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Scientists Discover Children’s Cells Living in Mothers’ Brains
Scientific American ^ | December 4, 2012 | Robert Martone

Posted on 12/07/2012 1:50:17 PM PST by NYer

The link between a mother and child is profound, and new research suggests a physical connection even deeper than anyone thought. The profound psychological and physical bonds shared by the mother and her child begin during gestation when the mother is everything for the developing fetus, supplying warmth and sustenance, while her heartbeat provides a soothing constant rhythm.

The physical connection between mother and fetus is provided by the placenta, an organ, built of cells from both the mother and fetus, which serves as a conduit for the exchange of nutrients, gasses, and wastes. Cells may migrate through the placenta between the mother and the fetus, taking up residence in many organs of the body including the lung, thyroid muscle, liver, heart, kidney and skin. These may have a broad range of impacts, from tissue repair and cancer prevention to sparking immune disorders.

It is remarkable that it is so common for cells from one individual to integrate into the tissues of another distinct person. We are accustomed to thinking of ourselves as singular autonomous individuals, and these foreign cells seem to belie that notion, and suggest that most people carry remnants of other individuals. As remarkable as this may be, stunning results from a new study show that cells from other individuals are also found in the brain. In this study, male cells were found in the brains of women and had been living there, in some cases, for several decades. What impact they may have had is now only a guess, but this study revealed that these cells were less common in the brains of women who had Alzheimer’s disease, suggesting they may be related to the health of the brain.

We all consider our bodies to be our own unique being, so the notion that we may harbor cells from other people in our bodies seems strange. Even stranger is the thought that, although we certainly consider our actions and decisions as originating in the activity of our own individual brains, cells from other individuals are living and functioning in that complex structure. However, the mixing of cells from genetically distinct individuals is not at all uncommon. This condition is called chimerism after the fire-breathing Chimera from Greek mythology, a creature that was part serpent part lion and part goat. Naturally occurring chimeras are far less ominous though, and include such creatures as the slime mold and corals.

 Microchimerism is the persistent presence of a few genetically distinct cells in an organism. This was first noticed in humans many years ago when cells containing the male “Y” chromosome were found circulating in the blood of women after pregnancy. Since these cells are genetically male, they could not have been the women’s own, but most likely came from their babies during gestation.

In this new study, scientists observed that microchimeric cells are not only found circulating in the blood, they are also embedded in the brain. They examined the brains of deceased women for the presence of cells containing the male “Y” chromosome. They found such cells in more than 60 percent of the brains and in multiple brain regions. Since Alzheimer’s disease is more common in women who have had multiple pregnancies, they suspected that the number of fetal cells would be greater in women with AD compared to those who had no evidence for neurological disease. The results were precisely the opposite: there were fewer fetal-derived cells in women with Alzheimer’s. The reasons are unclear.

Microchimerism most commonly results from the exchange of cells across the placenta during pregnancy, however there is also evidence that cells may be transferred from mother to infant through nursing. In addition to exchange between mother and fetus, there may be exchange of cells between twins in utero, and there is also the possibility that cells from an older sibling residing in the mother may find their way back across the placenta to a younger sibling during the latter’s gestation. Women may have microchimeric cells both from their mother as well as from their own pregnancies, and there is even evidence for competition between cells from grandmother and infant within the mother.

What it is that fetal microchimeric cells do in the mother’s body is unclear, although there are some intriguing possibilities. For example, fetal microchimeric cells are similar to stem cells in that they are able to become a variety of different tissues and may aid in tissue repair. One research group investigating this possibility followed the activity of fetal microchimeric cells in a mother rat after the maternal heart was injured: they discovered that the fetal cells migrated to the maternal heart and differentiated into heart cells helping to repair the damage. In animal studies, microchimeric cells were found in maternal brains where they became nerve cells, suggesting they might be functionally integrated in the brain. It is possible that the same may true of such cells in the human brain.

These microchimeric cells may also influence the immune system. A fetal microchimeric cell from a pregnancy is recognized by the mother’s immune system partly as belonging to the mother, since the fetus is genetically half identical to the mother, but partly foreign, due to the father’s genetic contribution. This may “prime” the immune system to be alert for cells that are similar to the self, but with some genetic differences. Cancer cells which arise due to genetic mutations are just such cells, and there are studies which suggest that microchimeric cells may stimulate the immune system to stem the growth of tumors. Many more microchimeric cells are found in the blood of healthy women compared to those with breast cancer, for example, suggesting that microchimeric cells can somehow prevent tumor formation. In other circumstances, the immune system turns against the self, causing significant damage. Microchimerism is more common in patients suffering from Multiple Sclerosis than in their healthy siblings, suggesting chimeric cells may have a detrimental role in this disease, perhaps by setting off an autoimmune attack.

This is a burgeoning new field of inquiry with tremendous potential for novel findings as well as for practical applications. But it is also a reminder of our interconnectedness.


TOPICS: Business/Economy; Culture/Society; Extended News
KEYWORDS: alzheimers; brain; cancer; cells; children; chimerism; godsgravesglyphs; helixmakemineadouble; immunesystem; life; microchimerism; motherhood; mothers; pregnancy; stemcells
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ABOUT THE AUTHOR(S)

Robert Martone is the Neuroscience therapeutic area lead for The Covance Biomarker Center of Excellence located in Greenfield, Indiana. He is a research scientist with extensive experience in drug discovery for neurodegenerative diseases.

1 posted on 12/07/2012 1:50:25 PM PST by NYer
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To: netmilsmom; thefrankbaum; Tax-chick; GregB; saradippity; Berlin_Freeper; Litany; SumProVita; ...

Fascinating!


2 posted on 12/07/2012 1:51:30 PM PST by NYer ("Before I formed you in the womb I knew you." --Jeremiah 1:5)
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To: SunkenCiv

Of possible interest to your list.


3 posted on 12/07/2012 1:55:17 PM PST by NYer ("Before I formed you in the womb I knew you." --Jeremiah 1:5)
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To: NYer
This explains some of Mom's supernatural skill at detecting ANYTHING I might have thought about doing wrong. ;)

/johnny

4 posted on 12/07/2012 1:57:39 PM PST by JRandomFreeper (Gone Galt)
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To: NYer

Goes a long way toward explaining why my ex became such a child-like dimbulb after having children...


5 posted on 12/07/2012 1:58:04 PM PST by Cyber Liberty (Obama considers the Third World morally superior to the United States.)
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To: NYer

If there are any of my brain cells in Mom’s cranium, she isn’t using them. She’s a Democrat.


6 posted on 12/07/2012 1:58:25 PM PST by Billthedrill
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To: JRandomFreeper

My mom always new where I hid my tobacco and would call me on it in front of my friends. (super secret in my sock btw) :^)


7 posted on 12/07/2012 1:59:52 PM PST by eyedigress ((zOld storm chaser from the west)/?)
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To: NYer

Very fascinating.

Now, if the scientific evidence accumulates that this does, without question, occur at the fetal development stage.....

Let the arguments begin!

Of course, the party of sCiEnCe will declare abortion on demand not murder, they will demand gorEbAlwarMing eLeVentY!!!111!! taxes and proceed to worship a 1/2 black man as the second coming.

To me, more evidence that God does, in fact, exist.


8 posted on 12/07/2012 1:59:58 PM PST by 98ZJ USMC
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To: NYer

So what happens when mother aborts 3 or 4 of her babies?


9 posted on 12/07/2012 2:00:07 PM PST by donna (Pray for revival.)
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To: NYer

Brings a whole new dimension into the veneration of the Blessed Virgin Mary Mother of God, doesn’t it :)


10 posted on 12/07/2012 2:01:44 PM PST by Bayard
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To: lonevoice

Okay, this is really interesting.


11 posted on 12/07/2012 2:02:43 PM PST by Pride in the USA
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To: donna

They stay on her mind.


12 posted on 12/07/2012 2:03:50 PM PST by eartrumpet
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To: NYer; Tax-chick
I realize that this is biology and not theology, and yet the truth about Jesus is both biology and theology. And what vistas this opens up on the relationship between Jesus and Mary!

We were discussing this last night at our RCIA lesson on Mary (I'm a member of the RCIA teaching team) --- we were talking about Mary's strong empathy with Jesus, to the extent that even when He was an infant, Simeon said that a sword would pierce Mary's heart and soul (like the sword that pierced Jesus) --- it was all there, on the level of empathy, from the beginning.

("And Mary kept these things, pondering them in her heart.")

I'm not too much into theo-bio-speculation. But it's something to think of, if a child's cells are microchimerizing the mother, and the Child is the Son of God.

13 posted on 12/07/2012 2:11:11 PM PST by Mrs. Don-o ("God bless the child that's got his own." Billie Holiday / Arthur Herzog Jr)
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To: Bayard

Yes! Absolutely right.


14 posted on 12/07/2012 2:12:54 PM PST by NYer ("Before I formed you in the womb I knew you." --Jeremiah 1:5)
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To: Mrs. Don-o; Bayard
I'm not too much into theo-bio-speculation. But it's something to think of, if a child's cells are microchimerizing the mother, and the Child is the Son of God.

See Bayard's comment at post #10.

15 posted on 12/07/2012 2:14:57 PM PST by NYer ("Before I formed you in the womb I knew you." --Jeremiah 1:5)
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To: Bayard

Great minds.... :o)


16 posted on 12/07/2012 2:19:25 PM PST by Mrs. Don-o ("God bless the child that's got his own." Billie Holiday / Arthur Herzog Jr)
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To: NYer

Finally. I can’t be blamed for my misdeeds.


17 posted on 12/07/2012 2:20:54 PM PST by Jyotishi (Seeking the truth, a fact at a time.)
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To: Mrs. Don-o; NYer; Salvation

I think it was Salvation who mentioned that there are cells remaining in a woman’s uterus from each child she bears. Iirc, it was in the context of the Assumption, because part of the body of the incarnate Son of God was still carried by His Mother on earth until she was assumed into Heaven.


18 posted on 12/07/2012 2:21:23 PM PST by Tax-chick (Get another cat.)
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To: NYer

Isn’t evolution wonderful? </sarc


19 posted on 12/07/2012 2:24:43 PM PST by SkyDancer (Live your life in such a way that the Westboro church will want to picket your funeral.)
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To: NYer

Raises the interesting possibility of undoing an abortion.


20 posted on 12/07/2012 2:26:26 PM PST by Vince Ferrer
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To: eartrumpet
(So what happens when mother aborts 3 or 4 of her babies?)

They stay on her mind.

That, my friend is, in my opinion, much more profound than your sparse words would belie.

Well said - and true.

21 posted on 12/07/2012 2:28:13 PM PST by Quality_Not_Quantity (Liars use facts when the truth doesn't suit their purposes.)
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To: NYer
Fascinating!

****************************

At the very least. :)

22 posted on 12/07/2012 2:30:15 PM PST by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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To: donna

“So what happens when mother aborts 3 or 4 of her babies?”

Perhaps that is why many (most?) mom’s can’t get over the fact that they had an abortion.


23 posted on 12/07/2012 2:34:23 PM PST by 21twelve (So I [God] gave them over to their stubborn hearts to follow their own devices. Psalm 81:12)
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To: All

I wonder if anyone has researched the frequency of Alzheimer’s in women who have had only daughters vs. women who have had only sons.

Or am I misunderstanding the article?


24 posted on 12/07/2012 2:40:14 PM PST by jacquej
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To: Jyotishi

> Finally. I can’t be blamed for my misdeeds.

Nor take credit for the good ones, I hasten to add.


25 posted on 12/07/2012 2:44:39 PM PST by Jyotishi (Seeking the truth, a fact at a time.)
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To: Jyotishi

time to run for President


26 posted on 12/07/2012 2:48:09 PM PST by MNDude
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To: NYer

Interesting. Thanks for posting.


27 posted on 12/07/2012 2:53:36 PM PST by convocation
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To: NYer

Did the researches identify the source of these cells by ringtone?


28 posted on 12/07/2012 2:53:36 PM PST by cookcounty ("For the first time in my adult life I am not proud of my country.")
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To: Vince Ferrer

Mmmm... not exactly, since if you got one of those microchimera cells to develop into a xygote, the xygote would be the identical twin (or clone) of the aborted child, not the aborted child himself.


29 posted on 12/07/2012 2:54:45 PM PST by Mrs. Don-o
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To: Mrs. Don-o

There are many Theological implications, such as man and wife becoming one and the sins of the father being visited on the sons unto 7 generations and many more that I haven’t incorporated into the new paradigm yet.
While this info is new, it may be just a tip of the iceberg as to how much integration there really is and what it truly means or doesn’t mean.


30 posted on 12/07/2012 2:56:49 PM PST by ResponseAbility (The truth of liberalism is the stupid can feel smart, the lazy entitled, and the immoral unashamed)
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To: 98ZJ USMC

“...if the scientific evidence accumulates that this does, without question, occur at the fetal development stage.....”

Yes.


31 posted on 12/07/2012 3:01:56 PM PST by Beowulf9
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To: NYer
You Were Always On My Mind
32 posted on 12/07/2012 3:03:44 PM PST by blam
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To: Mrs. Don-o

Just think of the fact that Jesus was to be descended from the line of David. There may be reasons we have no clue about yet as to why it was part of the plan.


33 posted on 12/07/2012 3:13:31 PM PST by ResponseAbility (The truth of liberalism is the stupid can feel smart, the lazy entitled, and the immoral unashamed)
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To: blam

Science now knows what parents have know for years: insanity is hereditary: you get it from your kids.


34 posted on 12/07/2012 3:16:15 PM PST by garyb
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To: MNDude

Hilarious!


35 posted on 12/07/2012 3:20:20 PM PST by Jyotishi (Seeking the truth, a fact at a time.)
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To: JRandomFreeper

“.. supernatural skill at detecting anything I might have thought about doing wrong”..

Yes, it does. Plus, didn’t you know Moms have eyes in the backs of their heads. Yesiree, we do. We know who did what even when we aren’t looking in that direction.


36 posted on 12/07/2012 3:21:59 PM PST by momtothree
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To: ntnychik; dixiechick2000; NYer

Amazing and thought provoking information.


37 posted on 12/07/2012 3:55:58 PM PST by potlatch (~One Heart Less In My Life~)
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To: NYer

This isn’t news to many fathers. My kids lived rent free in their Mother’s brain for decades...


38 posted on 12/07/2012 3:57:54 PM PST by DoughtyOne (Hurricane Sandy..., a week later and over 60 million Americans still didn't have power.)
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To: NYer

Yup. I’ve known this for a long time. I have two natural born sons. They don’t have my cells except in the form of genetic information but I’ve known for a long time of this connection with them.


39 posted on 12/07/2012 4:27:38 PM PST by Mercat (Adventures make you late for dinner. Bilbo Baggins)
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To: NYer

Mom said I was on her mind.


40 posted on 12/07/2012 4:33:34 PM PST by count-your-change (You don't have to be brilliant, not being stupid is enough.)
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To: ResponseAbility

We are more a part of each other -— the whole chain of our ancestors flowing in from the past, and the whole chain of descendants flowing from us into the future -— more part of each other than we think we are.


41 posted on 12/07/2012 5:38:30 PM PST by Mrs. Don-o (C'est la vie.)
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To: ResponseAbility
And that very odd, mysterious line from Genesis 3:15, where God is talking to the serpent Satan: "I will put enmity between you and the woman, between your seed and hers: that one will crush your head, and you shall lie in wait for his heel."

The idea of a woman's "seed" was hardly to be thought of in a Bronze Age culture, when a female was seen as a "field" in which a seed was planted, but not as contributing "seed" of her own. In point of fact, I believe the first undisputed observation of the human ovum was made in the 1820's. But way back in Genesis, you had this reference to the "seed" of a woman. The person is to come by the woman, and by her alone, without the concurrence of man. So this is not addressed to Adam and Eve, but to Eve alone; and then, so many generations later, Jesus Christ was born of a virgin. The genetic beginning of the savior who would "crush the serpent's head."

Mysterious. Interesting.

42 posted on 12/07/2012 6:01:04 PM PST by Mrs. Don-o (C'est la vie.)
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To: NYer

This may explain why Mothers are so close to, and protective of their children.


43 posted on 12/07/2012 6:01:47 PM PST by sissyjane (Obama lied, our HEROES died!)
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To: Mrs. Don-o
"We are more a part of each other -— the whole chain of our ancestors flowing in from the past, and the whole chain of descendants flowing from us into the future -— more part of each other than we think we are."

I agree...

And, I feel that way about all living things.

44 posted on 12/07/2012 6:02:21 PM PST by blam
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To: NYer

read later


45 posted on 12/07/2012 6:04:10 PM PST by lupie
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To: NYer
OMG. for 20+ years, my dear sister-in-law has said, "the placenta is made up of the mother's brain cells....which is why the more kids she has, the more kids she has...hahaha"

little did she know...she was smarter than us all.

46 posted on 12/07/2012 6:35:20 PM PST by ZinGirl (kids in college....can't afford a tagline right now)
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To: NYer

This explains so much! lol


47 posted on 12/07/2012 6:48:15 PM PST by TigersEye (Who is John Galt?)
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To: ResponseAbility

If I’m reading it correctly it was Joseph who was descended from the line of David. As this was patrilineal, why would any of that matter to a virgin birth?


48 posted on 12/07/2012 7:12:58 PM PST by onedoug
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To: NYer

As I suspected, the “color commentary” on this thread is the Stuff of Legend.

Fasten your seatbelts.


49 posted on 12/07/2012 7:21:57 PM PST by ROTB (Live holy, forgive all & pray in Jesus' name. Trust He is willing & able & eager to ANSWER BIG!)
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To: NYer

The tie between mother/parent and child is complex and profound and is not to be tampered with.


50 posted on 12/07/2012 7:32:07 PM PST by cyn (Benghazi.)
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