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Pfizer disputes suit claiming Zoloft doesn't work
Niami Herald ^ | 01.31.13 | LINDA A. JOHNSON

Posted on 01/31/2013 6:11:39 PM PST by neverdem

AP BUSINESS WRITER

TRENTON, N.J. -- The maker of Zoloft is being sued in an unusual case alleging the popular antidepressant has no more benefit than a dummy pill and that patients who took it should be reimbursed for their costs.

--snip--

He said Pfizer produced two studies showing Zoloft worked better than placebo - the FDA's requirement for approval - but most Zoloft studies showed its effect was the same as a placebo.

Dr. Michael Thase, who heads the mood and anxiety disorders program at the University of Pennsylvania's medical school, said research by others using the same unpublished studies concluded antidepressants have "a modest effect over placebo," on average about 15 percentage points...


TOPICS: Business/Economy; Culture/Society; News/Current Events
KEYWORDS: antidepressant; fda; pfizer; pfizerlawsuit; sertraline; ssri; zoloft
Other folks are suing over alleged birth defects attributed to Zoloft.
1 posted on 01/31/2013 6:11:52 PM PST by neverdem
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To: neverdem

Destroying a drug that has actually helped people with real problems will f**k up those peoples’ lives and the lives of those around them. What are you going to do for these people that need this drug? Tell them to do without, like elder care under Obamacare? Is there any medication that doesn’t have risks?


2 posted on 01/31/2013 6:29:57 PM PST by AlmaKing
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To: neverdem
This is a SSRI. According to Wikipedia on Zoloft (generically sertraline):

"Sertraline shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects; however, it does not cause weight gain, and its effects on both cognition and vigilance are relatively mild. In pregnant women taking sertraline, the drug was present in significant concentrations in fetal blood, and was also associated with a higher rate of various birth defects. Similarly to other antidepressants, the use of sertraline for depression may be associated with a higher rate of suicidality."

You know, little things like that ... makes one feel so much happier ...

3 posted on 01/31/2013 6:32:03 PM PST by imardmd1
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To: neverdem

I guess if it was on 60 minutes it must be true. /s


4 posted on 01/31/2013 6:57:25 PM PST by willk
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To: neverdem

It is about time to start class action lawsuits against these parasite lawyers. Anyone whose loved one dies because they stop taking the drug after hearing about this crap ought to sue the hell out of this attorney and his client.


5 posted on 01/31/2013 7:05:46 PM PST by willk
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To: El Gato; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; tiamat; PGalt; Dianna; ...
Details of Adam Lanza’s mental state not to be revealed until June

'Super' enzyme protects against dangers of oxygen

Scientists trick iron-eating bacteria into breathing electrons instead

First-Ever Guidelines for Children With Diabetes (type 2!)

FReepmail me if you want on or off my health and science ping list.

6 posted on 01/31/2013 7:10:39 PM PST by neverdem ( Xin loi min oi)
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To: imardmd1
I'm not so sure what's so special about that little passage in Wikipedia...Is this the first time you've ever looked up Zoloft or other SSRIs? Look up practically any other class of drug and you'll see an even longer list of side effects and contraindications and often cautions against use during pregnancy.

Anyway, you'll notice that your passage lists insomnia as one of the side effects. Might surprise you to know I have been plagued with insomnia ever since stopping Zoloft, and was troubled beforehand. This isn't particularly unusual and it is difficult to find another drug to treat the insomnia without introducing other side effects/hazards. This isn't particularly unusual and I've seen other patients discuss this beneficial side effect.

The increased incidence of suicidal ideation/attempts is due to energizing of the depressed patient. The patient who can't get out of bed finds it difficult to commit suicide. The patient who has not yet experienced the primary therapeutic effect but is experiencing increased energy is at increased risk. This is one of those unfortunate consequences of drug intervention for depression.

7 posted on 01/31/2013 7:16:32 PM PST by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: steve86

LOL duplicated a sentence preamble. Must be tripping out with SSRI discontinuation syndrome.


8 posted on 01/31/2013 7:18:45 PM PST by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: AlmaKing
I suggest you read “Prozac, Panacea or Pandora” and or “Your Drug May be Your Problem”

I think when you see the harm and loss of life that these horrific drugs cause you may have a different view.

9 posted on 01/31/2013 7:34:55 PM PST by Captain7seas (Fire Jane Lubchenco)
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To: Captain7seas

“I suggest you read “Prozac, Panacea or Pandora” and or “Your Drug May be Your Problem”

I think when you see the harm and loss of life that these horrific drugs cause you may have a different view.”

Let me guess, written by someone from the Church of Scientology or a holistic medicine quack?


10 posted on 01/31/2013 8:22:26 PM PST by willk
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To: steve86

If a person is being treated for depression with a drug, and if they’re at the point where they are energized by the drug, but not yet at therapeutic levels, maybe they should be kept in the hospital during that time. Or just keep them under close observation when they first start taking the drug.


11 posted on 01/31/2013 8:37:14 PM PST by virgil
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To: steve86
I'm not so sure what's so special about that little passage in Wikipedia.

Just identifying it for those who are aware of the role of SSRIs in PTSD suicides, rage-induced rampages, etc. -- which effects are usually not spelled out; as well as the tendency toward hard-to-shed dependencies.

The increased incidence of suicidal ideation/attempts is due to energizing of the depressed patient.

This is an interesting insight on depressive response. About 40 years ago, I was in such a state, but essentially pulled out of it with the comfort of family/friends, a brief vacation from daily responsibilities, and the passage of time. Seeing what has happened to others with SSRIs and benzodiazepines, I am eternally grateful that my experiences were at a time when the population was not yet soaked in psychotropic drug dependency.

12 posted on 01/31/2013 10:46:52 PM PST by imardmd1
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To: willk
Let me guess, written by someone from the Church of Scientology or a holistic medicine quack?

Let me guess, someone who depends on drugs because coping is just so damn hard to do?

If I was born in the "modern" world, no telling how drugged up I would be and how much of me would still exist. I had combinations of OCD/ADDS and even some hints of what may be Tourettes as a child growing up in the '50s. Kindergarten teachers told my folks to test me because my drawings resembled something Picasso might render, I was very anal about how things were organized, and had "nervous tics" which caused me to make constant squeaking noises in my throat, screw up my face, and even blurt out things I could believe I was saying as it occurred.

In today's world I'd be diagnosed and "treated" until I truly was handicapped. In the "crueler more backwards times" of the '50s, I learned to be self aware and to get a handle on what was going on. Rebelled in high school, but passed all the NY Regents and graduated a year early, spent 24 years in the military, got a college degree with a 4.0 GPA and have gotten along in life rather well. Never would have happened in a world where they "design" a drug, determine that it "appears to affect" certain "maladies" and then market it by saying it helps with never before diagnosed "maladies" and urges people to "ask your doctor if this drug with 87 known bad side effects and possibly 1 or 2 "benefits" is right for you"...

13 posted on 02/01/2013 5:43:11 AM PST by trebb (Allies no longer trust us. Enemies no longer fear us.)
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To: trebb
Some people can’t do what you did, but many more could.

I grew up in rural Nebraska, in an area that was very resistant to the drug pushers. In grade school, I was a wiggle worm and couldn’t sit still.

My kindergarten teacher would have me run laps around the school to “burn it off”. No matter what the weather. It worked. Today I would have been drugged to the gills and labeled a “special” case.

14 posted on 02/01/2013 6:22:44 AM PST by redgolum ("God is dead" -- Nietzsche. "Nietzsche is dead" -- God.)
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To: neverdem

Oh, it works, all right. Don’t take it for 3 days, and it gives you the “brain zaps” (bursts of heightened anxiety with a physiological tingling effect in the head). Someone very close to me experiences it.


15 posted on 02/01/2013 8:46:43 AM PST by backwoods-engineer ("Remember: Evil exists because good men don't kill the gov officials committing it." -- K. Hoffmann)
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To: redgolum

I agree - I was fortunate to be able to get my idiosyncrasies under control. I know too many folks who have children that the schools insisted needed to be medicated and where the schools turned out to be wrong. They use the medication of kids as a convenience and believe that they also have a broader and more nefarious plan as far as control goes.


16 posted on 02/01/2013 8:54:21 AM PST by trebb (Allies no longer trust us. Enemies no longer fear us.)
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To: steve86
This is one of those unfortunate consequences of drug intervention for depression

You are correct. It has been observed and noted since at least the early seventies that when an antidepressant begins to work, suicide risk goes up. This is true of all antidepressants, not Zoloft in particular. Conscientious practitioners know this and monitor their patients accordingly.

17 posted on 02/01/2013 10:57:36 AM PST by hinckley buzzard
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To: neverdem; AlmaKing; imardmd1; willk; steve86; Captain7seas; virgil; trebb; redgolum; ...

Every FReeper should listen to this podcast on Big Pharma.

http://www.econtalk.org/archives/2012/11/angell_on_big_p.html

Angell’s left of center, but Roberts holds her to reason. Her biggest revelation is the capture of the FDA by Big Pharma.

They no longer have to show all their study results and research universities sponsored by them cannot even see the results. That’s not good at all.

We need more transparency and an end to regulatory capture.

The other issue she brings up is that the government pays the same for a drug prescription as they do for talk-therapy. Talk-therapy is as effective as the drug, yet a psychiatrist can write 4-5 scrips in the time it takes to have a single session. Government has messed up all the incentives in the system.


18 posted on 02/01/2013 1:24:18 PM PST by 1010RD (First, Do No Harm)
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To: 1010RD

Yhanks — very thoughtful of you to send this on!


19 posted on 02/01/2013 4:21:39 PM PST by imardmd1 (Let the redeemed of The LORD say so, whom He hath redeemed from the hand of the enemy. (Ps. 107:2))
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