Skip to comments.Stress signal causes abnormal implantation location and pregnancy loss
Posted on 08/21/2012 11:10:29 AM PDT by Maelstorm
Pregnancy loss is a common and painful condition for gestational women, accounting for 25-40% of total pregnancy, having become a serious social-medical issue worldwide. Animal studies and clinical investigations have indicated that the cause of many mid-term miscarriage/abnormal pregnancy has been seeded very early during the onset of embryo implantation. Epidemiological study also showed that maternal stress at early pregnancy is strongly associated with various complications during ongoing gestation. However, whether and how the process of embryo implantation is affected by environmental factors such as stress induced sympathetic activation remained elusive. Considering the mammalian uterus is an organ with extensive sympathetic innervations, the research group leads by Prof. Enkui Duan at Institute of Zoology, Chinese Academy of Sciences hypothesized that it is possible that around the time of embryo implantation, stress-induced sympathetic activation may directly affect embryo-maternal interactions through adrenergic receptors, therefore affecting the quality of ongoing pregnancy.
By using mouse model, the research group found an unexpected, transient effect of β2-Adrenoceptor (β2-AR) activation (Day4 postcoitus) in disrupting embryo spacing at implantation (without changing implantation timing), leading to substantially increased mid-term pregnancy loss. In vitro and in vivo studies demonstrated that the transient β2-AR activation abolished normal preimplantation uterine contractility, without adversely affecting blastocyst quality. The contractility inhibition is mediated by activation of cAMP-PKA pathway and accompanied with specific downregulation of lpa3, a gene previously found to be critical for uterine contraction and embryo spacing. These results recapitulated the concept that on-site intrauterine embryo location mediated by concerted uterine contraction is crucial for successful ongoing pregnancy.
(Excerpt) Read more at rpb.ioz.ac.cn ...
Well, well, well..........
The ole rush to judgement again!
Nope, sorry, this can’t be right. Four out of five experts at FreeRepublic agree this is bull$hit. There is no magic button that turns off the pregnancy machinery during rape.
Besides, this was probably written by a man, who knows nothing about women’s bodies.
I would bet that millions of government dollars have been spent on studies having something to do with preventing stress from destroying a pregnancy - probably funding supported by Democraats. For what it’s worth.
We’re in a society where science and facts don’t matter; all that matters is what the media can get people to believe.
I think that’s the definition of post-modernism, and it is one of the last steps before the death of a society.
This is a horrific insult to any women who has ever been impregnated by a rapist. Basically, you’re saying, just as that nitwit Akin said: if a women reports that she was raped and is then impregnated, it wasn’t rape after all? She enjoyed it? SHe asked for it?
I've been on the net for the last three hours trying to find something to bolster my comment of yesterday that wondered whether a raped woman secreted adrenaline or some other antigen that would make her womb inhospitable to unwanted sperm.
Freepers tore into me for my stupidity!
This should be very simple to determine. I’m sure there are statistics on pregnancy rates of rape victims. This can be compared to the risk of pregnancy for a one-time sexual encounter.
Are you being serious or just doing a darn good immitation of an FR bed wetter?
This is a horrific insult to any women who has ever been impregnated by a rapist. That would be a false perception.
Usually it is dems that are insulted by truth. We do know that rape and incest pregnancies, are extremely rare.
“Freepers tore into me for my stupidity!”
That should be a major insult to “real” freepers.
Then you must be really P.Oed at Akin. First he spoke your truth then he apologized and called it a lie.
If they are saying that women so traumatized and shaken are at a higher risk of miscarriage, then yes, that’s likely true.
That’s a long way from what Akin said.
Nice find. There is a difference between reduce the chance and eliminate all possibility, and so there is a difference between rare and non-existant. The first problem is that most people aren’t up for subtle distinctions, and the second is that poorly phrased it is a loosing issue. That said, if one is interested in truth and life, the facts are worth thinking about.
This issue involves statistics and probability. I think you didn't understand the point of the article.
A ChiCom study. Really?
Thanks, Maelstrom. I’m still of the opinion that factors such as this are not enough to make pregnancy resulting from rape “rare,” but it’s useful to see the research and the possible mechanisms at work.
I’m not going to criticize this for being an experiment on mice, because one of the articles I posted, that acute stress may induce ovulation, largely relied on animal models as well.
Human reproduction differs from the reproduction of other mammals and I don’t think animal experiments can settle the quesstion.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.