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Infectious disease: TB's revenge
Nature News ^ | 02 January 2013 | Leigh Phillips

Posted on 01/04/2013 12:28:01 AM PST by neverdem

The world is starting to win the war against tuberculosis, but drug-resistant forms pose a new threat.

If there was any doubt that tuberculosis (TB) was fighting back, it was dispelled in 2005, at the Church of Scotland Hospital in the village of Tugela Ferry, South Africa. Doctors at the hospital, in a rough, remote corner of KwaZulu-Natal province, were hardened to people dying from gunshots and AIDS. But even they were puzzled and frightened when patients with HIV who were responding well to antiretroviral drugs began dying — rapidly — from TB.

With ordinary TB, patients start to feel better after a few weeks or months on a selection of four mainstay antibiotics. But of the 542 people with TB at the hospital in 2005 and early 2006, 221 (41%) had a multi-drug-resistant (MDR) form, against which these therapies are mostly powerless. Worse, 53 of them did not even respond to the few antibiotics that form a second line of defence. Eventually, doctors had nothing left to try: all but one of the 53 died, half of them within 16 days of diagnosis. It was the first major outbreak of what became known as extensively drug-resistant (XDR) TB — and a wake-up call to the world that TB had taken a turn for the worse1.

In the early 1980s, TB cases had dropped to such low rates that Western policy-makers frequently talked of eradication of the disease. Then came...

--snip--

Worldwide, TB is now the leading cause of death among people with HIV.

The resurgence of ordinary TB set the stage for drug-resistant forms. Resistance develops when people do not stick to their drug regimens — which typically last six months for drug-sensitive TB and 20 months for MDR-TB — allowing naturally occurring resistant mutants to grow and evolve...

(Excerpt) Read more at nature.com ...


TOPICS: Culture/Society; News/Current Events; Testing
KEYWORDS: mdrtb; tb; tuberculosis; xdrtb

1 posted on 01/04/2013 12:28:12 AM PST by neverdem
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To: neverdem

tb, malaria, cholera still kill millions, but we spend all the research money on combating aids


2 posted on 01/04/2013 1:08:13 AM PST by Cronos (**Marriage is about commitment, cohabitation is about convenience.**)
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To: neverdem

It’s difficult to get most people in the 3rd world in particular to stick to a drug regimen of even a few weeks. The compliance rate for 6 or 20 months’ therapy is probably in the low single digits. Not only that, a lot of the supply will end up being resold to people who don’t need it, don’t understand it, are not given proper instructions on how to use it and also will not comply even if they did.

Therefore it’s impossible to prevent these new mutant strains from developing while these “last resort” antibiotics are distributed to patients who are misusing them.


3 posted on 01/04/2013 1:28:59 AM PST by expat1000
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To: neverdem

“Worldwide, TB is now the leading cause of death among people with HIV.”

Unfortunately, there are lots of drug resistant bugs winging their way into the US every day. Not to worry, tight immigration policies, strict border controls and incredibly cutting-edge ObamaCare technologies will slay the beast. Save us, Ms Sebelius.


4 posted on 01/04/2013 3:30:04 AM PST by Artie (We are surrounded by MORONS)
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To: expat1000

Looks like the Democrats are about to lose a major part of their constituency.


5 posted on 01/04/2013 3:57:56 AM PST by Enterprise ("Those who can make you believe absurdities can make you commit atrocities." Voltaire)
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To: neverdem

Modern science can eradicate as many diseases as it wants.

The muslims will find some way to bring them back, spread them and improve them.

Like polio.


6 posted on 01/04/2013 4:13:36 AM PST by Hardraade (http://junipersec.wordpress.com (Vendetta))
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To: Enterprise
Turns out that may happen sooner than anyone can expect.

Obama's crowd have gutted the units in NIH that do epidemiological studies ~ and reduced their funding to almost nothing. This coming plague is going to be upon us before anyone knows it ~ and the death rate among the Obama voters should be mindboggling.

I think that could explain the Democrat loss of 4 to 6 million voters between 2008 and 2012 (accounting for both dead former voters and new registrants).

Several of their own voter registration protection projects reported that they found whole neighborhoods devoid of voters they knew had actually been there in prior years ~ which while praiseworthy does not address the obvious questions ~ were those merely fake voters used for vote fraud, or did they move away, or were they real voters who died at a very high rate.

The Democrat party's Axelrods probably want to know because this stuff is a gamechanger.

Remember, the acolytes of the Antichrist are not smarter than average, nor can they see any further into the future ~ maybe less actually, but they are a brutal bunch who will stoop to any level to murder the innocent. We already know who they are ~ they support the Free Fire School Zones law, abortion on demand, open borders, ....... ~ your basic Democrat party programs. They imagine plague is on their side.

7 posted on 01/04/2013 5:29:40 AM PST by muawiyah
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To: Enterprise

>>Looks like the Democrats are about to lose a major part of their constituency.

There’s billions more available.


8 posted on 01/04/2013 5:44:29 AM PST by expat1000
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To: neverdem
"drug companies have lacked market incentives"

It's all the fault of those evil drug companies. They should forgo the profit motive in order to improve society.........then we could ALL live like the north Koreans.

9 posted on 01/04/2013 6:15:29 AM PST by norwaypinesavage (Galileo: In science, the authority of a thousand is not worth the humble reasoning of one individual)
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To: muawiyah

They imagine plague is on their side.

***
Very insightful. Chilling.


10 posted on 01/04/2013 6:19:12 AM PST by Bigg Red (Sorry, Mr. Franklin, I guess we couldn't keep it.)
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To: neverdem

We can thank gays and Africans for this scourge.
Both are like walking petri dishes mixing up pathogens to spread to the wider world.

A quarantine of these careless populations would have nipped this in the bud, but this was not politically correct, so we must all pay the price. They should have at least made it, “Miss your meds once, and you are in quarantine.”


11 posted on 01/04/2013 6:32:34 AM PST by Bon mots (Abu Ghraib: 47 Times on the front page of the NY Times | Benghazi: 2 Times)
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To: neverdem

We can thank gays, junkies and Africans for this scourge.
Both are like walking petri dishes mixing up pathogens to spread to the wider world.

A quarantine of these careless populations would have nipped this in the bud, but this was not politically correct, so we must all pay the price. They should have at least made it, “Miss your meds once, and you are in quarantine.”


12 posted on 01/04/2013 6:32:57 AM PST by Bon mots (Abu Ghraib: 47 Times on the front page of the NY Times | Benghazi: 2 Times)
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To: Bon mots

There are Libertarians among us who advocate on behalf of the junkies ~ and so do George Sorros and his friends ~ they aid in the spread of deadly diseases.


13 posted on 01/04/2013 6:59:58 AM PST by muawiyah
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To: neverdem

But even they were puzzled and frightened when patients with HIV who were responding well to antiretroviral drugs began dying — rapidly — from TB.
____________________________
People with pooor immune function are dying of TB. No kidding. What is new?


14 posted on 01/04/2013 7:08:10 AM PST by Chickensoup (Leftist Totalitarian Fascism coming to a country like yours.)
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To: muawiyah
Here's some possible scenarios of what could happen after TB on steroids (TBOS) arrives:

Gays in general will be wiped out. Gay Hollywood and entertainment will be gone. Gay politicians will be gone. (There is one politician in particular that I suspect has HIV. If he has it, I hope he gets TBOS.) Gay marriage will be forgotten.

The elderly will be wiped out.

The ghettos will be essentially depopulated. The poor will otherwise suffer huge percentages of deaths because they live in congested areas and many of the poor already have bad health.

Children will be hit hard because they tend to be congregated in places like Government schools.

There will be so much overall loss of life that birth control pills and condoms will cease to be free for single females. Society will direct a volcanic wrath on them and tell them to find a man, marry him, stay at home, and produce many children. Single women will no longer be welcome in the work place, and society will be yelling at men and telling them to go back to work. Any single woman who has an abortion will be looked at like she has leprosy. Feminism will be gone.

15 posted on 01/04/2013 8:52:34 AM PST by Enterprise ("Those who can make you believe absurdities can make you commit atrocities." Voltaire)
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To: Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
FReepmail me if you want on or off my combined microbiology/immunology ping list.
16 posted on 01/04/2013 9:51:58 AM PST by neverdem ( Xin loi min oi)
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To: Enterprise
There may already be a TB epidemic of serious proportions but we might not realize it.

The death rates differ by ethnicity ~ some groups are more readily wiped out than are others. I've never read much about age group differentials ~ although there is one for pneumonia ~ which might be what you are thinking about.

I suspect it will have an imprint rather like that of hanta virus. The young adults will die first simply because more of them are out socializing ~ at work, at play, and wherever. The very young, and the elderly will be hit less often. You'll end up with a civilization bracketed by the old and the young ~ and only those societies heavily mechanized, automated, computerized, roboticized and using the latest in modern work methods will survive as civilizations. The rest will collapse into the dustheaps of history ~ much as they did back in the mid 1400s to 1600s in the Americas.

17 posted on 01/04/2013 11:02:26 AM PST by muawiyah
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To: neverdem

Is there a vaccine for TB?


18 posted on 01/04/2013 12:07:18 PM PST by tbw2
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To: muawiyah

We’ve also stopped federal development of new antibiotics, putting more work into AIDS vaccines than antibiotics. And pharmaceutical companies, to my knowledge, haven’t announced many new antibiotics.


19 posted on 01/04/2013 12:09:07 PM PST by tbw2
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To: Enterprise

We would also see a scream to close the border. So many TB cases are illegal immigrants coming across the border to work, and they can spread the disease to the already ill in hospitals, the elderly in nursing homes and very young in childcare facilities. The parents of infected young children and parents will be less likely to use such facilities in the future, or to permit the hiring of illegal immigrants in the future.


20 posted on 01/04/2013 12:13:55 PM PST by tbw2
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To: tbw2

“Is there a vaccine for TB?”

From my understanding, no. In recent years, my kids have been tested for TB almost every time they have a well check. Our pediatrician explained that since so many “immigrants” come to the U.S. and are in our area (MD)... the rise of TB has been seen. Not only can this be passed at schools but fast food restaurants, malls, pretty much everywhere. I asked, “why can’t we vaccinate them?” Answer: no vaccine for TB (at least this is what I’e been told)


21 posted on 01/04/2013 12:34:47 PM PST by momtothree
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To: tbw2
Is there a vaccine for TB?

Yes, but they need a better one. Go back to the source. Here's an excerpt:

"The Bacillus Calmette–Guérin (BCG) vaccine, first used in the 1920s, helped. But BCG is now effective mainly against childhood TB, which is not infectious, rather than the adult form."

22 posted on 01/04/2013 4:07:10 PM PST by neverdem ( Xin loi min oi)
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To: momtothree; tbw2
Check comment# 22. There's a half@ss one called BCG. It can give a false positive with the tuberculin skin test.
23 posted on 01/04/2013 4:27:52 PM PST by neverdem ( Xin loi min oi)
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To: muawiyah
FReepers will survive because we are glued to our computer screens 24x7.

Cheers!

24 posted on 01/05/2013 6:06:03 AM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: tbw2
The only way any sort of scream like that would go up is if Obama's daughters caught TB and spread it around school ~ and their numerous world wide trips may well have already infected them.

Then there are the foreign guests their putative baby-daddy brings into their home ~ definitely a potential TB vector there ~ particularly the state dinners!,

I doubt that crowd is worried about it yet

25 posted on 01/05/2013 6:10:57 AM PST by muawiyah
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To: grey_whiskers

Self imposed physical isolation is the only way to get through these Great Plagues ~


26 posted on 01/05/2013 6:12:49 AM PST by muawiyah
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To: muawiyah
The State Dinners?

Now that would be effin' IRONIC.

NO Cheers, unfortunately.

27 posted on 01/05/2013 6:13:34 AM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: neverdem

http://www.cdc.gov/tb/publications/factsheets/statistics/TBTrends.htmThis is the latest CDC annual report ~ and it shows TB declining in the US, but it still exists. Notice that Washington DC is one of the hotspots ~ as expected. Note, this has nothing to do with resistant forms, particularly a hypothetical extra fast resistant form that could sweep through non-TB resistant populations like ‘ ....... ‘ through a goose! Pay close attention to current rates per census group. Freepers will survive!


28 posted on 01/05/2013 6:21:12 AM PST by muawiyah
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To: grey_whiskers
State Dinners as a serious vector ~ way back in the days when there were no antibiotics effective against much of anything, state dinners were much less frequent, and, when held, were smaller with a far more select group invited.

That was a consequence of the use of standard quarantine rules developed over the previous thousand years or so.

Many of us here are old enough to remember the way polio was first treated ~ before Salk ~ the public swimming pools were closed. Chillun' did not attend large youth camps. If one kid in your neighborhood or social circle got infected you let others know, and reduced your hectic social schedule.

Democrats like to hold JFK out as some sort of cultural exemplar ~ aside from his notorious sexual misadventures, he had had all his WWII shots, and his Senator shots, and whatever other shots ~ as had most of that crowd, and they were no longer spreading TB and several other diseases.

He still took a risk when he depended on the 'protective umbrella' theory that was just then aborning in the minds of epidemiologists ~ to wit; you don't need to make everyone immune ~ if you simply have 3/4 of them immune, you break up the ability of the virus or bacteria to find hosts suitable for further procreation. Or, alternatively, that if you have innoculated 3/4 of them, the others will catch protective viral types from them!

When drug resistant viruses or bacteria with further immunity to vaccines come along, it's like someone threw fresh meat to a lion!

The day some one of the top echelon in the Obama regime comes down with drug resistant TB, you might never see any more state dinners ~ and attendance at foreign symposia might become restricted ~ fur sure, only a handful of organizationally isolated Obamistas ~ like Susan Rice ~ will be going around the UN.

I'd watch for those reactions ~ we may actually have seen some.

29 posted on 01/05/2013 6:40:30 AM PST by muawiyah
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To: grey_whiskers; neverdem
I guess everyone thinks Hillary was in the hospital recovering from a blood clot and not a bout with TB.

Then there's Chavez ~ fur shur he's had his guts removed but it's a respiratory problem that's got him down and he was just up and speaking the other day. Now that old reprobate is lying on his back intubated and respirated, and unable to absorb oxygem.

Is that symptomatic of cancer or is that TB, or possibly drug resistant pneumonia?

30 posted on 01/05/2013 6:45:33 AM PST by muawiyah
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To: muawiyah

To a democrat death is no impediment to further voting


31 posted on 01/05/2013 6:49:17 AM PST by Mom MD (Liberals are slinkies. Good for nothing but they make you smile when you push them down stairs.)
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To: neverdem

I consider live garlic to be one of the four food groups, so hopefully the nasties hiss and scream and poof into a puff of smoke as soon as they try to get in my bloodstream...there’s so much garlic juice in my blood all my corpuscles have long bushy mustaches ;^)


32 posted on 01/05/2013 7:15:40 AM PST by fattigermaster
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To: muawiyah; grey_whiskers
Is that symptomatic of cancer or is that TB, or possibly drug resistant pneumonia?

Can't say. Since he had cancer, his immune system wasn't up to snuff. Thanks for the link, muawiyah. Happy New Year!

33 posted on 01/05/2013 12:19:12 PM PST by neverdem ( Xin loi min oi)
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