If the opposition does not play the “what does it matter” clip 24/7, they deserve to loose.
In what formerly was America Hildebeast's irritating, near-hysterical, and insensitive outburst ("What difference...does it make...")would be an fatal impediment to her being elected POTUS. But in the America of 2016 the typical Demorat voter will only be concerned with "what's in it for me" if I vote for Clinton. So something which, by conventional wisdom, should be a potent weapon, is rendered irrelevant. Just my opinion.