I would go with at least three guns, not just one. I like a pump action shotgun for close-in home defense; I’m partial to the Remington 887, which I consider slightly more rugged than their also excellent 870. Ammo - buckshot, almost any brand, tactical loads for all but the last shell loaded, and that’s a magnum as a reminder that you need to reload if you lose count. I like an AR-15 for longer distances and for venison (.22 LR conversion kits are cheap and allow you to practice with the same weapon, barrel, and sights for much less money), and I’m partial to Armalite if money is no object, but in my opinion it’s hard to make a bad choice with an AR. Frangible ammunition “to avoid overpenetration of walls”, not for shoot to kill purposes. Finally, it would be nice to have something lighter than the long guns, and I prefer a 1911 semi-automatic. My choice there is .45 cal, but the best caliber depends on your size, age, and home situation. As for 1911 makers, you get what you pay for for the most part, and budget drives that choice. Again, frangible ammo for self-defense.
Question: any thoughts on optics/lasers/etc for those weapons? I am a bit of a traditionalist and have stuck with iron sights my whole life - and I’m very good with those. I am ready to consider other options.
“I am a bit of a traditionalist and have stuck with iron sights my whole life”
Iron sights have one big advantage...never need batteries.