I agree with you about genetics. I knew a woman who was in her 70's, she was thin, and exercised and the only meat she ate was boneless, skinless chicken breasts. She had high cholesterol numbers, and last I talked to her, her doctor had put her on two cholesterol medicines because just one wasn't helping with her cholesterol numbers. There I sat, overweight, my exercise routine was walking around the mall a couple of times, and I am a Atkins type of person. My bp and cholesterol are both just fine.
A really good book that explains why low-carb is not only the best way to maintain proper weight, but also the most heart healthy diet: