likely correct on the placement of the foot, however,
I doubt he really believes intercourse does not equal pregnancy when the conditions are right. I believe he was suggesting the possibility was perhaps reduced based on some studies done on animals. Not to suggest any relationship, but stressed cows are less likely to conceive or maintain a pregnancy. I know, I know.

With the time line for other candidates to get in the race, the problem is now the GOP’s to deal with.


50 posted on 08/21/2012 4:27:58 PM PDT by wita
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