Vin Suprynowicz, in his book “Send in the Waco Killers”, noted that before Prohibition was passed, everyone understood and agreed that the prohibition of alcohol would be unconstitutional without a Constitutionall Amendment.
But, after the FDR years of alphabet agencies and regulations, even as Prohibition was being repealed, there was no Constitutional issues raised when Congress passed the drug prohibition laws.
Very true. I love the look on my friends’ faces when I asked them why booze needed a constitutional amendment, but drugs didn’t. Thanks in part to Scalia, interstate commerce trumps all now.